The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Role of intramyocelluar lipids in human health
Open accessAbstract
Intramyocellular lipid (IMCL) is predominantly stored as intramuscular triglyceride (IMTG) in lipid droplets and is utilized as metabolic fuel during physical exercise. IMTG is also implicated in muscle insulin resistance (IR) in type 2 diabetes. However, it has become apparent that lipid moieties such as ceramide and diacylglycerol are the likely culprits of IR. This article reviews current knowledge of IMCL-mediated IR and important areas of investigation, including myocellular lipid transport and lipid droplet proteins. Several crucial questions remain unanswered, such as the identity of specific ceramide and diacylglycerol species that mediate IR in human muscle and their subcellular location. Quantitative lipidomics and proteomics of targeted subcellular organelles will help to better define the mechanisms underlying pathological IMCL accumulation and IR.
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“Improvements in insulin sensitivity with exercise are induced by a myriad of alterations (34–37), while our data suggest that improvements in cellular redox status play a prominent role.”
From Defects in mitochondrial efficiency and H2O2 emissions in obese women are restored to a lean phenotype with aerobic exercise training (2015) · cites this paper as [36]
In the citing paper
“Enhanced mitochondrial content and function can sustain greater energetic flux and oxidation of substrates, decreasing the accumulation of lipotoxic intermediates that promote inflammation and oxidative stress [382].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [382]
In the citing paper
“The link between IMCL and insulin resistance was confirmed in biopsies from individuals with obesity and T2DM (Goodpaster et al, 2000; Coen & Goodpaster, 2012).”
From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Coen & Goodpaster, 2012
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Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321
Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
Zimmermann, R., Bogner‐Strauß, J. G., Haemmerle, G., Schoiswohl, G., Birner‐Gruenberger, R., Riederer, M., Lass, A., Neuberger, G., Eisenhaber, F., Hermetter, A., et al. (2004) · Science · doi:10.1126/science.1100747 · Cited by 2,121
Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990
The Mitochondrial Carnitine Palmitoyltransferase System — From Concept to Molecular Analysis
McGarry, J. D., & Brown, N. F. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00001.x · Cited by 1,616 · cited 1×
“If destined for oxidation, the fatty acyl CoA is then transported into mitochondria via the action of carnitine palmitoyl transferase I (CPTI), which is expressed on the outer mitochondrial membrane [6].”
BackgroundYu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561
Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390
Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253
Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.002 · Cited by 1,232
Goodpaster, B. H. (2001) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.12.5755 · Cited by 1,194
Self-citationFAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling
Zechner, R., Zimmermann, R., Eichmann, T. O., Kohlwein, S. D., Haemmerle, G., Lass, A., & Madeo, F. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.018 · Cited by 1,169
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Research works printed but not linked: 3
- Himwich, 1927, The respiratory quotient of exercising muscle, Am. J. Physiol., 81, 485
- Stratford, 2004, Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B, J. Biol. Chem., 279, 36608, 10.1074/jbc.M406499200 · DOI · Paper page
- Novgorodov, 2011, Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA, J. Biol. Chem., 286, 25352, 10.1074/jbc.M110.214866 · DOI
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Sorted by citations
Items 201–220 of 220
Tilves, C., Zmuda, J. M., Kuipers, A. L., Nair, S., Carr, J., Terry, J., Peddada, S., Wheeler, V. W., & Miljkovic, I. (2021) · Obesity Science & Practice · doi:10.1002/osp4.529 · Cited by 2
“While individuals with obesity and type 2 diabetes have more low‐attenuation muscle area,(48) the mechanistic relationship between intramuscular lipids and insulin resistance is still not well understood, with increased intramyocellular lipids possibly representing increased fuel storage or reflecting accumulation of…”
BackgroundOsteosarcopenia as a Lipotoxic Disease
Saedi, A. A., Goodman, C. A., Myers, D. E., Hayes, A., & Duque, G. (2019) · Springer eBooks · doi:10.1007/978-3-030-25890-0_6 · Cited by 4
MRS Studies of Muscle and Heart in Obesity and Diabetes
Prompers, J. J., & Nicolay, K. (2016) · Wiley eBooks · doi:10.1002/9780470034590.emrstm1462 · Cited by 4
Terada, T. (2014) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r30m4k
Myosteatosis and Dyslipidemia: Linking Muscle Quality to Cardiometabolic Risk
Moon, J. Y., & Jung, C.-H. (2026) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2026.15.3.445 · Cited by 1
Katsanos, C. S., Tran, L., Hoffman, N., Roust, L., Filippis, E. D., Mandarino, L. J., Johnsson, K. A., Belohlavek, M., & Buras, M. R. (2024) · bioRxiv · doi:10.1101/2024.06.11.598550 · Cited by 1
“Humans with obesity and insulin resistance display accumulation of lipids in skeletal muscle (1,2,3).”
Li, Y.-Y. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.153776 · Cited by 1
Regulation of intracellular lipid storage and utilization
Zembroski, A. S., & Buhman, K. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819404-1.00008-7 · Cited by 2
Frontiers in Skeletal Muscle Wasting, Regeneration and Stem Cells
Pinheiro, C. H. D. J., & Guimarães-Ferreira, L. (2016) · Frontiers research topics · doi:10.3389/978-2-88919-832-0 · Cited by 1
“In skeletal muscle, lipotoxic species interfere with insulin signaling and are thought to be partly responsible for insulin resistance in obesity (reviewed in Timmers et al., 2008; Bosma et al., 2012; Coen and Goodpaster, 2012).”
BackgroundLiu, T., Chen, N.-X., Du, R., Zhu, M.-Y., Cao, J., Zhu, Q., Xu, X.-L., Li, Y.-J., Jin, X.-H., Weng, Y.-R., et al. (2026) · Endocrine · doi:10.1007/s12020-026-04815-0
“…circulating tri-glycerides, ectopic lipid deposition, and insulin-resistant states can induce lipotoxic stress, chronic low-grade inflam - mation, and disruptions of anabolic-catabolic homeostasis within skeletal muscle, thereby contributing to accelerated and disproportionate muscle loss [7–9].”
Abdelmonaem, M., Ugwoke, C. K., Alibegović, A., Cvetko, E., Umek, N., Grdadolnik, J., & Zupančič, B. (2026) · Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2026.128893
Muscle in fat trouble: The rise of IMAT in metabolic and musculoskeletal disease
Weik, V., Birkenfeld, A. L., Peter, A., Weigert, C., & Dreher, S. I. (2026) · Molecular Metabolism · doi:10.1016/j.molmet.2026.102424 · Cited by 1
“This finding suggests that IMCL is not only possibly involved in insulin resistance or type 2 diabetes but acts as an essential fuel depot for the oxidative metabolism of muscle [11,13,14].”
Liu, Y., Tian, D.-J., Guo, Y.-P., Wang, W., Li, H., Xu, J.-X., Zhao, D.-D., & Wan, B. (2026) · Scientific Reports · doi:10.1038/s41598-026-37567-y
“In addition to exacerbating inflammation and cartilage damage, muscle fat infiltration induces metabolic changes, including increased nitric oxide production and insulin resistance 47 .”
Pasanta, D., Tungjai, M., & Kothan, S. (2018) · Polish Journal of Radiology · doi:10.5114/pjr.2018.81147
“Recently, evidence has suggested that IMCL are positively correlated with insulin resistance in type 2 diabetes [2-4], and they are also an important energy supply [5,6].”
BackgroundInsulin-like Growth Factor-I Regulates the FAT/CD36 Expression in C2C12 Skeletal Muscle Cells
Kim, H. J., Yoon, H. M., Kim, T. Y., & Lee, W. J. (2016) · Journal of Life Science · doi:10.5352/jls.2016.26.7.758
“는 운동 중 중요한 대사적 연료로 사용되지만[11], 산화율이 저장량에 미치지 못할 경우 중성지방과 지방산 대사 물질 축 적을 야기하여 비만이나 인슐린 저항성 증가의 원인이 된다”
Stanhope, K. L. (2015) · Wiley eBooks · doi:10.1002/9781119121725.ch5 · Cited by 1
All organ exercise for metabolic health
Boström, P. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.03.011
Myocellular lipid droplets and insulin sensitivity
Gemmink (2017) · Research Publications (Maastricht University) · doi:10.26481/dis.20170524ag
“8 The prevalence of type 2 diabetes is increasing worldwide [1].”
BackgroundInfluential
Metadata
- Authors
- Coen, P. M., & Goodpaster, B. H.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Goodpaster, Bret H.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 23
- Issue
- 8
- Pages
- 391-398
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC4908975
- OpenAlex
- W2017044391
- Cited by
- 252
- References
- 100
- Citations by year
- 2026: 17 · 2025: 13 · 2024: 11 · 2023: 13 · 2022: 16 · 2021: 13 · 2020: 14 · 2019: 18 · 2018: 23 · 2017: 18 · 2016: 24 · 2015: 25 · 2014: 23 · 2013: 24
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG021961, P30AG024827)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- intramyocellular lipid, intramuscular triglycerides, lipid droplets, muscle insulin resistance, type 2 diabetes, ceramide, diacylglycerol, lipid droplet proteins, lipidomics, proteomics
- MeSH terms
- Animals, Biological Transport, Ceramides, Diabetes Mellitus, Type 2, Diglycerides, Energy Metabolism, Fatty Acids, Humans, Insulin Resistance, Lipids, Mitochondria, Muscle, Triglycerides, Organelles, Exercise, Muscle, Skeletal, Muscle Cells, Lipid Metabolism
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