From Planar Cell Polarity to Ciliogenesis and Back: The Curious Tale of the PPE and CPLANE proteins
Open accessAbstract
Why some genes are more popular than others remains an open question, but one example of this phenomenon involves the genes controlling planar cell polarity (PCP), the polarization of cells within a plane of a tissue. Indeed, the so-called 'core' PCP genes such as dishevelled, frizzled, and prickle have been extensively studied both in animal models and by human genetics. By contrast, other genes that influence PCP signaling have received far less attention. Among the latter are inturned, fuzzy, and fritz, but recent work should bring these once obscure regulators into the limelight. We provide here a brief history of planar polarity effector (PPE) and CPLANE (ciliogenesis and planar polarity effector) proteins, discuss recent advances in understanding their molecular mechanisms of action, and describe their roles in human disease.
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Although apical-basal polarity is well known, many epithelial cells are also polarized along the perpendicular axis, parallel to the epithelial sheet, a property referred to as PCP.
“Although apical–basal polarity is well known, many epithelial cells are also polarized along the perpendicular axis, parallel to the epithelial sheet. This tissue property is referred to as PCP (Devenport, 2014; Adler and Wallingford, 2017).”
From Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation (2019) · cites this paper as Adler and Wallingford, 2017
PCP polarizes many animal tissues along a body or organ axis.
“First discovered in flies, PCP polarizes many animal tissues along a body or organ axis.”
From Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation (2019) · cites this paper as Adler and Wallingford, 2017
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Self-citation
- Authors
- Adler, P. N., & Wallingford, J. B.
- Affiliations
- University of Virginia (US)
- The University of Texas at Austin (US)
- Corresponding author
- Wallingford, John B.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 27
- Issue
- 5
- Pages
- 379-390
- ISSN
- 0962-8924 (ISSN-L)
- PMC
- PMC5403552
- OpenAlex
- W2580668525
- Cited by
- 68
- References
- 93
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 10 · 2023: 3 · 2022: 8 · 2021: 8 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 3
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL117164)
- National Institute of General Medical Sciences (R01GM104853, R01GM086627)
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD084072, R01HD090163, R01HD085901)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Keywords
- planar cell polarity, ciliogenesis, Fritz, PCP signaling, human disease, Dishevelled, Frizzled receptors, prickles
- MeSH terms
- Animals, Cilia, Disease, Humans, Membrane Proteins, Actin Cytoskeleton, Cell Polarity, Organogenesis
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