Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

Alternative isoform regulation in human tissue transcriptomes

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Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

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Mechanisms of Alternative Pre-Messenger RNA Splicing

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The Spliceosome: Design Principles of a Dynamic RNP Machine

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Messenger-RNA-binding proteins and the messages they carry

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The MicroRNA miR-124 Promotes Neuronal Differentiation by Triggering Brain-Specific Alternative Pre-mRNA Splicing

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HITS-CLIP yields genome-wide insights into brain alternative RNA processing

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A Global View of Gene Activity and Alternative Splicing by Deep Sequencing of the Human Transcriptome

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Alternative splicing: increasing diversity in the proteomic world

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The SR protein family of splicing factors: master regulators of gene expression

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Alternative Splicing: New Insights from Global Analyses

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Exon Recognition in Vertebrate Splicing

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Sorting out the complexity of SR protein functions

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Splicing regulation: From a parts list of regulatory elements to an integrated splicing code

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Protein phosphatase 1 – targeted in many directions

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Alternative pre-mRNA splicing: the logic of combinatorial control

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Structure and evolution of transcriptional regulatory networks

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Specific interactions between proteins implicated in splice site selection and regulated alternative splicing

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Phosphorylation and functions of the RNA polymerase II CTDPreprint

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Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1

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The snoRNA HBII-52 Regulates Alternative Splicing of the Serotonin Receptor 2C

Kishore, S., & Stamm, S. (2005) · Science · doi:10.1126/science.1118265 · Cited by 699 · see citing works

A Slow RNA Polymerase II Affects Alternative Splicing In Vivo

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Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

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SMN Deficiency Causes Tissue-Specific Perturbations in the Repertoire of snRNAs and Widespread Defects in Splicing

Zhang, Z., Lotti, F., Dittmar, K. A., Younis, I., Wan, L., Kasim, M., & Dreyfuss, G. (2008) · Cell · doi:10.1016/j.cell.2008.03.031 · Cited by 610 · see citing works

Recognition of Trimethylated Histone H3 Lysine 4 Facilitates the Recruitment of Transcription Postinitiation Factors and Pre-mRNA Splicing

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A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons

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An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells

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ESRP1 and ESRP2 Are Epithelial Cell-Type-Specific Regulators of FGFR2 Splicing

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A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy

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Distinct Binding Specificities and Functions of Higher Eukaryotic Polypyrimidine Tract-Binding Proteins

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An RNA map predicting Nova-dependent splicing regulation

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Nova regulates brain-specific splicing to shape the synapse

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SR Splicing Factors Serve as Adapter Proteins for TAP-Dependent mRNA Export

Huang, Y., Gattoni, R. C., Stévenin, J., & STEITZ, J. A. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00089-3 · Cited by 480 · see citing works

Genome-wide Prediction of Mammalian Enhancers Based on Analysis of Transcription-Factor Binding Affinity

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The human SWI/SNF subunit Brm is a regulator of alternative splicing

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Control of alternative RNA splicing and gene expression by eukaryotic riboswitches

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A novel role for shuttling SR proteins in mRNA translationPreprint

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Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing.Preprint

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Direct Coupling of Transcription and mRNA Processing through the Thermogenic Coactivator PGC-1

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ASF/SF2-Regulated CaMKIIδ Alternative Splicing Temporally Reprograms Excitation-Contraction Coupling in Cardiac Muscle

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Isolation of an active step I spliceosome and composition of its RNP core

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Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor.

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Neuronal regulation of alternative pre-mRNA splicing

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The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities.

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Regulation of Fas Alternative Splicing by Antagonistic Effects of TIA-1 and PTB on Exon Definition

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The splicing factor SC35 has an active role in transcriptional elongation

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Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells.Preprint

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Spinal Muscular Atrophy: A Deficiency in a Ubiquitous Protein; a Motor Neuron-Specific Disease

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SR Proteins Function in Coupling RNAP II Transcription to Pre-mRNA Splicing

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The Mkk3/6-p38–Signaling Cascade Alters the Subcellular Distribution of Hnrnp A1 and Modulates Alternative Splicing Regulation

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The Splicing Factor BBP Interacts Specifically with the Pre-mRNA Branchpoint Sequence UACUAAC

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The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x

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Alternative RNA splicing in the nervous system

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Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines

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hnRNP A1 Relocalization to the Stress Granules Reflects a Role in the Stress Response

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Ribonucleoprotein Assembly Defects Correlate with Spinal Muscular Atrophy Severity and Preferentially Affect a Subset of Spliceosomal snRNPs

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Crossregulation and Functional Redundancy between the Splicing Regulator PTB and Its Paralogs nPTB and ROD1

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DNA Damage Regulates Alternative Splicing through Inhibition of RNA Polymerase II Elongation

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Coupling of Transcription with Alternative Splicing

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Splicing factor SFRS1 recognizes a functionally diverse landscape of RNA transcriptsPreprint

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Determinants of Exon 7 Splicing in the Spinal Muscular Atrophy Genes, SMN1 and SMN2

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5′ Splice Site Mutations in tau Associated with the Inherited Dementia FTDP-17 Affect a Stem-Loop Structure That Regulates Alternative Splicing of Exon 10

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Mutually Exclusive Splicing of the Insect Dscam Pre-mRNA Directed by Competing Intronic RNA Secondary Structures

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ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation

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Identification of alternative splicing regulators by RNA interference in Drosophila

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The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing.Preprint

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Riboswitch RNAs: using RNA to sense cellular metabolismPreprint

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A molecular link between SR protein dephosphorylation and mRNA export

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Cell signalling and the control of pre-mRNA splicing

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Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF.

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Involvement of SR Proteins in mRNA Surveillance

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Intronic CA‐repeat and CA‐rich elements: a new class of regulators of mammalian alternative splicing

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Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock

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The splicing regulator TIA‐1 interacts with U1‐C to promote U1 snRNP recruitment to 5′ splice sites

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Determinants of SR protein specificity

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Intronic Binding Sites for hnRNP A/B and hnRNP F/H Proteins Stimulate Pre-mRNA Splicing

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Rapid, Transcript-Specific Changes in Splicing in Response to Environmental Stress

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Oncoprotein TLS Interacts with Serine-Arginine Proteins Involved in RNA Splicing

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The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia

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Alternative splicing: current perspectives

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hnRNP A1 functions with specificity in repression of SMN2 exon 7 splicing

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RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20

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Determination of the RNA Binding Specificity of the Heterogeneous Nuclear Ribonucleoprotein (hnRNP) H/H′/F/2H9 Family

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The SR Protein SRp38 Represses Splicing in M Phase Cells

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Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: Creation of an SRp40-specific splicing enhancer

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Pre-mRNA Secondary Structures Influence Exon Recognition

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Multisite RNA Binding and Release of Polypyrimidine Tract Binding Protein during the Regulation of c-src Neural-Specific Splicing

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Tissue-specific splicing factor gene expression signatures

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Dynamic Antagonism between ETR-3 and PTB Regulates Cell Type-Specific Alternative Splicing

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Role of HuD and other RNA‐binding proteins in neural development and plasticity

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Architectural limits on split genes

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Protein kinase A phosphorylation modulates transport of the polypyrimidine tract-binding protein

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Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome

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RBM5/Luca-15/H37 Regulates Fas Alternative Splice Site Pairing after Exon Definition

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The hnRNP A1 protein regulates HIV‐1 tat splicing via a novel intron silencer element

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Pre-mRNA splicing in the absence of an SR protein RS domainPreprint

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Chromatin, transcript elongation and alternative splicing

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A genome-wide in situhybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain

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