The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Chaperone-mediated autophagy: a unique way to enter the lysosome world
Open accessAbstract
All cellular proteins undergo continuous synthesis and degradation. This permanent renewal is necessary to maintain a functional proteome and to allow for rapid changes in levels of specific proteins with regulatory purposes. Although for a long time lysosomes were considered unable to contribute to the selective degradation of individual proteins, the discovery of chaperone-mediated autophagy (CMA) changed this notion. Here, we review the characteristics that set CMA apart from other types of lysosomal degradation and the subset of molecules that confer cells the capability to identify individual cytosolic proteins and direct them across the lysosomal membrane for degradation.
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Cites
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452
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Self-citationMicroautophagy of Cytosolic Proteins by Late Endosomes
Sahu, R., Kaushik, S., Clement, C. C., Cannizzo, E. S., Scharf, B., Follenzi, A., Potolicchio, I., Nieves, E., Cuervo, A. M., & Santambrogio, L. (2011) · Developmental Cell · doi:10.1016/j.devcel.2010.12.003 · Cited by 902
Self-citationCargo recognition failure is responsible for inefficient autophagy in Huntington’s disease
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Self-citationVogiatzi, T., Xilouri, M., Vekrellis, K., & Stefanis, L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801992200 · Cited by 683
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing
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Consequences of the selective blockage of chaperone-mediated autophagy
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Self-citationHarnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein
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Cited by
The role of autophagy in neurodegenerative disease
Nixon, R. A. (2013) · Nature Medicine · doi:10.1038/nm.3232 · Cited by 2,059
Molecular definitions of autophagy and related processes
Galluzzi, L., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cecconi, F., Choi, A. M., Chu, C. T., Codogno, P., Colombo, M. I., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201796697 · Cited by 1,646
Self-citationThe Biology of Proteostasis in Aging and Disease
Labbadia, J., & Morimoto, R. I. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-033955 · Cited by 1,472
Degradation of misfolded proteins in neurodegenerative diseases: Therapeutic targets and strategies
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The lysosome: from waste bag to potential therapeutic target
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Metadata
- Authors
- Kaushik, S., & Cuervo, A. M.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 22
- Issue
- 8
- Pages
- 407-417
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2021919397
- Cited by
- 850
- References
- 12
- FWCI
- 8.26
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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