The DOI matches its Crossref record; 65 of the 68 references it cites were found in a registry or an index.
Red not dead: signaling in and from erythrocytes
Abstract
The oxygen required to meet metabolic needs of all tissues is delivered by the erythrocyte, a small, flexible cell which, in mammals, is devoid of a nucleus and mitochondria. Despite its simple appearance, this 'bag of hemoglobin' has an important role in its own distribution, enabling the delivery of oxygen to precisely meet localized metabolic need. When an erythrocyte enters an area in which tissue oxygen demand exceeds supply, a signaling pathway is activated resulting in the release of adenosine 5'-triphosphate (ATP). This ATP acts in a paracrine fashion to increase vascular caliber resulting in increased oxygen delivery. Defects in this pathway are found in erythrocytes of humans with type 2 diabetes (DM2) and could contribute to the perfusion abnormalities in skeletal muscle associated with this disease.
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“Subsequently, several reports have shown that all mammalian Mo-containing enzymes [XO, aldehyde oxidase (AO), sulfite oxidase, and the mitochondrial amidoxime-reducing component (mARC)] are able to reduce nitrite at different intrinsic rates (Table 4) (575, 880, 990).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [880]
In the citing paper
“Both mARC enzymes can reduce nitrite to NO in a process very sensitive to oxygen-mediated inhibition (Table 4) (880).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [880]
Citations
Cites
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Self-citationRelease of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnia
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Deformation-induced ATP release from red blood cells requires CFTR activity
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3 of the 68 references couldn’t be matched to a known paper.
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Items 101–123 of 123
Cardiovascular Response During Exercise
Furst, B. (2019) · Springer eBooks · doi:10.1007/978-3-030-25062-1_17 · Cited by 1
Sphingosine Increases ATP Release From Red Blood Cells
Misiti, F. (2022) · The Open Biochemistry Journal · doi:10.2174/1874091x-v16-e2204210 · Cited by 1
Assessment of Tissue Oxygenation
Piagnerelli, M., Dierick, A., & der Linden, P. V. (2010) · doi:10.1002/9781444319583.ch18 · Cited by 1
Evolutionary Aspect of the Rhythmic System
Furst, B. (2013) · Springer eBooks · doi:10.1007/978-1-4471-5277-4_12
The Effect of Combined C-Peptide and Zinc on Cellular Function
Spence, D. M. (2011) · Humana Press eBooks · doi:10.1007/978-1-61779-391-2_3
“Currently, there are two main mechanisms describing the RBC as a possible determinant in blood fl ow, specifi cally, its ability to release nitric oxide (NO) directly into the bloodstream resulting in subsequent relaxation of the smooth muscle cells and vessel dilation [ 3, 4 ] and its ability to release ATP [ 5, 6 ] .”
BackgroundCardiovascular Response During Exercise
Furst, B. (2013) · Springer eBooks · doi:10.1007/978-1-4471-5277-4_17
The Dynamic Roles of Red Blood Cell in Microcirculation
Zhou, S. (2019) · RIT Scholar Works (Rochester Institute of Technology)
Changes in the Biophysical Properties of Lymphocytes Under Mechanical Stress
Sladkova, E. A., Александровна, Ш. Е., Tishchenko, А. Y., & Skorkina, M. Y. (2019) · BIOPHYSICS · doi:10.1134/s0006350919040195
Skorkina, M. Y., Шевченко, Т. С., Taranenko, A. S., Shentseva, E. S., & Zakirova, L. R. (2021) · PubMed Central · doi:10.22092/ari.2021.355848.1727
Evolutionary Aspect of the Rhythmical System
Furst, B. (2019) · Springer eBooks · doi:10.1007/978-3-030-25062-1_12
Sphingosine Increases ATP Release From Red Blood Cells
Misiti, F. (2022) · The Open Biochemistry Journal · doi:10.2174/874091x-v16-e2204210
Silkin, Y. A., Silkin, M. Y., Silkina, E. N., & Omelchenko, S. I. (2025) · Vestnik Moskovskogo universiteta Seria 16 Biologia · doi:10.55959/msu0137-0952-16-80-2-8
Lu, G., Li, C., Xu, N., Yao, Y., Sun, H., Huang, X., Grzegorzek, M., & Zeng, Q. (2025) · Lecture notes in electrical engineering · doi:10.1007/978-981-96-2771-4_45
Lu, G., Fan, Z., Gao, M., Chen, J., Meng, Q., Yang, H., Sun, H., Jiang, T., Yao, Y., Grzegorzek, M., et al. (2025) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2025.108595
Poitras, V. J. (2009) · University Microfilms International eBooks
Silkin, Y. A., Silkin, M. Y., Silkina, E. N., & Omelchenko, S. O. (2025) · Moscow University Biological Sciences Bulletin · doi:10.3103/s0096392525600723
“…and cells and a decrease in the saturation of intracellular hemoglobin with oxygen lead to ATP release from mammalian erythrocytes (hamster, rabbit, rat, human); this led to a local expansion of arterioles and capillaries through the activation of P2 receptors of the vascular endothelium [15].”
Rôle du complexe VDAC1/TSPO1 au cours de l'érythropoïèse humaine, focus sur la mitophagie
Moras, M. (2020) · theses.fr (ABES) · doi:10.70675/a4c63cc2z949az4474zb1acz38e7f433fd35
Blood Cells Far from Equilibrium: Redox Adaptation in Health and Disease
Anastasiadi, A. T., & D'Alessandro, A. (2026) · Antioxidants · doi:10.3390/antiox15060723
Haiman, Z. B., Anastasiadi, A. T., Delaporta, P., Stephenson, D., Dzieciątkowska, M., Nemkov, T. G., Page, G. P., Chouliara, V., Glentis, S., Adam, A., et al. (2026) · American Journal of Hematology · doi:10.1002/ajh.70538
Enhancement of platelet activation and aggregation by erytrocytes: role of red cells in thrombosis
Bartholomew, A. E. (2009) · UA Campus Repository (The University of Arizona)
Metadata
- Authors
- Sprague, R. S., Stephenson, A. H., & Ellsworth, M. L.
- Affiliations
- Saint Louis University (US)
- ORCID
- Sprague, Randy S.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 18
- Issue
- 9
- Pages
- 350-355
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W1992160483
- Cited by
- 124
- References
- 68
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 11 · 2018: 8 · 2017: 6 · 2016: 6 · 2015: 6 · 2014: 8 · 2013: 7 · 2012: 8
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL051298, HL-51298, HL64180, R01HL056249, R01HL064180, HL56249, HL 39226)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Erythrocyte Function and Pathophysiology
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- erythrocytes, ATP release, paracrine signaling, oxygen delivery, vascular caliber, type 2 diabetes, skeletal muscle perfusion
- MeSH terms
- Energy Metabolism, Erythrocytes, Humans, Oxygen, Signal Transduction
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