The Elusive P2X7 Macropore

Di Virgilio, Francesco, Schmalzing, Günther, Markwardt, Fritz·2018·Trends in Cell Biology

Cited by (280)

Items 201–280 of 280

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    Iven-Alex von Mücke-Heim, Judit Oldekamp, Michael W. Metzger, Sarah Kläffgen, Hao Tang, Sandra M. Walser, Nina Dedic, Gerhard Rammes, Florian Holsboer, Wolfgang Wurst et al. · 2025 · Purinergic Signalling
  2. ATP/P2X7 receptor signal aggravates ischemic stroke injury by activating Th17 cells via STAT3/IL-21 pathway
    Wenying Liu, Denghui Li, Mengjie Zhang, Jun Yin, Peng Wang, Paiyu Liu, Zhiqiang Song, Bing Ni, Yanmeng Peng · 2025 · Frontiers in Immunology
  3. Established Protocols for cRNA Expression and Voltage-Clamp Characterization of the P2X7 Receptor in Xenopus laevis Oocytes
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  4. Molecular insights into P2X signalling cascades in acute kidney injury
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  5. P2X7 receptors: a bibliometric review from 2002 to 2023
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  6. P2X7 regulates ependymo-radial glial cell proliferation in adult Danio rerio following spinal cord injury
    Eva E. Stefanova, Julian Vincent T. Dychiao, Mavis C. Chinn, Matin Borhani, Angela L. M. Scott · 2024 · Biology Open
  7. Role of purinoreceptors in the release of extracellular vesicles and consequences on immune response and cancer progression
    Thomas Duret, Mohammed I. Y. Elmallah, Jérôme Rollin, Philippe Gatault, Lin‐Hua Jiang, Sébastien Roger · 2024 · Biomedical Journal
  8. The eATP/P2×7R Axis Drives Quantum Dot‐Nanoparticle Induced Neutrophil Recruitment in the Pulmonary Microcirculation
    Chenxi Li, Qiongliang Liu, Lianyong Han, Haiyun Zhang, Roland Immler, Birgit Rathkolb, Judith Secklehner, Martin Hrabě de Angelis, Ali Önder Yildirim, Dagmar Zeuschner et al. · 2024 · Advanced Science
  9. Methodological guidelines for P2X receptor assays and data interpretation
    Dariusz C. Górecki, Elena Adinolfi, Sahil Adriouch, Robson Coutinho‐Silva, Tobías Engel, Flóra Gölöncsér, Friedrich Haag, Péter Illés, Kenneth A. Jacobson, Friedrich Koch‐Nolte et al. · 2026 · Cell Death and Disease
  10. Recombinant Analogs of Sea Anemone Kunitz-Type Peptides Influence P2X7 Receptor Activity in Neuro-2a Cells
    Еvgeny А. Pislyagin, Ekaterina S. Menchinskaya, Irina N. Gladkikh, Кветкина Александра Николаевна, Oksana V. Sintsova, Daria V. Popkova, Sergey Kozlovskiy, Tatiana Y. Gorpenchenko, Лихацкая Галина Николаевна, Leonid A. Kaluzhskiy et al. · 2023 · Marine Drugs
  11. Cell Type-Specific Expression of Purinergic P2X Receptors in the Hypothalamus
    Jana Cihakova, Milorad Ivetic, Hana W. Zemkova · 2025 · International Journal of Molecular Sciences
  12. Implications of COVID-19 in Parkinson’s disease: the purinergic system in a therapeutic-target perspective to diminish neurodegeneration
    Júlia Leão Batista Simões, Geórgia de Carvalho Braga, Samantha Webler Eichler, Gilnei Bruno da Silva, Margarete Dulce Bagatini · 2024 · Purinergic Signalling
  13. P2X7 Receptors and TMEM16 Channels Form a Hub with Implications for Macropore Formation and Current Facilitation
    Kate Dunning, Adeline Martz, Francisco Andrés Peralta, Federico Cevoli, Éric Boué‐Grabot, Antoine Taly, Vincent Compan, Fanny Gautherat, Patrick Wolf, Thierry Chataigneau et al. · 2021 · Research Square
  14. A Bibliometric Analysis of P2X7R in Cardiovascular Diseases from 2005 to 2024
    Juanjuan Tan, Wenqi Zhou, Zhiye Guo, Li Cheng, Yalong Kang, Qiong Wang, Jing Dong, Haifang Wang, Qi Zhang, Li Shen et al. · 2025 · Current Cardiology Reviews
  15. Traditional Chinese Medicine Natural Products Targeting Shared Mechanisms of T2DM and AD: Potential Therapeutic Insights
    Bingbing Song, DongJie Yue, Huiying Yan, Lina Feng, Mingquan Li · 2025 · Drug Design Development and Therapy
  16. Role of P2X7 Receptor on Hypoxia-Induced Vascular Endothelial Growth Factor Gene Expression in H9c2 Rat Cardiomyocytes
    Anfal F. Bin Dayel, Reem M. Alhejji, Asma S. Alonazi, Nouf Mohamed Al-Rasheed · 2025 · Journal of Cardiovascular Development and Disease
  17. Analgesic effect of cinobufagin is mediated by human-selective P2X7R antagonism governed by distinct extracellular domains
    Ke‐Xin Yu, Min Li, Yuchen Jin, Miao Zhao, Zeliang Wang, Haibo Yu · 2025 · Neuropharmacology
  18. Extracellular ATP and the central nervous system
    Fernanda Tibolla Viero, Guilherme Shigueto Vilar Higa, Jean Bezerra Silva, Natalia Turrini, Guilherme de Araujo Juvenal, Allan de Carvalho, Lucas Marques, Roberto De Pasquale, Henning Ulrich · 2026 · Elsevier eBooks
  19. Synthesis and characterization of new P2X7 receptor antagonists as antitumor agents
    Marianna Grignolo, Andrea Spinaci, Ludovica Ricci, Anna Pegoraro, Luigia Ruo, Catia Lambertucci, Daniele Vitone, Marcello Leopoldo, Enza Lacivita, Federica Fortuna et al. · 2026 · Biomedicine & Pharmacotherapy
  20. Latest advances on the role of P2X Receptors in colorectal inflammation and cancer
    Luigia Ruo, Federica Fortuna, Marianna Grignolo, Anna Pegoraro, Elena Adinolfi · 2026 · Purinergic Signalling
  21. Microglial physiology and function
    Alexei Verkhratsky, Arthur Morgan Butt · 2023 · Elsevier eBooks
  22. Could P2X7 receptor be a potencial target in neonatal sepsis?
    Sales Fialho, Patrick Trieu‐Cuot, Paula Ferreira, Laura Oliveira · 2024 · International Immunopharmacology
  23. An association study of polymorphisms in the P2RX7 gene in an Iranian population with the risk of type 2 diabetes mellitus
    Homa Noori, Majid Rajabian, Mahdi Majidpour, Mahboobeh Sabeti Akbar-Abad, Ramin Saravani · 2025 · Egyptian Journal of Medical Human Genetics
  24. Activation of the Rat P2X7 Receptor by Functionally Different ATP Activation Sites
    F Markwárdt, Malte Berthold, Sanaria Hawro Yakoob, Guenther Schmalzing · 2025 · Cells
  25. Role of caspases, apoptosis and additional factors in pathology of Alzheimer's disease
    Anil Gupta · 2021 · Elsevier eBooks
  26. Using Symmetrical Organic Cation Solutions to Study P2X7 Ion Permeation
    Kate Dunning, Laurie Peverini, Thomas Grütter · 2022 · Methods in molecular biology
  27. The role of the purinergic ligand-gated ion channel 7 receptor in common digestive system cancers
    Xin Wang, Qingqing Yu, Xue Bai, Xinyu Li, Yanli Sun, Xiaoxiang Peng, Ronglan Zhao · 2023 · European Journal of Cancer Prevention
  28. Immunomodulatory Effects of a M2-Conditioned Medium (PRS®CK STORM): Theory on the Possible Complex Mechanism of Action through Anti-Inflammatory Modulation of the TLR System and the Purinergic System
    Juan Pedro Lapuente · 2022 · Biochemistry
  29. Characterization of the Active Enantiomer and Mapping of the Stereospecific Intermolecular Pattern of a Reference P2X7 Allosteric Antagonist
    Andrew McGown, Nicolas Renault, Amélie Barczyk, Jordan Nafie, Luciano Barluzzi, Daniel Guest, Graham John Tizzard, Simon John Coles, David Leach, Daniel von Emloh et al. · 2025 · ACS Pharmacology & Translational Science
  30. Clostridioides difficile meets the adenosine system: the art of manipulating host homeostasis
    Katia Fettucciari, Luigi Cari, Andrea Spaterna, Rachele DEL SORDO, Filippo Tavanti, Pierfrancesco Marconi, Gabrio Bassotti · 2025 · Journal of Biomedical Science
  31. Increased spinal adenosine after subacute cervical injury correlates with sustained upregulation of CD39 and CD73 in microglia
    Mackenzie R. Berschel, Mária Nikodémová, Jose R. Oberto, Alexandria B. Marciante, Alysha L. Michaelson, Gordon S. Mitchell · 2025 · Neurochemistry International
  32. Targeting the purinergic P2X7 receptor in epilepsy: Cell types matter
    Tobías Engel, Valentina Salari, Meng-Juan Sun, Meghma Mitra · 2026 · Neuropharmacology
  33. Discovery of novel anthraquinone-based P2X7R antagonist that reinvigorates anti-tumor immunity and overcomes PD-1 resistance in breast cancer
    Chenyu Liang, Simin Wang, Xiaozhen Liu, Xin Eric Wang, Benjun Yuan, Xuyang Wang, Wei Liu, Tianyou Wang, Chuanjun Song, Yongfang Yao et al. · 2026 · European Journal of Medicinal Chemistry
  34. Inflammation, oxidative stress and purinergic signaling in pituitary neuroendocrine tumors (PitNETs)
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  35. Novel Therapeutic Targets for Treating Alzheimer’s Disease
    Magham Sai Varshini, Ammu V. V. V. Ravi Kiran, Kusuma Kumari Garikapati, Praveen Thaggikuppe Krishnamurthy, Vaishali Manikrao Patil, Renat R. Khaydarov · 2023 · Springer eBooks
  36. Purinergic Signaling and its Role in the Stem Cell Differentiation
    Sumera Zaib, Areeba, Imtiaz Ali Khan · 2023 · Mini-Reviews in Medicinal Chemistry
  37. Two serial filters control P2X7 cation selectivity, Ser342 in the central pore and lateral acidic residues at the cytoplasmic interface
    F Markwárdt, Eike Christian Schön, Mihaela Raycheva, Aparna Sai Malisetty, Sanaria Hawro Yakoob, Malte Berthold, Guenther Schmalzing · 2024 · PNAS Nexus
  38. Papel dos receptores purinérgicos em modelo animal de doença de Parkinson
    Ágatha Oliveira‐Giacomelli · 2018
  39. Establishing the therapeutic potential of the P2X7 receptor ion channel in amyotrophic lateral sclerosis
    Anjila Dongol · 2018 · Research Online (University of Wollongong)
  40. Purinergic signalling in osteosarcoma
    Luke Tattersall · 2019 · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
  41. How lipid specific T cells become effectors
    Haiguang Wang · 2019 · University of Minnesota Digital Conservancy (University of Minnesota)
  42. Acute Microglial Responses to Single Non-Epileptogenic vs. Epileptogenic Seizures in Mouse Hippocampus
    Alberto Sepulveda‐Rodriguez · 2019 · DigitalGeorgetown (Georgetown University Library)
  43. 乳癌抑制遺伝子BRCA1の機能解析 : CDK2-BRCA1-NPM pathway(第105回日本外科学会定期学術集会)
    智彦 太田, 文文 呉, 亮介 速水, 工 佐藤, 護 福田 · 2005 · 日本外科学会雑誌
  44. Identification of residues in the first transmembrane domain of the P2X7 that regulates receptor trafficking, sensitization, and dye uptake function
    Marian Rupert, Anirban Bhattacharya, Sonja Sivcev, Michal Knězů, Jana Cimicka, Hana W. Zemkova · 2023 · Journal of Neurochemistry
  45. Acupuncture for Counteracting P2X4 and P2X7 Receptor Involvement in Neuroinflammation
    Yong Tang, Patrizia Rubini, Haiyan Yin, Péter Illés · 2023 · Springer eBooks
  46. Expression of the Purinergic P2X7 Receptor in Murine MOPC315.BM Myeloma Cells
    Eva Risborg Høyer, Melisa Demir, Lasse K. Bak, Niklas Rye Jørgensen, Ankita Agrawal · 2023 · Receptors
  47. Editorial: Therapy resistance in tumor microenvironment: metabolic reprogramming and purinergic signaling
    Michele Zanoni, Henrique Borges da Silva, Elena Adinolfi · 2023 · Frontiers in Oncology
  48. Hiperalgesia muscular persistente
    Beatriz Botasso Gomes · 2022
  49. eATP/P2X7R axis drives nanoparticle induced neutrophil recruitment in the pulmonary microcirculation
    Chenxi Li, Qiongliang Liu, Lianyong Han, Roland Immler, Birgit Rathkolb, Judith Secklehner, Martin Hrabě de Angelis, Ali Önder Yildirim, Annette Nicke, Leo M. Carlin et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  50. Progress in undestanding of relationship between P2X7R and pancreatic ductal adenocarcinoma
    Zhao-Chun Chi · 2025 · World Chinese Journal of Digestology
  51. Targeting P2X Receptors—Current Progress in Sepsis
    Lan Luo, Qian Zhao, Yun-Fen Tian, Meisha Sun, Mazhong Zhang, Bin Wang · 2025 · International Journal of Inflammation
  52. Physiological roles and therapeutic potential of the purinergic P2X7 receptor
    Calvin Dunker, Stefan Gross, Laura Vinnenberg, Ann‐Kathrin Prinz, Oliver Koch, Anna Junker · 2025 · Elsevier eBooks
  53. Additional file 2 of Human P2X7 receptor variants Gly150Arg and Arg276His polymorphisms have differential effects on risk association and cellular functions in pancreatic cancer
    Lara Magni, Yu, Haoran, Nynne M. Christensen, Mette Homann Poulsen, Alexander Frueh, Ganga Deshar, Astrid Zedlitz Johansen, Johansen, Julia S., Stephan Alexander Pless, Jørgensen, Niklas R. et al. · 2024 · Figshare
  54. Additional file 4 of P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilization
    Gaohong Sheng, Gao, Yuan, Qing Ding, Zhang, Ruizhuo, Wang, Tianqi, Jing, Shaoze, Zhao, Hongqi, Ma, Tian, Wu, Hua, Yang, Yong · 2023 · Figshare
  55. Additional file 5 of P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilization
    Gaohong Sheng, Gao, Yuan, Qing Ding, Zhang, Ruizhuo, Wang, Tianqi, Jing, Shaoze, Zhao, Hongqi, Ma, Tian, Wu, Hua, Yang, Yong · 2023 · Figshare
  56. Additional file 3 of P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilization
    Gaohong Sheng, Gao, Yuan, Qing Ding, Zhang, Ruizhuo, Wang, Tianqi, Jing, Shaoze, Zhao, Hongqi, Ma, Tian, Wu, Hua, Yang, Yong · 2023 · Figshare
  57. Additional file 2 of P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilization
    Gaohong Sheng, Gao, Yuan, Qing Ding, Zhang, Ruizhuo, Wang, Tianqi, Jing, Shaoze, Zhao, Hongqi, Ma, Tian, Wu, Hua, Yang, Yong · 2023 · Figshare
  58. Additional file 1 of Human P2X7 receptor variants Gly150Arg and Arg276His polymorphisms have differential effects on risk association and cellular functions in pancreatic cancer
    Lara Magni, Yu, Haoran, Nynne M. Christensen, Mette Homann Poulsen, Alexander Frueh, Ganga Deshar, Astrid Zedlitz Johansen, Johansen, Julia S., Stephan Alexander Pless, Jørgensen, Niklas R. et al. · 2024 · Figshare
  59. Additional file 6 of P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilization
    Gaohong Sheng, Gao, Yuan, Qing Ding, Zhang, Ruizhuo, Wang, Tianqi, Jing, Shaoze, Zhao, Hongqi, Ma, Tian, Wu, Hua, Yang, Yong · 2023 · Figshare
  60. Additional file 1 of P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilization
    Gaohong Sheng, Gao, Yuan, Qing Ding, Zhang, Ruizhuo, Wang, Tianqi, Jing, Shaoze, Zhao, Hongqi, Ma, Tian, Wu, Hua, Yang, Yong · 2023 · Figshare
  61. Additional file 1 of Protocol for Evaluating In Vivo the Activation of the P2RX7 Immunomodulator
    Serena Janho dit Hreich, Thierry Juhel, Paul M Hofman, Valérie Vouret‐Craviari · 2023 · Figshare
  62. Rat P2X7 Receptor Show Functional Independence Between Macropore Formation and Scavenger Activity
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  63. Extracellular ATP in cancer
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  64. P2X receptors
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  65. Tumor growth inhibitory activity of the P2X7 receptor antagonist AZ10606120 in two cell lines of human glioblastoma
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  66. Étude de l'augmentation du trafic en surface des récepteurs P2X4 de l’ATP à l’aide de nouveaux modèles murins transgéniques : implications dans les processus mnésiques et la sclérose latérale amyotrophique
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  67. Études structurales et fonctionnelles des récepteurs P2X7
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  68. Biophysical & molecular characterisation of P2X7 receptors & TMEM16F channels complex unravel novel immunoregulatory targets
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  69. ATP and major affective disorders: the involvement of P2X receptors in pathophysiology
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  70. P2X7 receptor-mediated astrocytic atrophy in the hippocampus of mice after status epilepticus
    Xuan Li, Muhammad Tahir Khan, Elek Sylvester Vizi, Beáta Sperlágh, Si-Si Lin, Alexei Verkhratsky, Patrizia Rubini, Yong Tang, Péter Illés · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  71. P2X7R in skin diseases: Pathological mechanisms and therapeutic potential
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  72. Molecular Hybridization of Clinically Relevant P2X7 Antagonists
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  73. P2X7 receptor-dependent microglia-astrocyte coupling in Alzheimer's disease: from eATP sensing to synaptic and proteostatic failure
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  74. Effects on mouse melanoma and immune cells of P2X7 receptor positive allosterism by clemastine
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  75. Molecular dynamics of GDP and GTP binding to the human purinoreceptor 7 receptor ballast domain
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  76. Towards Improved P2X7R Cellular Models for Alzheimer’s Disease Drug Discovery
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  77. ATP is not always pro-inflammatory: rethinking purinergic signalling in cancer and autoimmunity
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  78. ATP
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  79. BindingDB Entry 50015307: Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists.
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  80. BindingDB Entry 50020135: From lead to clinic: A review of the structural design of P2X7R antagonists.
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