The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Nampt: linking NAD biology, metabolism and cancer
Open accessAbstract
Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide to nicotinamide mononucleotide (NMN), a key NAD intermediate. Previously identified as a cytokine PBEF and controversially claimed as an insulin-mimetic hormone visfatin, Nampt has recently drawn much attention in different fields, including NAD biology, metabolism, and inflammation. As an NAD biosynthetic enzyme, Nampt regulates the activity of NAD-consuming enzymes such as sirtuins and influences a variety of metabolic and stress responses. Nampt also plays an important role in the regulation of insulin secretion in pancreatic β cells. Nampt appears to have another function as an immunomodulatory cytokine and plays a role in inflammation. This review summarizes these various functional aspects of Nampt and discusses its potential roles in diseases, including type 2 diabetes and cancer.
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2 retracted
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
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RetractedTranscriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
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“Silent information regulator 2 (Sir2), as the prototypical enzyme of this group, regulates the replicative life span of yeast mother cells[48].”
Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor
Yu, S.-W., Wang, H., Poitras, M. F., Coombs, C., Bowers, W. J., Federoff, H. J., Poirier, G. G., Dawson, T. M., & Dawson, V. L. (2002) · Science · doi:10.1126/science.1072221 · Cited by 1,826
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Milne, J. C., Lambert, P. D., Schenk, S., Carney, D. P., Smith, J. J., Gagne, D. J., Jin, L., Boss, O., Perni, R. B., Vu, C. B., et al. (2007) · Nature · doi:10.1038/nature06261 · Cited by 1,707 · cited 1×
“Because sirtuins have recently emerged as promising pharmaceutical targets to develop therapeutic interventions against age-associated diseases[59,60], the systemic enhancement of NAD biosynthesis might provide another pharmacological means to activate Sirt1 and to convey benefits against age-associated diseases[61].”
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,603
The Sir2 Family of Protein Deacetylases
Blander, G., & Guarente, L. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073651 · Cited by 1,495
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
Rogina, B., & Helfand, S. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404184101 · Cited by 1,361
Cited by
Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648
NAD + in aging, metabolism, and neurodegeneration
Verdin, E. (2015) · Science · doi:10.1126/science.aac4854 · Cited by 1,319
Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome
Maury, E., & Brichard, S. M. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.031 · Cited by 1,026
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways
Houtkooper, R. H., Cantó, C., Wanders, R. J., & Auwerx, J. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0026 · Cited by 899
Obesity and diabetes: the increased risk of cancer and cancer-related mortality
Gallagher, E. J., & LeRoith, D. (2015) · Physiological Reviews · doi:10.1152/physrev.00030.2014 · Cited by 806
Metadata
- Authors
- Garten, A., Petzold, S., Körner, A., Imai, S.-I., & Kiess, W.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 20
- Issue
- 3
- Pages
- 130-138
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W2092950801
- Cited by
- 398
- References
- 96
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Garten, A., Petzold, S., Körner, A., Imai, S.-I., & Kiess, W. (2009). Nampt: linking NAD biology, metabolism and cancer. Trends in Endocrinology & Metabolism. https://doi.org/10.1016/j.tem.2008.10.004
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