The Elusive P2X7 Macropore

Molecular Physiology of P2X Receptors

North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Muñoz-Planillo, R., Kuffa, P., Martínez-Colón, G. J., Smith, B. L., Rajendiran, T. M., & Núñez, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.016 · Cited by 2,167

The Cytolytic P 2Z Receptor for Extracellular ATP Identified as a P 2X Receptor (P2X 7 )

Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., & Buell, G. (1996) · Science · doi:10.1126/science.272.5262.735 · Cited by 1,739

Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor

Pelegrı́n, P., & Surprenant, A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601378 · Cited by 1,490

The P2X7 Receptor in Infection and Inflammation

Di Virgilio, F., Dal Ben, D., Sarti, A. C., Giuliani, A. L., & Falzoni, S. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.020 · Cited by 1,267

Altered Cytokine Production in Mice Lacking P2X7Receptors

Solle, M., Labasi, J. M., Perregaux, D. G., Stam, E. J., Petrushova, N., Koller, B. H., Griffiths, R., & Gabel, C. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006781200 · Cited by 924

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

Yang, D., He, Y., Muñoz-Planillo, R., Liu, Q., & Núñez, G. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.009 · Cited by 622

Pathophysiology and Therapeutic Potential of Purinergic Signaling

Burnstock, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.5 · Cited by 618

Nanobodies and nanobody-based human heavy chain antibodies as antitumor therapeutics

Bannas, P., Hambach, J., & Koch-Nolte, F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01603 · Cited by 572

Ischemia Opens Neuronal Gap Junction Hemichannels

Thompson, R. J., Zhou, N., & MacVicar, B. A. (2006) · Science · doi:10.1126/science.1126241 · Cited by 560

Synthetic 1,4-Naphthoquinones inhibit P2X7 receptors in murine neuroblastoma cells

Pislyagin, Е. А., Kozlovskiy, S., Menchinskaya, E. S., Chingizova, E. A., Николаевна, Л. Г., Gorpenchenko, T. Y., Sabutski, Y. E., Полоник, С. Г., & Aminin, D. L. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115975 · Cited by 23

P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilization

Sheng, G., Gao, Y., Ding, Q., Zhang, R., Wang, T., Jing, S., Zhao, H., Ma, T., Wu, H. K., & Yang, Y. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03985-z · Cited by 24

Oxidative phosphorylation in HIV-1 infection: impacts on cellular metabolism and immune function

Rodriguez, N., Fortune, T., Hegde, E., Weinstein, M. P., Keane, A. M., Mangold, J. F., & Swartz, T. H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1360342 · Cited by 25

TRP ion channels: Proteins with conformational flexibility

López-Romero, A. E., Hernández‐Araiza, I., Torres‐Quiroz, F., Tovar‐y‐Romo, L. B., Islas, L. D., & Rosenbaum, T. (2019) · Channels · doi:10.1080/19336950.2019.1626793 · Cited by 23

Overview of the role of purinergic signaling and insights into its role in cancer therapy

Virgilio, F. D., Vultaggio-Poma, V., Tarantini, M., & Giuliani, A. L. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108700 · Cited by 25

P2X7 Receptors and TMEM16 Channels Are Functionally Coupled with Implications for Macropore Formation and Current Facilitation

Dunning, K., Martz, A., Peralta, F. A., Cevoli, F., Boué‐Grabot, É., Compan, V., Gautherat, F., Wolf, P., Chataigneau, T., & Grütter, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126542 · Cited by 22

P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma

Arnaud-Sampaio, V. F., Bento, C. A., Glaser, T., Adinolfi, E., Ulrich, H., & Lameu, C. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.966404 · Cited by 23

HSV-1 employs UL56 to antagonize expression and function of cGAMP channels

Blest, H. T. W., Redmond, A., Avissar, J., Barker, J., Bridgeman, A., Fowler, G., Chauveau, L., Hertzog, J., Vendrell, I., Fischer, R., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114122 · Cited by 21

Altered donor P2X7 activity in human leukocytes correlates with P2RX7 genotype but does not affect the development of graft-versus-host disease in humanised mice

Adhikary, S. R., Geraghty, N. J., Cuthbertson, P., Sluyter, R., & Watson, D. (2019) · Purinergic Signalling · doi:10.1007/s11302-019-09651-8 · Cited by 22

The P2X7 Receptor in Oncogenesis and Metastatic Dissemination: New Insights on Vesicular Release and Adenosinergic Crosstalk

Adinolfi, E., Marchi, E. D., Grignolo, M., Szymczak, B., & Pegoraro, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813906 · Cited by 22

P2X7 Receptor in Dendritic Cells and Macrophages: Implications in Antigen Presentation and T Lymphocyte Activation

Acuña‐Castillo, C., Escobar, A. F., García-Gómez, M., Bachelet, V. C., Huidobro-Toro, J. P., Sauma, D., & Barrera‐Avalos, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052495 · Cited by 21

Enlightening activation gating in P2X receptors

Sattler, C., & Benndorf, K. (2022) · Purinergic Signalling · doi:10.1007/s11302-022-09850-w · Cited by 21

P2X7 Receptor-Related Genetic Mouse Models – Tools for Translational Research in Psychiatry

Urbina-Treviño, L., von Mücke-Heim, I.-A., & Deussing, J. M. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.876304 · Cited by 23

The Role of IL-18 in P2RX7-Mediated Antitumor Immunity

Hreich, S. J. D., Hofman, P. M., & Vouret‐Craviari, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119235 · Cited by 21

Macrophage P2Y6R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses

Yin, L., Zhang, E., Mao, T., Zhu, Y., Ni, S., Li, Y., Liu, C., Fang, Y., Ni, K., Lu, Y., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.06.008 · Cited by 21

Purinergic and Adenosinergic Signaling in Pancreatobiliary Diseases

Faraoni, E. Y., Ju, C., Robson, S. C., Eltzschig, H. K., & Bailey, J. M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.849258 · Cited by 19

Aerobic glycolysis of bronchial epithelial cells rewires Mycoplasma pneumoniae pneumonia and promotes bacterial elimination

He, J., Xiu, F., Chen, Y., Yang, Y., Liu, H., Xi, Y., Liu, L., Li, X., Wu, Y., Luo, H., et al. (2024) · Infection and Immunity · doi:10.1128/iai.00248-23 · Cited by 21

Dioscin ameliorates diabetes cognitive dysfunction via adjusting P2X7R/NLRP3 signal

Lu, Z., Yao, Y., Wang, J., & Peng, J. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108314 · Cited by 19

The Purinergic System as a Target for the Development of Treatments for Bipolar Disorder

Gonçalves, M. C. B., Andrejew, R., & Gubert, C. (2022) · CNS Drugs · doi:10.1007/s40263-022-00934-0 · Cited by 19

Evolutionary Origin of the P2X7 C-ter Region: Capture of an Ancient Ballast Domain by a P2X4-Like Gene in Ancient Jawed Vertebrates

Rump, A., Smolander, O., Boudinot, S. R., Kanellopoulos, J., & Boudinot, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00113 · Cited by 19

Evaluation of P2X7 Receptor Function in Tumor Contexts Using rAAV Vector and Nanobodies (AAVnano)

Demeules, M., Scarpitta, A., Abad, C., Gondé, H., Hardet, R., Pinto-Espinoza, C., Eichhoff, A. M., Schäfer, W., Haag, F., Koch‐Nolte, F., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01699 · Cited by 23

Purinergic-associated immune responses in neurodegenerative diseases

Carracedo, S., Launay, A., Déchelle-Marquet, P.-A., Faivre, É., Blum, D. L., Delarasse, C., & Boué‐Grabot, É. (2024) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2024.102693 · Cited by 20

The P2X7 receptor in mood disorders: Emerging target in immunopsychiatry, from bench to bedside

von Mücke-Heim, I.-A., & Deussing, J. M. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109366 · Cited by 19

The impact of the P2X7 receptor on the tumor immune microenvironment and its effects on tumor progression

Zou, Y.-T., Li, J., Chai, J.-Y., Hu, Y., Zhang, W., & Zhang, Q. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149513 · Cited by 20

P2X7 is a cytotoxic receptor….maybe not: implications for cancer

Virgilio, F. D. (2020) · Purinergic Signalling · doi:10.1007/s11302-020-09735-w · Cited by 17

P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia

Calovi, S., Mut-Arbona, P., Tod, P., Iring, A., Nicke, A., Mato, S., Vizi, E. S., Tønnesen, J., & Sperlágh, B. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.566251 · Cited by 18

Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage

Gómez, G. I., Alvear, T. F., Roa, D. A., Farias-Pasten, A., Vergara, S. A., Mellado, L. A., Martínez-Araya, C. J., Prieto‐Villalobos, J., García‐Rodríguez, C., Sánchez, N., et al. (2024) · Biological Research · doi:10.1186/s40659-024-00493-2 · Cited by 19

Cannabinoids Induce Cell Death and Promote P2X7 Receptor Signaling in Retinal Glial Progenitors in Culture

Freitas, H. R., Isaac, A. R., Silva, T. M., Diniz, G. O. F., Dabdab, Y. D. S., Bockmann, E. C., Guimarães, M. Z. P., Calaza, K. D. C., Mello, F. G. D., Ventura, A. L. M., et al. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1537-y · Cited by 17

P2X Receptors: Potential Therapeutic Targets for Symptoms Associated With Lung Cancer — A Mini Review

Mai, Y., Guo, Z., Yin, W., Zhong, N., Dicpinigaitis, P. V., & Chen, R. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.691956 · Cited by 17

The Secreted Virulence Factor NADase of Group A Streptococcus Inhibits P2X7 Receptor-Mediated Release of IL-1β

Westerlund, E., Valfridsson, C., Yi, D. X., & Persson, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01385 · Cited by 17

Restraint of Human Skin Fibroblast Motility, Migration, and Cell Surface Actin Dynamics, by Pannexin 1 and P2X7 Receptor Signaling

Flores‐Muñoz, C., Maripillán, J., Vásquez-Navarrete, J., Novoa-Molina, J., Ceriani, R., Sánchez, H. A., Abbott, A. C., Oppenheimer, C. W., Brown, D. I., Cárdenas, A. M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031069 · Cited by 17

Assessing the Association of Mitochondrial Function and Inflammasome Activation in Murine Macrophages Exposed to Select Mitotoxic Tri-Organotin Compounds

Childers, G. M., Perry, C. A., Blachut, B., Martin, N. P., Bortner, C. D., Sieber, S. O., Li, J., Fessler, M. B., & Harry, G. J. (2021) · Environmental Health Perspectives · doi:10.1289/ehp8314 · Cited by 16

Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists

Patberg, M., Isaak, A., Füsser, F. T., Zacarı́as, N. V. O., Vinnenberg, L., Schulte, J., Michetti, L., Grey, L., van der Horst, C., Hundehege, P., et al. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113838 · Cited by 16

The Purinergic Landscape of Type 2 Diabetes Mellitus

García-Jacobo, R. E., Bergamin, L. S., Vultaggio-Poma, V., Thorstenberg, M. L., Tarantini, M., García-Hernández, M. H., & Virgilio, F. D. (2022) · Molecules · doi:10.3390/molecules27061838 · Cited by 16

Evaluation of nanobody-based biologics targeting purinergic checkpoints in tumor models in vivo

Demeules, M., Scarpitta, A., Hardet, R., Gondé, H., Abad, C., Blandin, M., Menzel, S., Duan, Y., Rissiek, B., Magnus, T., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1012534 · Cited by 15

Ligand-Gated Ion Channels: Prognostic and Therapeutic Implications for Gliomas

Hey, G. E., Rao, R., Carter, A. M., Reddy, A., Valle, D., Patel, A., Patel, D., Lucke-Wold, B. P., Krummel, D. P., & Sengupta, S. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13050853 · Cited by 16

Human P2X7 receptors – Properties of single ATP-gated ion channels

Markwárdt, F. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114307 · Cited by 16

P2 receptor-mediated signaling in the physiological and pathological brain: From development to aging and disease

Mut-Arbona, P., & Sperlágh, B. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109541 · Cited by 16

Duality of P2X7 Receptor in Amyotrophic Lateral Sclerosis

Volonté, C., Amadio, S., Liguori, F., & Fabbrizio, P. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01148 · Cited by 15

Regulation of extracellular ATP of human erythrocytes treated with α-hemolysin. Effects of cell volume, morphology, rheology and hemolysis

Denis, M. F. L., Lefevre, S. D., Alvarez, C., Lauri, N., Enrique, N., Rinaldi, D. E., González‐Lebrero, R. M., Dezillio, L. E. V., Espelt, M. V., Stringa, P. L., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.01.018 · Cited by 15

Stimulation of P2X7 Enhances Whole Body Energy Metabolism in Mice

Giacovazzo, G., Fabbrizio, P., Apolloni, S., Coccurello, R., & Volonté, C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00390 · Cited by 14

Detection and Functional Evaluation of the P2X7 Receptor in hiPSC Derived Neurons and Microglia-Like Cells

Francistiová, L., Vörös, K., Lovász, Z., Dinnyés, A., & Kobolák, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.793769 · Cited by 14

Agonists, Antagonists, and Modulators of P2X7 Receptors

Müller, C. E., & Namasivayam, V. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2384-8_2 · Cited by 14

Understanding interspecies drug response variations between human and rodent P2X7 receptors

Guo, C.-R., Sheng, D., Li, J., Li, T., Yao, J., Zhang, R., Huang, Y., Zhao, Y., Wang, D., Chen, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65847-0 · Cited by 13

Role of the P2X7 receptor in breast cancer progression

Du, Y., Cao, Y., Song, W., Wang, X., Yu, Q., Peng, X., & Zhao, R. (2024) · Purinergic Signalling · doi:10.1007/s11302-024-10039-6 · Cited by 13

P2X7 Receptors as a Therapeutic Target in Cerebrovascular Diseases

Cisneros-Mejorado, A., Pérez‐Samartín, A., Domercq, M., Arellano, R. O., Gottlieb, M., Koch‐Nolte, F., & Matute, C. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00092 · Cited by 16

P2X1 and P2X7 Receptor Overexpression Is a Negative Predictor of Survival in Muscle-Invasive Bladder Cancer

Ledderose, S., Rodler, S., Eismann, L., Ledderose, G., Rudelius, M., JUNGER, W. G., & Ledderose, C. (2023) · Cancers · doi:10.3390/cancers15082321 · Cited by 13

The P2X7 purinergic receptor in intervertebral disc degeneration

Penolazzi, L., Bergamin, L. S., Lambertini, E., Vultaggio-Poma, V., Sarti, A. C., BONIS, P. D., Virgilio, F. D., & Piva, R. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30611 · Cited by 12

Caveolin-1 forms a complex with P2X7 receptor and tunes P2X7-mediated ATP signaling in mouse bone marrow-derived macrophages

Sawai, Y., Suzuki, Y., Asagiri, M., Hida, S., Kondo, R., Zamponi, G. W., Giles, W. R., Imaizumi, Y., & Yamamura, H. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00303.2023 · Cited by 13

How goblet cells respond to dry eye: adaptive and pathological roles of voltage-gated calcium channels and P2X7 purinoceptors

Puro, D. G. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00086.2020 · Cited by 12

Elevated Serum Purine Levels in Schizophrenia: A Reverse Translational Study to Identify Novel Inflammatory Biomarkers

Kristóf, Z., Baranyi, M., Tod, P., Mut-Arbona, P., Demeter, K., Bitter, I., & Sperlágh, B. (2022) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyac026 · Cited by 13

ATP indirectly stimulates hippocampal CA1 and CA3 pyramidal neurons via the activation of neighboring P2X7 receptor-bearing astrocytes and NG2 glial cells, respectively

Zhang, Y., Yin, H., Rubini, P., Illés, P., & Tang, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.944541 · Cited by 13

Altered purinergic receptor expression in the frontal cortex in schizophrenia

Alnafisah, R. S., Lundh, A., Asah, S. M., Hoeflinger, J., Wolfinger, A., Hamoud, A.-R. A., McCullumsmith, R. E., & O'Donovan, S. M. (2022) · Schizophrenia · doi:10.1038/s41537-022-00312-1 · Cited by 12

Mechanosensitive ATP release in the lungs: New insights from real-time luminescence imaging studies

Grygorczyk, R., Boudreault, F., Tan, J. J., Ponomarchuk, O., Sokabe, M., & Furuya, K. (2019) · Current topics in membranes · doi:10.1016/bs.ctm.2019.02.001 · Cited by 12

The P2X7 receptor/NLRP3 inflammasome signaling axis in sepsis: molecular mechanisms, organ-specific pathophysiology, and emerging therapeutic strategies

Üstündağ, H. (2026) · Purinergic Signalling · doi:10.1007/s11302-026-10140-y · Cited by 12

Improved ANAP incorporation and VCF analysis reveal details of P2X7 current facilitation and a limited conformational interplay between ATP binding and the intracellular ballast domain

Durner, A., Durner, E., & Nicke, A. (2023) · eLife · doi:10.7554/elife.82479 · Cited by 11

The Role of P2X7 Purinoceptors in the Pathogenesis and Treatment of Muscular Dystrophies

Zabłocki, K., & Górecki, D. C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119434 · Cited by 11

Lidocaine pretreatment attenuates inflammatory response and protects against sepsis-induced acute lung injury via inhibiting potassium efflux-dependent NLRP3 activation

Su, K., Li, X., Hong, F., Jin, M., & Xue, F.-S. (2023) · Inflammation Research · doi:10.1007/s00011-023-01810-3 · Cited by 11

Production, characterization, and application of a monoclonal antibody specific for the extracellular domain of human P2X7R

Li, M., Luo, S., Zhang, Y., Jia, L., Yang, C., Peng, X., & Zhao, R. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10340-0 · Cited by 11

Mechanosensitive release of ATP in the urinary bladder mucosa

Mutafova–Yambolieva, V. N. (2024) · Purinergic Signalling · doi:10.1007/s11302-024-10063-6 · Cited by 10

Design, Synthesis, and in vitro Evaluation of P2X7 Antagonists

Pournara, D. T., Durner, A., Kritsi, E., Papakostas, A., Zoumpoulakis, P. G., Nicke, A., & Koufaki, M. (2020) · ChemMedChem · doi:10.1002/cmdc.202000303 · Cited by 10

Unorthodox localization of P2X7 receptor in subcellular compartments of skeletal system cells

Penolazzi, L., Notarangelo, M. P., Lambertini, E., Vultaggio-Poma, V., Tarantini, M., Virgilio, F. D., & Piva, R. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1180774 · Cited by 9

Deregulated calcium signaling in blood cancer: Underlying mechanisms and therapeutic potential

Immanuel, T., Li, J., Green, T. N., Bogdanova, A. Y., & Kalev‐Zylinska, M. L. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1010506 · Cited by 9

Virulence and molecular adaptation of human urogenital mycoplasmas: a review

Roachford, O. S. E., Nelson, K. E., & Mohapatra, B. R. (2019) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2019.1607556 · Cited by 9

ATP-gated P2X7 receptor as a potential target for prostate cancer

Qiao, C., Tang, Y., Li, Q., Zhu, X., Peng, X., & Zhao, R. (2022) · Human Cell · doi:10.1007/s13577-022-00729-x · Cited by 11

Progress in the relationship between P2X7R and colorectal cancer

Bai, X., Li, X., Qiao, C., Tang, Y., Zhao, R., & Peng, X. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07939-4 · Cited by 9

Ligand-independent activation of the P2X7 receptor by Hsp90 inhibition stimulates motor neuron apoptosis

Strayer, A. L., Dennys, C. N., Ricart, K. C., Bae, N., Beckman, J. S., Franco, M. C., & Estévez, Á. G. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370219853798 · Cited by 10

Extracellular Purine Metabolism—Potential Target in Multiple Sclerosis

Laketa, D., & Lavrnja, I. C. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04104-9 · Cited by 9

A patent review of P2X7 receptor antagonists to treat inflammatory diseases (2018–present)

Iqbal, J., Bano, S., Khan, I. A., & Huang, Q. (2024) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2024.2363885 · Cited by 8

Different localization of P2X4 and P2X7 receptors in native mouse lung - lack of evidence for a direct P2X4-P2X7 receptor interaction

Sierra‐Marquez, J., Schaller, L., Sassenbach, L., Ramírez-Fernández, A., Alt, P., Rissiek, B., Zimmer, B., Schredelseker, J., Hector, J., Stähler, T., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1425938 · Cited by 8

Inflammasomes: potential therapeutic targets in hematopoietic stem cell transplantation

Luo, J., Zhou, Y., Wang, M., Zhang, J. L., & Jiang, E. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01974-3 · Cited by 9

New insights into pathogenisis and therapies of P2X7R in Parkinson’s disease

Wei, S., Song, X., Mou, Y., Yang, T., Wang, H., Wang, H., Ren, C., & Song, X. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-00980-7 · Cited by 10

A live-cell assay for the real-time assessment of extracellular ATP levels

Niles, A. L., Cali, J. J., & Lazar, D. F. (2021) · Analytical Biochemistry · doi:10.1016/j.ab.2021.114286 · Cited by 8

The role of extracellular ATP and P2X receptors in the pathogenesis of HIV-1

Rodriguez, N., Fortune, T., Vuong, T., & Swartz, T. H. (2023) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2023.102358 · Cited by 8

Deficiency of purinergic P2X4 receptor alleviates experimental autoimmune hepatitis in mice

Liu, Z., Sun, M., Liu, W., Feng, F., Li, X., Jin, C., Zhang, Y., & Wang, J. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116033 · Cited by 8

Human P2X7 receptor variants Gly150Arg and Arg276His polymorphisms have differential effects on risk association and cellular functions in pancreatic cancer

Magni, L., Yu, H., Christensen, N. M., Poulsen, M. H., Frueh, A., Deshar, G., Johansen, A. Z., Johansen, J. S., Pless, S. A., Jørgensen, N. R., et al. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03339-9 · Cited by 8

The Pannexin 1 Channel and the P2X7 Receptor Are in Complex Interplay to Regulate the Release of Soluble Ectonucleotidases in the Murine Bladder Lamina Propria

Branco, M. S. L. A., Cruz, A. G., Peri, L. E., & Mutafova–Yambolieva, V. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129964 · Cited by 8

Embers of the Past: Early Childhood Traumas Interact with Variation in P2RX7 Gene Implicated in Neuroinflammation on Markers of Current Suicide Risk

Kristóf, Z., Gál, Z., Török, D., Eszlári, N., Sütöri, S., Sperlágh, B., Anderson, I. M., Deakin, J. F. W., Bagdy, G., Juhász, G., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020865 · Cited by 7

Genetic Variations in the P2X7 Receptor: Opportunities and Challenges for Drug Development

Cheah, J. S. Y., Skarratt, K. K., Fuller, S. J., & Balle, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110265 · Cited by 7

The multifaceted role of extracellular ATP in sperm function: From spermatogenesis to fertilization

Cao, H., Li, L., Liu, S., Wang, Y., Liu, X., Yang, F., & Dong, W. (2023) · Theriogenology · doi:10.1016/j.theriogenology.2023.10.019 · Cited by 9

Calcium Signalling in Microglia

Garaschuk, O., & Verkhratsky, A. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_7 · Cited by 7

Overexpression or knockdown of the P2X7 receptor regulates the progression of non-small cell lung cancer, involving GSK-3β and JNK signaling pathways

Yu, Q., Peng, X., Xu, G., Bai, X., Cao, Y., Du, Y., Wang, X., & Zhao, R. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177421 · Cited by 7

Carboxyl terminus of Pannexin-1 plays a crucial role in P2X7 receptor-mediated signaling

Purohit, R., & Bera, A. K. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.04.081 · Cited by 7

P2X7: a receptor with a split personality that raises new hopes for anti-cancer therapy

Sarti, A. C., Vultaggio-Poma, V., & Virgilio, F. D. (2021) · Purinergic Signalling · doi:10.1007/s11302-021-09783-w · Cited by 7

Focus on P2X7R in microglia: its mechanism of action and therapeutic prospects in various neuropathic pain models

Zhang, K., Ran, R., Zhang, C., Wang, L., & Zhang, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1555732 · Cited by 6

P2X7 Receptor Facilitates Cardiomyocyte Autophagy After Myocardial Infarction via Nox4/PERK/ATF4 Signaling Pathway

Zhang, S., Bi, Y., Xiang, K., & Tang, Y. (2025) · Cell Biochemistry and Function · doi:10.1002/cbf.70078 · Cited by 7

The P2X7 purinoceptor in pathogenesis and treatment of dystrophino- and sarcoglycanopathies

Górecki, D. C., & Rumney, R. M. H. (2023) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2023.102357 · Cited by 6

P2X7 receptors and pannexin1 hemichannels shape presynaptic transmission

Vitureira, N., Rafael, A., & Abudara, V. (2023) · Purinergic Signalling · doi:10.1007/s11302-023-09965-8 · Cited by 7

Influence of extracellular ATP on mammalian sperm physiology

López‐González, I., Oseguera-López, I., Castillo, R., & Darszon, A. (2024) · Reproduction Fertility and Development · doi:10.1071/rd23227 · Cited by 6

Purinergic Ca2+ Signaling as a Novel Mechanism of Drug Tolerance in BRAF-Mutant Melanoma

Stauffer, P. E., Brinkley, J., Jacobson, D. A., Quaranta, V., & Tyson, D. R. (2024) · Cancers · doi:10.3390/cancers16132426 · Cited by 8

Flow cytometry: An accurate tool for screening P2RX7 modulators

Barczyk, A., Roy, H. B., Jouy, N., Renault, N., Hottin, A., Millet, R., Vouret‐Craviari, V., Adriouch, S., Idziorek, T., & Dezitter, X. (2020) · Cytometry Part A · doi:10.1002/cyto.a.24287 · Cited by 6

Purinergic P2X7R as a potential target for pancreatic cancer

Yu, Q., Wang, X., Li, X., Bai, X., Zhao, R., & Peng, X. (2023) · Clinical & Translational Oncology · doi:10.1007/s12094-023-03123-7 · Cited by 6

Knockout and Knock-in Mouse Models to Study Purinergic Signaling

Rumney, R. M. H., & Górecki, D. C. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9717-6_2 · Cited by 6

Integrated transcriptomic and functional analyses reveal that NOX2 inhibition rewires the inflammatory landscape of macrophages

Muthukumarasamy, I., Buel, S. M., Hurley, J., & Dordick, J. S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1731888 · Cited by 5

Antinociceptive effect and anti-inflammatory activity of 1,4-naphthoquinones in mice

Kozlovskiy, S., Pislyagin, Е. А., Menchinskaya, E. S., Chingizova, E. A., Sabutski, Y. E., Полоник, С. Г., Агафонова, И. Г., & Aminin, D. L. (2024) · Exploration of neuroscience · doi:10.37349/en.2024.00035 · Cited by 5

P2X7 receptor: A receptor closely linked with sepsis-associated encephalopathy

Fan, Z., Wang, K., Zhao, X., & Sun, X. (2024) · Open Life Sciences · doi:10.1515/biol-2022-0775 · Cited by 5

Channel plan: control of adaptive immune responses by pannexins

Santiago-Carvalho, I., Ishikawa, M., & da Silva, H. B. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.09.009 · Cited by 5

Research Progress in the Relationship Between P2X7R and Cervical Cancer

Tang, Y., Qiao, C., Li, Q., Zhu, X., Zhao, R., & Peng, X. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-01022-w · Cited by 5

Protocol for Evaluating In Vivo the Activation of the P2RX7 Immunomodulator

Hreich, S. J. D., Juhel, T., Hofman, P. M., & Vouret‐Craviari, V. (2023) · Biological Procedures Online · doi:10.1186/s12575-022-00188-6 · Cited by 5

How is the P2X7 receptor signaling pathway involved in epileptogenesis?

Wei, C., Fu, M., Zhang, H., & Yao, B. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105675 · Cited by 6

ATP-Gated P2X7 Receptors Require Chloride Channels To Promote Inflammation in Human Macrophages

Janks, L., Sprague, R. S., & Egan, T. M. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801101 · Cited by 45

Inherent P2X7 Receptors Regulate Macrophage Functions during Inflammatory Diseases

Ren, W.-J., Rubini, P., Tang, Y., Engel, T., & Illés, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010232 · Cited by 70

P2X7R large pore is partially blocked by pore forming proteins antagonists in astrocytes

Faria, R. X., Reis, R. A. D. M., Ferreira, L. G. B., de Mello, P. F. T. C., & Moraes, M. O. (2016) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-016-9649-9 · Cited by 21

Role of purinoceptors in immune-mediated disease (therapies targeting the P2X7 receptor)

Tsukimoto, M., Harada, H., & Degawa, M. (2007) · Drug Discovery Today Therapeutic Strategies · doi:10.1016/j.ddstr.2007.06.002 · Cited by 14

P2X7 Receptor Mediated Increase In Cell Membrane Permeability

Cankurtaran-Sayar, Ș., & Sayar, K. (2018) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.1501/tıpfak_000000993