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What are lipoproteins doing in the brain?
Open accessAbstract
Lipoproteins in plasma transport lipids between tissues, however, only high-density lipoproteins (HDL) appear to traverse the blood-brain barrier (BBB); thus, lipoproteins found in the brain must be produced within the central nervous system. Apolipoproteins E (ApoE) and ApoJ are the most abundant apolipoproteins in the brain, are mostly synthesized by astrocytes, and are found on HDL. In the hippocampus and other brain regions, lipoproteins help to regulate neurobehavioral functions by processes that are lipoprotein receptor-mediated. Moreover, lipoproteins and their receptors also have roles in the regulation of body weight and energy balance, acting through lipoprotein lipase (LPL) and the low-density lipoprotein (LDL) receptor-related protein (LRP). Thus, understanding lipoproteins and their metabolism in the brain provides a new opportunity with potential therapeutic relevance.
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“Most cholesterol in CNS is synthesized in situ, because the transport of lipoprotein-mediated peripheral cholesterol to brain is blocked by BBB [29, 30].”
From MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease (2016) · cites this paper as [30]
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“Homeostatic GVU regulation in APOEch seems to be determined by CLU and APOE gene expression, possibly via cholesterol efflux and lipid regulation on the BBB [125]”
From Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection (2023) · cites this paper as [125]
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Metadata
- Authors
- Wang, H., & Eckel, R. H.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Wang, Hong
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 25
- Issue
- 1
- Pages
- 8-14
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC4062975
- OpenAlex
- W1994756206
- Cited by
- 234
- References
- 68
- Citations by year
- 2026: 17 · 2025: 19 · 2024: 14 · 2023: 24 · 2022: 25 · 2021: 29 · 2020: 27 · 2019: 8 · 2018: 14 · 2017: 15 · 2016: 12 · 2015: 18 · 2014: 11
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK089309)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- lipoproteins, brain, high-density lipoprotein, apolipoprotein E, clusterin, blood-brain barrier, astrocytes, lipoprotein receptors, hippocampus, neurobehavior, energy balance, lipoprotein lipase, LDL receptor-related protein, lipoprotein metabolism
- MeSH terms
- Animals, Apolipoproteins E, Blood-Brain Barrier, Brain, Humans, Lipoprotein Lipase, Lipoproteins, Neurons, Receptors, LDL, CD36 Antigens, Membrane Microdomains, Low Density Lipoprotein Receptor-Related Protein-1, Mice
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