Cited by 252Lipid metabolism and biosynthesisMetabolism, Diabetes, and CancerAdipose Tissue and Metabolism

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Role of intramyocelluar lipids in human health

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Coen, Paul M., Goodpaster, Bret H.·2012·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2012.05.009PMC PMC4908975

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Abstract

Intramyocellular lipid (IMCL) is predominantly stored as intramuscular triglyceride (IMTG) in lipid droplets and is utilized as metabolic fuel during physical exercise. IMTG is also implicated in muscle insulin resistance (IR) in type 2 diabetes. However, it has become apparent that lipid moieties such as ceramide and diacylglycerol are the likely culprits of IR. This article reviews current knowledge of IMCL-mediated IR and important areas of investigation, including myocellular lipid transport and lipid droplet proteins. Several crucial questions remain unanswered, such as the identity of specific ceramide and diacylglycerol species that mediate IR in human muscle and their subcellular location. Quantitative lipidomics and proteomics of targeted subcellular organelles will help to better define the mechanisms underlying pathological IMCL accumulation and IR.

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Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321
Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
Zimmermann, R., Bogner‐Strauß, J. G., Haemmerle, G., Schoiswohl, G., Birner‐Gruenberger, R., Riederer, M., Lass, A., Neuberger, G., Eisenhaber, F., Hermetter, A., et al. (2004) · Science · doi:10.1126/science.1100747 · Cited by 2,121
Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance
Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990
The Mitochondrial Carnitine Palmitoyltransferase System — From Concept to Molecular Analysis
McGarry, J. D., & Brown, N. F. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00001.x · Cited by 1,616 · cited 1×
“If destined for oxidation, the fatty acyl CoA is then transported into mitochondria via the action of carnitine palmitoyl transferase I (CPTI), which is expressed on the outer mitochondrial membrane [6].”
Background
Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle
Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561
Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α
Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.002 · Cited by 1,232
Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes
Goodpaster, B. H. (2001) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.12.5755 · Cited by 1,194
Self-citation
FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling
Zechner, R., Zimmermann, R., Eichmann, T. O., Kohlwein, S. D., Haemmerle, G., Lass, A., & Madeo, F. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.018 · Cited by 1,169
Regional adiposity and morbidity.
Kissebah, A. H., & Krakower, G. R. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.4.761 · Cited by 1,132
The biogenesis and functions of lipid bodies in animals, plants and microorganisms
Murphy, D. J. (2001) · Progress in Lipid Research · doi:10.1016/s0163-7827(01)00013-3 · Cited by 966
Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species
García‐Ruiz, C., Colell, A., Marı́, M., Morales, A., & Fernández-Checa, J. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.17.11369 · Cited by 808
Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease
Glatz, J. F. C., Luiken, J. J. F. P., & Bonen, A. (2010) · Physiological Reviews · doi:10.1152/physrev.00003.2009 · Cited by 776
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
Haemmerle, G., Moustafa, T., Wölkart, G., Büttner, S., Schmidt, A. G., van de Weijer, T., Hesselink, M. K. C., Jaeger, D., Kienesberger, P. C., Zierler, K. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2439 · Cited by 767
The Perfect Storm: Obesity, Adipocyte Dysfunction, and Metabolic Consequences
de Ferranti, S. D., & Mozaffarian, D. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.100156 · Cited by 755
Ceramide in the eukaryotic stress response
Hannun, Y. A., & Luberto, C. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01694-3 · Cited by 727
Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans
Adams, J. M., Pratipanawatr, T., Berria, R., Wang, E. L., DeFronzo, R. A., Sullards, M. C., & Mandarino, L. J. (2004) · Diabetes · doi:10.2337/diabetes.53.1.25 · Cited by 677
PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores
Bickel, P. E., Tansey, J. T., & Welte, M. A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.04.002 · Cited by 671
Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects.
Jacob, S., Machann, J., Rett, K., Brechtel, K., Volk, A., Renn, W., Maerker, E., Matthaei, S., Schick, F., Claussen, C. D., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.5.1113 · Cited by 643
A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids
Chavez, J. A., Knotts, T. A., Wang, L.-P., Li, G., Dobrowsky, R. T., Florant, G. L., & Summers, S. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212307200 · Cited by 617
Many Ceramides
Hannun, Y. A., & Obeid, L. M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.254359 · Cited by 544
Intramuscular lipid content is increased in obesity and decreased by weight loss
Goodpaster, B. H., Theriault, R., Watkins, S. C., & Kelley, D. E. (2000) · Metabolism · doi:10.1016/s0026-0495(00)80010-4 · Cited by 526 · cited 13×
“Muscle DAG content is elevated in obese and T2D subjects [63] and is increased following acute IR induced by lipid infusion [56].”
BackgroundInfluentialSelf-citation
The G0/G1 Switch Gene 2 Regulates Adipose Lipolysis through Association with Adipose Triglyceride Lipase
Yang, X., Lü, X., Lombès, M., Rha, G. B., Chi, Y., Guerin, T. M., Smart, E. J., & Liu, J. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.003 · Cited by 490
Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women
Talanian, J. L., Galloway, S. D. R., Heigenhauser, G. J. F., Bonen, A., & Spriet, L. L. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01098.2006 · Cited by 460
The Relative Value of Fat and Carbohydrate as Sources of Muscular Energy
Krogh, A., & Lindhard, J. (1920) · Biochemical Journal · doi:10.1042/bj0140290 · Cited by 411
Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
Bonen, A., Parolin, M. L., Steinberg, G. R., Calles‐Escandon, J., Tandon, N. N., Glatz, J. F. C., Luiken, J. J. F. P., Heigenhauser, G. J. F., & Dyck, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1065fje · Cited by 410
Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid–induced insulin resistance
Schenk, S., & Horowitz, J. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30566 · Cited by 407
Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance
Amati, F., Dubé, J. J., Alvarez-Carnero, E., Edreira, M. M., Chomentowski, P., Coen, P. M., Switzer, G. E., Bickel, P. E., Stefanovic-Racic, M., Toledo, F. G. S., et al. (2011) · Diabetes · doi:10.2337/db10-1221 · Cited by 395
Self-citation
Proposed mechanisms for the induction of insulin resistance by oxidative stress
Bloch-Damti, A., & Bashan, N. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.1553 · Cited by 388
Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance
Kabayama, K., Sato, T., Saito, K., Loberto, N., Prinetti, A., Sonnino, S., Kinjo, M., Igarashi, Y., & Inokuchi, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703650104 · Cited by 388
Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption
Ussher, J. R., Koves, T. R., Cadete, V. J. J., Zhang, L., Jaswal, J. S., Swyrd, S. J., Lopaschuk, D. G., Proctor, S. D., Keung, W., Muoio, D. M., et al. (2010) · Diabetes · doi:10.2337/db09-1293 · Cited by 381
Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited
Dubé, J. J., Amati, F., Stefanovic-Racic, M., Toledo, F. G. S., Sauers, S. E., & Goodpaster, B. H. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00769.2007 · Cited by 378
Self-citation
Effects of Intravenous and Dietary Lipid Challenge on Intramyocellular Lipid Content and the Relation With Insulin Sensitivity in Humans
Bachmann, O. P., Dahl, D. B., Brechtel, K., Machann, J., Haap, M., Maier, T., Loviscach, M., Stumvoll, M., Claussen, C. D., Schick, F., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2579 · Cited by 369 · cited 1×
“Moreover, lipid infusion and a high-fat diet increased IMCL and impaired insulin sensitivity [29].”
Background
Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet–induced insulin resistance
Bruce, C. R., Hoy, A. J., Turner, N., Watt, M. J., Allen, T. L., Carpenter, K., Cooney, G. J., Febbraio, M. A., & Kraegen, E. W. (2009) · Diabetes · doi:10.2337/db08-1078 · Cited by 363
Skeletal muscle lipid metabolism with obesity
Hulver, M. W., Berggren, J. R., Cortright, R. N., Dudek, R. W., Thompson, R. P., Pories, W. J., MacDonald, K. G., Cline, G. W., Shulman, G. I., Dohm, G. L., et al. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00514.2002 · Cited by 339
Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning
Ong, K. T., Mashek, M. T., Bu, S. Y., Greenberg, A. S., & Mashek, D. G. (2010) · Hepatology · doi:10.1002/hep.24006 · Cited by 339
Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites
Lee, J. S., Pinnamaneni, S. K., Eo, S. J., Cho, I. H., Pyo, J. H., Kim, C. K., Sinclair, A. J., Febbraio, M. A., & Watt, M. J. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01438.2005 · Cited by 325
Skeletal muscle membrane lipid composition is related to adiposity and insulin action.
Pan, D. A., Lillioja, S., Milner, M. R., Kriketos, A. D., Baur, L. A., Bogardus, C., & Storlien, L. H. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118350 · Cited by 304
Exercise training increases lipid metabolism gene expression in human skeletal muscle
Tunstall, R. J., Mehan, K. A., Wadley, G. D., Collier, G. R., Bonen, A., Hargreaves, M., & Cameron-Smith, D. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00475.2001 · Cited by 292
Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide
Dubé, J. J., Amati, F., Toledo, F. G. S., Stefanović-Račić, M., Rossi, A. P., Coen, P. M., & Goodpaster, B. H. (2011) · Diabetologia · doi:10.1007/s00125-011-2065-0 · Cited by 282
Self-citation
Unique Regulation of Adipose Triglyceride Lipase (ATGL) by Perilipin 5, a Lipid Droplet-associated Protein
Wang, H., Bell, M., Sreenevasan, U., Hu, H., Liu, J., Dalen, K. T., Londos, C., Yamaguchi, T., Rizzo, M. A., Coleman, R., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.207779 · Cited by 279
1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo.
Turinsky, J., O'Sullivan, D. M., & Bayly, B. P. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44844-7 · Cited by 269
TIP47 functions in the biogenesis of lipid droplets
Bulankina, A. V., Deggerich, A., Wenzel, D., Mutenda, K. E., Wittmann, J., Rudolph, M. G., Burger, K. N. J., & Höning, S. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200812042 · Cited by 268
Ceramide Interaction with the Respiratory Chain of Heart Mitochondria
Di Paola, M., Cocco, T., & Lorusso, M. (2000) · Biochemistry · doi:10.1021/bi9924415 · Cited by 262
Divergent response of metabolite transport proteins in human skeletal muscle after sprint interval training and detraining
Burgomaster, K. A., Cermak, N. M., Phillips, S. M., Benton, C. R., Bonen, A., & Gibala, M. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00503.2006 · Cited by 255
Adaptations of glutathione antioxidant system to endurance training are tissue and muscle fiber specific
Leeuwenburgh, C., Hollander, J., Leichtweis, S. B., Griffiths, M. A., Gore, M. T., & Ji, L. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.1.r363 · Cited by 250
DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells
Montell, E., Turini, M., Marotta, M., Roberts, M., Noé, V., Ciudad, C. J., Macé, K., & Gómez-Foix, A. M. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.2.e229 · Cited by 245
Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue
Watt, M. J., Holmes, A. G., Pinnamaneni, S. K., GARNHAM, A. P., Steinberg, G. R., Kemp, B. E., & Febbraio, M. A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00361.2005 · Cited by 241
Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content
Coen, P. M., Dubé, J. J., Amati, F., Stefanović-Račić, M., Ferrell, R. E., Toledo, F. G. S., & Goodpaster, B. H. (2009) · Diabetes · doi:10.2337/db09-0988 · Cited by 236
Self-citation
Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state
van Loon, L. J. C., & Goodpaster, B. H. (2006) · Pflügers Archiv · doi:10.1007/s00424-005-1509-0 · Cited by 232
Self-citation
The nature of protein kinase C activation by physically defined phospholipid vesicles and diacylglycerols.
Boni, L. T., & Rando, R. R. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85156-6 · Cited by 232
Intramyocellular lipids form an important substrate source during moderate intensity exercise in endurance‐trained males in a fasted state
van Loon, L. J. C., Koopman, R., Stegen, J. H. C. H., Wagenmakers, A. J. M., KEIZER, H. A., & Saris, W. H. M. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.052431 · Cited by 231
Interactions of Perilipin-5 (Plin5) with Adipose Triglyceride Lipase
Granneman, J. G., Moore, H. P., Mottillo, E. P., Zhu, Z., & Zhou, L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.180711 · Cited by 222
Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content
Toledo, F. G. S., Menshikova, E. V., Azuma, K., Radiková, Z., Kelley, C. A., Ritov, V. B., & Kelley, D. E. (2008) · Diabetes · doi:10.2337/db07-1429 · Cited by 218
Adipose Tissue Expression of the Lipid Droplet–Associating Proteins S3-12 and Perilipin Is Controlled by Peroxisome Proliferator–Activated Receptor-γ
Dalen, K. T., Schoonjans, K., Ulven, S. M., Weedon-Fekjær, M. S., Bentzen, T. G., Koutníková, H., Auwerx, J. H., & Nebb, H. I. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1243 · Cited by 212
Proteome of Skeletal Muscle Lipid Droplet Reveals Association with Mitochondria and Apolipoprotein A-I
Zhang, H., Wang, Y., Li, J., Yu, J., Pu, J., Li, L., Zhang, H., Zhang, S., Gong, P., Yang, F., et al. (2011) · Journal of Proteome Research · doi:10.1021/pr200553c · Cited by 211
Evaluation of exercise and training on muscle lipid metabolism
Bergman, B. C., Butterfield, G. E., Wolfel, E. E., Casazza, G. A., Lopaschuk, G. D., & Brooks, G. A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.1.e106 · Cited by 207
Fatty Acid Oxidation by Skeletal Muscle During Rest and Activity
Fritz, I. B., Davis, D. G., Holtrop, R. H., et al. (1958) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1958.194.2.379 · Cited by 207
Utilization of blood‐borne and intramuscular substrates during continuous and intermittent exercise in man.
Essén, B., Hagenfeldt, L., & Kaijser, L. (1977) · The Journal of Physiology · doi:10.1113/jphysiol.1977.sp011726 · Cited by 198
Concentrations of glycerides and phospholipids in rat heart and gastrocnemius muscles. Effects of alloxan-diabetes and perfusion
Denton, R., & Pj, R. (1967) · Biochemical Journal · doi:10.1042/bj1040416 · Cited by 198
Functional differences in lipid metabolism in resting skeletal muscle of various fiber types
Dyck, D. J., Peters, S. J., Glatz, J. F. C., Górski, J., KEIZER, H. A., Kiens, B., Liu, S., Richter, E. A., Spriet, L. L., Vusse, G. J., et al. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.3.e340 · Cited by 186
Muscle contractile activity increases fatty acid metabolism and transport and FAT/CD36
Bonen, A., Dyck, D. J., Ibrahimi, A., & Abumrad, N. A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.4.e642 · Cited by 171
Muscular diacylglycerol metabolism and insulin resistance
Timmers, S., Schrauwen, P., & den Bosch, J. D. V. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.12.002 · Cited by 163
Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans
Bergman, B. C., Hunerdosse, D. M., Kerege, A. A., Playdon, M. C., & Perreault, L. (2012) · Diabetologia · doi:10.1007/s00125-011-2419-7 · Cited by 159
JNK3 Signaling Pathway Activates Ceramide Synthase Leading to Mitochondrial Dysfunction
Yu, J., Novgorodov, S. A., Chudakova, D. A., Zhu, H., Bielawska, A. E., Bielawski, J., Obeid, L. M., Kindy, M. S., & Gudz, T. I. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701812200 · Cited by 157
Intramuscular triacylglycerol utilization in human skeletal muscle during exercise: is there a controversy?
Watt, M. J., Heigenhauser, G. J. F., & Spriet, L. L. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00197.2002 · Cited by 156
Skeletal muscle lipid oxidation and obesity: influence of weight loss and exercise.
Berggren, J. R., Boyle, K. E., Chapman, W. H., & Houmard, J. A. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00354.2007 · Cited by 151
Effect of Weight Loss on Insulin Sensitivity and Intramuscular Long-Chain Fatty Acyl-CoAs in Morbidly Obese Subjects
Houmard, J. A., Tanner, C. J., Yu, C., Cunningham, P. G., Pories, W. J., MacDonald, K. G., & Shulman, G. I. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2959 · Cited by 151
Concentration of Triglycerides, Phospholipids and Glycogen in Skeletal Muscle and of Free Fatty Acids and β‐Hydroxybutyric Acid in Blood in Man in Response to Exercise
Carlson, L. A., Ekelund, L. G., & Fröberg, S. O. (1971) · European Journal of Clinical Investigation · doi:10.1111/eci.1971.1.4.248 · Cited by 146
Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake
De Bock, K., Derave, W., Eijnde, B. O., Hesselink, M. K., Koninckx, E., Rose, A. J., Schrauwen, P., Bonen, A., Richter, E. A., & Hespel, P. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01195.2007 · Cited by 144
Energy balance in obesity
Webber, J. (2003) · Proceedings of The Nutrition Society · doi:10.1079/pns2003256 · Cited by 138
Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training
Alsted, T. J., Nybo, L., Schweiger, M., Fledelius, C., Jacobsen, P., Zimmermann, R., Zechner, R., & Kiens, B. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90912.2008 · Cited by 135
Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity
Skovbro, M., Baranowski, M., Skov-Jensen, C., Flint, A., Dela, F., Górski, J., & Helge, J. W. (2008) · Diabetologia · doi:10.1007/s00125-008-1014-z · Cited by 133
Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans
Badin, P.-M., Louche, K., Mairal, A., Liebisch, G., Schmitz, G., Rustan, A. C., Smith, S. R., Langin, D., & Moro, C. (2011) · Diabetes · doi:10.2337/db10-1364 · Cited by 132
Contribution of FAT/CD36 to the regulation of skeletal muscle fatty acid oxidation: an overview
Holloway, G. P., Luiken, J. J. F. P., Glatz, J. F. C., Spriet, L. L., & Bonen, A. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2008.01878.x · Cited by 127
Impaired plasma fatty acid oxidation in extremely obese women
Thyfault, J. P., Kraus, R. M., Hickner, R. C., Howell, A. W., Wolfe, R. R., & Dohm, G. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00177.2004 · Cited by 122
Stimulation of hormone-sensitive lipase activity by contractions in rat skeletal muscle
Langfort, J., Ploug, T., Ihlemann, J., Holm, C., & Galbo, H. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3510207 · Cited by 114
Inhibition of ADRP prevents diet-induced insulin resistance
Varela, G. M., Antwi, D. A., Dhir, R. N., Yin, X., Singhal, N. S., Graham, M. J., Crooke, R. M., & Ahima, R. S. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90204.2008 · Cited by 113
Kinetics of intramuscular triglyceride fatty acids in exercising humans
Guo, Z., Burguera, B., & Jensen, M. D. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.5.2057 · Cited by 110
Adipocyte Differentiation-Related Protein and OXPAT in Rat and Human Skeletal Muscle: Involvement in Lipid Accumulation and Type 2 Diabetes Mellitus
Minnaard, R., Schrauwen, P., Schaart, G., Jörgensen, J. A., Lenaers, E., Mensink, M., & Hesselink, M. K. C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0352 · Cited by 104
Intramyocellular Lipid Changes in Men and Women during Aerobic Exercise: A 1H-Magnetic Resonance Spectroscopy Study
White, L. J., Ferguson, M. A., McCoy, S. C., & Kim, H. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031006 · Cited by 81
Skeletal Muscle Fatty Acid Handling in Insulin Resistant Men
van Hees, A. M. J., Jans, A., Hul, G. B. J., Roche, H. M., Saris, W. H. M., & Blaak, E. E. (2011) · Obesity · doi:10.1038/oby.2011.10 · Cited by 71
Different mechanisms can alter fatty acid transport when muscle contractile activity is chronically altered
Koonen, D. P. Y., Benton, C. R., Arumugam, Y., Tandon, N. N., Calles-Escandón, J., Glatz, J. F. C., Luiken, J. J. F. P., & Bonen, A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00531.2003 · Cited by 65
Short‐Term Effects of Dietary Fatty Acids on Muscle Lipid Composition and Serum Acylcarnitine Profile in Human Subjects
Kien, C. L., Everingham, K., Stevens, R. D., Fukagawa, N. K., & Muoio, D. M. (2010) · Obesity · doi:10.1038/oby.2010.135 · Cited by 64
Adipophilin distribution and colocalisation with lipid droplets in skeletal muscle
Shaw, C. S., Sherlock, M., Stewart, P. M., & Wagenmakers, A. J. M. (2009) · Histochemistry and Cell Biology · doi:10.1007/s00418-009-0558-4 · Cited by 59
Paradoxical Increase in TAG and DAG Content Parallel the Insulin Sensitizing Effect of Unilateral DGAT1 Overexpression in Rat Skeletal Muscle
Timmers, S., den Bosch, J. D. V., Hesselink, M. K. C., van Beurden, D., Schaart, G., Ferraz, M. J., Losen, M. H., Martínez‐Martínez, P., Baets, M. H. D., Aerts, J. M. F. G., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014503 · Cited by 53
Effects of Plasma Adrenaline on Hormone‐Sensitive Lipase at Rest and during Moderate Exercise in Human Skeletal Muscle
Watt, M. J., Stellingwerff, T., Heigenhauser, G. J. F., & Spriet, L. L. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.043133 · Cited by 50
High triacylglycerol turnover rate in human skeletal muscle
Sacchetti, M., Saltin, B., Olsen, D. B., & van Hall, G. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.075135 · Cited by 50
The ceramide transporter and the Goodpasture antigen binding protein: one protein – one function?
Mencarelli, C., Losen, M. H., Hammels, C., Vry, J. D., Hesselink, M. K. C., Steinbusch, H. W. M., Baets, M. H. D., & Martínez‐Martínez, P. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06673.x · Cited by 40
Impaired ?-adrenergically mediated lipolysis in skeletal muscle of obese subjects
Blaak, E. E., Schiffelers, S. L. H., Saris, W. H. M., Mensink, M., & Kooi, M. E. (2004) · Diabetologia · doi:10.1007/s00125-004-1471-y · Cited by 38
Subcellular localization of skeletal muscle lipid droplets and PLIN family proteins OXPAT and ADRP at rest and following contraction in rat soleus muscle
MacPherson, R. E. K., Herbst, E. A. F., Reynolds, E. J., Vandenboom, R., Roy, B. D., & Peters, S. J. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00163.2011 · Cited by 35
Diabetes mellitus is associated with increased intramyocellular triglyceride, but not diglyceride, content in obese humans
Anastasiou, C. A., Kavouras, S. A., Lentzas, Y., Gova, A., Sidossis, L. S., & Melidonis, A. (2009) · Metabolism · doi:10.1016/j.metabol.2009.05.019 · Cited by 34
Assessment of intramuscular triglycerides: contribution to metabolic abnormalities
Dubé, J., & Goodpaster, B. H. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000241664.38385.12 · Cited by 31
Self-citation
Long-Chain Fatty Acid Combustion Rate Is Associated with Unique Metabolite Profiles in Skeletal Muscle Mitochondria
Seifert, E. L., Fiehn, O., Bézaire, V., Bickel, D. R., Wohlgemuth, G., Adams, S. H., & Harper, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009834 · Cited by 30
The twists and turns of sphingolipid pathway in glucose regulation
Deevska, G. M., & Nikolova‐Karakashian, M. (2010) · Biochimie · doi:10.1016/j.biochi.2010.05.016 · Cited by 30
A single prior bout of exercise protects against palmitate-induced insulin resistance despite an increase in total ceramide content
Thrush, A. B., Harasim‐Symbor, E., Chabowski, A., Gulli, R. A., Stefanyk, L. E., & Dyck, D. J. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00091.2010 · Cited by 25

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Research works printed but not linked: 3

Himwich, 1927, The respiratory quotient of exercising muscle, Am. J. Physiol., 81, 485
Stratford, 2004, Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B, J. Biol. Chem., 279, 36608, 10.1074/jbc.M406499200 · DOI · Paper page
Novgorodov, 2011, Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA, J. Biol. Chem., 286, 25352, 10.1074/jbc.M110.214866 · DOI

Sorted by citations

Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis
Kalinkovich, A., & Livshits, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.008 · Cited by 882
Sugar consumption, metabolic disease and obesity: The state of the controversy
Stanhope, K. L. (2016) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2015.1084990 · Cited by 739
“It is also possible that other factors such as inflammation and oxidative stress (51), are contributors to, or possibly mediators of, muscle insulin resistance (52).”
Intermuscular fat: a review of the consequences and causes
Addison, O., Marcus, R. L., LaStayo, P. C., & Ryan, A. S. (2014) · International Journal of Endocrinology · doi:10.1155/2014/309570 · Cited by 656
“While not frequently isolated as a separate fat depot by itself, there also exists a smaller group of lipids stored within the muscle cells themselves known as intramyocellular lipids or IMCL; IMCL has been reviewed extensively elsewhere [47].”
Background
Obesity-Associated Oxidative Stress: Strategies Finalized to Improve Redox State
Savini, I., Catani, M. V., Evangelista, D., Gasperi, V., & Avigliano, L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140510497 · Cited by 527
“Ectopic-fat deposition blocks glucose transport and insulin signaling: lipid accumulation in skeletal muscle has been associated with altered insulin sensitivity [87] and tissues from obese patients are resistant to the action of insulin [71].”
Background
Resveratrol and diabetes: from animal to human studies
Szkudelski, T., & Szkudelska, K. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.013 · Cited by 364

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Authors: Coen, P. M., & Goodpaster, B. H.
Affiliations: University of Pittsburgh (US)
Corresponding author: Goodpaster, Bret H.
ORCID: Coen, Paul M.
Goodpaster, Bret H.
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2012-08
Volume: 23
Issue: 8
Pages: 391-398
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2012.05.009
PMC: PMC4908975
OpenAlex: W2017044391
Cited by: 252
References: 100
Citations by year: 2026: 17 · 2025: 13 · 2024: 11 · 2023: 13 · 2022: 16 · 2021: 13 · 2020: 14 · 2019: 18 · 2018: 23 · 2017: 18 · 2016: 24 · 2015: 25 · 2014: 23 · 2013: 24
FWCI: 1.92
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG021961, P30AG024827)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: intramyocellular lipid, intramuscular triglycerides, lipid droplets, muscle insulin resistance, type 2 diabetes, ceramide, diacylglycerol, lipid droplet proteins, lipidomics, proteomics
MeSH terms: Animals, Biological Transport, Ceramides, Diabetes Mellitus, Type 2, Diglycerides, Energy Metabolism, Fatty Acids, Humans, Insulin Resistance, Lipids, Mitochondria, Muscle, Triglycerides, Organelles, Exercise, Muscle, Skeletal, Muscle Cells, Lipid Metabolism

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Role of intramyocelluar lipids in human health

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