Cited by 106Hypothalamic control of reproductive hormonesRegulation of Appetite and ObesityReproductive Biology and Fertility

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Energy balance and puberty onset: emerging role of central mTOR signaling

Roa, Juan, Tena-Sempere, Manuel·2010·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2010.05.003

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Abstract

The onset of puberty is gated by body energy reserves and nutritional cues. The adipose hormone leptin is an essential signal for the metabolic control of puberty, through mechanisms that are yet to be fully characterized. Mammalian target of rapamycin (mTOR), an energetic cell sensor, operates at specific hypothalamic nuclei as a transducer for leptin effects on feeding and energy homeostasis. This review summarizes recent experimental evidence supporting a role for central mTOR signaling in puberty onset. These findings are discussed in the context of topical developments in the field, such as recognition of the roles of the cAMP responsive element-binding protein regulated transcription coactivator-1 (Crtc1) and kisspeptins in the metabolic control of reproduction, thus highlighting novel mechanisms responsible for coupling puberty and energy homeostasis.

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Authors: Roa, J., & Tena-Sempere, M.
Affiliations: University of Córdoba (ES)
ORCID: Roa, Juan
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2010-09
Volume: 21
Issue: 9
Pages: 519-528
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2010.05.003
OpenAlex: W2134113504
Cited by: 106
References: 74
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 10 · 2020: 9 · 2019: 9 · 2018: 14 · 2017: 4 · 2016: 9 · 2015: 9 · 2014: 4 · 2013: 5 · 2012: 13
FWCI: 1.22
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords: puberty onset, mTOR signaling, leptin, hypothalamus, energy homeostasis, CRTC1, kisspeptin, energy balance, reproductive development
MeSH terms: Animals, Energy Metabolism, Humans, Puberty, Signal Transduction, Leptin, TOR Serine-Threonine Kinases

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Energy balance and puberty onset: emerging role of central mTOR signaling

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