Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression

Colledge, Marcie; Snyder, Eric M.; Crozier, Robert A.; Soderling, Jacquelyn A.; Jin, Yetao; Langeberg, Lorene K.; Lu, Hua; Bear, Mark F.; Scott, John D.

doi:10.1016/s0896-6273(03)00687-1

Cited by 567Neuroscience and Neuropharmacology ResearchUbiquitin and proteasome pathwaysGenetics and Neurodevelopmental Disorders

Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression

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Colledge, Marcie, Snyder, Eric M., Crozier, Robert A., Soderling, Jacquelyn A., Jin, Yetao, Langeberg, Lorene K., Lu, Hua, Bear, Mark F. +1 more·2003·Neuron

DOI 10.1016/s0896-6273(03)00687-1PMC PMC3963808

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Abstract

PSD-95 is a major scaffolding protein of the postsynaptic density, tethering NMDA- and AMPA-type glutamate receptors to signaling proteins and the neuronal cytoskeleton. Here we show that PSD-95 is regulated by the ubiquitin-proteasome pathway. PSD-95 interacts with and is ubiquitinated by the E3 ligase Mdm2. In response to NMDA receptor activation, PSD-95 is ubiquitinated and rapidly removed from synaptic sites by proteasome-dependent degradation. Mutations that block PSD-95 ubiquitination prevent NMDA-induced AMPA receptor endocytosis. Likewise, proteasome inhibitors prevent NMDA-induced AMPA receptor internalization and synaptically induced long-term depression. This is consistent with the notion that PSD-95 levels are an important determinant of AMPA receptor number at the synapse. These data suggest that ubiquitination of PSD-95 through an Mdm2-mediated pathway is critical in regulating AMPA receptor surface expression during synaptic plasticity.

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GluA1 phosphorylation directly regulates trafficking, but there are other phosphatase substrates, including PSD-95 and Stargazin, that are also involved in synaptic AMPAR removal during LTD.
“GluA1 phosphorylation directly regulates trafficking, but there are other phosphatase substrates, including PSD-95 and Stargazin, that are also involved in synaptic AMPAR removal during LTD.”
From AKAP150-Anchored Calcineurin Regulates Synaptic Plasticity by Limiting Synaptic Incorporation of Ca2+-Permeable AMPA Receptors (2012) · cites this paper as Colledge et al., 2003
The Discussion and the section on PSD-95 ubiquitination link PSD-95 to NMDA-induced AMPA receptor removal, and the paper reports that proteasome inhibitors block LTD (page numbers unavailable). It suggests PP2B may participate in PSD-95 degradation, but does not establish PSD-95 as a direct phosphatase substrate; the Introduction mentions stargazin in AMPA receptor targeting, not as a phosphatase substrate involved in receptor removal during LTD. (LLM, conf=0.86)
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NMDA-cLTD activation of CaN and PP1/2A negatively regulates PSD-95 postsynaptic clustering and binding to Stargazin to promote AMPAR removal.
“In particular, NMDA-cLTD activation of CaN and PP1/2A negatively regulates PSD-95 postsynaptic clustering and binding to Stargazin to promote AMPAR removal”
From AKAP150-Anchored Calcineurin Regulates Synaptic Plasticity by Limiting Synaptic Incorporation of Ca2+-Permeable AMPA Receptors (2012) · cites this paper as Colledge et al., 2003
The Discussion reports that NMDA receptor activation triggers PSD-95 ubiquitination and removal from synaptic sites, potentially allowing AMPA receptor endocytosis. The paper also reports that inhibiting PP2B (calcineurin) prevents NMDA-induced PSD-95 loss, and the Introduction notes that PSD-95 binds stargazin. It does not show that PP1/PP2A mediate this process or that NMDA stimulation reduces PSD-95’s binding to stargazin. (LLM, conf=0.85)
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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116 · see citing works
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588 · see citing works
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
Honda, R., Tanaka, H., & Yasuda, H. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01480-4 · Cited by 1,951 · see citing works
PEST sequences and regulation by proteolysis
RECHSTEINER, M. C., & Rogers, S. W. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)10031-1 · Cited by 1,645 · see citing works
Themes and variations on ubiquitylation
Weissman, A. M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35056563 · Cited by 1,472 · see citing works
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
de Oca Luna, R. M., Wagner, D. S., & Lozano, G. (1995) · Nature · doi:10.1038/378203a0 · Cited by 1,420 · cited 2× · see citing works
“We cotransfected from mice lacking Mdm2 (Montes de Oca Luna et al., 1995).”
Synaptic plasticity: LTP and LTD
Bear, M. F., & Malenka, R. C. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90101-5 · Cited by 1,355 · see citing works
Self-citation
PSD-95 Involvement in Maturation of Excitatory Synapses
El-Husseini, A. E.-D., Schnell, E., Chetkovich, D. M., Nicoll, R. A., & Bredt, D. S. (2000) · Science · doi:10.1126/science.290.5495.1364 · Cited by 1,303 · see citing works
Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein.
Migaud, M., Charlesworth, P., Dempster, M., Webster, L. C., Watabe, A. M., Makhinson, M., He, Y., Ramsay, M. F., Morris, R. G. M., Morrison, J. H., et al. (1998) · Nature · doi:10.1038/24790 · Cited by 1,160 · see citing works
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
Lee, H.-K., Barbarosie, M., Kameyama, K., Bear, M. F., & Huganir, R. L. (2000) · Nature · doi:10.1038/35016089 · Cited by 1,116 · see citing works
Self-citation
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N. T., Kawasaki, Y., Wenthold, R. J., Bredt, D. S., & Nicoll, R. A. (2000) · Nature · doi:10.1038/35050030 · Cited by 1,111 · see citing works
Reinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting
Ehlers, M. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00129-x · Cited by 1,096 · see citing works
Subunit-Specific Rules Governing AMPA Receptor Trafficking to Synapses in Hippocampal Pyramidal Neurons
Shi, S.-H., Hayashi, Y., Esteban, J. A., & Malinow, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00321-x · Cited by 1,094 · see citing works
Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression
Mulkey, R. M., Endo, S., Shenolikar, S., & Malenka, R. C. (1994) · Nature · doi:10.1038/369486a0 · Cited by 1,083 · see citing works
Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons.
Lu, W.-Y., Man, H.-Y., Ju, W., Trimble, W., Macdonald, J., & Wang, Y.-T. (2001) · Neuron · doi:10.1016/s0896-6273(01)00194-5 · Cited by 978 · see citing works
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
Ehlers, M. D. (2003) · Nature Neuroscience · doi:10.1038/nn1013 · Cited by 977 · see citing works
Mutation of the Angelman Ubiquitin Ligase in Mice Causes Increased Cytoplasmic p53 and Deficits of Contextual Learning and Long-Term Potentiation
Jiang, Y.-H., Armstrong, D., Albrecht, U., Atkins, C. M., Noebels, J. L., Eichele, G., Sweatt, J. D., & Beaudet, A. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80596-6 · Cited by 852 · see citing works
Calcium Influx via the NMDA Receptor Induces Immediate Early Gene Transcription by a MAP Kinase/ERK-Dependent Mechanism
Xia, Z., Dudek, H., Miranti, C. K., & Greenberg, M. E. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-17-05425.1996 · Cited by 794 · see citing works
Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD
Beattie, E. C., Carroll, R. C., Yu, X., Morishita, W., Yasuda, H., von Zastrow, M., & Malenka, R. C. (2000) · Nature Neuroscience · doi:10.1038/81823 · Cited by 745 · see citing works
Regulation of AMPA Receptor–Mediated Synaptic Transmission by Clathrin-Dependent Receptor Internalization
Man, H., Lin, J., Ju, W. H., Ahmadian, G., Liu, L., Becker, L. E., Sheng, M., & Wang, Y. T. (2000) · Neuron · doi:10.1016/s0896-6273(00)81067-3 · Cited by 698 · see citing works
Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity
Lüscher, C., Xia, H., Beattie, E. C., Carroll, R. C., von Zastrow, M., Malenka, R. C., & Nicoll, R. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)81119-8 · Cited by 692 · see citing works
Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number
Schnell, E., Sizemore, M., Karimzadegan, S., Chen, L., Bredt, D. S., & Nicoll, R. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172511199 · Cited by 691 · see citing works
Mapping of the p53 and mdm-2 Interaction Domains
Chen, J., Maréchal, V., & Levine, A. J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.4107 · Cited by 689 · see citing works
Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68
Chen, H., Lanzetta, K. M., Pascarelle, S. M., & Yahata, N. (2000) · RePEc: Research Papers in Economics · Cited by 680 · see citing works
NMDA Induces Long-Term Synaptic Depression and Dephosphorylation of the GluR1 Subunit of AMPA Receptors in Hippocampus
Lee, H.-K., Kameyama, K., Huganir, R. L., & Bear, M. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80632-7 · Cited by 668 · see citing works
Self-citation
The ARF/p53 pathway.
Sherr, C. J., & Weber, J. D. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)00038-6 · Cited by 654 · see citing works
Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase
Banke, T. G., Bowie, D., Lee, H.-K., Huganir, R. L., Schousboe, A., & Traynelis, S. F. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00089.2000 · Cited by 652 · see citing works
Synaptic Strength Regulated by Palmitate Cycling on PSD-95
El-Husseini, A., Schnell, E., Dakoji, S., Sweeney, N. T., Zhou, Q., Prange, O., Gauthier-Campbell, C., Aguilera-Moreno, A., Nicoll, R. A., & Bredt, D. S. (2002) · Cell · doi:10.1016/s0092-8674(02)00683-9 · Cited by 569 · see citing works
Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization
Lin, J., Ju, W. H., Foster, K. A., Lee, S. H., Ahmadian, G., Wyszynski, M. W., Wang, Y. T., & Sheng, M. (2000) · Nature Neuroscience · doi:10.1038/81814 · Cited by 554 · see citing works
Internalization of ionotropic glutamate receptors in response to mGluR activation
Snyder, E. M., Philpot, B. D., Huber, K. M., Dong, X., Fallon, J. R., & Bear, M. F. (2001) · Nature Neuroscience · doi:10.1038/nn746 · Cited by 539 · see citing works
Self-citation
Forebrain-Specific Calcineurin Knockout Selectively Impairs Bidirectional Synaptic Plasticity and Working/Episodic-like Memory
Zeng, H., Chattarji, S., Barbarosie, M., Rondi-Reig, L., Philpot, B. D., Miyakawa, T., Bear, M. F., & Tonegawa, S. (2001) · Cell · doi:10.1016/s0092-8674(01)00585-2 · Cited by 498 · see citing works
Self-citation
Targeting of PKA to Glutamate Receptors through a MAGUK-AKAP Complex
Colledge, M., Dean, R. A., Scott, G. K., Langeberg, L. K., Huganir, R. L., & Scott, J. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00013-1 · Cited by 467 · see citing works
Self-citation
Ubiquitin in chains
Pickart, C. M. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01681-9 · Cited by 454 · see citing works
Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68
Chen, H., Lanzetta, K. M., Pascarelle, S., & Yahata, N. (2000) · Nature · doi:10.1038/35046031 · Cited by 447 · see citing works
Dynamin-dependent endocytosis of ionotropic glutamate receptors
Carroll, R. C., Beattie, E. C., Xia, H., Lüscher, C., Altschuler, Y., Nicoll, R. A., Malenka, R. C., & von Zastrow, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.14112 · Cited by 421 · see citing works
Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons
Liao, D., Zhang, X., O’Brien, R., Ehlers, M., & Huganir, R. L. (1999) · Nature Neuroscience · doi:10.1038/4540 · Cited by 395 · see citing works
Ubiquitination-dependent mechanisms regulate synaptic growth and function
DiAntonio, A., Haghighi, A. P., Portman, S. L., Lee, J. D., Amaranto, A. M., & Goodman, C. S. (2001) · Nature · doi:10.1038/35086595 · Cited by 383 · see citing works
Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons
Rosenmund, C., Carr, D. W., Bergeson, S. E., Nilaver, G., Scott, J. D., & Westbrook, G. L. (1994) · Nature · doi:10.1038/368853a0 · Cited by 371 · see citing works
Self-citation
Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
Hegde, A. N., Inokuchi, K., Pei, W., Casadio, A., Ghirardi, M., Chain, D. G., Martin, K. C., Kandel, E. R., & Schwartz, J. H. (1997) · Cell · doi:10.1016/s0092-8674(00)80188-9 · Cited by 356 · see citing works
Postsynaptic Density-95 Mimics and Occludes Hippocampal Long-Term Potentiation and Enhances Long-Term Depression
Stein, V., House, D. R. C., Bredt, D. S., & Nicoll, R. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05503.2003 · Cited by 341 · see citing works
Molecular organization of the postsynaptic specialization
Sheng, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111146298 · Cited by 336 · see citing works
PSD‐95 regulates synaptic transmission and plasticity in rat cerebral cortex
Béïque, J.-C., & Andrade, R. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.031369 · Cited by 313 · see citing works
Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation
Gardiol, D., Kühne, C., Glaunsinger, B. A., Lee, S. S., Javier, R., & Banks, L. (1999) · Oncogene · doi:10.1038/sj.onc.1202920 · Cited by 303 · see citing works
Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins
Glaunsinger, B. A., Lee, S. S., Thomas, M., Banks, L., & Javier, R. T. (2000) · Oncogene · doi:10.1038/sj.onc.1203906 · Cited by 297 · see citing works
Ubiquitin and AP180 Regulate the Abundance of GLR-1 Glutamate Receptors at Postsynaptic Elements in C. elegans
Burbea, M., Dreier, L., Dittman, J. S., Grunwald, M. E., & Kaplan, J. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00749-3 · Cited by 294 · see citing works
Involvement of a Postsynaptic Protein Kinase A Substrate in the Expression of Homosynaptic Long-Term Depression
Kameyama, K., Lee, H.-K., Bear, M. F., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80633-9 · Cited by 283 · see citing works
Self-citation
Multi-PDZ Domain Protein MUPP1 Is a Cellular Target for both Adenovirus E4-ORF1 and High-Risk Papillomavirus Type 18 E6 Oncoproteins
Lee, S. S., Glaunsinger, B. A., Mantovani, F., Banks, L., & Javier, R. T. (2000) · Journal of Virology · doi:10.1128/jvi.74.20.9680-9693.2000 · Cited by 266 · see citing works
Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease
Wilson, S. M., Bhattacharyya, B. J., Rachel, R. A., Coppola, V., Tessarollo, L., Householder, D. B., Fletcher, C., Miller, R. J., Copeland, N. G., & Jenkins, N. A. (2002) · Nature Genetics · doi:10.1038/ng1006 · Cited by 265 · see citing works
Bidirectional, activity-dependent regulation of glutamate receptors in the adult hippocampus in vivo.
Heynen, A., Quinlan, E., Bae, D. C., & Bear, M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00130-6 · Cited by 237 · see citing works
Self-citation
The Ubiquitin Proteasome System Acutely Regulates Presynaptic Protein Turnover and Synaptic Efficacy
Speese, S. D., Trotta, N., Rodesch, C. K., Aravamudan, B., & Broadie, K. S. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00338-5 · Cited by 236 · see citing works
The ubiquitin–proteasome cascade is required for mammalian long‐term memory formation
Lopez‐Salon, M., Alonso, M., Vianna, M. R. M., Viola, H., E Souza, T. M., Izquierdo, I., Pasquini, J. M., & Medina, J. H. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01806.x · Cited by 224 · see citing works
Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression
Tavalin, S. J., Colledge, M., Hell, J. W., Langeberg, L. K., Huganir, R. L., & Scott, J. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03044.2002 · Cited by 222 · see citing works
Self-citation
β1-Adrenergic Receptor Association with PSD-95
Hu, L. A., Tang, Y., Miller, W. E., Cong, M., Lau, A. G., Lefkowitz, R. J., & Hall, R. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005938200 · Cited by 166 · see citing works
Ubiquitin and the synapse
Hegde, A. N., & DiAntonio, A. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn961 · Cited by 158 · see citing works
Independent mechanisms for long-term depression of AMPA and NMDA responses.
Selig, D. K., Hjelmstad, G., Herron, C., Nicoll, R., & Malenka, R. (1995) · Neuron · doi:10.1016/0896-6273(95)90045-4 · Cited by 137 · see citing works
The Ubiquitin Proteasome System Functions as an Inhibitory Constraint on Synaptic Strengthening
Zhao, Y., Hegde, A. N., & Martin, K. C. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00332-4 · Cited by 136 · see citing works
Imaging kinase–AKAP79–phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy
Oliveria, S. F., Gomez, L. L., & Dell'Acqua, M. L. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200209127 · Cited by 129 · see citing works
Subunit Composition ofN-Methyl-d-aspartate Receptors in the Central Nervous System that Contain the NR2D Subunit
Dunah, A. W., Luo, J., Wang, Y., Yasuda, R. P., & Wolfe, B. B. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.3.429 · Cited by 125 · see citing works
Eye opening induces a rapid dendritic localization of PSD-95 in central visual neurons
Yoshii, A., Sheng, M., & Constantine‐Paton, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0335785100 · Cited by 111 · see citing works
Internalization of the Kv1.4 Potassium Channel Is Suppressed by Clustering Interactions with PSD-95
Jugloff, D. G. M., Khanna, R., Schlichter, L. C., & Jones, O. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1357 · Cited by 104 · see citing works
New Roles for Ubiquitin in the Assembly and Function of Neuronal Circuits
Murphey, R. K., & Godenschwege, T. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00943-1 · Cited by 72 · see citing works
A Role of the Ubiquitin–Proteasome System in Neuropathic Pain
Moss, A., Blackburn-Munro, G., Garry, E. M., Blakemore, J., Dickinson, T., Rosie, R., Mitchell, R., & Fleetwood-Walker, S. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-04-01363.2002 · Cited by 62 · see citing works
Ubiquitin-mediated proteolysis in learning and memory
Chain, D. G., Schwartz, J. H., & Hegde, A. N. (1999) · Molecular Neurobiology · doi:10.1007/bf02742438 · Cited by 61 · see citing works
Ubiquitination--More Than Two to Tango
Joazeiro, C. A. P., & Hunter, T. R. (2000) · Science · doi:10.1126/science.289.5487.2061 · Cited by 41 · see citing works
AMPA RECEPTOR TRAFFICKING AND
Malinow, R., & Malenka, R. C. (2002) · Cited by 1 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

[2]2. Bear, M.F. ∙ Malenka, R.C. Synaptic plasticityLTP and LTD Curr. Opin. Neurobiol. 1994; 4:389-399 Crossref Scopus (1098) PubMed Google Scholar

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LTP and LTD
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works
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Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323 · see citing works
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Kim, E., & Sheng, M. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1517 · Cited by 1,566 · see citing works
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Wong, W., & Scott, J. D. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1527 · Cited by 1,073 · see citing works
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Sheng, M., & Hoogenraad, C. C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060805.160029 · Cited by 1,003 · see citing works
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Shepherd, J. D., & Huganir, R. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123516 · Cited by 978 · see citing works
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Pawson, T. J. (2004) · Cell · doi:10.1016/s0092-8674(03)01077-8 · Cited by 816 · see citing works
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Tai, H.-C., & Schuman, E. M. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2499 · Cited by 532 · see citing works
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Hou, L., Antion, M. D., Hu, D., Spencer, C. M., Paylor, R., & Klann, E. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.005 · Cited by 469 · see citing works
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Waung, M. W., Pfeiffer, B. E., Nosyreva, E. D., Ronesi, J. A., & Huber, K. M. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.014 · Cited by 474 · see citing works
MEMBRANE-ASSOCIATED GUANYLATE KINASES REGULATE ADHESION AND PLASTICITY AT CELL JUNCTIONS
Funke, L., Dakoji, S., & Bredt, D. S. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133339 · Cited by 469 · see citing works
Dysregulated Metabotropic Glutamate Receptor-Dependent Translation of AMPA Receptor and Postsynaptic Density-95 mRNAs at Synapses in a Mouse Model of Fragile X Syndrome
Muddashetty, R. S., Kelić, S., Gross, C., Xu, M., & Bassell, G. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0937-07.2007 · Cited by 421 · see citing works
The Angelman syndrome ubiquitin ligase localizes to the synapse and nucleus, and maternal deficiency results in abnormal dendritic spine morphology
Dindot, S. V., Antalffy, B. A., Bhattacharjee, M. B., & Beaudet, A. L. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm288 · Cited by 418 · see citing works
Deubiquitylases From Genes to Organism
Clague, M. J., Barsukov, I., Coulson, J. M., Liu, H., Rigden, D. J., & Urbé, S. (2013) · Physiological Reviews · doi:10.1152/physrev.00002.2013 · Cited by 422 · see citing works
Linking neurodevelopmental and synaptic theories of mental illness through DISC1
Brandon, N. J., & Sawa, A. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3120 · Cited by 422 · see citing works
Regulation of hippocampal synaptic plasticity by BDNF
Leal, G., Afonso, P. M., Salazar, I. L., & Duarte, C. B. (2015) · Brain Research · doi:10.1016/j.brainres.2014.10.019 · Cited by 410 · see citing works
MECHANISMS OF VERTEBRATE SYNAPTOGENESIS
Waites, C. L., Craig, A. M., & Garner, C. C. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144336 · Cited by 483 · see citing works
Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses
Almeida, C. G., Tampellini, D., Takahashi, R. H., Greengard, P., Lin, M. T., Snyder, E. M., & Gouras, G. K. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.02.008 · Cited by 397 · see citing works
Self-citation
Mitochondrial Trafficking to Synapses in Cultured Primary Cortical Neurons
Chang, D. T. W., Honick, A. S., & Reynolds, I. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1012-06.2006 · Cited by 391 · see citing works
Metabotropic Glutamate Receptor Activation Regulates Fragile X Mental Retardation Protein and Fmr1 mRNA Localization Differentially in Dendrites and at Synapses
Antar, L. N., Afroz, R., Dictenberg, J. B., Carroll, R. C., & Bassell, G. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0099-04.2004 · Cited by 360 · see citing works
Reversible Inhibition of PSD-95 mRNA Translation by miR-125a, FMRP Phosphorylation, and mGluR Signaling
Muddashetty, R. S., Nalavadi, V. C., Gross, C., Yao, X., Xing, L., Laur, O., Warren, S. T., & Bassell, G. J. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.05.006 · Cited by 364 · see citing works
Homeostatic plasticity and NMDA receptor trafficking
Pérez-Otaño, I., & Ehlers, M. D. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.03.004 · Cited by 356 · see citing works
BDNF Induces Transport of PSD-95 to Dendrites Through PI3K-AKT Signaling After NMDA Receptor Activation
Yoshii, A., & Constantine-Paton, M. (2007) · Nature Neuroscience · doi:10.1038/nn1903 · Cited by 345 · see citing works
ORGANELLES AND TRAFFICKING MACHINERY FOR POSTSYNAPTIC PLASTICITY
Kennedy, M. J., & Ehlers, M. D. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112808 · Cited by 346 · see citing works
Rapid Redistribution of Synaptic PSD-95 in the Neocortex In Vivo
Gray, N. W., Weimer, R. M., Bureau, I., & Svoboda, K. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040370 · Cited by 338 · see citing works
Multiple Autism-Linked Genes Mediate Synapse Elimination via Proteasomal Degradation of a Synaptic Scaffold PSD-95
Tsai, N.-P., Wilkerson, J. R., Guo, W., Maksimova, M. A., DeMartino, G. N., Cowan, C. W., & Huber, K. M. (2012) · Cell · doi:10.1016/j.cell.2012.11.040 · Cited by 316 · see citing works
Ube3a is required for experience-dependent maturation of the neocortex
Yashiro, K., Riday, T. T., Condon, K. H., Roberts, A. C., Bernardo, D. R., Prakash, R., Weinberg, R. J., Ehlers, M. D., & Philpot, B. D. (2009) · Nature Neuroscience · doi:10.1038/nn.2327 · Cited by 328 · see citing works
Delayed Stabilization of Dendritic Spines in Fragile X Mice
Cruz-Martin, A., Crespo, M., & Portera-Cailliau, C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0577-10.2010 · Cited by 321 · see citing works
Activity-dependent dynamics and sequestration of proteasomes in dendritic spines
Bingol, B., & Schuman, E. M. (2006) · Nature · doi:10.1038/nature04769 · Cited by 347 · see citing works
NS21: Re-defined and modified supplement B27 for neuronal cultures
Chen, Y., Stevens, B., Chang, J., Milbrandt, J., Barres, B. A., & Hell, J. W. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.03.013 · Cited by 301 · see citing works
Organization of the core structure of the postsynaptic density
Chen, X., Winters, C. A., Azzam, R. N., Li, X., Galbraith, J. A., Leapman, R. D., & Reese, T. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800897105 · Cited by 290 · see citing works
A Balance of Protein Synthesis and Proteasome-Dependent Degradation Determines the Maintenance of LTP
Fonseca, R., Vabulas, R. M., Hartl, F. U., Bonhoeffer, T., & Nägerl, U. V. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.015 · Cited by 310 · see citing works
Synaptic Accumulation of PSD-95 and Synaptic Function Regulated by Phosphorylation of Serine-295 of PSD-95
Kim, M. J., Futai, K., Jo, J., Hayashi, Y., Cho, K., & Sheng, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.007 · Cited by 278 · see citing works
Soluble β-Amyloid1-40Induces NMDA-Dependent Degradation of Postsynaptic Density-95 at Glutamatergic Synapses
Roselli, F., Tirard, M., Lu, J., Hutzler, P., Lamberti, P., Livrea, P., Morabito, M. A., & Almeida, O. F. X. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3034-05.2005 · Cited by 276 · see citing works
Deconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and Disease
Bingol, B., & Sheng, M. (2011) · Neuron · doi:10.1016/j.neuron.2010.11.006 · Cited by 275 · see citing works
Architecture of the Mouse Brain Synaptome
Zhu, F., Cizeron, M., Qiu, Z., Benavides‐Piccione, R., Kopanitsa, M. V., Skene, N., Koniaris, B., DeFelipe, J., Fransén, E. A., Komiyama, N. H., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.007 · Cited by 272 · see citing works
Subunit Rules Governing the Sorting of Internalized AMPA Receptors in Hippocampal Neurons
Lee, S. H., Simonetta, A., & Sheng, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.015 · Cited by 268 · see citing works
Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines
Bingol, B., Wang, C.-F., Arnott, D., Cheng, D., Peng, J., & Sheng, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.024 · Cited by 268 · see citing works
Ubiquitination in postsynaptic function and plasticity
Mabb, A. M., & Ehlers, M. D. (2010) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100109-104129 · Cited by 255 · see citing works
Neuronal LRP1 Functionally Associates with Postsynaptic Proteins and Is Required for Normal Motor Function in Mice
May, P., Rohlmann, A., Bock, H. H., Zurhove, K., Marth, J. D., Schomburg, E. D., Noebels, J. L., Beffert, U., Sweatt, J. D., Weeber, E. J., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.8872-8883.2004 · Cited by 236 · see citing works
Regulation of the proteasome by neuronal activity and calcium/calmodulin-dependent protein kinase II
Djakovic, S. N., Schwarz, L. A., Barylko, B., DeMartino, G. N., & Patrick, G. N. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.021956 · Cited by 236 · see citing works
AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive aging
Henley, J. M., & Wilkinson, K. A. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.1/jhenley · Cited by 236 · see citing works
The DLGAP family: neuronal expression, function and role in brain disorders
Rasmussen, A. H., Rasmussen, H. B., & Silahtaroglu, A. (2017) · Molecular Brain · doi:10.1186/s13041-017-0324-9 · Cited by 234 · see citing works
An SCF-like ubiquitin ligase complex that controls presynaptic differentiation
Liao, E. H., Hung, W., Abrams, B. S., & Zhen, M. (2004) · Nature · doi:10.1038/nature02647 · Cited by 233 · see citing works
Cdk5: a multifaceted kinase in neurodegenerative diseases
Cheung, Z. H., & Ip, N. Y. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.11.003 · Cited by 233 · see citing works
Neuregulin 1 Promotes Excitatory Synapse Development and Function in GABAergic Interneurons
Ting, A. K. L., Chen, Y., Wen, L., Yin, D., Shen, C., Tao, Y., Liu, X., Xiong, W., & Mei, L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2538-10.2011 · Cited by 216 · see citing works
Excitation control: balancing PSD-95 function at the synapse
Keith, D. J. (2008) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.004.2008 · Cited by 206 · see citing works
Role of Ubiquitylation in Cellular Membrane Transport
Staub, O., & Rotin, D. (2006) · Physiological Reviews · doi:10.1152/physrev.00020.2005 · Cited by 207 · see citing works
Posttranslational regulation of AMPA receptor trafficking and function
Lü, W., & Roche, K. W. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.09.008 · Cited by 197 · see citing works
Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD.
Xu, W., Schlüter, O. M., Steiner, P., Czervionke, B. L., Sabatini, B., & Malenka, R. C. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.027 · Cited by 193 · see citing works
Emerging Roles for Ubiquitin and Protein Degradation in Neuronal Function
Yi, J. J., & Ehlers, M. D. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.1.4 · Cited by 224 · see citing works
MAGUKs, Synaptic Development, and Synaptic Plasticity
Zheng, C.-Y., Seabold, G. K., Hořák, M., & Petralia, R. S. (2011) · The Neuroscientist · doi:10.1177/1073858410386384 · Cited by 186 · see citing works
Protein homeostasis and synaptic plasticity
Cajigas, I. J., Will, T. J., & Schuman, E. M. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.173 · Cited by 185 · see citing works
A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors
Bhattacharyya, S., Biou, V., Xu, W., Schlüter, O., & Malenka, R. C. (2009) · Nature Neuroscience · doi:10.1038/nn.2249 · Cited by 185 · see citing works
Developmental Switch in Synaptic Mechanisms of Hippocampal Metabotropic Glutamate Receptor-Dependent Long-Term Depression
Nosyreva, E. D., & Huber, K. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3652-04.2005 · Cited by 182 · see citing works
APCCdh1 mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity
Fu, A. K. Y., Hung, K.-W., Fu, W., Shen, C., Chen, Y., Xia, J., Lai, K., & Ip, N. Y. (2010) · Nature Neuroscience · doi:10.1038/nn.2715 · Cited by 181 · see citing works
A‐kinase anchoring proteins: From protein complexes to physiology and disease
Carnegie, G. K., Means, C. K., & Scott, J. D. (2009) · IUBMB Life · doi:10.1002/iub.168 · Cited by 175 · see citing works
Self-citation
Opposing effects of PSD‐93 and PSD‐95 on long‐term potentiation and spike timing‐dependent plasticity
Carlisle, H. J., Fink, A. E., Grant, S. G. N., & O’Dell, T. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.163469 · Cited by 172 · see citing works
PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity
Xu, W. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.03.001 · Cited by 171 · see citing works
Impaired ubiquitin–proteasome system activity in the synapses of Huntington's disease mice
Wang, J., Wang, C.-E., Orr, A. L., Tydlacka, S., Li, S., & Li, X. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200709080 · Cited by 168 · see citing works
The Anaphase-Promoting Complex Regulates the Abundance of GLR-1 Glutamate Receptors in the Ventral Nerve Cord of C. elegans
Juo, P., & Kaplan, J. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.010 · Cited by 164 · see citing works
Synaptic adhesion molecules and PSD-95
Han, K., & Kim, E. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.011 · Cited by 163 · see citing works
Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover
Heo, S., Diering, G. H., Na, C. H., Nirujogi, R. S., Bachman, J. L., Pandey, A., & Huganir, R. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720956115 · Cited by 163 · see citing works
PICK1 is a calcium‐sensor for NMDA‐induced AMPA receptor trafficking
Hanley, J. G., & Henley, J. M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600801 · Cited by 162 · see citing works
Involvement of Protein Synthesis and Degradation in Long-Term Potentiation of Schaffer Collateral CA1 Synapses
Karpova, A., Mikhaylova, M., Thomas, U., Knöpfel, T., & Behnisch, T. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4573-05.2006 · Cited by 162 · see citing works
Copper: from neurotransmission to neuroproteostasis
Opazo, C., Greenough, M. A., & Bush, A. I. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00143 · Cited by 159 · see citing works
Nedd4‐mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking
Lin, A. W., Hou, Q., Jarzylo, L. A., Amato, S., Gilbert, J. P., Shang, F., & Man, H. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07221.x · Cited by 158 · see citing works
Routes, destinations and delays: recent advances in AMPA receptor trafficking
Henley, J. M., Barker, E. A., & Glebov, O. O. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.02.004 · Cited by 158 · see citing works
Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination
Kato, A., Rouach, N., Nicoll, R. A., & Bredt, D. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501769102 · Cited by 153 · see citing works
The ubiquitin-proteasome pathway and synaptic plasticityPreprint
Hegde, A. N. (2010) · Learning & Memory · doi:10.1101/lm.1504010 · Cited by 151 · see citing works
Protein quality control in Alzheimer's disease by the ubiquitin proteasome system
de Vrij, F. M. S., Fischer, D. F., VANLEEUWEN, F., & Hol, E. M. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.10.001 · Cited by 152 · see citing works
Ubiquitin and Protein Turnover in Synapse Function
Yi, J. J., & Ehlers, M. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.008 · Cited by 150 · see citing works
Calpain and Synaptic Function
Wu, H., & Lynch, D. R. (2006) · Molecular Neurobiology · doi:10.1385/mn:33:3:215 · Cited by 151 · see citing works
Human Immunodeficiency Virus Protein Tat Induces Synapse Loss via a Reversible Process That Is Distinct from Cell Death
Kim, H. J., Martemyanov, K. A., & Thayer, S. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2958-08.2008 · Cited by 146 · see citing works
Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane
Gerges, N. Z., Backos, D. S., Rupasinghe, C. N., Spaller, M. R., & Esteban, J. A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601065 · Cited by 147 · see citing works
Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice
Dong, Y., Li, S., Lu, Y., Li, X., Liao, Y., Peng, Z., Li, Y., Hou, L., Yuan, Z., & Cheng, J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01842-0 · Cited by 146 · see citing works
Ubiquitin-proteasome-mediated local protein degradation and synaptic plasticity
Hegde, A. N. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.005 · Cited by 141 · see citing works
Discrete synaptic states define a major mechanism of synapse plasticity
Montgomery, J. M., & Madison, D. V. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.10.006 · Cited by 158 · see citing works
Regulation of Synaptic Structure by Ubiquitin C-Terminal Hydrolase L1
Cartier, A. E., Djakovic, S. N., Salehi, A., Wilson, S. M., Masliah, E., & Patrick, G. N. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1817-09.2009 · Cited by 141 · see citing works
Characterization of the brain 26S proteasome and its interacting proteins
Tai, H. (2010) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2010.00012 · Cited by 136 · see citing works
cAMP-Dependent Protein Kinase Postsynaptic Localization Regulated by NMDA Receptor Activation through Translocation of an A-Kinase Anchoring Protein Scaffold Protein
Smith, K. E., Gibson, E. S., & Dell’Acqua, M. L. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3092-05.2006 · Cited by 141 · see citing works
The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function
Wang, Q., Charych, E. I., Pulito, V. L., Lee, J. B., Graziane, N., Crozier, R. A., Revilla-Sanchez, R., Kelly, M. P., Dunlop, A. J., Murdoch, H., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.87 · Cited by 141 · see citing works
Self-citation
Activity-Independent Regulation of Dendrite Patterning by Postsynaptic Density Protein PSD-95
Charych, E. I., Akum, B. F., Goldberg, J. S., Jörnsten, R. J., Rongo, C., Zheng, J. Q., & Firestein, B. L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2379-06.2006 · Cited by 141 · see citing works
AKAP150-Anchored Calcineurin Regulates Synaptic Plasticity by Limiting Synaptic Incorporation of Ca2+-Permeable AMPA Receptors
Sanderson, J. L., Gorski, J. A., Gibson, E. S., Lam, P., Freund, R. K., Chick, W. S., & Dell'Acqua, M. L. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3326-12.2012 · Cited by 137 · see citing works
“In particular, NMDA-cLTD activation of CaN and PP1/2A negatively regulates PSD-95 postsynaptic clustering and binding to Stargazin to promote AMPAR removal (Colledge et al., 2003; Tomita et al., 2005; Kim et al., 2007; Opazo et al., 2010).”
Background
NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95
Compans, B., Camus, C., Kallergi, E., Sposini, S., Martineau, M., Butler, C., Kechkar, A., Klaassen, R. V., Retailleau, N., B, T. J. S. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23133-9 · Cited by 136 · see citing works
A reduced number of metabotropic glutamate subtype 5 receptors are associated with constitutive homer proteins in a mouse model of fragile X syndrome
Giuffrida, R., Musumeci, S., D'Antoni, S., Bonaccorso, C. M., Giuffrida-Stella, A. M., Oostra, B. A., & Catania, M. V. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0932-05.2005 · Cited by 119 · see citing works
Ubiquitin pathways in neurodegenerative disease
Atkin, G., & Paulson, H. L. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00063 · Cited by 136 · see citing works
Phosphorylation of Threonine-19 of PSD-95 by GSK-3 is Required for PSD-95 Mobilization and Long-Term Depression
Nelson, C. D., Kim, M. J., Hsin, H., Chen, Y., & Sheng, M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0131-13.2013 · Cited by 134 · see citing works
Role of the ubiquitin–proteasome system in brain ischemia: Friend or foe?
Caldeira, M. V., Salazar, I. L., Curcio, M., Canzoniero, L. M. T., & Duarte, C. B. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.10.003 · Cited by 134 · see citing works
PSD-95 and PSD-93 Play Critical But Distinct Roles in Synaptic Scaling Up and Down
Sun, Q., & Turrigiano, G. G. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5616-10.2011 · Cited by 135 · see citing works
Synaptic protein degradation by the ubiquitin proteasome system
Bingol, B., & Schuman, E. M. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.08.016 · Cited by 129 · see citing works
The ubiquitin–proteasome system as a critical regulator of synaptic plasticity and long-term memory formation
Jarome, T. J., & Helmstetter, F. J. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.03.009 · Cited by 133 · see citing works
Dephosphorylation-Induced Ubiquitination and Degradation of FMRP in Dendrites: A Role in Immediate Early mGluR-Stimulated Translation
Nalavadi, V. C., Muddashetty, R. S., Gross, C., & Bassell, G. J. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5057-11.2012 · Cited by 128 · see citing works
UBE3A Regulates Synaptic Plasticity and Learning and Memory by Controlling SK2 Channel Endocytosis
Sun, J., Zhu, G., Liu, Y., Standley, S., Ji, A., Tunuguntla, R., Wang, Y., Claus, C., Luo, Y., Baudry, M., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.023 · Cited by 131 · see citing works
Activity-Dependent Ubiquitination of GABAA Receptors Regulates Their Accumulation at Synaptic Sites
Saliba, R. S., Michels, G., Jacob, T. C., Pangalos, M., & Moss, S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3277-07.2007 · Cited by 150 · see citing works

Summary
Colledge, M., Snyder, E. M., Crozier, R. A., Soderling, J. A., Jin, Y., Langeberg, L. K., Lu, H., Bear, M. F., & Scott, J. D. (2014)
Self-citation
Selection
Paton, A. (1995) · BMJ · doi:10.1136/bmj.310.6974.269a
Cyclin-Dependent Kinase 5 Regulates PSD-95 Ubiquitination in Neurons
Bianchetta, M. J., Lam, T. T., Jones, S. N., & Morabito, M. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2388-11.2011 · Cited by 63 · see citing works
A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors
Bhattacharyya, S., Biou, V., Xu, W., Schlüter, O., & Malenka, R. C. (2009) · Nature Neuroscience · doi:10.1038/nn.2249 · Cited by 185 · see citing works
Acute Inactivation of PSD-95 Destabilizes AMPA Receptors at Hippocampal Synapses
Yudowski, G. A., Olsen, O., Adesnik, H., Marek, K. W., & Bredt, D. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053965 · Cited by 31 · see citing works

Authors: Colledge, M., Snyder, E. M., Crozier, R. A., Soderling, J. A., Jin, Y., Langeberg, L. K., Lu, H., Bear, M. F., & Scott, J. D.
Affiliations: Howard Hughes Medical Institute (US)
Oregon Health & Science University (US)
Corresponding author: Scott, John D.
ORCID: Crozier, Robert A.
Langeberg, Lorene K.
Lu, Hua
Bear, Mark F.
Scott, John D.
Venue: Neuron
Publisher: Elsevier BV
Published: 2003-10
Volume: 40
Issue: 3
Pages: 595-607
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(03)00687-1
PMC: PMC3963808
OpenAlex: W2151538478
Cited by: 567
References: 65
Citations by year: 2026: 8 · 2025: 16 · 2024: 20 · 2023: 11 · 2022: 12 · 2021: 24 · 2020: 20 · 2019: 23 · 2018: 18 · 2017: 21 · 2016: 20 · 2015: 36 · 2014: 22 · 2013: 30 · 2012: 26
FWCI: 9.49
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3577 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01GM048231, GM-48231, R37GM048231)
National Institute of Neurological Disorders and Stroke (NS 39321, P01NS039321)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: PSD-95, ubiquitination, MDM2, proteasomal degradation, AMPA receptors, receptor internalization, NMDA receptor activation, postsynaptic density, synaptic plasticity, long-term depression, glutamate receptors
MeSH terms: Disks Large Homolog 4 Protein, Acetylcysteine, Analysis of Variance, Animals, Animals, Newborn, Epitopes, Calcium, Cells, Cultured, Drug Interactions, Electric Stimulation, Embryo, Mammalian, Endocytosis, Colforsin, Hippocampus, Humans, Immunoglobulin G, Immunohistochemistry, Immunosuppressive Agents, Kidney, Leupeptins, Membrane Potentials, Membrane Proteins, Mutation, Nerve Tissue Proteins, Neural Inhibition, Neurons, Nuclear Proteins, Proto-Oncogene Proteins, Synapses, Time Factors, Transfection, Blotting, Western, Cysteine Proteinase Inhibitors, N-Methylaspartate, Tacrolimus, Synapsins, Receptors, AMPA, Patch-Clamp Techniques, Excitatory Amino Acid Agonists, Rats, Long-Evans, Ubiquitin, Intracellular Signaling Peptides and Proteins, Rats, Proto-Oncogene Proteins c-mdm2, In Vitro Techniques

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Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression

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