Indoleamine 2,3 dioxygenase and metabolic control of immune responses

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

Uyttenhove, C., Pilotte, L., Théate, I., Stroobant, V., Colau, D., Parmentier, N., Boon, T., & Van den Eynde, B. J. (2003) · Nature Medicine · doi:10.1038/nm934 · Cited by 2,305 · see citing works

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Opitz, C. A., Litzenburger, U. M., Sahm, F., Ott, M., Tritschler, I., Trump, S., Schumacher, T., Jestaedt, L., Schrenk, D., Weller, M., et al. (2011) · Nature · doi:10.1038/nature10491 · Cited by 1,898 · see citing works

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

Mezrich, J. D., Fechner, J. H., Zhang, X., Johnson, B. P., Burlingham, W. J., & Bradfield, C. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903670 · Cited by 1,617 · see citing works

Modulation of tryptophan catabolism by regulatory T cells

Fallarino, F., Grohmann, U., Hwang, K. W., Orabona, C., Vacca, C., Bianchi, R., Belladonna, M. L., Fioretti, M. C., Alegre, M., & Puccetti, P. (2003) · Nature Immunology · doi:10.1038/ni1003 · Cited by 1,375 · see citing works

Coping with stress: eIF2 kinases and translational control

Wek, R. C., Jiang, H.-Y., & Anthony, T. G. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340007 · Cited by 1,290 · see citing works

GCN2 Kinase in T Cells Mediates Proliferative Arrest and Anergy Induction in Response to Indoleamine 2,3-Dioxygenase

Munn, D. H., Sharma, M. D., Baban, B., Harding, H. P., Zhang, Y., Ron, D., & Mellor, A. L. (2005) · Immunity · doi:10.1016/j.immuni.2005.03.013 · Cited by 1,275 · see citing works

Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy

Muller, A. J., DuHadaway, J. B., Donover, P. S., Sutanto-Ward, E., & Prendergast, G. C. (2005) · Nature Medicine · doi:10.1038/nm1196 · Cited by 1,064 · see citing works

Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism

Taylor, M. W., & Feng, G. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.11.1907934 · Cited by 1,060 · see citing works

The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells

Fallarino, F., Grohmann, U., You, S., McGrath, B. C., Cavener, D. R., Vacca, C., Orabona, C., Bianchi, R., Belladonna, M. L., Volpi, C., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.6752 · Cited by 1,042 · see citing works

L-arginine availability regulates T-lymphocyte cell-cycle progression.

Rodriguez, P. C., Quiceno, D. G., & Ochoa, A. C. (2007) · Blood · doi:10.1182/blood-2006-06-031856 · Cited by 926 · see citing works

Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes

Munn, D. H., Sharma, M. D., Hou, D., Baban, B., Lee, J. R., Antonia, S. J., Messina, J. L., Chandler, P., Koni, P. A., & Mellor, A. L. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21583 · Cited by 852 · see citing works

Regulation of Immune Responses by mTOR

Powell, J. D., Pollizzi, K. N., Heikamp, E. B., & Horton, M. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075024 · Cited by 836 · see citing works

Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase

Sharma, M. D., Baban, B., Chandler, P., Hou, D., Singh, N., Yagita∥, H., Azuma, M., Blazar, B. R., Mellor, A. L., & Munn, D. H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31911 · Cited by 791 · see citing works

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

Pallotta, M. T., Orabona, C., Volpi, C., Vacca, C., Belladonna, M. L., Bianchi, R., Servillo, G., Brunacci, C., Calvitti, M., Bicciato, S., et al. (2011) · Nature Immunology · doi:10.1038/ni.2077 · Cited by 705 · see citing works

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

Nguyen, N. T., Kimura, A., Nakahama, T., Chinen, I., Masuda, K., Nohara, K., Fujii‐Kuriyama, Y., & Kishimoto, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014465107 · Cited by 685 · see citing works

ATF4-dependent transcription mediates signaling of amino acid limitation

Kilberg, M. S., Shan, J., & Su, N. Y. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.05.008 · Cited by 595 · see citing works

Kynurenine Pathway Metabolites in Humans: Disease and Healthy States

Chen, Y.-Q., & Guillemin, G. (2009) · International Journal of Tryptophan Research · doi:10.4137/ijtr.s2097 · Cited by 589 · see citing works

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

Pilotte, L., Larrieu, P., Stroobant, V., Colau, D., Dolušić, E., Frédérick, R., Plaen, E. D., Uyttenhove, C., Wouters, J., Masereel, B., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113873109 · Cited by 576 · see citing works

Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity

Liu, X., Shin, N., Koblish, H. K., Yang, G., Wang, Q., Wang, K., Leffet, L., Hansbury, M., Thomas, B. A., Rupar, M. J., et al. (2010) · Blood · doi:10.1182/blood-2009-09-246124 · Cited by 549 · see citing works

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

Romani, L., Fallarino, F., De Luca, A., Montagnoli, C., D’Angelo, C., Zelante, T., Vacca, C., Bistoni, F., Fioretti, M. C., Grohmann, U., et al. (2008) · Nature · doi:10.1038/nature06471 · Cited by 535 · see citing works

A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma

Hamid, O., Schmidt, H., Nissan, A., Ridolfi, L., Aamdal, S., Hansson, J., Guida, M., Hyams, D. M., Gómez, H., Bastholt, L., et al. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-204 · Cited by 534 · see citing works

Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of T H 17 to Regulatory T Cells in HIV Disease

Favre, D., Mold, J. E., Hunt, P. W., Kanwar, B., Loke, P., Seu, L., Barbour, J. D., Lowe, M. M., Jayawardene, A., Aweeka, F. T., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000632 · Cited by 526 · see citing works

Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido

Balachandran, V. P., Cavnar, M. J., Zeng, S., Bamboat, Z. M., Ocuin, L. M., Obaid, H., Sorenson, E. C., Popow, R., Ariyan, C. E., Rossi, F., et al. (2011) · Nature Medicine · doi:10.1038/nm.2438 · Cited by 523 · see citing works

Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21

Shields, J. D., Kourtis, I. C., Tomei, A. A., Roberts, J., & Swartz, M. A. (2010) · Science · doi:10.1126/science.1185837 · Cited by 506 · see citing works

Novel Tryptophan Catabolic Enzyme IDO2 Is the Preferred Biochemical Target of the Antitumor Indoleamine 2,3-Dioxygenase Inhibitory Compound d -1-Methyl-Tryptophan

Metz, R. A., DuHadaway, J. B., Kamasani, U. R., Laury‐Kleintop, L. D., Muller, A. J., & Prendergast, G. C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1872 · Cited by 468 · see citing works

The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation

Chen, W., Liang, X., Peterson, A. J., Munn, D. H., & Blazar, B. R. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.8.5396 · Cited by 453 · see citing works

Kynurenine is an endothelium-derived relaxing factor produced during inflammation

Wang, Y., Liu, H., McKenzie, G. A., Witting, P. K., Stasch, J., Hahn, M. G., Changsirivathanathamrong, D., Wu, B. J., Ball, H. J., Thomas, S. R., et al. (2010) · Nature Medicine · doi:10.1038/nm.2092 · Cited by 446 · see citing works

Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice

Ball, H. J., Sánchez-Pérez, Á., Weiser, S., Austin, C., Astelbauer, F., Miu, J., McQuillan, J. A., Stocker, R., Jermiin, L. S., & Hunt, N. H. (2007) · Gene · doi:10.1016/j.gene.2007.04.010 · Cited by 433 · see citing works

Metabolic pathways in T cell fate and function

Gerriets, V. A., & Rathmell, J. C. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.01.010 · Cited by 425 · see citing works

Halofuginone Inhibits T H 17 Cell Differentiation by Activating the Amino Acid Starvation Response

Sundrud, M. S., Koralov, S. B., Feuerer, M., Calado, D. P., Kozhaya, A. E., Rhule-Smith, A., Lefebvre, R. E., Unutmaz, D., Mazitschek, R., Waldner, H., et al. (2009) · Science · doi:10.1126/science.1172638 · Cited by 422 · see citing works

Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes

Sharma, M. D., Hou, D., Liu, Y., Koni, P. A., Metz, R. A., Chandler, P., Mellor, A. L., He, Y., & Munn, D. H. (2009) · Blood · doi:10.1182/blood-2008-12-195354 · Cited by 406 · see citing works

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

Keller, T. L., Zocco, D., Sundrud, M. S., Hendrick, M., Edenius, M., Yum, J., Kim, Y. J., Lee, H., Cortese, J. F., Wirth, D. F., et al. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.790 · Cited by 395 · see citing works

Gut CD103 + dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction

Matteoli, G., Mazzini, E., Iliev, I. D., Mileti, E., Fallarino, F., Puccetti, P., Chieppa, M., & Rescigno, M. (2010) · Gut · doi:10.1136/gut.2009.185108 · Cited by 377 · see citing works

Revving the Engine: Signal Transduction Fuels T Cell Activation

Jones, R. G., & Thompson, C. B. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.008 · Cited by 349 · see citing works

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

Cobbold, S. P., Adams, E., Farquhar, C. A., Nolan, K. F., Howie, D., Lui, K. O., Fairchild, P. J., Mellor, A. L., Ron, D., & Waldmann, H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903919106 · Cited by 336 · see citing works

Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens

Suffia, I., Reckling, S. K., Piccirillo, C. A., Goldszmid, R. S., & Belkaid, Y. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052056 · Cited by 311 · see citing works

Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression.

Kim, H., Chen, L. L., Lim, G., Sung, B., Wang, S.-X., McCabe, M. F., Rusanescu, G., Yang, L.-L., Tian, Y.-H., & Mao, J. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61884 · Cited by 310 · see citing works

Induction of IDO by Bacille Calmette-Guérin Is Responsible for Development of Murine Depressive-Like Behavior

O'Connor, J., Lawson, M., André, C., Briley, E. M., Szegedi, S., Lestage, J., Castanon, N., Herkenham, M., Dantzer, R., & Kelley, K. (2009) · Journal of Immunology · doi:10.4049/jimmunol.0802722 · Cited by 305 · see citing works

IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism

Löb, S., Königsrainer, A., Zieker, D., Brücher, B. L. D. M., Rammensee, H., Opelz, G., & Terness, P. (2008) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-008-0513-6 · Cited by 305 · see citing works

Interferon-γ-Responsive Nonhematopoietic Cells Regulate the Immune Response to Mycobacterium tuberculosis

Desvignes, L., & Ernst, J. (2009) · Immunity · doi:10.1016/j.immuni.2009.10.007 · Cited by 239 · see citing works

Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells

Dejean, A. S., Beisner, D. R., Ch’en, I. L., Kerdiles, Y. M., Babour, A., Arden, K. C., Castrillón, D. H., DePinho, R. A., & Hedrick, S. Μ. (2009) · Nature Immunology · doi:10.1038/ni.1729 · Cited by 235 · see citing works

HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase–dependent mechanism

Manches, O., Munn, D. H., Fallahi, A., Lifson, J. D., Chaperot, L., Plumas, J., & Bhardwaj, N. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34823 · Cited by 228 · see citing works

SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis

Orabona, C., Pallotta, M. T., Volpi, C., Fallarino, F., Vacca, C., Bianchi, R., Belladonna, M. L., Fioretti, M. C., Grohmann, U., & Puccetti, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810278105 · Cited by 205 · see citing works

Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase

Ravishankar, B., Liu, H., Shinde, R. S., Chandler, P., Baban, B., Tanaka, M., Munn, D. H., Mellor, A. L., Karlsson, M. C. I., & McGaha, T. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117736109 · Cited by 199 · see citing works

CD40Ig treatment results in allograft acceptance mediated by CD8+CD45RClow T cells, IFN-γ, and indoleamine 2,3-dioxygenase

Guillonneau, C., Hill, M., Hubert, F., Chiffoleau, E., Hervé, C., Li, X., Heslan, M., Usal, C., Tesson, L., Ménoret, S., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28801 · Cited by 192 · see citing works

Toward the identification of a tolerogenic signature in IDO-competent dendritic cells

Orabona, C., Puccetti, P., Vacca, C., Bicciato, S., Luchini, A., Fallarino, F., Bianchi, R., Velardi, E., Perruccio, K., Velardi, A., et al. (2005) · Blood · doi:10.1182/blood-2005-10-4077 · Cited by 186 · see citing works

Studying the immunosuppressive role of indoleamine 2,3-dioxygenase: tryptophan metabolites suppress rat allogeneic T-cell responses in vitro and in vivo

Bauer, T. M., Jiga, L. P., Chuang, J.-J., Randazzo, M., Opelz, G., & Terness, P. (2004) · Transplant International · doi:10.1111/j.1432-2277.2004.00031.x · Cited by 181 · see citing works

External influences on the immune system via activation of the aryl hydrocarbon receptor

Stockinger, B., Hirota, K., Duarte, J. H., & Veldhoen, M. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.01.008 · Cited by 178 · see citing works

Reprogrammed Foxp3+ Regulatory T Cells Provide Essential Help to Support Cross-presentation and CD8+ T Cell Priming in Naive Mice

Sharma, M. D., Hou, D., Baban, B., Koni, P. A., He, Y., Chandler, P., Blazar, B. R., Mellor, A. L., & Munn, D. H. (2010) · Immunity · doi:10.1016/j.immuni.2010.11.022 · Cited by 174 · see citing works

Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells

Boasso, A., Herbeuval, J., Hardy, A. W., Winkler, C., & Shearer, G. M. (2004) · Blood · doi:10.1182/blood-2004-06-2089 · Cited by 171 · see citing works

Inducing CTLA-4–Dependent Immune Regulation by Selective CD28 Blockade Promotes Regulatory T Cells in Organ Transplantation

Poirier, N., Azimzadeh, A. M., Zhang, T., Dilek, N., Mary, C., Nguyen, B., Tillou, X., Wu, G., Reneaudin, K., Hervouet, J., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000116 · Cited by 169 · see citing works

Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality

Jasperson, L. K., Bucher, C. M., Panoskaltsis‐Mortari, A., Taylor, P. A., Mellor, A. L., Munn, D. H., & Blazar, B. R. (2007) · Blood · doi:10.1182/blood-2007-06-096081 · Cited by 145 · see citing works

Blocking IDO activity to enhance anti-tumor immunity

Munn, D. H. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e414 · Cited by 136 · see citing works

CDllc+ cells modulate pulmonary immune responses by production of indoleamine 2,3-dioxygenase.

Swanson, K., Zheng, Y., Heidler, K., Mizobuchi, T., & Wilkes, D. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0268oc · Cited by 129 · see citing works

Mechanism and Localization of CD8 Regulatory T Cells in a Heart Transplant Model of Tolerance

Li, X. L., Ménoret, S., Bézie, S., Caron, L., Chabannes, D., Hill, M., Halary, F. A., Angin, M., Heslan, M., Usal, C., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000120 · Cited by 120 · see citing works

Blockade of Indoleamine 2,3-Dioxygenase Protects Mice against Lipopolysaccharide-Induced Endotoxin Shock

Jung, I. D., Lee, M. G., Chang, J. H., Lee, J. S., Jeong, Y.-I., Lee, C. M., Park, W. S., Han, J., Seo, S., Lee, S. Y., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803104 · Cited by 117 · see citing works

IL-17 and Therapeutic Kynurenines in Pathogenic Inflammation to Fungi

Romani, L. R., Zelante, T., LUCA, A. D., Fallarino, F., & Puccetti, P. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5157 · Cited by 117 · see citing works

Blocking IDO activity to enhance anti-tumor immunity

David, H. M. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/414 · Cited by 114 · see citing works

Opposing Biological Functions of Tryptophan Catabolizing Enzymes During Intracellular Infection

Divanovic, S., Sawtell, N. M., Trompette, A., Warning, J. I., Dias, A., Cooper, A. M., Yap, G. S., Arditi, M., Shimada, K., DuHadaway, J. B., et al. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir621 · Cited by 113 · see citing works

Influenza‐Induced Expression of Indoleamine 2,3‐Dioxygenase Enhances Interleukin‐10 Production and Bacterial Outgrowth during Secondary Pneumococcal Pneumonia

van der Sluijs, K. F., Nijhuis, M., Levels, J. H. M., Florquin, S., Mellor, A. L., Jansen, H. M., der Poll, T. V., & Lutter, R. (2006) · The Journal of Infectious Diseases · doi:10.1086/498911 · Cited by 111 · see citing works

Reduced Cytotoxic Function of Effector CD8+ T Cells Is Responsible for Indoleamine 2,3-Dioxygenase-Dependent Immune Suppression

Liu, H., Liu, L., Liu, K., Bizargity, P., Hancock, W. W., & Visner, G. A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900408 · Cited by 94 · see citing works

Toxicology and pharmacokinetics of 1-methyl-d-tryptophan: Absence of toxicity due to saturating absorption

Jia, L., Schweikart, K. M., Tomaszewski, J. E., Page, J. G., Noker, P. E., Buhrow, S. A., Reid, J. M., Ames, M. M., & Munn, D. H. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.07.017 · Cited by 93 · see citing works

The roles of mast cells in anticancer immunity

Dalton, D. K., & Noelle, R. J. (2012) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-012-1246-0 · Cited by 93 · see citing works

Severe Tryptophan Starvation Blocks Onset of Conventional Persistence and Reduces Reactivation of Chlamydia trachomatis

Leonhardt, R. M., Lee, S., Kavathas, P., & Cresswell, P. (2007) · Infection and Immunity · doi:10.1128/iai.00668-07 · Cited by 92 · see citing works

Cell‐autonomous control of interferon type I expression by indoleamine 2,3‐dioxygenase in regulatory CD19+ dendritic cells

Manlapat, A., Kahler, D. J., Chandler, P., Munn, D. H., & Mellor, A. L. (2007) · European Journal of Immunology · doi:10.1002/eji.200636690 · Cited by 91 · see citing works

3-Hydroxykynurenine Suppresses CD4 + T-Cell Proliferation, Induces T-Regulatory-Cell Development, and Prolongs Corneal Allograft Survival

Zaher, S. S., Germain, C., Fu, H., Larkin, F., & George, A. J. T. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5793 · Cited by 86 · see citing works

Leishmania major Attenuates Host Immunity by Stimulating Local Indoleamine 2,3-Dioxygenase Expression

Makala, L., Baban, B., Lemos, H. D. P., El‐Awady, A., Chandler, P., Hou, D., Munn, D. H., & Mellor, A. L. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiq095 · Cited by 82 · see citing works

Orally Administered Eicosapentaenoic Acid Induces Rapid Regression of Atherosclerosis Via Modulating the Phenotype of Dendritic Cells in LDL Receptor-Deficient Mice

Nakajima, K., Yamashita, T., Kita, T., Takeda, M., Sasaki, N., Kasahara, K., Shinohara, M., Rikitake, Y., Ishida, T., Yokoyama, M., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.229443 · Cited by 81 · see citing works

Activation of indoleamine 2,3-dioxygenase-induced tryptophan degradation in advanced atherosclerotic plaques: Tampere Vascular Study

Niinisalo, P., Oksala, N., Levula, M., Pelto‐Huikko, M., Järvinen, O., Salenius, J., Kytömäki, L., Soini, J. T., Kähönen, M. A. P., Laaksonen, R., et al. (2009) · Annals of Medicine · doi:10.3109/07853890903321559 · Cited by 80 · see citing works

Human CD 1c ( BDCA ‐1)+ myeloid dendritic cells secrete IL ‐10 and display an immuno‐regulatory phenotype and function in response to E scherichia coli

Kassianos, A. J., Hardy, M. Y., Ju, X., Vijayan, D., Ding, Y., Vulink, A. J. E., McDonald, K. J., Jongbloed, S. L., Wadley, R. B., Wells, C. A., et al. (2012) · European Journal of Immunology · doi:10.1002/eji.201142098 · Cited by 79 · see citing works

IDO and Regulatory T Cell Support Are Critical for Cytotoxic T Lymphocyte-Associated Ag-4 Ig-Mediated Long-Term Solid Organ Allograft Survival

Sucher, R., Fischler, K., Oberhuber, R., Kronberger, I. E., Margreiter, C., Öllinger, R., Schneeberger, S., Fuchs, D., Werner, E. R., Watschinger, K., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002777 · Cited by 79 · see citing works

The Absence of IDO Upregulates Type I IFN Production, Resulting in Suppression of Viral Replication in the Retrovirus-Infected Mouse

Hoshi, M., Saito, K., Hara, A., Taguchi, A., Ohtaki, H., Tanaka, R., Fujigaki, H., Osawa, Y., Takemura, M., Matsunami, H., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901150 · Cited by 78 · see citing works

Sleeping Beauty‐based gene therapy with indoleamine 2,3‐dioxygenase inhibits lung allograft fibrosis

Liu, H., Liu, L., Fletcher, B. S., & Visner, G. A. (2006) · The FASEB Journal · doi:10.1096/fj.06-6228fje · Cited by 78 · see citing works

Inflammatory stimuli reduce survival of serotonergic neurons and induce neuronal expression of indoleamine 2,3-dioxygenase in rat dorsal raphe nucleus organotypic brain slices

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