Cited by 169Circadian rhythm and melatoninPancreatic function and diabetesDiabetes Treatment and Management

Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats

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Agil, Ahmad, Rosado, Isaac, Ruiz, Rosario, Figueroa, Adriana, Zen, Nourahouda, Fernández‐Vázquez, Gumersindo·2012·Journal of Pineal Research

Abstract

Abstract: The aim of this study was to investigate the effects of melatonin on glucose homeostasis in young male Zucker diabetic fatty (ZDF) rats, an experimental model of metabolic syndrome and type 2 diabetes mellitus (T2DM). ZDF rats (n = 30) and lean littermates (ZL) (n = 30) were used. At 6 wk of age, both lean and fatty animals were subdivided into three groups, each composed of ten rats: naive (N), vehicle treated (V), and melatonin treated (M) (10 mg/kg/day) for 6 wk. Vehicle and melatonin were added to the drinking water. ZDF rats developed DM (fasting hyperglycemia, 460 ± 39.8 mg/dL; HbA 1 c 8.3 ± 0.5%) with both insulin resistance (HOMA‐IR 9.28 ± 0.9 versus 1.2 ± 0.1 in ZL) and decreased β‐cell function (HOMA1‐%B) by 75%, compared with ZL rats. Melatonin reduced fasting hyperglycemia by 18.6% (P < 0.05) and HbA 1 c by 11% (P < 0.05) in ZDF rats. Also, melatonin lowered insulinemia by 15.9% (P < 0.05) and HOMA‐IR by 31% (P < 0.01) and increased HOMA1‐%B by 14.4% (P < 0.05). In addition, melatonin decreased hyperleptinemia by 34% (P < 0.001) and raised hypoadiponectinemia by 40% (P < 0.001) in ZDF rats. Moreover, melatonin reduced serum free fatty acid levels by 13.5% (P < 0.05). These data demonstrate that oral melatonin administration ameliorates glucose homeostasis in young ZDF rats by improving both insulin action and β‐cell function. These observations have implications on melatonin’s possible use as a new pharmacologic therapy for improving glucose homeostasis and of obesity‐related T2DM, in young subjects.

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Crossref · 10.1111/j.1600-079x.2011.00928.x

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  • Although associations of cortisol and melatonin concentrations to insulin action have been reported in the literature, the authors did not find such a link in the present study.

    “Therefore, although associations of cortisol and melatonin concentrations to insulin action have been reported in the literature (29,30), we did not find such a link in the present study.”

    From Diurnal Pattern of Insulin Action in Type 1 Diabetes (2013) · cites this paper as [30]

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  1. Robertson RP. Beta-cell deterioration during diabetes: whatÕs in the gun? Trends Endocrinol Metab 2009; 20:388-393.

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Authors
Agil, A., Rosado, I., Ruiz, R., Figueroa, A., Zen, N., & Fernández‐Vázquez, G.
Affiliations
  • Universidad de Granada (ES)
  • Carlos III Hospital (ES)
Corresponding author
Agil, Ahmad
Venue
Journal of Pineal Research
Publisher
Wiley
Published
2011-08-25
Volume
52
Issue
2
Pages
203-210
ISSN
  • 0742-3098 (ISSN-L)
  • 1600-079X
OpenAlex
W1793372331
Cited by
169
References
71
Citations by year
2026: 3 · 2025: 6 · 2024: 12 · 2023: 5 · 2022: 6 · 2021: 18 · 2020: 11 · 2019: 9 · 2018: 15 · 2017: 12 · 2016: 13 · 2015: 16 · 2014: 21 · 2013: 14 · 2012: 8
FWCI
6.35
Type
journal article
Language
en
Open access
Locations
  • Journal of Pineal Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • European Commission
  • Universidad de Granada
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
melatonin, glucose homeostasis, Zucker diabetic fatty rats, type 2 diabetes, insulin resistance, beta-cell function, hyperleptinemia, adiponectin, free fatty acids, fasting hyperglycemia, metabolic syndrome, obesity, young adults
MeSH terms
Animals, Antioxidants, Diabetes Mellitus, Type 2, Disease Models, Animal, Fatty Acids, Nonesterified, Glucose, Homeostasis, Hyperglycemia, Insulin, Male, Melatonin, Rats, Zucker, Metabolic Syndrome, Rats

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