β-Cell deterioration during diabetes: what’s in the gun?

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442 · see citing works

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011 · see citing works

A genome-wide association study identifies novel risk loci for type 2 diabetes

Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S., et al. (2007) · Nature · doi:10.1038/nature05616 · Cited by 2,993 · see citing works

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I. W., Chen, H., Roix, J. J., Kathiresan, S., Hirschhorn, J. N., Daly, M. J., et al. (2007) · Science · doi:10.1126/science.1142358 · Cited by 2,843 · see citing works

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

Scott, L. J., Mohlke, K. L., Bonnycastle, L. L., Willer, C. J., Li, Y., Duren, W. L., Erdos, M. R., Stringham, H. M., Chines, P. S., Jackson, A. U., et al. (2007) · Science · doi:10.1126/science.1142382 · Cited by 2,753 · see citing works

The Wellcome Trust Case Control Consortium, U.K.

Mossman, K. (2008) · Scientific American · doi:10.1038/scientificamerican0108-42a · Cited by 2,714 · see citing works

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes

Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232 · see citing works

Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

Zeggini, E., Weedon, M. N., Lindgren, C. M., Frayling, T. M., Elliott, K. S., Lango, H., Timpson, N. J., Perry, J. R. B., Rayner, N. W., Freathy, R. M., et al. (2007) · Science · doi:10.1126/science.1142364 · Cited by 2,194 · see citing works

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

Larsen, C. M., Faulenbach, M., Vaag, A., Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, T., & Donath, M. Y. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065213 · Cited by 1,798 · see citing works

Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells

Tiedge, M., Lortz, S., Drinkgern, J., & Lenzen, S. (1997) · Diabetes · doi:10.2337/diab.46.11.1733 · Cited by 1,211 · see citing works

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

Eizirik, D. L., Cardozo, A. K., & Cnop, M. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0015 · Cited by 1,173 · see citing works

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

Maedler, K., Sergeev, P., Ris, F., Oberholzer, J., Joller‐Jemelka, H. I., Spinas, G. A., Kaiser, N., Halban, P. A., & Donath, M. Y. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92172 · Cited by 1,114 · see citing works

Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications

Unger, R. H. (1995) · Diabetes · doi:10.2337/diab.44.8.863 · Cited by 1,100 · see citing works

Glucolipotoxicity: fuel excess and β-cell dysfunction

Poitout, V., & Robertson, R. P. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0023 · Cited by 1,092 · see citing works

Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes

Robertson, R. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400019200 · Cited by 1,078 · see citing works

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

Steinthorsdottir, V., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Jonsdottir, T., Walters, G. B., Styrkarsdottir, U., Gretarsdottir, S., Emilsson, V., Ghosh, S., et al. (2007) · Nature Genetics · doi:10.1038/ng2043 · Cited by 1,072 · see citing works

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

Maedler, K., Sergeev, P., Ris, F., Oberholzer, J., Joller‐Jemelka, H. I., Spinas, G. A., Kaiser, N., Halban, P. A., & Donath, M. Y. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215318 · Cited by 1,006 · see citing works

Increased Number of Islet-Associated Macrophages in Type 2 Diabetes

Ehses, J. A., Perren, A. A., Eppler, E., Ribaux, P., Pospisilik, J. A., Maor-Cahn, R., Guéripel, X., Ellingsgaard, H., Schneider, M. K. J., Biollaz, G., et al. (2007) · Diabetes · doi:10.2337/db06-1650 · Cited by 783 · see citing works

Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.

Kaneto, H., Kajimoto, Y., Miyagawa, J., Matsuoka, T., Fujitani, Y., Umayahara, Y., Hanafusa, T., Matsuzawa, Y., Yamasaki, Y., & Hori, M. (1999) · Diabetes · doi:10.2337/diabetes.48.12.2398 · Cited by 713 · see citing works

Signal transduction of stress via ceramide

Mathias, S., Peña, L. A., & Kolesnick, R. (1998) · Biochemical Journal · doi:10.1042/bj3350465 · Cited by 673 · see citing works

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

Haataja, L., Gurlo, T., Huang, C. J., & Butler, P. C. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0037 · Cited by 612 · see citing works

Initiation and execution of lipotoxic ER stress in pancreatic β-cells

Cunha, D. A., Hekerman, P., Ladrière, L., Bazarra-Castro, A., Ortis, F., Wakeham, M. C., Moore, F., Rasschaert, J., Cardozo, A. K., Bellomo, E. A., et al. (2008) · Journal of Cell Science · doi:10.1242/jcs.026062 · Cited by 593 · see citing works

Free Fatty Acids and Cytokines Induce Pancreatic β-Cell Apoptosis by Different Mechanisms: Role of Nuclear Factor-κB and Endoplasmic Reticulum Stress

Kharroubi, I., Ladrière, L., Cardozo, A. K., Doğusan, Z., Cnop, M., & Eizirik, D. L. (2004) · Endocrinology · doi:10.1210/en.2004-0478 · Cited by 582 · see citing works

Reactive Oxygen Species as a Signal in Glucose-Stimulated Insulin Secretion

Pi, J., Bai, Y., Zhang, Q., Wong, V. A., Floering, L. M., Daniel, K. W., Reece, J. M., Deeney, J. T., Andersen, M. E., Corkey, B. E., et al. (2007) · Diabetes · doi:10.2337/db06-1601 · Cited by 570 · see citing works

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

Scheuner, D., & Kaufman, R. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0039 · Cited by 525 · see citing works

CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse

Grankvist, K., Marklund, S. L., & Täljedal, I. ‐. (1981) · Biochemical Journal · doi:10.1042/bj1990393 · Cited by 517 · see citing works

Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

Ihara, Y., Toyokuni, S., Uchida, K., Odaka, H., Tanaka, T., Ikeda, H., Hiai, H., Seino, Y., & Yamada, Y. (1999) · Diabetes · doi:10.2337/diabetes.48.4.927 · Cited by 506 · see citing works

A Sustained Increase in Plasma Free Fatty Acids Impairs Insulin Secretion in Nondiabetic Subjects Genetically Predisposed to Develop Type 2 Diabetes

Kashyap, S., Belfort, R., Gastaldelli, A., Pratipanawatr, T., Berria, R., Pratipanawatr, W., Bajaj, M., Mandarino, L., DeFronzo, R., & Cusi, K. (2003) · Diabetes · doi:10.2337/diabetes.52.10.2461 · Cited by 503 · see citing works

Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

Prentki, M., & Corkey, B. E. (1996) · Diabetes · doi:10.2337/diab.45.3.273 · Cited by 478 · see citing works

Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants

Tanaka, Y., Gleason, C. E., Tran, P. O. T., Harmon, J. S., & Robertson, R. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10857 · Cited by 460 · see citing works

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients

Marchetti, P., Bugliani, M., Lupi, R., Marselli, L., Masini, M., Boggi, U., Filipponi, F., Weir, G. C., Eizirik, D. L., & Cnop, M. (2007) · Diabetologia · doi:10.1007/s00125-007-0816-8 · Cited by 413 · see citing works

Increased β-Cell Apoptosis Prevents Adaptive Increase in β-Cell Mass in Mouse Model of Type 2 Diabetes

Butler, A. E., Janson, J., Soeller, W. C., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.9.2304 · Cited by 411 · see citing works

Effects of Vitamin E on Cardiovascular and Microvascular Outcomes in High-Risk Patients With Diabetes

Lonn, E., Yusuf, S., Hoogwerf, B. J., Pogue, J., Yi, Q., Zinman, B., Bosch, J., Dagenais, G. R., Mann, J. F. E., Gerstein, H. C., et al. (2002) · Diabetes Care · doi:10.2337/diacare.25.11.1919 · Cited by 366 · see citing works

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

Maedler, K., Sergeev, P., Ris, F., Oberholzer, J., Joller‐Jemelka, H. I., Spinas, G. A., Kaiser, N., Halban, P. A., & Donath, M. Y. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15318 · Cited by 363 · see citing works

Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion

Leloup, C., Tourrel-Cuzin, C., Magnan, C., Karaca, M., Castel, J., Carneiro, L., Colombani, A.-L., Ktorza, A., Casteilla, L., & Pénicaud, L. (2009) · Diabetes · doi:10.2337/db07-1056 · Cited by 361 · see citing works

Thioredoxin-Interacting Protein

Chen, J., Saxena, G., Mungrue, I. N., Lusis, A. J., & Shalev, A. (2008) · Diabetes · doi:10.2337/db07-0715 · Cited by 350 · see citing works

A role for glutathione peroxidase in protecting pancreatic β cells against oxidative stress in a model of glucose toxicity

Tanaka, Y., Tran, P. O. T., Harmon, J. S., & Robertson, R. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192445199 · Cited by 316 · see citing works

Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells

Tiedge, M., Lortz, S., Drinkgern, J., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.11.1733 · Cited by 304 · see citing works

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications

Unger, R. H. (1995) · Diabetes · doi:10.2337/diabetes.44.8.863 · Cited by 283 · see citing works

Troglitazone Lowers Islet Fat and Restores Beta Cell Function of Zucker Diabetic Fatty Rats

Shimabukuro, M., Zhou, Y.-T., Lee, Y., & Unger, R. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3547 · Cited by 249 · see citing works

Leptin modulates β cell expression of IL-1 receptor antagonist and release of IL-1β in human islets

Maedler, K., Sergeev, P., Ehses, J. A., Máthé, Z., Bosco, D., Berney, T., Dayer, J., Reinecke, M., Halban, P. A., & Donath, M. Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305683101 · Cited by 248 · see citing works

Palmitate Inhibition of Insulin Gene Expression Is Mediated at the Transcriptional Level via Ceramide Synthesis

Kelpe, C. L., Moore, P. C., Parazzoli, S. D., Wicksteed, B. L., Rhodes, C. J., & Poitout, V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302548200 · Cited by 239 · see citing works

Oxidative Stress-mediated, Post-translational Loss of MafA Protein as a Contributing Mechanism to Loss of Insulin Gene Expression in Glucotoxic Beta Cells

Harmon, J. S., Stein, R. W., & Robertson, R. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410345200 · Cited by 234 · see citing works

Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations.

Robertson, R. P., Zhang, H. J., Pyzdrowski, K. L., & Walseth, T. F. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115865 · Cited by 232 · see citing works

Chronic oxidative stress as a mechanism for glucose toxicity of the beta cell in type 2 diabetes

Robertson, R. P., Zhou, H., Zhang, T., & Harmon, J. S. (2007) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-007-0026-5 · Cited by 222 · see citing works

Cytokines and β-Cell Biology: from Concept to Clinical Translation

Donath, M. Y., Størling, J., Berchtold, L. A., Billestrup, N., & Mandrup-Poulsen, T. R. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0033 · Cited by 219 · see citing works

Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis

Zraika, S., Hull, R. L., Udayasankar, J., Aston‐Mourney, K., Subramanian, S. L., Kisilevsky, R., Szarek, W. A., & Kahn, S. E. (2009) · Diabetologia · doi:10.1007/s00125-008-1255-x · Cited by 215 · see citing works

Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.

Olson, L. K., Redmon, J. B., Towle, H. C., & Robertson, R. P. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116596 · Cited by 212 · see citing works

The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression

Sharma, A. K., Olson, L. K., Robertson, R. P., & Stein, R. W. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.9.7491105 · Cited by 164 · see citing works

The defective glucose sensitivity of the B cell in non insulin dependent diabetes. Improvement after twenty hours of normoglycaemia

Vague, P., & Moulin, J.-P. (1982) · Metabolism · doi:10.1016/0026-0495(82)90125-1 · Cited by 146 · see citing works

Antecedent Hyperglycemia, Not Hyperlipidemia, Is Associated With Increased Islet Triacylglycerol Content and Decreased Insulin Gene mRNA Level in Zucker Diabetic Fatty Rats

Harmon, J. S., Gleason, C. E., Tanaka, Y., Poitout, V., & Robertson, R. P. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2481 · Cited by 140 · see citing works

Effects of hemipancreatectomy on pancreatic alpha and beta cell function in healthy human donors.

Seaquist, E. R., & Robertson, R. P. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115779 · Cited by 128 · see citing works

Is There a Role for Locally Produced Interleukin-1 in the Deleterious Effects of High Glucose or the Type 2 Diabetes Milieu to Human Pancreatic Islets?

Welsh, N., Cnop, M., Kharroubi, I., Bugliani, M., Lupi, R., Marchetti, P., & Eizirik, D. L. (2005) · Diabetes · doi:10.2337/diabetes.54.11.3238 · Cited by 125 · see citing works

Evidence for a Role of Superoxide Generation in Glucose-Induced β-Cell Dysfunction In Vivo

Tang, C., Han, P., Oprescu, A. I., Lee, S. J. C., Gyulkhandanyan, A. V., Chan, G. N. Y., Wheeler, M. B., & Giacca, A. (2007) · Diabetes · doi:10.2337/db07-0279 · Cited by 119 · see citing works

Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

Prentki, M., & Corkey, B. E. (1996) · Diabetes · doi:10.2337/diabetes.45.3.273 · Cited by 108 · see citing works

Determinants of glucose toxicity and its reversibility in the pancreatic islet β-cell line, HIT-T15

Gleason, C. E., Gonzalez, M., Harmon, J. S., & Robertson, R. P. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e997 · Cited by 99 · see citing works

Silymarin as an Adjunct to Glibenclamide Therapy Improves Long-Term and Postprandial Glycemic Control and Body Mass Index in Type 2 Diabetes

Hussain, S. A. (2007) · Journal of Medicinal Food · doi:10.1089/jmf.2006.089 · Cited by 77 · see citing works

Impairment of glucose-induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice.

Jansson, L. E., Eizirik, D. L., PIPELEERS, D. G., Borg, L. A. H., Hellerström, C., & Andersson, A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118115 · Cited by 69 · see citing works

Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress

Hull, R. L., Zraika, S., Udayasankar, J., Aston‐Mourney, K., Subramanian, S. L., & Kahn, S. E. (2009) · Diabetologia · doi:10.1007/s00125-009-1329-4 · Cited by 67 · see citing works

d-Glyceraldehyde Causes Production of Intracellular Peroxide in Pancreatic Islets, Oxidative Stress, and Defective Beta Cell Function via Non-mitochondrial Pathways

Takahashi, H., Tran, P. O. T., LeRoy, E., Harmon, J. S., Tanaka, Y., & Robertson, R. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403070200 · Cited by 52 · see citing works

Differentiation between glucose-induced desensitization of insulin secretion and beta-cell exhaustion in the HIT-T15 cell line.

Kilpatrick, E. D., & Robertson, R. P. (1998) · Diabetes · doi:10.2337/diabetes.47.4.606 · Cited by 33 · see citing works

The role of mitochondria in the pathogenesis of type 2 diabetes

Patti, M.-E., & Corvera, S. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0027 · Cited by 551 · see citing works

The molecular mechanisms of pancreatic β-cell glucotoxicity: recent findings and future research directions.

Bensellam, M., Laybutt, D., & Jonas, J. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.08.003 · Cited by 282 · see citing works

Oxidative stress and the ageing endocrine system

Vitale, G., Salvioli, S., & Franceschi, C. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.29 · Cited by 269 · see citing works

Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity

Ying, W., Lee, Y. S., Dong, Y. W., Seidman, J. S., Yang, M., Isaac, R., Seo, J. B., Yang, B.-H., Wollam, J., Riopel, M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.003 · Cited by 268 · see citing works

Regulatory T cells in obesity: the leptin connection

Matarese, G., Procaccini, C., Rosa, V. D., Horváth, T. L., & Cava, A. L. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.04.002 · Cited by 186 · see citing works

ANIMAL MODELS OF DISEASE: Classification and etiology of diabetes in dogs and cats

Nelson, R. W., & Reusch, C. E. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0202 · Cited by 185 · see citing works

Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats

Agil, A., Rosado, I., Ruiz, R., Figueroa, A., Zen, N., & Fernández‐Vázquez, G. (2012) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00928.x · Cited by 169 · see citing works

Melatonin ameliorates low‐grade inflammation and oxidative stress in young Zucker diabetic fatty rats

Agil, A., Reiter, R. J., Jiménez‐Aranda, A., Arias, R. I., Navarro‐Alarcón, M., Marchal, J. A., Adem, A., & Fernández‐Vázquez, G. (2012) · Journal of Pineal Research · doi:10.1111/jpi.12012 · Cited by 159 · see citing works

In Vivo Pancreatic β-Cell–Specific Expression of Antiaging Gene Klotho: A Novel Approach for Preserving β-Cells in Type 2 Diabetes

Lin, Y., & Sun, Z. (2014) · Diabetes · doi:10.2337/db14-0632 · Cited by 123 · see citing works

PPAR-γ Activation Restores Pancreatic Islet SERCA2 Levels and Prevents β-Cell Dysfunction under Conditions of Hyperglycemic and Cytokine Stress

Kono, T., Ahn, G., Moss, D. R., Gann, L., Zarain‐Herzberg, Á., Nishiki, Y., Fueger, P. T., Ogihara, T., & Evans‐Molina, C. (2012) · Molecular Endocrinology · doi:10.1210/me.2011-1181 · Cited by 115 · see citing works

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes

Marselli, L., Piron, A., Suleiman, M., Colli, M. L., Yi, X., Khamis, A., Carrat, G., Rutter, G. A., Bugliani, M., Giusti, L., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108466 · Cited by 115 · see citing works

The Mammalian Tribbles Homolog TRIB3, Glucose Homeostasis, and Cardiovascular Diseases

Prudente, S., Sesti, G., Pandolfi, A., Andreozzi, F., Consoli, A., & Trischitta, V. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1042 · Cited by 111 · see citing works

G protein-coupled receptors as targets for anti-diabetic therapeutics

Oh, D. Y., & Olefsky, J. M. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.4 · Cited by 110 · see citing works

Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration

Ye, R., Holland, W. L., Gordillo, R., Wang, M., Wang, Q. A., Shao, M., Morley, T. S., Gupta, R. K., Stahl, A., & Scherer, P. E. (2014) · eLife · doi:10.7554/elife.03851 · Cited by 100 · see citing works

Hydrogen sulphide protects mouse pancreatic β‐cells from cell death induced by oxidative stress, but not by endoplasmic reticulum stress

Taniguchi, S., Kang, L., Kimura, T., & Niki, I. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01119.x · Cited by 99 · see citing works

The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs

Puckett, D. L., Alquraishi, M. I., Chowanadisai, W., & Bettaieb, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031171 · Cited by 93 · see citing works

New insights into the role of connexins in pancreatic islet function and diabetes

Farnsworth, N. L., & Benninger, R. K. P. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.02.035 · Cited by 86 · see citing works

The role of peroxisome proliferator‐activated receptor γ in pancreatic β cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitus

Gupta, D., Kono, T., & Evans‐Molina, C. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01299.x · Cited by 83 · see citing works

Clinical and Genetic Determinants of Progression of Type 2 Diabetes: A DIRECT Study

Zhou, K., Donnelly, L. A., Morris, A. D., Franks, P. W., Jennison, C., Palmer, C. N. A., & Pearson, E. R. (2013) · Diabetes Care · doi:10.2337/dc13-1995 · Cited by 79 · see citing works

Bone marrow-derived mesenchymal stem cells ameliorate chronic high glucose-induced β-cell injury through modulation of autophagy

Zhao, K., Hao, H., Liu, J., Tong, C., Cheng, Y., Xie, Z., Zang, L., Mu, Y., & Han, W. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.230 · Cited by 72 · see citing works

UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells

Costes, S., Gurlo, T., Rivera, J. F., & Butler, P. C. (2014) · Autophagy · doi:10.4161/auto.28478 · Cited by 67 · see citing works

Unsaturated fatty acids as cytoprotective agents in the pancreatic β-cell

Morgan, N. G., & Dhayal, S. (2010) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2010.02.018 · Cited by 63 · see citing works

Diet and prevention of type 2 diabetes mellitus: beyond weight loss and exercise

Palacios, O. M., Kramer, M. W., & Maki, K. C. (2018) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2019.1554430 · Cited by 65 · see citing works

A review on potential anti-diabetic mechanisms of chitosan and its derivatives

Priyanka, D., Prashanth, K. V. H., & Tharanathan, R. N. (2022) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2022.100188 · Cited by 58 · see citing works

The effect of different volumes of high-intensity interval training on proinsulin in participants with the metabolic syndrome: a randomised trial

Ramos, J. S., Dalleck, L. C., Borrani, F., Mallard, A. R., Clark, B., Keating, S. E., Fassett, R. G., & Coombes, J. S. (2016) · Diabetologia · doi:10.1007/s00125-016-4064-7 · Cited by 56 · see citing works

Protection of Pancreatic β-Cells from Various Stress Conditions Is Mediated by DJ-1

Inberg, A., & Michal Linial, B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.109751 · Cited by 55 · see citing works

Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis

Han, J., Song, B., Kim, J., Kodali, V. K., Pottekat, A., Wang, M., Hassler, J. R., Wang, S., Pennathur, S., Back, S. H., et al. (2015) · Diabetes · doi:10.2337/db14-1357 · Cited by 52 · see citing works

Low Level Pro-inflammatory Cytokines Decrease Connexin36 Gap Junction Coupling in Mouse and Human Islets through Nitric Oxide-mediated Protein Kinase Cδ

Farnsworth, N. L., Walter, R. L., Hemmati, A., Westacott, M. J., & Benninger, R. K. P. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.679506 · Cited by 48 · see citing works

Pancreatic β-cell dysfunction in polycystic ovary syndrome: role of hyperglycemia-induced nuclear factor-κB activation and systemic inflammation

Malin, S. K., Kirwan, J. P., Sia, C. L., & González, F. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00510.2014 · Cited by 49 · see citing works

Glucose regulation of β ‐cell stress in type 2 diabetes

Leibowitz, G., Bachar-Wikström, E., Shaked, M., Sinai, A., Ketzinel‐Gilad, M., Cerasi, E., & Kaiser, Ν. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01280.x · Cited by 46 · see citing works

The Role of Beta Cell Recovery in Type 2 Diabetes Remission

Suleiman, M., Marselli, L., Cnop, M., Eizirik, D. L., Luca, C. D., Femia, F. R., Tesi, M., Guerra, S. D., & Marchetti, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137435 · Cited by 45 · see citing works

Cinnamtannin D-1 Protects Pancreatic β-Cells from Palmitic Acid-Induced Apoptosis by Attenuating Oxidative Stress

Wang, T., Sun, P. G., Chen, L., Huang, Q., Chen, K., Jia, Q., Li, Y., & Wang, H. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf500387d · Cited by 44 · see citing works

Pancreatic Ultrastructural Enhancement Due to Telmisartan Plus Sitagliptin Treatment in Diet-Induced Obese C57BL/6 Mice

Souza‐Mello, V., Gregório, B. M., Lucas, B. R., Faria, T. D. S., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2011) · Pancreas · doi:10.1097/mpa.0b013e3182153922 · Cited by 43 · see citing works

Polyphenolic Extracts from Olea europea L. Protect Against Cytokine-Induced β-Cell Damage Through Maintenance of Redox Homeostasis

Cumaoğlu, A., Arı, N., Kartal, M., & Karasu, Ç. (2011) · Rejuvenation Research · doi:10.1089/rej.2010.1111 · Cited by 43 · see citing works

Feline Diabetes Mellitus

Reusch, C. E. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-4456-5.00007-9 · Cited by 34 · see citing works

Reactive Oxygen Species (ROS) in Metabolic Disease—Don’t Shoot the Metabolic Messenger

Lindsay, R. T., & Rhodes, C. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062622 · Cited by 35 · see citing works

Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell Dysfunction

Puddu, A., Sanguineti, R., Mach, F., Dallegri, F., Viviani, G., & Montecucco, F. (2013) · Mediators of Inflammation · doi:10.1155/2013/750540 · Cited by 35 · see citing works

Induction of receptor for advanced glycation end products by insufficient leptin action triggers pancreatic β‐cell failure in type 2 diabetes

Han, D. G., Yamamoto, Y., Munesue, S., Motoyoshi, S., Saito, H., Win, M. T. T., Watanabe, T., Tsuneyama, K., & Yamamoto, H. (2013) · Genes to Cells · doi:10.1111/gtc.12036 · Cited by 32 · see citing works

Hyperglycemia and Loss of Redox Homeostasis in COVID-19 Patients

Soto, M. E., Guarner‐Lans, V., Díaz‐Díaz, E., Manzano-Pech, L., Chavarría, A. P., Valdez‐Vázquez, R. R., Aisa-Álvarez, A., Saucedo‐Orozco, H., & Pérez-Torres, I. (2022) · Cells · doi:10.3390/cells11060932 · Cited by 31 · see citing works

Diabetes mellitus type 2 as an underlying, comorbid or consequent state of mental disorders

Borovčanin, M., Vesić, K., Petrović, I., Jovanović, I., & Mijailović, N. R. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i5.481 · Cited by 30 · see citing works

Protective effect of hydrogen sulfide on pancreatic beta-cells

Okamoto, M., Ishizaki, T., & Kimura, T. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.11.007 · Cited by 30 · see citing works

Connexin36 contributes to INS-1E cells survival through modulation of cytokine-induced oxidative stress, ER stress and AMPK activity

Allagnat, F., Klee, P., Cardozo, A. K., Meda, P., & Haefliger, J. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.134 · Cited by 29 · see citing works

Could the high consumption of high glycaemic index carbohydrates and sugars, associated with the nutritional transition to the Western type of diet, be the common cause of the obesity epidemic and the worldwide increasing incidences of Type 1 and Type 2 diabetes?

Sjöblad, S. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.02.027 · Cited by 30 · see citing works

Glucose-Stimulated Oxidative Stress in Mononuclear Cells Is Related to Pancreatic β-Cell Dysfunction in Polycystic Ovary Syndrome

Malin, S. K., Kirwan, J. P., Sia, C. L., & González, F. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3177 · Cited by 29 · see citing works

DPP-4 (CD26) inhibitor sitagliptin exerts anti-inflammatory effects on rat insulinoma (RINm) cells via suppressing NF-κB activation

Hu, X., Liu, S., Liu, X., Zhang, J., Liang, Y. J., & Yan, L. (2016) · Endocrine · doi:10.1007/s12020-016-1073-8 · Cited by 29 · see citing works

Endurance training stimulates growth and survival pathways and the redox balance in rat pancreatic islets

Calegari, V. C., Abrantes, J. L. F., Silveira, L. R., de Paula, F. M. M., Costa, J. M., Rafacho, A., Velloso, L. A., Carneiro, E. M., Bosqueiro, J. R., Boschero, A. C., et al. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00318.2011 · Cited by 28 · see citing works

RACking up ceramide-induced islet β-cell dysfunction

Kowluru, A., & Kowluru, R. A. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.04.026 · Cited by 27 · see citing works

Cinnamtannin D1 Protects Pancreatic β‑Cells from Glucolipotoxicity-Induced Apoptosis by Enhancement of Autophagy In Vitro and In Vivo

Wang, X.-Y., Zhu, B.-R., Jia, Q., Li, Y., Wang, T., & Wang, H. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c04898 · Cited by 26 · see citing works

Gestational Diabetes Mellitus: A Positive Predictor of Type 2 Diabetes?

Rice, G. E., Illanes, S. E., & Mitchell, M. D. (2012) · International Journal of Endocrinology · doi:10.1155/2012/721653 · Cited by 26 · see citing works

S1P Signaling Pathways in Pathogenesis of Type 2 Diabetes

He, Q., Bo, J., Shen, R., Li, Y., Zhang, Y., Zhang, J., Yang, J., & Liu, Y. (2021) · Journal of Diabetes Research · doi:10.1155/2021/1341750 · Cited by 23 · see citing works

Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics

Ouaamari, A. E., Zhou, J.-Y., Liew, C. W., Shirakawa, J., Dirice, E., Gedeon, N., Kahraman, S., Jesus, D. F. D., Bhatt, S., Kim, J.-S., et al. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00587 · Cited by 23 · see citing works

Hyperglycemia downregulates Connexin36 in pancreatic islets via the upregulation of ICER-1/ICER-1γ

Haefliger, J., Rohner‐Jeanrenaud, F., Caille, D., Charollais, A., Meda, P., & Allagnat, F. (2013) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0054 · Cited by 22 · see citing works

A formulation of grape seed, Indian gooseberry, turmeric and fenugreek helps controlling type 2 diabetes mellitus in advanced-stage patients

Banerji, S., & Banerjee, S. (2016) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2016.06.012 · Cited by 21 · see citing works

Exendin‐4 overcomes cytokine‐induced decreases in gap junction coupling via protein kinase A and Epac2 in mouse and human islets

Farnsworth, N. L., Walter, R., Piscopio, R. A., Schleicher, W. E., & Benninger, R. K. P. (2018) · The Journal of Physiology · doi:10.1113/jp276106 · Cited by 21 · see citing works

Combined effect of hydrogen sulphide donor and losartan in experimental diabetic nephropathy in rats

Kaur, M., Sachdeva, S., Bedi, O., Kaur, T., & Kumar, P. (2015) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/s40200-015-0185-7 · Cited by 20 · see citing works

Chinese Medicine FTZ Recipe Protects against High-Glucose-Induced Beta Cell Injury through Alleviating Oxidative Stress

Bei, W., Wang, Y., Chen, J., Zhang, J., Wang, L., Gu, Z., Hu, Y., Huang, Y., Xu, W., Lei, Z., et al. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/6378786 · Cited by 19 · see citing works

Boron containing compounds promote the survival and the maintenance of pancreatic β-cells

Aydın, S., Demirci, S., Doğan, A., Sağraç, D., Kaşıkcı, E., & Şahi̇n, F. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-05002-3 · Cited by 18 · see citing works

Protective effects of Tat-DJ-1 protein against streptozotocin-induced diabetes in a mice model

Yeo, H. J., Yeo, E. J., Shin, M. J., Choi, Y. J., Lee, C. H., Kwon, H. Y., Kim, D. W., Eum, W. S., & Choi, S. Y. (2018) · BMB Reports · doi:10.5483/bmbrep.2018.51.7.101 · Cited by 18 · see citing works

Cytoprotective Effects of Polyphenols against Oxidative Damage

Martínez, V., Mitjans, M., & Vinardell, M. P. (2013) · Polyphenols in Human Health and Disease · doi:10.1016/b978-0-12-398456-2.00022-0 · Cited by 17 · see citing works

Low concentrations of bisphenol A promote the activation of the mitochondrial apoptotic pathway on Beta‐TC‐6 cells via the generation of intracellular reactive oxygen species and mitochondrial superoxide

Anastasiou, I. A., Eleftheriadou, I., Tentolouris, A., Sarantis, P., Angelopoulou, A., Katsaouni, A., Mourouzis, I. S., Karamouzis, M. V., Gorgoulis, V. G., Pantos, C. I., et al. (2022) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23099 · Cited by 16 · see citing works

Cardiorespiratory fitness is positively associated with increased pancreatic beta cell function independent of fatness in individuals with the metabolic syndrome: Fitness versus fatness

Ramos, J. S., Dalleck, L. C., Borrani, F., Fassett, R. G., & Coombes, J. S. (2016) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2016.04.007 · Cited by 15 · see citing works

Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS‐1 (832/3) cell glucose‐stimulated insulin secretion

Sandhu, H. K., Neuman, J. C., Schaid, M. D., Davis, S. E., Connors, K. M., Challa, R., Guthery, E., Fenske, R. J., Patibandla, C., BREYER, R. M., et al. (2021) · Pharmacology Research & Perspectives · doi:10.1002/prp2.736 · Cited by 14 · see citing works

Systematic investigation into the role of intermittent high glucose in pancreatic beta-cells.

Shao, C., Gu, J., Meng, X., Zheng, H., & Wang, D. (2015) · PubMed Central · Cited by 15 · see citing works

Ferroptosis Signaling in Pancreatic β-Cells: Novel Insights & Therapeutic Targeting

Elumalai, S., Karunakaran, U., Moon, J. S., & Won, K. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213679 · Cited by 16 · see citing works

Pyruvate kinase, muscle isoform 2 promotes proliferation and insulin secretion of pancreatic β-cells via activating Wnt/CTNNB1 signaling.

Wang, S., Yang, Z., Gao, Y., Li, Q., Su, Y., Wang, Y., Zhang, Y., Man, H., & Liu, H. (2015) · PubMed Central · Cited by 12 · see citing works

Quality of life among adult patients living with diabetes in Rwanda: a cross-sectional study in outpatient clinics

Lygidakis, C., Uwizihiwe, J. P., Bia, M., Uwinkindi, F., Kallestrup, P., & Vögele, C. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-043997 · Cited by 12 · see citing works

Dual Opposing Roles of Metallothionein Overexpression in C57BL/6J Mouse Pancreatic β-Cells

Chen, S., Han, J., & Liu, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137583 · Cited by 11 · see citing works

Activation of Insulin Signaling in Adipocytes and Myotubes by Sarcopoterium Spinosum Extract

Ben‐Shachar, M., Rozenberg, K., Skalka, N., Wollman, A., Michlin, M., & Rosenzweig, T. (2019) · Nutrients · doi:10.3390/nu11061396 · Cited by 11 · see citing works

A Combined Analysis of 48 Type 2 Diabetes Genetic Risk Variants Shows No Discriminative Value to Predict Time to First Prescription of a Glucose Lowering Drug in Danish Patients with Screen Detected Type 2 Diabetes

Hornbak, M., Allin, K. H., Jensen, M. L., Lau, C. J., Witte, D. R., Jørgensen, M. E., Sandbæk, A., Lauritzen, T., Andersson, Å., Pedersen, O. B., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104837 · Cited by 9 · see citing works

Linking Diabetic Complications to Sorbitol Oxidation, Oxidative Stress and Metabolic Suppression

Williamson, J. R. (2012) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000219 · Cited by 8 · see citing works

Hypoglycemic drugs induce antioxidant aldehyde dehydrogenase activity and remain high in patients with glycemic control in type 2 diabetes

Picazo, A., Jiménez‐Osorio, A. S., Zúñiga-Mejía, P., Pedraza‐Chaverrí, J., Monroy, A., Rodríguez-Arellano, M. E., & Barrera‐Oviedo, D. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.02.027 · Cited by 8 · see citing works

Angiotensin II-induced JNK activation is mediated by NAD(P)H oxidase in isolated rat pancreatic islets

Alves, E. D. S., Haidar, A. A., Quadros, C. D., Carvalho, D. S., Morgan, D., Rocha, M. D. S., Curi, R., Carpinelli, Â. R., & Hirata, A. E. (2012) · Regulatory Peptides · doi:10.1016/j.regpep.2012.01.003 · Cited by 7 · see citing works

Reactive Oxygen Species and Antioxidants in Pancreatic β-Cell Function – Yin and Yang

Pi, J., Zhang, Q., & Andersen, M. E. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_159 · Cited by 7 · see citing works

Free Radicals and Metabolic Disorders

Cohen, G., Riahi, Y., & Sasson, S. (2012) · Wiley eBooks · doi:10.1002/9781119953678.rad057 · Cited by 7 · see citing works

Preparation of Methylated Products of A‐type Procyanidin Trimers in Cinnamon Bark and Their Protective Effects on Pancreatic β‐Cell

Chen, L., Chen, L., Wang, T., Yuan, P., Chen, K., Jia, Q., Wang, H., & Li, Y. (2016) · Journal of Food Science · doi:10.1111/1750-3841.13294 · Cited by 6 · see citing works

Clinical Determinants of Diabetes Progression in Multiethnic Asians with Type 2 Diabetes – A 3-Year Prospective Cohort Study

Liu, S., Liu, J., Gurung, R. L., Chan, C., Yeo, D., Ang, K., Tang, W. E., Subramaniam, T., Sum, C. F., & Lim, S. C. (2019) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v48n7p217 · Cited by 6 · see citing works

β‐Cell mass and function in human type 2 diabetes

Marchetti, P., & Ferrannini, E. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch24 · Cited by 6 · see citing works

Suppression of free fatty acid receptor 1 expression in pancreatic β-cells in obese type 2 diabetic db/db mice: a potential role of pancreatic and duodenal homeobox factor 1

Kohara, K., Obata, A., Kimura, T., Shimoda, M., Moriuchi, S., Okauchi, S., Hirukawa, H., Mune, T., Kaku, K., & Kaneto, H. (2018) · Endocrine Journal · doi:10.1507/endocrj.ej18-0203 · Cited by 5 · see citing works

Deficiency of voltage-gated proton channel Hv1 attenuates streptozotocin-induced β-cell damage

Wang, X., Wang, X., Qin, J., Lv, J., Wang, Y., Zhang, T., & Li, S. J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.03.092 · Cited by 5 · see citing works

Yiqi Huazhuo decoction increases insulin secretion in type 2 diabetic rats by regulating the pancreatic GPR40-IP3R-1 signaling pathway

Wu, D., Weng, S., Xu, S., Li, Y., & Zhou, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1136778 · Cited by 3 · see citing works

Proposed mechanisms of action participating in the hypoglycemic effect of the traditionally used Croton guatemalensis Lotsy and junceic acid, its main compound

Moreno-Vargas, A. D., Adolfo Andrade-cetto, A., Espinoza-Hernández, F. A., & Mata-Torres, G. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1436927 · Cited by 2 · see citing works

Increased hexosamine biosynthetic pathway flux alters cell–cell adhesion in INS-1E cells and murine islets

Lofrumento, D. D., Miraglia, A., Pesa, V. L., Treglia, A. S., Chieppa, M., Nuccio, F. D., Nicolardi, G., Miele, C., Bèguinot, F., Garbi, C., et al. (2023) · Endocrine · doi:10.1007/s12020-023-03412-9 · Cited by 1 · see citing works

Hv1-deficiency protects β cells from glucotoxicity through regulation of NOX4 level

Wang, X., Gao, Y., Jiang, D., Wang, Y., Du, H., Lv, J., & Li, S. J. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.03.195 · Cited by 1 · see citing works

The effects of cannabinoids on insulin secretion

Anderson, R. L. (2011) · Nottingham ePrints (University of Nottingham)

The Beta Cell in Metabolic Syndrome

Zarrouki, B., Fontès, G., Semache, M., Amyot, J., & Poitout, V. (2013) · Springer eBooks · doi:10.1007/978-3-319-01008-3_5

Dysfunction and Death of Pancreatic Beta Cells in Type 2 Diabetes

Ortega‐Camarillo, C. (2019) · Springer eBooks · doi:10.1007/978-3-030-11815-0_12

Efficacy of short‑term intensive treatment with insulin pump to improve islet β‑cell function in newly diagnosed type 2 diabetes via inhibition of oxidative stress

Liu, H., & Gao, Y. M. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7821

Glucocorticoid Action in the Mediobasal Hypothalamus Regulates Glucose Production In Vivo

Beaulieu-Bayne, E. (2019) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3-eahb-a894

Differences between studying an islet β cell and studying whole pancreatic islets: immunological implications

(2017) · Journal of Clinical & Experimental Immunology · doi:10.33140/jcei/01/02/00002

Beta Cell Death Mechanism in Type 2 Diabetes: An Overview

Siagian, M. A. R., Tazkira, B. Z., & Herawati, L. (2022) · International Journal Of Scientific Advances · doi:10.51542/ijscia.v3i6.7

Dysfunction and Death of Pancreatic Beta-Cells in Type 2 Diabetes

Ortega‐Camarillo, C. (2023) · Springer eBooks · doi:10.1007/978-3-031-25519-9_13

Effects of STZ-Induced Diabetes on Zinc, Boron and Antioxidant Defense Mechanisms in Rats

Miloğlu, F. D., Gündoğdu, G., Bayrak, B., Kadıoğlu, Y., & Yuksel, B. (2025) · Nigerian Journal of Clinical Practice · doi:10.4103/njcp.njcp_566_24

Maternal exposure to ozone during pregnancy and risk of gestational diabetes in a Beijing pregnancy cohort study

Wang, J., Liu, X., Wu, D., Peng, B., Zhang, Y., ZHANG, Y., Wang, Y., Lin, L., & Ma, X. (2026) · BMC Public Health · doi:10.1186/s12889-026-27290-8

Glucolipotoxicity: fuel excess and β-cell dysfunction

Poitout, V., & Robertson, R. P. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0023 · Cited by 1,092 · see citing works

Glucose regulation of islet stress responses and β‐cell failure in type 2 diabetes

Jonas, J., Bensellam, M., Duprez, J., Elouil, H., Guiot, Y., & Pascal, S. M. A. (2009) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2009.01112.x · Cited by 118 · see citing works

β-cell failure as a complication of diabetes

Chang-Chen, K. J., Mullur, R., & Bernal-Mizrachi, E. (2008) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-008-9101-5 · Cited by 225 · see citing works

The mechanisms of glucose toxicity impairing the function of β-cells

Wang, Y. (2008) · International Journal of Internal Medicine

Glucolipotoxicity and beta cells in type 2 diabetes mellitus: Target for durable therapy?

van Raalte, D. H., & Diamant, M. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(11)70012-2 · Cited by 83 · see citing works