Cited by 158Inflammasome and immune disordersCell death mechanisms and regulationinterferon and immune responses

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Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins

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De Schutter, Elke, Roelandt, Ria, Riquet, Franck B., Van Camp, Guy, Wullaert, Andy, Vandenabeele, Peter·2021·Trends in Cell Biology

DOI 10.1016/j.tcb.2021.03.004

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Abstract

The gasdermin (GSDM) family has evolved as six gene clusters (GSDMA-E and Pejvakin, PJVK), and GSDM proteins are characterized by a unique N-terminal domain (N-GSDM). With the exception of PJVK, the N-GSDM domain is capable of executing plasma membrane permeabilization. Depending on the cell death modality, several protease- and kinase-dependent mechanisms directly regulate the activity of GSDME and GSDMD, the two most widely expressed and best-studied GSDMs. We provide an overview of all GSDMs in terms of biological function, tissue expression, activation, regulation, and structure. In-depth phylogenetic analysis reveals that GSDM genes show many gene duplications and deletions, suggesting that strong evolutionary forces and a unique position of the PJVK gene are associated with the occurrence of complex inner-ear development in vertebrates.

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Authors: De Schutter, E., Roelandt, R., Riquet, F. B., Van Camp, G., Wullaert, A., & Vandenabeele, P.
Affiliations: Vlaams Instituut voor Biotechnologie (BE)
Université de Lille (FR)
Corresponding author: Vandenabeele, Peter
ORCID: Roelandt, Ria
Riquet, Franck B.
Wullaert, Andy
Vandenabeele, Peter
Venue: Trends in Cell Biology
Publisher: Elsevier BV
Published: 2021-06
Volume: 31
Issue: 6
Pages: 500-513
ISSN: 0962-8924 (ISSN-L)
DOI: 10.1016/j.tcb.2021.03.004
OpenAlex: W3139151250
Cited by: 158
References: 84
Citations by year: 2026: 17 · 2025: 24 · 2024: 35 · 2023: 34 · 2022: 36 · 2021: 10
FWCI: 3.02
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Trends in Cell Biology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
LillOA (Université de Lille (University Of Lille)) (submittedVersion, other-oa)
Funders: Fonds Wetenschappelijk Onderzoek (FAF-F/2020/1505, 30826052, BOF20/IBF/039, BOF16/MET_V/007)
Universiteit Gent (BOF24Y2019003201)
Vlaams Instituut voor Biotechnologie
Universiteit Antwerpen (42/FA020000/FFB190208)
Stichting Tegen Kanker (FAF-F/2016/865)
Fonds De La Recherche Scientifique - FNRS (3G044718, 3G044818, 1.5.091.18N, S008419N, 3G0H5517)
European Commission
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords: gasdermin, gasdermin D, gasdermin E, plasma membrane permeabilization, N-terminal domain, cell death, gene family evolution, gene duplication, gene deletion, phylogenetic analysis, inner ear development, protease regulation, kinase regulation, protein structure
MeSH terms: Animals, Biology, Cell Membrane, Neoplasm Proteins, Phylogeny, Cell Death

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Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins

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