The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Metabolic reprogramming, caloric restriction and aging
Open accessAbstract
Caloric restriction (CR) without malnutrition slows the aging process and extends lifespan in diverse species by unknown mechanisms. The inverse linear relationship between calorie intake and lifespan suggests that regulators of energy metabolism are important in CR’s actions. Studies in several species reveal tissue-specific changes in energy metabolism with CR and suggest that metabolic reprogramming plays a critical role in its mechanism of aging retardation. We herein describe common signatures of CR and suggest how they may slow aging. We discuss recent advances in understanding the function of key metabolic regulators that likely coordinate the response to altered nutrient availability with CR, and how the pathways they regulate may retard the aging process.
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Cites
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Cited by
AMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network
Salminen, A., & Kaarniranta, K. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.005 · Cited by 860
Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
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Short-term calorie restriction enhances skeletal muscle stem cell function
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T Cell Replicative Senescence in Human Aging
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Metadata
- Authors
- Anderson, R. M., & Weindruch, R.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 21
- Issue
- 3
- Pages
- 134-141
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W2128329787
- Cited by
- 301
- References
- 72
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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