Cited by 217Sirtuins and Resveratrol in MedicineMitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

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SIRT3 regulates progression and development of diseases of aging

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McDonnell, Eoin, Peterson, Brett S., Bomze, Howard M., Hirschey, Matthew D.·2015·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2015.06.001PMC PMC4558250

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Abstract

The mitochondrial sirtuin SIRT3 is a protein deacylase that influences almost every major aspect of mitochondrial biology, including nutrient oxidation, ATP generation, reactive oxygen species (ROS) detoxification, mitochondrial dynamics, and the mitochondrial unfolded protein response (UPR). Interestingly, mice lacking SIRT3 (SIRT3KO), either spontaneously or when crossed with mouse models of disease, develop several diseases of aging at an accelerated pace, such as cancer, metabolic syndrome, cardiovascular disease, and neurodegenerative diseases, and, thus, might be a valuable model of accelerated aging. In this review, we discuss functions of SIRT3 in pathways involved in diseases of aging and how the lack of SIRT3 might accelerate the aging process. We also suggest that further studies on SIRT3 will help uncover important new pathways driving the aging process.

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Authors: McDonnell, E., Peterson, B. S., Bomze, H. M., & Hirschey, M. D.
Affiliations: Duke University (US)
Corresponding author: Hirschey, Matthew D.
ORCID: Bomze, Howard M.
Hirschey, Matthew D.
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2015-09
Volume: 26
Issue: 9
Pages: 486-492
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2015.06.001
PMC: PMC4558250
OpenAlex: W1491563504
Cited by: 217
References: 97
Citations by year: 2026: 11 · 2025: 16 · 2024: 18 · 2023: 21 · 2022: 31 · 2021: 21 · 2020: 17 · 2019: 22 · 2018: 16 · 2017: 23 · 2016: 18 · 2015: 2
FWCI: 2.05
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (R01AA022146)
National Institute on Aging (R01AG045351, P30AG028716)
National Cancer Institute (T32CA059365)
National Institute of General Medical Sciences (T32GM007184, T32GM007105)
National Institute of Diabetes and Digestive and Kidney Diseases (R24DK085610)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: SIRT3, mitochondrial sirtuins, aging, age-related diseases, SIRT3 knockout mice, accelerated aging, mitochondrial dynamics, mitochondrial unfolded protein response, reactive oxygen species scavenging, cancer, metabolic syndrome, cardiovascular disease, neurodegenerative diseases
MeSH terms: Aging, Animals, Disease, Humans, Longevity, Mice, Sirtuin 3

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SIRT3 regulates progression and development of diseases of aging

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