The DOI matches its Crossref record; 73 of the 74 references it cites were found in a registry or an index.
Energy balance and puberty onset: emerging role of central mTOR signaling
Abstract
The onset of puberty is gated by body energy reserves and nutritional cues. The adipose hormone leptin is an essential signal for the metabolic control of puberty, through mechanisms that are yet to be fully characterized. Mammalian target of rapamycin (mTOR), an energetic cell sensor, operates at specific hypothalamic nuclei as a transducer for leptin effects on feeding and energy homeostasis. This review summarizes recent experimental evidence supporting a role for central mTOR signaling in puberty onset. These findings are discussed in the context of topical developments in the field, such as recognition of the roles of the cAMP responsive element-binding protein regulated transcription coactivator-1 (Crtc1) and kisspeptins in the metabolic control of reproduction, thus highlighting novel mechanisms responsible for coupling puberty and energy homeostasis.
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“In mammals, GnRH release is also regulated by the orexigenic neuropeptide Y (NPY) and kisspeptin, which relays both sex steroid and leptin signaling to GnRH neurons (49).”
From Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in Platynereis (2020) · cites this paper as [49]
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Cites
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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
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Franz, D. N., Belousova, E., Sparagana, S., Bebin, E. M., Frost, M., Kuperman, R., Witt, O., Kohrman, M. H., Flamini, J. R., Wu, J. Y., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(12)61134-9 · Cited by 794
Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms
Pinilla, L., Aguilar, E., Diéguez, C., Millar, R. P., & Tena‐Sempere, M. (2012) · Physiological Reviews · doi:10.1152/physrev.00037.2010 · Cited by 843
“[Adapted from Roa and Tena-Sempere (377).]”
BackgroundMethodInfluentialD’Occhio, M. J., Baruselli, P. S., & Campanile, G. (2018) · Theriogenology · doi:10.1016/j.theriogenology.2018.11.010 · Cited by 263
Metabolic control of puberty: Roles of leptin and kisspeptins
Sanchez-Garrido, M. A., & Tena‐Sempere, M. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.01.014 · Cited by 250
Evolution of Leptin Structure and Function
Denver, R. J., Bonett, R. M., & Boorse, G. C. (2011) · Neuroendocrinology · doi:10.1159/000328435 · Cited by 245
“Leptin is permissive for the onset of puberty in mammals, perhaps acting via the cellular energy sensor mammalian target of rapamycin (mTOR) [”
Background
Metadata
- Authors
- Roa, J., & Tena-Sempere, M.
- Affiliations
- University of Córdoba (ES)
- ORCID
- Roa, Juan
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 21
- Issue
- 9
- Pages
- 519-528
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W2134113504
- Cited by
- 106
- References
- 74
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 10 · 2020: 9 · 2019: 9 · 2018: 14 · 2017: 4 · 2016: 9 · 2015: 9 · 2014: 4 · 2013: 5 · 2012: 13
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- puberty onset, mTOR signaling, leptin, hypothalamus, energy homeostasis, CRTC1, kisspeptin, energy balance, reproductive development
- MeSH terms
- Animals, Energy Metabolism, Humans, Puberty, Signal Transduction, Leptin, TOR Serine-Threonine Kinases
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