Cdk5: a multifaceted kinase in neurodegenerative diseases
Abstract
Since the identification of cyclin-dependent kinase-5 (Cdk5) as a tau kinase and member of the Cdk family almost 20 years ago, deregulation of Cdk5 activity has been linked to an array of neurodegenerative diseases. As knowledge on the etiopathological mechanisms of these diseases evolved through the years, Cdk5 has also been implicated in additional cellular events that are affected under these pathological conditions. From the role of Cdk5 in the regulation of synaptic functions to its involvement in autophagy deregulation, significant insights have been obtained regarding the role of Cdk5 as a key regulator of neurodegeneration. Here, we summarize recent findings on the involvement of Cdk5 in the pathophysiological mechanisms underlying various neurodegenerative diseases.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
CDK5 is essential for synaptic plasticity and neurodegeneration.
“For instance, CDK5 is essential for synaptic plasticity and neurodegeneration [51].”
From Association of SPI1 haplotypes with altered SPI1 gene expression and Alzheimer’s disease risk (2022) · cites this paper as [51]
Cites
Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
Cuervo, A. M., Stefanis, L., Fredenburg, R., Lansbury, P. T., & Sulzer, D. (2004) · Science · doi:10.1126/science.1101738 · Cited by 2,024 · see citing works
Zempel, H., Thies, E., Mandelkow, E., & Mandelkow, E.-M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2357-10.2010 · Cited by 686 · see citing works
Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression
Colledge, M., Snyder, E. M., Crozier, R. A., Soderling, J. A., Jin, Y., Langeberg, L. K., Lu, H., Bear, M. F., & Scott, J. D. (2003) · Neuron · doi:10.1016/s0896-6273(03)00687-1 · Cited by 567 · see citing works
Fischer, A., Sananbenesi, F., Pang, P. T., Lu, B., & Tsai, L.-H. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.033 · Cited by 277 · see citing works
Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex
Zhang, J., Li, H., Yabut, O., Fitzpatrick, H., D'Arcangelo, G., & Herrup, K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5628-09.2010 · Cited by 96 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The cellular basis of dendrite pathology in neurodegenerative diseases
Kweon, J. H., Kim, S., & Lee, S. B. (2017) · BMB Reports · doi:10.5483/bmbrep.2017.50.1.131 · Cited by 73 · see citing works
Association of SPI1 haplotypes with altered SPI1 gene expression and Alzheimer’s disease risk
Cao, H., Initiative, A. D. N., Zhou, X., Chen, Y., Ip, F. C. F., Chen, Y., Lai, N. C. H., Lo, R. M. N., Tong, E. P. S., Mok, V. C. T., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215311 · Cited by 28 · see citing works
“CDK5 is essential for synaptic plasticity and neurode650 generation [51].”
Self-citationCuinat, S., Bézieau, S., Deb, W., Mercier, S., Vignard, V., Isidor, B., Küry, S., & Ebstein, F. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2023.101130 · Cited by 10 · see citing works
- Authors
- Cheung, Z. H., & Ip, N. Y.
- Affiliations
- Hong Kong University of Science and Technology (HK)
- Corresponding author
- Ip, Nancy Y.
- ORCID
- Ip, Nancy Y.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 22
- Issue
- 3
- Pages
- 169-175
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2156114958
- Cited by
- 233
- References
- 5
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 14 · 2023: 14 · 2022: 19 · 2021: 13 · 2020: 15 · 2019: 17 · 2018: 23 · 2017: 20 · 2016: 9 · 2015: 17 · 2014: 32 · 2013: 16 · 2012: 7
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- cyclin-dependent kinase 5, neurodegenerative diseases, tau phosphorylation, tau kinases, synaptic function
- MeSH terms
- Animals, Autophagy, Cell Survival, Humans, Signal Transduction, Neurodegenerative Diseases, Cyclin-Dependent Kinase 5
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
