Connecting metabolism and reproduction: roles of central energy sensors and key molecular mediators

Roa, Juan; Tena-Sempere, Manuel

doi:10.1016/j.mce.2014.09.027

Cited by 136Hypothalamic control of reproductive hormonesRegulation of Appetite and ObesityReproductive Biology and Fertility

Connecting metabolism and reproduction: roles of central energy sensors and key molecular mediators

Roa, Juan, Tena-Sempere, Manuel·2014·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2014.09.027

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Abstract

It is well established that pubertal activation of the reproductive axis and maintenance of fertility are critically dependent on the magnitude of body energy reserves and the metabolic state of the organism. Hence, conditions of impaired energy homeostasis often result in deregulation of puberty and reproduction, whereas gonadal dysfunction can be associated with the worsening of the metabolic profile and, eventually, changes in body weight. While much progress has taken place in our knowledge about the neuroendocrine mechanisms linking metabolism and reproduction, our understanding of how such dynamic interplay happens is still incomplete. As paradigmatic example, much has been learned in the last two decades on the reproductive roles of key metabolic hormones (such as leptin, insulin and ghrelin), their brain targets and the major transmitters and neuropeptides involved. Yet, the molecular mechanisms whereby metabolic information is translated and engages into the reproductive circuits remain largely unsolved. In this work, we will summarize recent developments in the characterization of the putative central roles of key cellular energy sensors, such as mTOR, in this phenomenon, and will relate these with other molecular mechanisms likely contributing to the brain coupling of energy balance and fertility. In doing so, we aim to provide an updated view of an area that, despite still underdeveloped, may be critically important to fully understand how reproduction and metabolism are tightly connected in health and disease.

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The precise site of action of insulin at the hypothalamic level in vivo remains in question.
“However, the precise site of action of insulin at the hypothalamic level in vivo remains in question.107”
From Pubertal development and regulation (2016) · cites this paper as [107]

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Authors: Roa, J., & Tena-Sempere, M.
Affiliations: Instituto de Salud Carlos III (ES)
ORCID: Roa, Juan
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2014-11
Volume: 397
Issue: 1-2
Pages: 4-14
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2014.09.027
OpenAlex: W2043547122
Cited by: 136
References: 127
Citations by year: 2026: 3 · 2025: 10 · 2024: 8 · 2023: 7 · 2022: 11 · 2021: 11 · 2020: 13 · 2019: 9 · 2018: 11 · 2017: 18 · 2016: 22 · 2015: 13
FWCI: 2.78
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Ministerio de Economía and Competitividad, Spain (BFU 2008-00984, BFU2011-25021)
Junta de Andalucía, Spain (P08-CVI-03788, P12-FQM-01943)
Instituto de Salud Carlos III (RCMN C03/08, PI042082)
EU (DEER FP7-ENV-2007-1)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords: energy homeostasis, puberty, fertility, mTOR, leptin, insulin, ghrelin, neuropeptides, gonadal dysfunction, body weight, neuroendocrine regulation of reproduction
MeSH terms: Animals, Energy Metabolism, Fertility, Homeostasis, Humans, Neuropeptides, Reproduction, Sexual Maturation, Transcription Factors, STAT3 Transcription Factor, AMP-Activated Protein Kinases, Phosphatidylinositol 3-Kinase, TOR Serine-Threonine Kinases, Kisspeptins

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Connecting metabolism and reproduction: roles of central energy sensors and key molecular mediators

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