The DOI matches its Crossref record; 152 of the 152 references it cites were found in a registry or an index.
Rab GTPase Function in Endosome and Lysosome Biogenesis
Abstract
Eukaryotic cells maintain a highly organized endolysosomal system. This system regulates the protein and lipid content of the plasma membrane, it participates in the intracellular quality control machinery and is needed for the efficient removal of damaged organelles. This complex network comprises an endosomal membrane system that feeds into the lysosomes, yet also allows recycling of membrane proteins, and probably lipids. Moreover, lysosomal degradation provides the cell with macromolecules for further growth. In this review, we focus primarily on the role of the small Rab GTPases Rab5 and Rab7 as organelle markers and interactors of multiple effectors on endosomes and lysosomes and highlight their role in membrane dynamics, particularly fusion along the endolysosomal pathway.
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Cites
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Molecular machines governing exocytosis of synaptic vesicles
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Cited by
Regulation and Function of Mitochondria–Lysosome Membrane Contact Sites in Cellular Homeostasis
Wong, Y. C., Kim, S., Peng, W., & Krainc, D. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.02.004 · Cited by 341
Lőrincz, P., & Juhász, G. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.10.028 · Cited by 328
Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired
Liang, W., Sagar, S., Ravindran, R., Najor, R. H., Quiles, J. M., Chi, L., Diao, R. Y., Woodall, B. P., Leon, L. J., Zumaya, E., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40680-5 · Cited by 273
Targeting lysosomes in human disease: from basic research to clinical applications
Cao, M., Luo, X., Wu, K., & He, X. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00778-y · Cited by 225
Borchers, A.-C., Langemeyer, L., & Ungermann, C. (2021) · Journal of Cell Biology · doi:10.1083/jcb.202105120 · Cited by 181
Self-citation
Metadata
- Authors
- Langemeyer, L., Fröhlich, F., & Ungermann, C.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 28
- Issue
- 11
- Pages
- 957-970
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2883789999
- Cited by
- 394
- References
- 152
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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