The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Eaten alive: novel insights into autophagy from multicellular model systems
Open accessAbstract
Autophagy delivers cytoplasmic material to lysosomes for degradation. First identified in yeast, the core genes that control this process are conserved in higher organisms. Studies of mammalian cell cultures have expanded our understanding of the core autophagy pathway, but cannot reveal the unique animal-specific mechanisms for the regulation and function of autophagy. Multicellular organisms have different types of cells that possess distinct composition, morphology, and organization of intracellular organelles. In addition, the autophagic machinery integrates signals from other cells and environmental conditions to maintain cell, tissue and organism homeostasis. Here, we highlight how studies of autophagy in flies and worms have identified novel core autophagy genes and mechanisms, and provided insight into the context-specific regulation and function of autophagy.
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“Of note, the apoptotic and autophagic machineries are highly interconnected during developmental cell death [796].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [796]
In the citing paper
“In this context, the autophagic apparatus also drives the developmental clearance of apoptotic cells [796].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [796]
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1 retracted
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RetractedRepertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Autophagy: Renovation of Cells and Tissues
Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,615
Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214
Pankiv, S., Clausen, T. H., Lamark, T., Brech, A., Bruun, J.-A., Outzen, H., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702824200 · Cited by 4,578
Autophagy and Viruses: Adversaries or Allies?
Dong, X., & Levine, B. (2013) · Journal of Innate Immunity · doi:10.1159/000346388 · Cited by 4,444
Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila
Moy, R. H., & Cherry, S. R. (2013) · Journal of Innate Immunity · doi:10.1159/000350326 · Cited by 3,551
Post-embryonic cell lineages of the nematode, Caenorhabditis elegans
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Items 101–101 of 101
Targeting lysosome-dependent cell death in cancer: towards therapeutic strategies
Li, Y., Feng, J., Dong, X., Yuan, Z., Zheng, L.-L., Zhang, L., & Wang, L. (2026) · Biomarker Research · doi:10.1186/s40364-026-00969-1 · Cited by 1
“The functional integrity of core autophagy components is a prerequisite for this mode of cell death [175].”
Metadata
- Authors
- Zhang, H., & Baehrecke, E. H.
- Affiliations
- Chinese Academy of Sciences (CN)
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Zhang, Hong
- Baehrecke, Eric H.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 25
- Issue
- 7
- Pages
- 376-387
- ISSN
- 0962-8924 (ISSN-L)
- PMC
- PMC4475674
- OpenAlex
- W2067636508
- Cited by
- 102
- References
- 118
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 1 · 2022: 11 · 2021: 13 · 2020: 7 · 2019: 12 · 2018: 13 · 2017: 10 · 2016: 16 · 2015: 7
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Cancer Institute (R01CA159314, CA159314)
- National Institute of General Medical Sciences (GM111658, GM079431, R01GM079431, R01GM111658)
- National Institute of Allergy and Infectious Diseases (AI099708, R01AI099708)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- autophagy, multicellular organisms, Drosophila, Caenorhabditis elegans, autophagy-related genes, lysosomal degradation, tissue homeostasis, cell-to-cell communication, autophagy regulation
- MeSH terms
- Animals, Autophagy, Drosophila melanogaster, Gene Expression Regulation, Homeostasis, Humans, Lysosomes, Models, Biological, Organ Specificity, Protein Kinases, Saccharomyces cerevisiae, Species Specificity, Ubiquitins, Signal Transduction, Caenorhabditis elegans
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