The Elusive P2X7 Macropore
Di Virgilio, Francesco, Schmalzing, Günther, Markwardt, Fritz·2018·Trends in Cell Biology
Cited by (280)
Items 201–280 of 280
- Establishment and behavioural characterization of a novel constitutive P2X7 receptor knockout mouse lineIven-Alex von Mücke-Heim, Judit Oldekamp, Michael W. Metzger, Sarah Kläffgen, Hao Tang, Sandra M. Walser, Nina Dedic, Gerhard Rammes, Florian Holsboer, Wolfgang Wurst et al. · 2025 · Purinergic Signalling
- ATP/P2X7 receptor signal aggravates ischemic stroke injury by activating Th17 cells via STAT3/IL-21 pathwayWenying Liu, Denghui Li, Mengjie Zhang, Jun Yin, Peng Wang, Paiyu Liu, Zhiqiang Song, Bing Ni, Yanmeng Peng · 2025 · Frontiers in Immunology
- Established Protocols for cRNA Expression and Voltage-Clamp Characterization of the P2X7 Receptor in Xenopus laevis OocytesGünther Schmalzing, F Markwárdt · 2022 · Methods in molecular biology
- Molecular insights into P2X signalling cascades in acute kidney injurySwati Mishra, Vishwadeep Shelke, Neha Dagar, Maciej Lech, Anil Bhanudas Gaikwad · 2024 · Purinergic Signalling
- P2X7 receptors: a bibliometric review from 2002 to 2023Haiting Tang, Wei Wei, Yu Luo, Xiaoqing Lu, Jun Chen, Shenqiao Yang, Fei Wu, Haiyan Zhou, Wenbin Ma, Xin Yang · 2024 · Purinergic Signalling
- P2X7 regulates ependymo-radial glial cell proliferation in adult Danio rerio following spinal cord injuryEva E. Stefanova, Julian Vincent T. Dychiao, Mavis C. Chinn, Matin Borhani, Angela L. M. Scott · 2024 · Biology Open
- Role of purinoreceptors in the release of extracellular vesicles and consequences on immune response and cancer progressionThomas Duret, Mohammed I. Y. Elmallah, Jérôme Rollin, Philippe Gatault, Lin‐Hua Jiang, Sébastien Roger · 2024 · Biomedical Journal
- The eATP/P2×7R Axis Drives Quantum Dot‐Nanoparticle Induced Neutrophil Recruitment in the Pulmonary MicrocirculationChenxi Li, Qiongliang Liu, Lianyong Han, Haiyun Zhang, Roland Immler, Birgit Rathkolb, Judith Secklehner, Martin Hrabě de Angelis, Ali Önder Yildirim, Dagmar Zeuschner et al. · 2024 · Advanced Science
- Methodological guidelines for P2X receptor assays and data interpretationDariusz C. Górecki, Elena Adinolfi, Sahil Adriouch, Robson Coutinho‐Silva, Tobías Engel, Flóra Gölöncsér, Friedrich Haag, Péter Illés, Kenneth A. Jacobson, Friedrich Koch‐Nolte et al. · 2026 · Cell Death and Disease
- Recombinant Analogs of Sea Anemone Kunitz-Type Peptides Influence P2X7 Receptor Activity in Neuro-2a CellsЕvgeny А. Pislyagin, Ekaterina S. Menchinskaya, Irina N. Gladkikh, Кветкина Александра Николаевна, Oksana V. Sintsova, Daria V. Popkova, Sergey Kozlovskiy, Tatiana Y. Gorpenchenko, Лихацкая Галина Николаевна, Leonid A. Kaluzhskiy et al. · 2023 · Marine Drugs
- Cell Type-Specific Expression of Purinergic P2X Receptors in the HypothalamusJana Cihakova, Milorad Ivetic, Hana W. Zemkova · 2025 · International Journal of Molecular Sciences
- Implications of COVID-19 in Parkinson’s disease: the purinergic system in a therapeutic-target perspective to diminish neurodegenerationJúlia Leão Batista Simões, Geórgia de Carvalho Braga, Samantha Webler Eichler, Gilnei Bruno da Silva, Margarete Dulce Bagatini · 2024 · Purinergic Signalling
- P2X7 Receptors and TMEM16 Channels Form a Hub with Implications for Macropore Formation and Current FacilitationKate Dunning, Adeline Martz, Francisco Andrés Peralta, Federico Cevoli, Éric Boué‐Grabot, Antoine Taly, Vincent Compan, Fanny Gautherat, Patrick Wolf, Thierry Chataigneau et al. · 2021 · Research Square
- A Bibliometric Analysis of P2X7R in Cardiovascular Diseases from 2005 to 2024Juanjuan Tan, Wenqi Zhou, Zhiye Guo, Li Cheng, Yalong Kang, Qiong Wang, Jing Dong, Haifang Wang, Qi Zhang, Li Shen et al. · 2025 · Current Cardiology Reviews
- Traditional Chinese Medicine Natural Products Targeting Shared Mechanisms of T2DM and AD: Potential Therapeutic InsightsBingbing Song, DongJie Yue, Huiying Yan, Lina Feng, Mingquan Li · 2025 · Drug Design Development and Therapy
- Role of P2X7 Receptor on Hypoxia-Induced Vascular Endothelial Growth Factor Gene Expression in H9c2 Rat CardiomyocytesAnfal F. Bin Dayel, Reem M. Alhejji, Asma S. Alonazi, Nouf Mohamed Al-Rasheed · 2025 · Journal of Cardiovascular Development and Disease
- Analgesic effect of cinobufagin is mediated by human-selective P2X7R antagonism governed by distinct extracellular domainsKe‐Xin Yu, Min Li, Yuchen Jin, Miao Zhao, Zeliang Wang, Haibo Yu · 2025 · Neuropharmacology
- Extracellular ATP and the central nervous systemFernanda Tibolla Viero, Guilherme Shigueto Vilar Higa, Jean Bezerra Silva, Natalia Turrini, Guilherme de Araujo Juvenal, Allan de Carvalho, Lucas Marques, Roberto De Pasquale, Henning Ulrich · 2026 · Elsevier eBooks
- Synthesis and characterization of new P2X7 receptor antagonists as antitumor agentsMarianna Grignolo, Andrea Spinaci, Ludovica Ricci, Anna Pegoraro, Luigia Ruo, Catia Lambertucci, Daniele Vitone, Marcello Leopoldo, Enza Lacivita, Federica Fortuna et al. · 2026 · Biomedicine & Pharmacotherapy
- Latest advances on the role of P2X Receptors in colorectal inflammation and cancerLuigia Ruo, Federica Fortuna, Marianna Grignolo, Anna Pegoraro, Elena Adinolfi · 2026 · Purinergic Signalling
- Microglial physiology and functionAlexei Verkhratsky, Arthur Morgan Butt · 2023 · Elsevier eBooks
- Could P2X7 receptor be a potencial target in neonatal sepsis?Sales Fialho, Patrick Trieu‐Cuot, Paula Ferreira, Laura Oliveira · 2024 · International Immunopharmacology
- An association study of polymorphisms in the P2RX7 gene in an Iranian population with the risk of type 2 diabetes mellitusHoma Noori, Majid Rajabian, Mahdi Majidpour, Mahboobeh Sabeti Akbar-Abad, Ramin Saravani · 2025 · Egyptian Journal of Medical Human Genetics
- Activation of the Rat P2X7 Receptor by Functionally Different ATP Activation SitesF Markwárdt, Malte Berthold, Sanaria Hawro Yakoob, Guenther Schmalzing · 2025 · Cells
- Role of caspases, apoptosis and additional factors in pathology of Alzheimer's diseaseAnil Gupta · 2021 · Elsevier eBooks
- Using Symmetrical Organic Cation Solutions to Study P2X7 Ion PermeationKate Dunning, Laurie Peverini, Thomas Grütter · 2022 · Methods in molecular biology
- The role of the purinergic ligand-gated ion channel 7 receptor in common digestive system cancersXin Wang, Qingqing Yu, Xue Bai, Xinyu Li, Yanli Sun, Xiaoxiang Peng, Ronglan Zhao · 2023 · European Journal of Cancer Prevention
- Immunomodulatory Effects of a M2-Conditioned Medium (PRS®CK STORM): Theory on the Possible Complex Mechanism of Action through Anti-Inflammatory Modulation of the TLR System and the Purinergic SystemJuan Pedro Lapuente · 2022 · Biochemistry
- Characterization of the Active Enantiomer and Mapping of the Stereospecific Intermolecular Pattern of a Reference P2X7 Allosteric AntagonistAndrew McGown, Nicolas Renault, Amélie Barczyk, Jordan Nafie, Luciano Barluzzi, Daniel Guest, Graham John Tizzard, Simon John Coles, David Leach, Daniel von Emloh et al. · 2025 · ACS Pharmacology & Translational Science
- Clostridioides difficile meets the adenosine system: the art of manipulating host homeostasisKatia Fettucciari, Luigi Cari, Andrea Spaterna, Rachele DEL SORDO, Filippo Tavanti, Pierfrancesco Marconi, Gabrio Bassotti · 2025 · Journal of Biomedical Science
- Increased spinal adenosine after subacute cervical injury correlates with sustained upregulation of CD39 and CD73 in microgliaMackenzie R. Berschel, Mária Nikodémová, Jose R. Oberto, Alexandria B. Marciante, Alysha L. Michaelson, Gordon S. Mitchell · 2025 · Neurochemistry International
- Targeting the purinergic P2X7 receptor in epilepsy: Cell types matterTobías Engel, Valentina Salari, Meng-Juan Sun, Meghma Mitra · 2026 · Neuropharmacology
- Discovery of novel anthraquinone-based P2X7R antagonist that reinvigorates anti-tumor immunity and overcomes PD-1 resistance in breast cancerChenyu Liang, Simin Wang, Xiaozhen Liu, Xin Eric Wang, Benjun Yuan, Xuyang Wang, Wei Liu, Tianyou Wang, Chuanjun Song, Yongfang Yao et al. · 2026 · European Journal of Medicinal Chemistry
- Inflammation, oxidative stress and purinergic signaling in pituitary neuroendocrine tumors (PitNETs)Yenidis Teilor Scheibel, Symon Martins, André Paulo Turcatel, Francini Franscescon, Débora Tavares de Resende e Silva · 2026 · Purinergic Signalling
- Novel Therapeutic Targets for Treating Alzheimer’s DiseaseMagham Sai Varshini, Ammu V. V. V. Ravi Kiran, Kusuma Kumari Garikapati, Praveen Thaggikuppe Krishnamurthy, Vaishali Manikrao Patil, Renat R. Khaydarov · 2023 · Springer eBooks
- Purinergic Signaling and its Role in the Stem Cell DifferentiationSumera Zaib, Areeba, Imtiaz Ali Khan · 2023 · Mini-Reviews in Medicinal Chemistry
- Two serial filters control P2X7 cation selectivity, Ser342 in the central pore and lateral acidic residues at the cytoplasmic interfaceF Markwárdt, Eike Christian Schön, Mihaela Raycheva, Aparna Sai Malisetty, Sanaria Hawro Yakoob, Malte Berthold, Guenther Schmalzing · 2024 · PNAS Nexus
- Papel dos receptores purinérgicos em modelo animal de doença de ParkinsonÁgatha Oliveira‐Giacomelli · 2018
- Establishing the therapeutic potential of the P2X7 receptor ion channel in amyotrophic lateral sclerosisAnjila Dongol · 2018 · Research Online (University of Wollongong)
- Purinergic signalling in osteosarcomaLuke Tattersall · 2019 · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
- How lipid specific T cells become effectorsHaiguang Wang · 2019 · University of Minnesota Digital Conservancy (University of Minnesota)
- Acute Microglial Responses to Single Non-Epileptogenic vs. Epileptogenic Seizures in Mouse HippocampusAlberto Sepulveda‐Rodriguez · 2019 · DigitalGeorgetown (Georgetown University Library)
- 乳癌抑制遺伝子BRCA1の機能解析 : CDK2-BRCA1-NPM pathway(第105回日本外科学会定期学術集会)智彦 太田, 文文 呉, 亮介 速水, 工 佐藤, 護 福田 · 2005 · 日本外科学会雑誌
- Identification of residues in the first transmembrane domain of the P2X7 that regulates receptor trafficking, sensitization, and dye uptake functionMarian Rupert, Anirban Bhattacharya, Sonja Sivcev, Michal Knězů, Jana Cimicka, Hana W. Zemkova · 2023 · Journal of Neurochemistry
- Acupuncture for Counteracting P2X4 and P2X7 Receptor Involvement in NeuroinflammationYong Tang, Patrizia Rubini, Haiyan Yin, Péter Illés · 2023 · Springer eBooks
- Expression of the Purinergic P2X7 Receptor in Murine MOPC315.BM Myeloma CellsEva Risborg Høyer, Melisa Demir, Lasse K. Bak, Niklas Rye Jørgensen, Ankita Agrawal · 2023 · Receptors
- Editorial: Therapy resistance in tumor microenvironment: metabolic reprogramming and purinergic signalingMichele Zanoni, Henrique Borges da Silva, Elena Adinolfi · 2023 · Frontiers in Oncology
- Hiperalgesia muscular persistenteBeatriz Botasso Gomes · 2022
- eATP/P2X7R axis drives nanoparticle induced neutrophil recruitment in the pulmonary microcirculationChenxi Li, Qiongliang Liu, Lianyong Han, Roland Immler, Birgit Rathkolb, Judith Secklehner, Martin Hrabě de Angelis, Ali Önder Yildirim, Annette Nicke, Leo M. Carlin et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Progress in undestanding of relationship between P2X7R and pancreatic ductal adenocarcinomaZhao-Chun Chi · 2025 · World Chinese Journal of Digestology
- Targeting P2X Receptors—Current Progress in SepsisLan Luo, Qian Zhao, Yun-Fen Tian, Meisha Sun, Mazhong Zhang, Bin Wang · 2025 · International Journal of Inflammation
- Physiological roles and therapeutic potential of the purinergic P2X7 receptorCalvin Dunker, Stefan Gross, Laura Vinnenberg, Ann‐Kathrin Prinz, Oliver Koch, Anna Junker · 2025 · Elsevier eBooks
- Additional file 2 of Human P2X7 receptor variants Gly150Arg and Arg276His polymorphisms have differential effects on risk association and cellular functions in pancreatic cancerLara Magni, Yu, Haoran, Nynne M. Christensen, Mette Homann Poulsen, Alexander Frueh, Ganga Deshar, Astrid Zedlitz Johansen, Johansen, Julia S., Stephan Alexander Pless, Jørgensen, Niklas R. et al. · 2024 · Figshare
- Additional file 4 of P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilizationGaohong Sheng, Gao, Yuan, Qing Ding, Zhang, Ruizhuo, Wang, Tianqi, Jing, Shaoze, Zhao, Hongqi, Ma, Tian, Wu, Hua, Yang, Yong · 2023 · Figshare
- Additional file 5 of P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilizationGaohong Sheng, Gao, Yuan, Qing Ding, Zhang, Ruizhuo, Wang, Tianqi, Jing, Shaoze, Zhao, Hongqi, Ma, Tian, Wu, Hua, Yang, Yong · 2023 · Figshare
- Additional file 3 of P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilizationGaohong Sheng, Gao, Yuan, Qing Ding, Zhang, Ruizhuo, Wang, Tianqi, Jing, Shaoze, Zhao, Hongqi, Ma, Tian, Wu, Hua, Yang, Yong · 2023 · Figshare
- Additional file 2 of P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilizationGaohong Sheng, Gao, Yuan, Qing Ding, Zhang, Ruizhuo, Wang, Tianqi, Jing, Shaoze, Zhao, Hongqi, Ma, Tian, Wu, Hua, Yang, Yong · 2023 · Figshare
- Additional file 1 of Human P2X7 receptor variants Gly150Arg and Arg276His polymorphisms have differential effects on risk association and cellular functions in pancreatic cancerLara Magni, Yu, Haoran, Nynne M. Christensen, Mette Homann Poulsen, Alexander Frueh, Ganga Deshar, Astrid Zedlitz Johansen, Johansen, Julia S., Stephan Alexander Pless, Jørgensen, Niklas R. et al. · 2024 · Figshare
- Additional file 6 of P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilizationGaohong Sheng, Gao, Yuan, Qing Ding, Zhang, Ruizhuo, Wang, Tianqi, Jing, Shaoze, Zhao, Hongqi, Ma, Tian, Wu, Hua, Yang, Yong · 2023 · Figshare
- Additional file 1 of P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilizationGaohong Sheng, Gao, Yuan, Qing Ding, Zhang, Ruizhuo, Wang, Tianqi, Jing, Shaoze, Zhao, Hongqi, Ma, Tian, Wu, Hua, Yang, Yong · 2023 · Figshare
- Additional file 1 of Protocol for Evaluating In Vivo the Activation of the P2RX7 ImmunomodulatorSerena Janho dit Hreich, Thierry Juhel, Paul M Hofman, Valérie Vouret‐Craviari · 2023 · Figshare
- Rat P2X7 Receptor Show Functional Independence Between Macropore Formation and Scavenger ActivityJavier Mena, Elías Leiva‐Salcedo, Natalia Araya-Dapremont, Francisco Bravo-Cabezas, Ana Jane Villa, Geraldine Vivanco-Duarte, Ángel Mejía, Valentina Galarce-Keidong, Matías Lee, Francisca Espinola-Gonzales et al. · 2026 · International Journal of Molecular Sciences
- Extracellular ATP in cancerAnna Pegoraro, Mario Tarantini, Simonetta Falzoni, Anna Lisa Giuliani, Elena Adinolfi · 2026 · Elsevier eBooks
- P2X receptorsShangdong Liang, Lin Li · 2026 · Elsevier eBooks
- Tumor growth inhibitory activity of the P2X7 receptor antagonist AZ10606120 in two cell lines of human glioblastomaMichela Graziano, Silvia Bono, Michela Pizzoferrato, Chiara Ferraro, Flavia Grossi, Pierluigi Navarra, Maria Martire, Lucia Lisi · 2026 · Purinergic Signalling
- Étude de l'augmentation du trafic en surface des récepteurs P2X4 de l’ATP à l’aide de nouveaux modèles murins transgéniques : implications dans les processus mnésiques et la sclérose latérale amyotrophiqueÉléonore Bertin · 2019 · theses.fr (ABES)
- Études structurales et fonctionnelles des récepteurs P2X7Kate Dunning · 2020
- Biophysical & molecular characterisation of P2X7 receptors & TMEM16F channels complex unravel novel immunoregulatory targetsFederico Cevoli · 2022
- ATP and major affective disorders: the involvement of P2X receptors in pathophysiologySimona Mattova, Patrik Šimko, Elena Colzi, Erika Štammová, Nicol Urbanská, Maria Grigoroiu‐Serbânescu, Elisabetta Coppi, Terézia Kisková · 2026 · Purinergic Signalling
- P2X7 receptor-mediated astrocytic atrophy in the hippocampus of mice after status epilepticusXuan Li, Muhammad Tahir Khan, Elek Sylvester Vizi, Beáta Sperlágh, Si-Si Lin, Alexei Verkhratsky, Patrizia Rubini, Yong Tang, Péter Illés · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- P2X7R in skin diseases: Pathological mechanisms and therapeutic potentialW.T. Liu, Zhiqiang Tian, Li Zhang, Bing Ni, Zhiqiang Song · 2026 · Genes & Diseases
- Molecular Hybridization of Clinically Relevant P2X7 AntagonistsNicholas B. Lynch, Charleigh T. A. Agius, André D. J. McKenzie, Jessica O’Driscoll, Angus Tolmie, Taylor R. Garrett, Eryn L. Werry, Michael Kassiou · 2026 · ChemMedChem
- P2X7 receptor-dependent microglia-astrocyte coupling in Alzheimer's disease: from eATP sensing to synaptic and proteostatic failureYiwen Li, Shiming Liu, 蓝娇 · 2026 · Frontiers in Aging Neuroscience
- Effects on mouse melanoma and immune cells of P2X7 receptor positive allosterism by clemastineMaria Luiza Thorstenberg, Simonetta Falzoni, R.E. García-Jacobo, Letícia Scussel Bergamin, Mario Tarantini, Giulia Conversano, Anna Pegoraro, Francesco Di Virgilio, Elena Adinolfi, Anna Lisa Giuliani · 2026 · Purinergic Signalling
- Molecular dynamics of GDP and GTP binding to the human purinoreceptor 7 receptor ballast domainChristopher Slack, Georgina Elizabeth Menzies, Mark T. Young · 2026 · SSRN Electronic Journal
- Towards Improved P2X7R Cellular Models for Alzheimer’s Disease Drug DiscoveryCharleigh T. A. Agius, André D. J. McKenzie, Kim Woollett, Eryn L. Werry, Michael Kassiou · 2026 · ACS Chemical Neuroscience
- ATP is not always pro-inflammatory: rethinking purinergic signalling in cancer and autoimmunityMohamed S. Nafie, Mohamed Khaled Diab · 2026 · Purinergic Signalling
- ATPAnnamaria Lia, Paola Pizzo · 2026 · Trends in Endocrinology and Metabolism
- BindingDB Entry 50015307: Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50020135: From lead to clinic: A review of the structural design of P2X7R antagonists.BindingDB · 2024 · UC San Diego