SIRT3 regulates progression and development of diseases of aging

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590

The Hallmarks of Aging

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Inflammation and metabolic disorders

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ROS function in redox signaling and oxidative stress

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The Clonal Evolution of Tumor Cell Populations: Acquired genetic lability permits stepwise selection of variant sublines and underlies tumor progression.

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The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

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On Respiratory Impairment in Cancer Cells

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

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Mitochondrial dysfunction in the elderly: possible role in insulin resistance

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UCP2–SIRT3 Signaling Relieved Hyperglycemia-Induced Oxidative Stress and Senescence in Diabetic Retinopathy

Li, S., Sun, D., Chen, S., Zhang, S., Gu, Q., Shen, Y., Li, X., Xu, X., Wei, F., & Wang, N. (2024) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.65.1.14 · Cited by 27

Loss of sirtuin 4 leads to elevated glucose‐ and leucine‐stimulated insulin levels and accelerated age‐induced insulin resistance in multiple murine genetic backgrounds

Huynh, F. K., Hu, X., Lin, Z., Johnson, J. D., & Hirschey, M. D. (2017) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-017-0069-8 · Cited by 24

Dioscin Protects against Aβ1–42 Oligomers-Induced Neurotoxicity via the Function of SIRT3 and Autophagy

Zhang, Z., Han, K., Wang, C., Sun, C., & Jia, N. (2020) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c20-00046 · Cited by 24

SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction

Dhillon, R. S., Qin, Y., van Ginkel, P. R., Fu, V. X., Vann, J. M., Lawton, A. J., Green, C. L., Manchado-Gobatto, F. D. B., Gobatto, C. A., Lamming, D. W., et al. (2022) · Aging Cell · doi:10.1111/acel.13721 · Cited by 25

Neuroprotective role of retinal SIRT3 against acute photo-stress

Ban, N., Ozawa, Y., Osada, H., Lin, J. B., Toda, E., 渡辺, 光., Yuki, K., Kubota, S., Apte, R. S., & Tsubota, K. (2017) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-017-0017-8 · Cited by 24

Role of Oxidative Stress and Neuroinflammation in the Etiology of Alzheimer’s Disease: Therapeutic Options

Weinstock, M. (2025) · Antioxidants · doi:10.3390/antiox14070769 · Cited by 25

Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis.

Fan, H., Le, J., Sun, M., & Zhu, J. (2021) · PubMed Central · doi:10.22038/ijbms.2021.54905.12312 · Cited by 22

Metabolic Syndrome and Cardiac Remodeling Due to Mitochondrial Oxidative Stress Involving Gliflozins and Sirtuins

Sanz, R. L., Inserra, F., Menéndez, S. G., Mazzei, L. J., Ferder, L., & Manucha, W. A. (2023) · Current Hypertension Reports · doi:10.1007/s11906-023-01240-w · Cited by 24

A review on SIRT3 and its natural small molecule activators as a potential Preventive and therapeutic target

Liu, Y., Wei, H., & Li, J. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176155 · Cited by 22

Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies

Carbone, A., Linkova, N. S., Polyakova, V. O., Mironova, E. S., Hashimova, U., Gadzhiev, A. M., Safikhanova, K., Kvetnaia, T. V., Krylova, J., Tarquini, R., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218134 · Cited by 22

Sirtuin‐3 activation by honokiol restores mitochondrial dysfunction in the hippocampus of the hepatic encephalopathy rat model of ammonia neurotoxicity

Anamika, A., & Trigun, S. K. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22735 · Cited by 22

PPAR-γ promotes p38 MAP kinase-mediated endothelial cell permeability through activating Sirt3

Zhao, Z., Zhang, X., Dai, Y., Pan, K., Deng, Y., Meng, Y., & Xu, T. (2019) · BMC Neurology · doi:10.1186/s12883-019-1508-y · Cited by 22

Adjudin delays cellular senescence through Sirt3‑mediated attenuation of ROS production

Geng, K., Fu, N., Yang, X. Y., & Xia, W. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3917 · Cited by 22

Quercetin protects islet β-cells from oxidation-induced apoptosis via Sirt3 in T2DM.

Wang, J., Nie, Y., Dong, B., Cai, Z., Zeng, X.-K., Du, L., Zhu, X., & Yin, X. (2021) · PubMed Central · doi:10.22038/ijbms.2021.52005.11792 · Cited by 19

SIRT3-mediated deacetylation protects inner hair cell synapses in a H2O2-induced oxidative stress model in vitro

Zhao, C., Liang, W., Yang, Z., Chen, Z.-R., Du, Z., & Gong, S. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113280 · Cited by 19

How Many Sirtuin Genes Are Out There? Evolution of Sirtuin Genes in Vertebrates With a Description of a New Family Member

Opazo, J. C., Vandewege, M. W., Hoffmann, F. G., Zavala, K., Meléndez, C., Luchsinger, C., Cavieres, V. A., Vargas‐Chacoff, L., Morera, F. J., Burgos, P. V., et al. (2023) · Molecular Biology and Evolution · doi:10.1093/molbev/msad014 · Cited by 19

The Expression and Related Clinical Significance of SIRT3 in Non-Small-Cell Lung Cancer

Yang, G., Fu, B., Zhang, D., Sun, L., Chen, W., Bai, L., Gao, T., Lü, H., Wang, Z., Kong, Q.-Q., et al. (2017) · Disease Markers · doi:10.1155/2017/8241953 · Cited by 19

Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of genetically modified animals

Hoshino, S., Kobayashi, M., & Higami, Y. (2018) · Aging · doi:10.18632/aging.101557 · Cited by 20

The circadian clock at the intersection of metabolism and aging – emerging roles of metabolites

Dong, Y., Lam, S. M., Li, Y., Li, M., & Shui, G. (2025) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2025.04.014 · Cited by 22

With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions

Drechsler, S., Lynch, M. A., Novella, S., Navarro, H. G., Hecimovic, S. K., Barini, E., Tucci, V., Castro, R. E., Vandenbroucke, R. E., Osuchowski, M. F., et al. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.07.005 · Cited by 20

Focus on Molecular Functions of Anti-Aging Deacetylase SIRT3

Nahálková, J. (2022) · Biochemistry (Moscow) · doi:10.1134/s0006297922010035 · Cited by 18

The Role of Adenine Nucleotide Translocase in the Assembly of Respiratory Supercomplexes in Cardiac Cells

Parodi‐Rullán, R. M., Chapa‐Dubocq, X. R., Guzman‐Hernandez, R. A., Jang, S., Torres‐Ramos, C. A., Ayala‐Peña, S., & Javadov, S. A. (2019) · Cells · doi:10.3390/cells8101247 · Cited by 18

Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice

Hayashi, H., Cherpokova, D., Martinod, K., Witsch, T., Wong, S. L., Gallant, M., Cifuni, S. M., Guarente, L., & Wagner, D. D. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188341 · Cited by 17

Acetylation of Atp5f1c Mediates Cardiomyocyte Senescence via Metabolic Dysfunction in Radiation‐Induced Heart Damage

Zeng, Z., Xu, P., He, Y., Yi, Y., Liu, Z., Cai, J., Huang, L., & Liu, A. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4155565 · Cited by 16

Effect of scuba diving on the oxidant/antioxidant status, SIRT1 and SIRT3 expression in recreational divers after a winter nondive period

Perović, A., Sobočanec, S., Dabelić, S., Balog, T., & Dumić, J. (2018) · Free Radical Research · doi:10.1080/10715762.2017.1422211 · Cited by 16

Rescue of Mitochondrial SIRT3 Ameliorates Ischemia-like Injury in Human Endothelial Cells

Liu, X., Li, Y., Zhang, Z., Lü, J., Pei, G., & Huang, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169118 · Cited by 15

Chuanxiong Rhizoma regulates ferroptosis and the immune microenvironment in ischemic stroke through the JAK-STAT3 pathway

Ge, Q., Wang, Z., Yu, J., Feng, X., Li, J., Zhang, X., Wang, S., Wang, L., & Chen, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-82486-5 · Cited by 15

Regulatory role of acetylation on enzyme activity and fluxes of energy metabolism pathways

Moreno‐Sánchez, R., Gallardo‐Pérez, J. C., Pacheco-Velázquez, S. C., Robledo‐Cadena, D. X., Rodríguez‐Enríquez, S., Encalada, R., Saavedra, E., & Marín‐Hernández, Á. (2021) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2021.130021 · Cited by 15

IDH2 Deficiency Promotes Endothelial Senescence by Eliciting miR-34b/c-Mediated Suppression of Mitophagy and Increased ROS Production

Lee, I., Piao, S., Kim, S., Nagar, H., Choi, S., Kim, M., Vu, G.-H., Jeon, B. H., & Kim, C. (2023) · Antioxidants · doi:10.3390/antiox12030585 · Cited by 14

DVL/GSK3/ISL1 pathway signaling: unraveling the mechanism of SIRT3 in neurogenesis and AD therapy

Dai, N., Su, X., Li, A., Li, J., Jiang, D., & Wang, Y. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03925-8 · Cited by 14

Using comparative biology to understand how aging affects mitochondrial metabolism

Dhillon, R. S., & Denu, J. M. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.12.020 · Cited by 15

Role of SIRT3 in bone homeostasis and its application in preventing and treating bone diseases

Xu, K., Li, J., Wen, R., Chang, B., Cheng, Y., & Yi, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1248507 · Cited by 15

Elucidating the Role of Sirtuin 3 in Mammalian Oocyte Aging

Kordowitzki, P. (2024) · Cells · doi:10.3390/cells13181592 · Cited by 13

SIRT2 and SIRT3 expression correlates with redox imbalance and advanced clinical stage in patients with multiple myeloma

Allegra, A., Innao, V., Polito, F., Oteri, R., Alibrandi, A., Allegra, A. G., Oteri, G., Giorgio, R. M. D., Musolino, C., & Aguennouz, M. (2021) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2021.04.002 · Cited by 13

The Plasma Proteome Fingerprint Associated with Circulating Carotenoids and Retinol in Older Adults

Yamaguchi, Y., Zampino, M., Tanaka, T., Bandinelli, S., Moaddel, R., Fantoni, G., Candia, J., Ferrucci, L., & Semba, R. D. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab340 · Cited by 14

Tubeimoside I Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating SIRT3

Zhang, W., Fan, Z., Wang, F., Yin, L., Wu, J., Li, D., Song, S., Wang, X., Tang, Y., & Huang, C. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/9966355 · Cited by 13

Irisin Regulates Microglia M1/M2 Polarization and Promotes Autophagy Through the Sirt3 Pathway to Alleviate POCD

Li, C., Cong, Y., Song, W., Wu, Y., Gou, X., & Qi, S. (2025) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-025-10201-w · Cited by 12

Are the estrogen receptor and SIRT3 axes of the mitochondrial UPR key regulators of breast cancer subtype determination according to age?

Jenkins, E. C., Chattopadhyay, M., & Germain, D. (2021) · Aging and Cancer · doi:10.1002/aac2.12035 · Cited by 11

Peripheral Maintenance of the Axis SIRT1-SIRT3 at Youth Level May Contribute to Brain Resilience in Middle-Aged Amateur Rugby Players

Corpas, R., Solana, E., la Rosa, A. D., Sarroca, S., Griñán‐Ferré, C., Oriol, M., Corbella, E., Rodrı́guez-Farré, E., Viña, J., Pallàs, M., et al. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00352 · Cited by 13

Cardiac Damage in Hypertension: From Molecular Mechanisms to Novel Therapeutic Approaches

Gallo, G., & Rubattu, S. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125610 · Cited by 12

SIRT 3 was involved in Lycium barbarum seed oil protection testis from oxidative stress: in vitro and in vivo analyses

Yang, Z.-J., Wang, Y., Zhao, S., Hu, N., Chen, D., & Ma, H. (2021) · Pharmaceutical Biology · doi:10.1080/13880209.2021.1961822 · Cited by 12

Overexpression of SIRT3 disrupts mitochondrial proteostasis and cell cycle progression

Wang, X., Tang, H., Chen, Y., Chi, B., Wang, S., Lv, Y., Wu, D., Ge, R., & Deng, H. (2016) · Protein & Cell · doi:10.1007/s13238-016-0251-z · Cited by 10

Resveratrol Enhances the Anti-Cancer Effects of Cis-Platinum on Human Cervical Cancer Cell Lines by Activating the SIRT3 Relative Anti-Oxidative Pathway

Jiang, B., Tian, Q., Shu, C., Zhao, J., Xue, M., & Zhu, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.916876 · Cited by 10

Identification of small molecular inhibitors of SIRT3 by computational and biochemical approaches a potential target of breast cancer

Ullah, A., Rehman, N. U., Islam, W. U., Khan, F., Waqas, M. S., Halim, S. A., Jan, A., Muhsinah, A. B., Khan, A., & Al‐Harrasi, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-63177-7 · Cited by 9

Redox interactions of immune cells and muscle in the regulation of exercise-induced pain and analgesia: implications on the modulation of muscle nociceptor sensory neurons

Bussulo, S. K. D., Ferraz, C. R., de Carvalho, T. T., Verri, W. A., Jr., & Borghi, S. M. (2021) · Free Radical Research · doi:10.1080/10715762.2021.1953696 · Cited by 10

Nucleotide-binding sites can enhance N-acylation of nearby protein lysine residues

James, A. M., Smith, A. C., Ding, S., Houghton, J. W., Robinson, A. J., Antrobus, R., Fearnley, I. M., & Murphy, M. P. (2020) · Scientific Reports · doi:10.1038/s41598-020-77261-1 · Cited by 9

Plasma Proteomics Identifies B2M as a Regulator of Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction

Jheng, J.-R., DesJardin, J. T., Chen, Y.-Y., Huot, J. R., Bai, Y., Cook, T. G., Hibbard, L. M., Rupp, J. M., Fisher, A. J., Zhang, Y., et al. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.320270 · Cited by 8

On the interface of aging, cancer, and neurodegeneration with SIRT6 and L1 retrotransposon protein interaction network

Nahálková, J. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102496 · Cited by 9

A new view on functions of the lysine demalonylase activity of SIRT5

Nahálková, J. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121572 · Cited by 8

Curcumin preserves bone health compromised by diabetes by inhibiting osteoporosis through regulation of the SIRT3/FoxO3a signalling pathway

Mohammad, O. H., Yang, S., Ji, W., Ma, H., & Tao, R. (2025) · Scientific Reports · doi:10.1038/s41598-025-15165-8 · Cited by 7

Sirt3 Regulates Response to Oxidative Stress by Interacting with BER Proteins in Colorectal Cancer

Kabziński, J., Walczak, A., & Majsterek, I. (2022) · Genetics Research · doi:10.1155/2022/7299555 · Cited by 7

Interleukin-6 Drives Mitochondrial Dysregulation and Accelerates Physical Decline: Insights From an Inducible Humanized IL-6 Knock-In Mouse Model

Nidadavolu, L. S., Coşarderelioğlu, Ç., Gomez, A. M., Wu, Y., Bopp, T. S., Zhang, C., Nguyen, T. A., Marx-Rattner, R., Yang, H., Antonescu, C. M., et al. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad147 · Cited by 8

Is SIRT3 and Mitochondria a Reliable Target for Parkinson’s Disease and Aging? A Narrative Review

Kandy, A. T., Chand, J., Baba, M. Z., & Subramanian, G. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04486-w · Cited by 6

3′quant mRNA-Seq of Porcine Liver Reveals Alterations in UPR, Acute Phase Response, and Cholesterol and Bile Acid Metabolism in Response to Different Dietary Fats

Oczkowicz, M., Szmatoła, T., Świątkiewicz, M., Koseniuk, A., Smołucha, G., Witarski, W., & Wierzbicka, A. (2020) · Genes · doi:10.3390/genes11091087 · Cited by 6

Combination of Perindopril Erbumine and Huangqi-Danshen Decoction Protects Against Chronic Kidney Disease via Sirtuin3/Mitochondrial Dynamics Pathway

Wei, X., Wang, Y., Weng, J., Lao, Y., Deng, R., Lu, J., Yang, S., & Liu, X. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/5812105 · Cited by 6

Native chemical ligation approach to sensitively probe tissue acyl-CoA pools

James, A. M., Norman, A. A. I., Houghton, J. W., Prag, H. A., Logan, A., Antrobus, R., Hartley, R. C., & Murphy, M. P. (2022) · Cell chemical biology · doi:10.1016/j.chembiol.2022.04.005 · Cited by 5

Activating Mitochondrial Sirtuin 3 in Chondrocytes Alleviates Aging-Induced Fibrocartilage Layer Degeneration and Promotes Healing of Degenerative Rotator Cuff Injury

Xie, S., Guan, C., Huang, T., Yang, G., Hu, J., Sun, D., & Lü, H. (2023) · American Journal Of Pathology · doi:10.1016/j.ajpath.2023.03.013 · Cited by 5

Sirtuin Modulation as Novel Neuroprotective Strategy for Alzheimer’s Disease

Polito, L., Biella, G., & Albani, D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803690-7.00008-9 · Cited by 5

Mitochondrial dysfunction and kidney disease

Dalbhi, S. A., Alqarni, F., Bahatheq, N. M., Alrasheed, R. S., Alkhowaiter, R. A., & Alnughaimshi, A. A. (2019) · Journal of Nephropathology · doi:10.15171/jnp.2019.18 · Cited by 5

Lon protease and eiF2α are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells

Nagiah, S., Phulukdaree, A., & Chuturgoon, A. A. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.03.021 · Cited by 5

The m6A modification-mediated upregulation of ETS2 translation drives arsenic-induced spermatogonial senescence

Zhang, X., Zhang, Y., Liang, N.-N., Xu, S., Li, Q.-S., Song, Y., Zhang, W.-W., Wang, B., Wang, H., Huang, Y.-C., et al. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.08.053 · Cited by 4

Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice

Castro, D. R. G., Mazuk, J. R., Heine, E. M., Simpson, D., Pinches, R. S., Lozzi, C., Hoffman, K. L., Morrin, P., Mathis, D., Lebedev, M. V., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107375 · Cited by 4

Sirtuin3 confers protection against acute pulmonary embolism through anti-inflammation, and anti-oxidative stress, and anti-apoptosis properties: participation of the AMP-activated protein kinase/mammalian target of rapamycin pathway

Xu, C., Han, J., Jia, D., Cai, J., Yuan, J., & Ge, X. (2023) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.22-0175 · Cited by 4

Short-term effects induced by nicotinamide in ovariectomized females

Lima, N. C. G. C., de Souza, S. A. R., Vieira, B. D. S., Rizzi, J. S., de Andrade, T. A. M., de Oliveira, C. A., & do Amaral, M. E. C. (2020) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2020-0195 · Cited by 4

Mitochondria‐Targeting SIRT3 Activator Effectively Controls Bleomycin‐Induced Pulmonary Fibrosis

Devabattula, G., Bakchi, B., Sharma, A., Sidhartha, N. N., Dikundwar, A. G., Madhavi, V., & Godugu, C. (2025) · BioFactors · doi:10.1002/biof.70032 · Cited by 3

Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone

Nguyen, B. L., Kehmeier, M. N., Babcock, M. C., DuBose, L. E., Hildreth, K. L., Stauffer, B. L., Rosenberry, R., Keller, A. C., Steinke, K., Miles, K., et al. (2026) · Aging Cell · doi:10.1111/acel.70457 · Cited by 4

Sirtuin 3 Mediated by Spinal cMyc–Enhancer of Zeste Homology 2 Pathway Plays an Important Role in Human Immunodeficiency Virus-Related Neuropathic Pain Model

Zhu, X., Yi, H., Gu, J., Liu, S., Hayashi, K., Ikegami, D., Pardo, M., Toborek, M. J., Roy, S., Li, H., et al. (2024) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000006873 · Cited by 3

The protective effect of kaempferol on high glucose-stimulated renal tubular epithelial cells

Jiao, X., Li, Y., Wu, D., Zhang, X.-G., & Hou, F. (2025) · BMC Nephrology · doi:10.1186/s12882-025-04404-9 · Cited by 3

Sirtuins and Aging

Pukhalskaia, A. E., Kvetnoy, I. M., Linkova, N. S., Diatlova, A., Gutop, E. O., Kozlov, K. L., & Paltsev, M. A. (2023) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-023-01379-8 · Cited by 3

Pterostilbene Attenuates High-Intensity Swimming Exercise-Induced Glucose Absorption Dysfunction Associated with the Inhibition of NLRP3 Inflammasome-Induced IECs Pyroptosis

Lin, Z., Hou, P., Jing, J., Zhou, M., Wang, L., Wu, L., Zhu, J., Yi, L., & Mi, M. (2023) · Nutrients · doi:10.3390/nu15092036 · Cited by 3

Knockout of Sirtuin 3 in endothelial cells impairs endothelial‐dependent relaxation and myogenic response in mice

Chen, J., Zhang, J., Chen, Y., & Zeng, H. (2024) · Physiological Reports · doi:10.14814/phy2.70060 · Cited by 3

Exploring the Sirtuin Functionality in Ageing Through Human Protein Interaction Networks

Nahálková, J. (2020) · SN Computer Science · doi:10.1007/s42979-020-00192-1 · Cited by 3

SIRT3 attenuates AGEs-induced senescence in human granulosa cells through enhancing mitophagy

Li, S., Tang, M., Zhu, S., Zhang, Z., Cao, Y., & Xue, R. (2026) · Cell Biology and Toxicology · doi:10.1007/s10565-026-10138-7 · Cited by 2

The effect of 12-week aerobic trainings on mitochondrial biogenesis indicators in skeletal muscle among male rats

hashemkandi, R., Arshadi, S., Banaeifar, A., & Hajirasouli, M. (2020) · Medical Journal of Tabriz University of Medical Sciences and Health Services · doi:10.34172/mj.2020.055 · Cited by 2

The effect of six weeks High Intensity Interval Swimming Training and Resveratrol supplementation on the level of SIRT3 in left ventricular heart of aged rats

Rezaei, A. R., Gaeini, A. A., Choobineh, S., & Nuri, R. (2022) · Journal of Sport and Exercise Physiology · doi:10.52547/joeppa.15.3.25 · Cited by 2

Activation of SIRT3 / PRDX5 signaling inhibits apoptosis after acute spinal cord injury in mice

Ni, H., Sha, W., Xu, T., Zhu, Q., Huang, Q., Wang, J., Gu, Q., Zhu, Y., Wang, L., Tian, S., et al. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111510 · Cited by 2

Biomarkers of Replicative Senescence Revisited

Nehlin, J. O. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-26239-0_12 · Cited by 2

Aging, Free Radicals, and Reactive Oxygen Species: An Evolving Concept

Goswami, S. K. (2020) · Springer eBooks · doi:10.1007/978-981-32-9005-1_11 · Cited by 2

Long-chain fatty acids regulate SIRT3 expression by affecting intracellular NAD+ levels in large yellow croaker (Larimichthys crocea)

Chen, Q., Liu, Q., Hao, T., Cui, K., Zhao, Z., Mai, K., & Ai, Q. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.738015 · Cited by 2

SIRT4 Controls Macrophage Function and Wound Healing through Control of Protein Itaconylation in MicePreprint

Anderson, K. A., deSouza, B., Castellano‐Escuder, P., Lin, Z., Ilkayeva, O., Muehlbauer, M. J., Grimsrud, P. A., & Hirschey, M. D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.12.653532 · Cited by 3

Targeting SIRT3 signaling alleviates lung carcinoma progression by reducing hyperinsulinemia in postmenopausal obese mice: Protective intervention of betaxanthin

Li, B., Liu, J., Sun, Y., Song, M., Zhao, X., & Sun, Y. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106313 · Cited by 1

The function of SIRT3 explored through the substrate interaction networkPreprint

Nahálková, J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.10.414995 · Cited by 1

Elabela-APLNR Inhibits Cerebral Ischemia/Reperfusion Injury Through AMPK/SIRT3/PGC-1α and Akt/Nrf2 PathwaysPreprint

Wang, J., Duan, J., Huang, S., Hu, D., Chen, H., & Mu, F. (2020) · doi:10.21203/rs.3.rs-76159/v1 · Cited by 1

The protective effect of kaempferol on high glucose-stimulated renal tubular epithelial cellsPreprint

Jiao, X., Zhang, X., & Wu, D. (2022) · Research Square · doi:10.21203/rs.3.rs-2293571/v1 · Cited by 1

Oops! EMS mistakes--they're inevitable, stressful, painful and oh-so educational. This guide helps you classify them and avoid sweating the small stuff.

Murphy, P., & Taigman, M. (1998) · PubMed

Reactive Acyl-CoA Species and Deacylation by the Mitochondrial Sirtuins

Hershberger, K. A., & Hirschey, M. D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813499-3.00007-1

Sirt3 mediated by lentiviral vector in the periaqueductal gray suppresses morphine withdrawal in rats: A preliminary studyPreprint

Liu, S., Yi, H., Gu, J., Ikegami, D., Hayashi, K., & Hao, S. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/743062

The Impact of Bacteriophage on the Aging Brain and Inflammatory Response: Relevance to Parkinson’s Disease

Beauchamp, S. (2019) · doi:10.22215/etd/2019-13811

Sirtuins and life span extension

Lee, S., & Min, K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-814118-2.00006-9

Role of SIRT3 and Mitochondrial Dysfunction in Neurodegeneration

Hor, J., Santosa, M. M., & Ng, S. (2021) · Neuromethods · doi:10.1007/978-1-0716-1712-0_5

В фокусе молекулярные функции антивозрастной деацетилазы SIRT3

Nahálková, J. (2022) · Biochemistry (Moscow) · doi:10.31857/s0320972522020105

High Intensity Interval Training Is More Beneficial to Regulate Free Radicals and mtDNA Oxidative Damage in Aged Rats.Preprint

Askarian, A., Kordi, M. R., Choobineh, S., & Gaeini, A. A. (2022) · Research Square · doi:10.21203/rs.3.rs-1460621/v1

Sirt3 Regulates Radioresistance of Non-small Cell Lung Cancer through ATM-Chk2 PathwayPreprint

Cao, K., Chen, Y., Yijuan, H., Zebin, L., Tingting, L., Zhenyu, G., Cai, J., Jianguo, C., Yang, Y., & Gao, F. (2020) · doi:10.21203/rs.3.rs-20854/v1

SIRT3 deficiency decreases oxidative-metabolism capacity but increases lifespan under caloric restrictionPreprint

Dhillon, R. S., Qin, Y., van Ginkel, P. R., Fu, V. X., Vann, J. M., Lawton, A. J., Green, C. L., Manchado-Gobatto, F. D. B., Gobatto, C. A., Lamming, D. W., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.09.491205

SIRT3 and Cutaneous Cancers

Huang, C. Y., Radi, R., Baker, P., & Arbiser, J. L. (2023) · Interdisciplinary cancer research · doi:10.1007/16833_2022_109

The Effect of Interval Training and Omega-3 on Mitochondrial Biogenesis in the Liver Tissue of Nonalcoholic Fatty Liver Disease (NAFLD)Rats

Kazemi, M., Abdi, A., Mehrabani, J., & Barari, A. (2023) · Armaghane Danesh · doi:10.61186/armaghanj.28.5.4

Mitochondrial Dysfunction-Mediated Spermatogonium Stem Cell Senescence is Involved in Arsenic-Evoked Sperm Count DeclinePreprint

Zhang, X., Zhang, Y.-H., Liang, N., Luo, Y., Shanshan, X., Song, Y., Zhang, Y., Dong, X., Xue, H., Zhang, W., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4814970

Management and Modification of Flavonoids Against Nonalcoholic Fatty Liver Disease

Bai, W., Huang, B., Zhao, W., Liu, G., Yu, L., Lü, Z., & Wang, H. (2025) · Food Bioengineering · doi:10.1002/fbe2.70026

Midbrain microglia-integrated organoids as a next-generation tool for chronic morphine withdrawal research: A pilot studyPreprint

Yi, H., Liu, S., Zeier, Z. R., Candiotti, K. A., & Hao, S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.30.685622 · Cited by 1

Additional file 6 of ZMAT1 acts as a tumor suppressor in pancreatic ductal adenocarcinoma by inducing SIRT3/p53 signaling pathway

Ma, Z., Li, Z., Wang, S., Zhou, Z., Liu, C., Zhuang, H., Zhou, Q., Huang, S., Zhang, C., & 侯宝华 (2022) · Figshare · doi:10.6084/m9.figshare.19549527

SIRT3 regulates mitochondrial biogenesis in aging-related diseases

Li, H., & Cai, Z. (2022) · Journal of Biomedical Research · doi:10.7555/jbr.36.20220078 · Cited by 51

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging

Giralt, A., & Villarroya, F. (2012) · Biochemical Journal · doi:10.1042/bj20120030 · Cited by 258

Roles of SIRT3 in aging and aging-related diseases

You, Y., & Wang, Z. (2025) · International Journal of Biological Sciences · doi:10.7150/ijbs.115518 · Cited by 26

The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders

Gomes, P., Viana, S., Nunes, S., Rolo, A. P., Palmeira, C. M., & Reis, F. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100983 · Cited by 34

Mitochondrial Deacetylase SIRT3 and the Aging-related Diseases

Wang, Q. (2014) · Journal of Liaocheng University