The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The Sir2 Family of Protein Deacetylases
Abstract
▪ Abstract The yeast SIR protein complex has been implicated in transcription silencing and suppression of recombination. The Sir complex represses transcription at telomeres, mating-type loci, and ribosomal DNA. Unlike SIR3 and SIR4, the SIR2 gene is highly conserved in organisms ranging from archaea to humans. Interestingly, Sir2 is active as an NAD + -dependent deacetylase, which is broadly conserved from bacteria to higher eukaryotes. In this review, we discuss the role of NAD + , the unusual products of the deacetylation reaction, the Sir2 structure, and the Sir2 chemical inhibitors and activators that were recently identified. We summarize the current knowledge of the Sir2 homologs from different organisms, and finally we discuss the role of Sir2 in caloric restriction and aging.
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Cites
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Self-citationHDAC6 is a microtubule-associated deacetylase
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The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis
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Cited by
Mitochondria, Oxidants, and Aging
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Reactive oxygen species, cellular redox systems, and apoptosis
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Metadata
- Authors
- Blander, G., & Guarente, L.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2004-06
- Volume
- 73
- Issue
- 1
- Pages
- 417-435
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2123927456
- Cited by
- 1,495
- References
- 11
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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