The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
ATF4-dependent transcription mediates signaling of amino acid limitation
Open accessAbstract
Mammals respond to dietary nutrient fluctuations; for example, deficiency of dietary protein or an imbalance of essential amino acids activates an amino acid response (AAR) signal transduction pathway, consisting of detection of uncharged tRNA by GCN2 kinase, eIF2α phosphorylation, and ATF4 expression. In concert with heterodimerization partners, ATF4 activates specific genes via a C/EBP-ATF response element (CARE). This review outlines the ATF4-dependent transcriptional mechanisms associated with the AAR, focusing on progress during the last five years. Recent evidence suggests that maternal nutrient deprivation not only has immediate metabolic effects on the fetus, but also triggers gene expression changes in adulthood, possibly through epigenetic mechanisms. Therefore, understanding the transcriptional programs initiated by amino acid limitation is critical and timely.
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Cites
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
Vattem, K. M., & Wek, R. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400541101 · Cited by 1,696
Lee, Y.-Y., Cevallos, R. C., & Jan, E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806735200 · Cited by 264
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B’chir, W., Maurin, A.-C., Carraro, V., Averous, J., Jousse, C., Muranishi, Y., Parry, L., Stepien, G., Fafournoux, P., & Bruhat, A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt563 · Cited by 1,162
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Metadata
- Authors
- Kilberg, M. S., Shan, J., & Su, N.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 20
- Issue
- 9
- Pages
- 436-443
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W1980195461
- Cited by
- 591
- References
- 2
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Kilberg, M. S., Shan, J., & Su, N. (2009). ATF4-dependent transcription mediates signaling of amino acid limitation. Trends in Endocrinology & Metabolism. https://doi.org/10.1016/j.tem.2009.05.008
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