The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins
Open accessAbstract
The gasdermin (GSDM) family has evolved as six gene clusters (GSDMA-E and Pejvakin, PJVK), and GSDM proteins are characterized by a unique N-terminal domain (N-GSDM). With the exception of PJVK, the N-GSDM domain is capable of executing plasma membrane permeabilization. Depending on the cell death modality, several protease- and kinase-dependent mechanisms directly regulate the activity of GSDME and GSDMD, the two most widely expressed and best-studied GSDMs. We provide an overview of all GSDMs in terms of biological function, tissue expression, activation, regulation, and structure. In-depth phylogenetic analysis reveals that GSDM genes show many gene duplications and deletions, suggesting that strong evolutionary forces and a unique position of the PJVK gene are associated with the occurrence of complex inner-ear development in vertebrates.
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“The structures enriched in the gasdermin Pfam annotation adopted a similar conformation to that of the mammalian gasdermin N terminus, especially of gasdermin E, which is considered to be evolutionary ancient34.”
From Clustering predicted structures at the scale of the known protein universe (2023) · cites this paper as [34]
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Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
Liu, X., Zhang, Z., Ruan, J., Pan, Y., Magupalli, V. G., Wu, H., & Lieberman, J. (2016) · Nature · doi:10.1038/nature18629 · Cited by 3,202
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
Wang, Y., Gao, W., Shi, X., Ding, J., Liu, W., He, H., Wang, K., & Shao, F. (2017) · Nature · doi:10.1038/nature22393 · Cited by 3,199
A subcellular map of the human proteome
Thul, P. J., Åkesson, L., Wiking, M., Mahdessian, D., Geladaki, A., Ait Blal, H., Alm, T., Asplund, A., Björk, L., Breckels, L. M., et al. (2017) · Science · doi:10.1126/science.aal3321 · Cited by 2,813
Pore-forming activity and structural autoinhibition of the gasdermin family
Ding, J., Wang, K., Liu, W., She, Y., Sun, Q., Shi, J., Sun, H., Wang, D.-C., & Shao, F. (2016) · Nature · doi:10.1038/nature18590 · Cited by 2,771
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
He, W.-T., Wan, H., Hu, L., Chen, P., Wang, X., Huang, Z., Yang, Z.-H., Zhong, C.-Q., & Han, J. (2015) · Cell Research · doi:10.1038/cr.2015.139 · Cited by 2,517
Gasdermin E suppresses tumour growth by activating anti-tumour immunity
Zhang, Z., Zhang, Y., Xia, S., Kong, Q., Li, S., Liu, X., Junqueira, C., Meza‐Sosa, K. F., Mok, T. M. Y., Ansara, J., et al. (2020) · Nature · doi:10.1038/s41586-020-2071-9 · Cited by 1,721
Rogers, C., Fernandes-Alnemri, T., Mayes, L., Alnemri, D., Cingolani, G., & Alnemri, E. S. (2017) · Nature Communications · doi:10.1038/ncomms14128 · Cited by 1,510
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Newton, K., Strasser, A., Kayagaki, N., & Dixit, V. M. (2024) · Cell · doi:10.1016/j.cell.2023.11.044 · Cited by 1,068
Clustering predicted structures at the scale of the known protein universe
Barrio-Hernandez, I., Yeo, J., Jänes, J., Mirdita, M., Gilchrist, C. L. M., Wein, T., Varadi, M., Velankar, S., Beltrao, P., & Steinegger, M. (2023) · Nature · doi:10.1038/s41586-023-06510-w · Cited by 362
Molecular mechanisms of gasdermin D pore-forming activity
Devant, P., & Kagan, J. C. (2023) · Nature Immunology · doi:10.1038/s41590-023-01526-w · Cited by 280
Bacterial origins of human cell-autonomous innate immune mechanisms
Wein, T., & Sorek, R. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00705-4 · Cited by 241
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways
Vandenabeele, P., Bultynck, G., & Savvides, S. N. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00564-w · Cited by 220
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Metadata
- Authors
- De Schutter, E., Roelandt, R., Riquet, F. B., Van Camp, G., Wullaert, A., & Vandenabeele, P.
- Affiliations
- Vlaams Instituut voor Biotechnologie (BE)
- Université de Lille (FR)
- Corresponding author
- Vandenabeele, Peter
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 31
- Issue
- 6
- Pages
- 500-513
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W3139151250
- Cited by
- 158
- References
- 84
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 35 · 2023: 34 · 2022: 36 · 2021: 10
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- LillOA (Université de Lille (University Of Lille)) (submittedVersion, other-oa)
- Funders
- Fonds Wetenschappelijk Onderzoek (FAF-F/2020/1505, 30826052, BOF20/IBF/039, BOF16/MET_V/007)
- Universiteit Gent (BOF24Y2019003201)
- Vlaams Instituut voor Biotechnologie
- Universiteit Antwerpen (42/FA020000/FFB190208)
- Stichting Tegen Kanker (FAF-F/2016/865)
- Fonds De La Recherche Scientifique - FNRS (3G044718, 3G044818, 1.5.091.18N, S008419N, 3G0H5517)
- European Commission
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- gasdermin, gasdermin D, gasdermin E, plasma membrane permeabilization, N-terminal domain, cell death, gene family evolution, gene duplication, gene deletion, phylogenetic analysis, inner ear development, protease regulation, kinase regulation, protein structure
- MeSH terms
- Animals, Biology, Cell Membrane, Neoplasm Proteins, Phylogeny, Cell Death
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