The DOI matches its Crossref record; 87 of the 89 references it cites were found in a registry or an index.
Tissue factor as a link between inflammation and coagulation
Abstract
Due to its receptor activity for factor VII, tissue factor (TF) is primary initiator of the blood coagulation cascade and ensures rapid hemostasis in case of organ damage. Inflammatory cytokines, such as tumor necrosis factor-α or interleukins, strongly induce expression of both full-length TF as well as the alternatively spliced TF in endothelial and blood cells. Beyond its role in hemostasis, TF also has signaling activity and promotes pleiotropic inflammatory responses via protease-activated receptors in concert with other coagulation factors. Alteration of TF expression and TF alternative splicing provides an effective means to change the endothelial phenotype and modulate inflammatory responses of the vessel.
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“Vascular TF promotes thrombosis and vascular inflammation123, particularl y in patients with type 2 diabetes who have higher levels of circulating TMAO124–126.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [123]
Citations
Cites
Rivaroxaban in Patients with a Recent Acute Coronary Syndrome
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Understanding alternative splicing: towards a cellular code
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Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches
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Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes
Zampetaki, A., Kiechl, S., Drozdov, I., Willeit, P., Mayr, U., Prokopi, M., Mayr, A., Weger, S., Oberhollenzer, F., Bonora, E., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.226357 · Cited by 1,283
Blood-borne tissue factor: Another view of thrombosis
Giesen, P. L. A., Rauch, U., Bohrmann, B., Kling, D., Roqué, M., Fallon, J. T., Badimón, J. J., Himber, J., Riederer, M. A., & Nemerson, Y. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2311 · Cited by 990
Self-citationC-reactive protein induces human peripheral blood monocytes to synthesize tissue factor
Čermák, J., Key, N., Bach, R., Balla, J., Jacob, H., & Vercellotti, G. (1993) · Blood · doi:10.1182/blood.v82.2.513.513 · Cited by 838
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Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
Camerer, E., Huang, W., & Coughlin, S. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.10.5255 · Cited by 674
Role of tissue factor in embryonic blood vessel development
Carmeliet, P., Mackman, N., Moons, L., Luther, T., Gressèns, P., Vlaenderen, L. V., Demunck, H., Kasper, M. E., Breier, G., Evrard, P., et al. (1996) · Nature · doi:10.1038/383073a0 · Cited by 669
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Cited by
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Gut microbiota and cardiovascular disease.
Witkowski, M., Weeks, T. L., & Hazen, S. L. (2020) · Circulation Research · doi:10.1161/circresaha.120.316242 · Cited by 1,051
Self-citationGrover, S. P., & Mackman, N. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309846 · Cited by 689
Moll, G., Ankrum, J. A., Kamhieh-Milz, J., Bieback, K., Ringdén, O., Volk, H.-D., Geissler, S., & Reinke, P. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.12.006 · Cited by 440
Hu, L., Chen, S., Fu, Y., Gao, Z., Long, H., Ren, H., Zuo, Y., Li, H., Wang, J., Yu, W.-X., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa539 · Cited by 404
Merimi, M., Majzoub, R. E., Lagneaux, L., Agha, D. M., Bouhtit, F., Meuleman, N., Fahmi, H., Lewalle, P., Fayyad‐Kazan, M., & Najar, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.661532 · Cited by 180
Metadata
- Authors
- Witkowski, M., Landmesser, U., & Rauch, U.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- Stiftung Charité (DE)
- Corresponding author
- Rauch, Ursula
- Venue
- Trends in Cardiovascular Medicine
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 26
- Issue
- 4
- Pages
- 297-303
- ISSN
- 1050-1738 (ISSN-L)
- OpenAlex
- W2267226449
- Cited by
- 240
- References
- 89
- Citations by year
- 2026: 19 · 2025: 17 · 2024: 23 · 2023: 25 · 2022: 33 · 2021: 27 · 2020: 43 · 2019: 14 · 2018: 15 · 2017: 16 · 2016: 7
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cardiovascular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Health Sciences › Medicine › Hematology › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Keywords
- tissue factor, inflammation, coagulation, hemostasis, factor VII, TNF-α, interleukins, alternative splicing, protease-activated receptors, endothelial cells, endothelial phenotype, inflammatory cytokines
- MeSH terms
- Animals, Blood Coagulation, Gene Expression Regulation, Humans, Inflammation, Protein Conformation, Thromboplastin, Signal Transduction, Alternative Splicing, Inflammation Mediators
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