Cited by 102Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model OrganismsCalcium signaling and nucleotide metabolism

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Eaten alive: novel insights into autophagy from multicellular model systems

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Zhang, Hong, Baehrecke, Eric H.·2015·Trends in Cell Biology

DOI 10.1016/j.tcb.2015.03.001PMC PMC4475674

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Abstract

Autophagy delivers cytoplasmic material to lysosomes for degradation. First identified in yeast, the core genes that control this process are conserved in higher organisms. Studies of mammalian cell cultures have expanded our understanding of the core autophagy pathway, but cannot reveal the unique animal-specific mechanisms for the regulation and function of autophagy. Multicellular organisms have different types of cells that possess distinct composition, morphology, and organization of intracellular organelles. In addition, the autophagic machinery integrates signals from other cells and environmental conditions to maintain cell, tissue and organism homeostasis. Here, we highlight how studies of autophagy in flies and worms have identified novel core autophagy genes and mechanisms, and provided insight into the context-specific regulation and function of autophagy.

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See all 102

Authors: Zhang, H., & Baehrecke, E. H.
Affiliations: Chinese Academy of Sciences (CN)
University of Massachusetts Chan Medical School (US)
Corresponding author: Zhang, Hong
Baehrecke, Eric H.
ORCID: Zhang, Hong
Baehrecke, Eric H.
Venue: Trends in Cell Biology
Publisher: Elsevier BV
Published: 2015-07
Volume: 25
Issue: 7
Pages: 376-387
ISSN: 0962-8924 (ISSN-L)
DOI: 10.1016/j.tcb.2015.03.001
PMC: PMC4475674
OpenAlex: W2067636508
Cited by: 102
References: 118
Citations by year: 2026: 3 · 2025: 5 · 2024: 4 · 2023: 1 · 2022: 11 · 2021: 13 · 2020: 7 · 2019: 12 · 2018: 13 · 2017: 10 · 2016: 16 · 2015: 7
FWCI: 1.99
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Cell Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders: National Cancer Institute (R01CA159314, CA159314)
National Institute of General Medical Sciences (GM111658, GM079431, R01GM079431, R01GM111658)
National Institute of Allergy and Infectious Diseases (AI099708, R01AI099708)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords: autophagy, multicellular organisms, Drosophila, Caenorhabditis elegans, autophagy-related genes, lysosomal degradation, tissue homeostasis, cell-to-cell communication, autophagy regulation
MeSH terms: Animals, Autophagy, Drosophila melanogaster, Gene Expression Regulation, Homeostasis, Humans, Lysosomes, Models, Biological, Organ Specificity, Protein Kinases, Saccharomyces cerevisiae, Species Specificity, Ubiquitins, Signal Transduction, Caenorhabditis elegans

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Eaten alive: novel insights into autophagy from multicellular model systems

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