Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities
Open accessAbstract
Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin resistance response in non-adipose tissue such as myocardium, pancreas, skeletal muscle, liver, and kidney. Serum lipid abnormalities and renal ectopic lipid accumulation have been associated with the development of kidney diseases, in particular diabetic nephropathy. Chronic hyperinsulinemia, often seen in type 2 diabetes, plays a crucial role in blood and liver lipid metabolism abnormalities, thus resulting in increased non-esterified fatty acids (NEFA). Excessive lipid accumulation alters cellular homeostasis and activates lipogenic and glycogenic cell-signaling pathways. Recent evidences indicate that both quantity and quality of lipids are involved in renal damage associated to lipotoxicity by activating inflammation, oxidative stress, mitochondrial dysfunction, and cell-death. The pathological effects of lipotoxicity have been observed in renal cells, thus promoting podocyte injury, tubular damage, mesangial proliferation, endothelial activation, and formation of macrophage-derived foam cells. Therefore, this review examines the recent preclinical and clinical research about the potentially harmful effects of lipids in the kidney, metabolic markers associated with these mechanisms, major signaling pathways affected, the causes of excessive lipid accumulation, and the types of lipids involved, as well as offers a comprehensive update of therapeutic strategies targeting lipotoxicity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Parenchymal lipid deposition may induce lipotoxicity through the formation of toxic metabolites including ceramides and diacylglyceride that hamper the function of multiple kidney cell types, including podocytes.
“In addition, parenchymal lipid deposition may induce lipotoxicity (50) through the formation of toxic metabolites including ceramides and diacylglyceride that hamper the function of multiple kidney cell types, including podocytes (51).”
From GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity (2025) · cites this paper as [50]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
Perkovic, V., Jardine, M. J., Neal, B., Bompoint, S., Heerspink, H. J. L., Charytan, D. M., Edwards, R., Agarwal, R., Bakris, G., Bull, S., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1811744 · Cited by 6,189 · see citing works
Oxyl radicals, redox-sensitive signalling cascades and antioxidants
Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930 · see citing works
Diabetic Kidney Disease: Challenges, Progress, and Possibilities
Alicic, R. Z., Rooney, M. T., & Tuttle, K. R. (2017) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.11491116 · Cited by 2,898 · see citing works
Dynamics and functions of lipid droplets
Olzmann, J. A., & Carvalho, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0085-z · Cited by 2,740 · see citing works
Gleeson, M., Bishop, N. C., Stensel, D. J., Lindley, M. R., Mastana, S. S., & Nimmo, M. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3041 · Cited by 2,470 · see citing works
Lean, M. E., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., Peters, C., Zhyzhneuskaya, S., Al-Mrabeh, A., Hollingsworth, K. G., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)33102-1 · Cited by 2,095 · see citing works
Kang, H. M., Ahn, S. H., Choi, P., Ko, Y.-A., Han, S. H., Chinga, F., Park, A. S. D., Tao, J., Sharma, K., Pullman, J., et al. (2015) · Nature Medicine · doi:10.1038/nm.3762 · Cited by 1,555 · see citing works
Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes
Cnop, M., Welsh, N., Jonas, J.-C., Jörns, A., Lenzen, S., & Eizirik, D. L. (2005) · Diabetes · doi:10.2337/diabetes.54.suppl_2.s97 · Cited by 1,491 · see citing works
Mitochondrial energetics in the kidney
Bhargava, P., & Schnellmann, R. G. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.107 · Cited by 1,363 · see citing works
Dresner, A., Laurent, D., Marcucci, M., Griffin, M. E., Dufour, S., Cline, G. W., Slezak, L. A., Andersen, D. K., Hundal, R. S., Rothman, D. L., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5001 · Cited by 1,311 · see citing works
Krssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S. M., Rothman, D. L., Shulman, G. I., & Roden, M. (1999) · Diabetologia · doi:10.1007/s001250051123 · Cited by 1,264 · see citing works
Lean, M. E. J., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., Peters, C., Zhyzhneuskaya, S., Al-Mrabeh, A., Hollingsworth, K. G., et al. (2019) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(19)30068-3 · Cited by 981 · see citing works
Inflammation and Lipid Signaling in the Etiology of Insulin Resistance
Glass, C. K., & Olefsky, J. M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.001 · Cited by 942 · see citing works
Fatty acids, obesity, and insulin resistance: Time for a reevaluation
Karpe, F., Dickmann, J. R., & Frayn, K. N. (2011) · Diabetes · doi:10.2337/db11-0425 · Cited by 896 · see citing works
Perseghin, G., Scifo, P., De Cobelli, F., Pagliato, E., Battezzati, A., Arcelloni, C., Vanzulli, A., Testolin, G., Pozza, G., Del Maschio, A., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.8.1600 · Cited by 877 · see citing works
The Role of Insulin Resistance in Nonalcoholic Fatty Liver Disease
Utzschneider, K. M., & Kahn, S. E. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0587 · Cited by 858 · see citing works
Adiels, M., Olofsson, S.-O., Taskinen, M.-R., & Borén, J. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.160192 · Cited by 820 · see citing works
Walther, T. C., Chung, J., & Farese, R. V. (2017) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100616-060608 · Cited by 772 · see citing works
Yu, X.-H., Fu, Y., Zhang, D., Yin, K., & Tang, C. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2013.06.006 · Cited by 772 · see citing works
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
Okada-Iwabu, M., Yamauchi, T., Iwabu, M., Honma, T., Hamagami, K.-I., Matsuda, K., Yamaguchi, M., Tanabe, H., Kimura-Someya, T., Shirouzu, M., et al. (2013) · Nature · doi:10.1038/nature12656 · Cited by 757 · see citing works
Nonalcoholic Fatty Liver Disease, Hepatic Insulin Resistance, and Type 2 Diabetes
Birkenfeld, A. L., & Shulman, G. I. (2013) · Hepatology · doi:10.1002/hep.26672 · Cited by 740 · see citing works
Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis
D’Agati, V. D., Chagnac, A., de Vries, A. P. J., Levi, M., Porrini, E., Herman‐Edelstein, M., & Praga, M. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.75 · Cited by 726 · see citing works
Primary Membranous Nephropathy
Couser, W. G. (2017) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.11761116 · Cited by 692 · see citing works
Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy
Herman‐Edelstein, M., Scherzer, P., Tobar, A., Levi, M., & Gafter, U. (2013) · Journal of Lipid Research · doi:10.1194/jlr.p040501 · Cited by 652 · see citing works
Mitochondrial dysfunction in diabetic kidney disease
Forbes, J. M., & Thorburn, D. R. (2018) · Nature Reviews Nephrology · doi:10.1038/nrneph.2018.9 · Cited by 641 · see citing works
Guo, S. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0327 · Cited by 625 · see citing works
Benador, I. Y., Veliova, M., Mahdaviani, K., Petcherski, A., Wikström, J. D., Assali, E. A., Acín‐Pérez, R., Shum, M., de Oliveira, M. F., Cinti, S., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.003 · Cited by 621 · see citing works
Non-alcoholic fatty liver disease and obesity: Biochemical, metabolic and clinical presentations
Milić, S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i28.9330 · Cited by 595 · see citing works
Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo
Wang, X., Collins, H. L., Ranalletta, M., Fuki, I. V., Billheimer, J. T., Rothblat, G. H., Tall, A. R., & Rader, D. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32057 · Cited by 593 · see citing works
Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease
Mota, M., Banini, B. A., Cazanave, S. C., & Sanyal, A. J. (2016) · Metabolism · doi:10.1016/j.metabol.2016.02.014 · Cited by 570 · see citing works
Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases
Choi, H. M., Doss, H. M., & Kim, K. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041219 · Cited by 520 · see citing works
Vascular endothelial growth factor B controls endothelial fatty acid uptake
Hagberg, C. E., Falkevall, A., Wang, X., Larsson, E., Huusko, J., Nilsson, I., van Meeteren, L. A., Samén, E., Lu, L., Vanwildemeersch, M., et al. (2010) · Nature · doi:10.1038/nature08945 · Cited by 514 · see citing works
Fatty kidney: emerging role of ectopic lipid in obesity-related renal disease
de Vries, A. P. J., Ruggenenti, P. L., Ruan, X. Z., Praga, M., Cruzado, J. M., Bajema, I. M., D’Agati, V. D., Lamb, H. J., Barlovič, D. P., Hojs, R., et al. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70065-8 · Cited by 503 · see citing works
Chevalier, R. L. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00164.2016 · Cited by 486 · see citing works
Ertunc, M. E., & Hotamışlıgil, G. S. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r066514 · Cited by 485 · see citing works
Balancing the fat: lipid droplets and human disease
Krahmer, N., Farese, R. V., & Walther, T. C. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201100671 · Cited by 477 · see citing works
The impact of insulin resistance on the kidney and vasculature
Artunç, F., Schleicher, E. D., Weigert, C., Fritsche, A., Stefan, N., & Häring, H. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.145 · Cited by 474 · see citing works
Lipid Accumulation and Chronic Kidney Disease
Gai, Z., Wang, T., Visentin, M., Kullak-Ublick, G. A., Fu, X., & Wang, Z. (2019) · Nutrients · doi:10.3390/nu11040722 · Cited by 431 · see citing works
Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans
Szendroedi, J., Yoshimura, T., Phielix, E., Koliaki, C., Marcucci, M., Zhang, D., Jelenik, T., Müller, J., Herder, C., Nowotny, P., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409229111 · Cited by 415 · see citing works
Cherney, D. Z. I., Zinman, B., Inzucchi, S. E., Koitka-Weber, A., Mattheus, M., von Eynatten, M., & Wanner, C. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30182-1 · Cited by 383 · see citing works
NF-κB in inflammation and renal diseases
Zhang, H., & Sun, S.-C. (2015) · Cell & Bioscience · doi:10.1186/s13578-015-0056-4 · Cited by 383 · see citing works
Glucose handling by the kidney
Mather, A., & Pollock, C. A. (2011) · Kidney International · doi:10.1038/ki.2010.509 · Cited by 376 · see citing works
Roles of diacylglycerols and ceramides in hepatic insulin resistance
Petersen, M. C., & Shulman, G. I. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.04.004 · Cited by 373 · see citing works
Weinberg, J. M. (2006) · Kidney International · doi:10.1038/sj.ki.5001834 · Cited by 372 · see citing works
Renal lipid metabolism and lipotoxicity
Bobulescu, I. A. (2010) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e32833aa4ac · Cited by 366 · see citing works
Kahl, S., Gancheva, S., Straßburger, K., Herder, C., Machann, J., Katsuyama, H., Kabisch, S., Henkel, E., Kopf, S., Lagerpusch, M., et al. (2020) · Diabetes Care · doi:10.2337/dc19-0641 · Cited by 360 · see citing works
Fatty Kidney, Hypertension, and Chronic Kidney Disease: The Framingham Heart Study
Foster, M. C., Hwang, S.-J., Porter, S. A., Massaro, J. M., Hoffmann, U., & Fox, C. S. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.175315 · Cited by 356 · see citing works
SGLT2 Inhibitors and the Diabetic Kidney
Fioretto, P., Zambon, A., Rossato, M., Busetto, L., & Vettor, R. (2016) · Diabetes Care · doi:10.2337/dcs15-3006 · Cited by 348 · see citing works
Increasing Body Mass Index and Obesity in the Incident ESRD Population
Kramer, H., Saranathan, A., Luke, A., Durazo-Arvizú, R., Cao, G., Hou, S., & Cooper, R. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005111241 · Cited by 345 · see citing works
Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms
Gnudi, L., Coward, R. J., & Long, D. A. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.07.002 · Cited by 333 · see citing works
Sberna, A.-L., Bouillet, B., Rouland, A., Brindisi, M., Nguyen, A., Mouillot, T., Duvillard, L., Denimal, D., Loffroy, R., Vergès, B. L., et al. (2017) · Diabetic Medicine · doi:10.1111/dme.13565 · Cited by 322 · see citing works
AMPK-Mediated Regulation of Lipid Metabolism by Phosphorylation
Wang, Q., Liu, S., Zhai, A., Zhang, B., & Tian, G. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b17-00724 · Cited by 315 · see citing works
Podocyte Number in Normotensive Type 1 Diabetic Patients With Albuminuria
White, K., Bilous, R. W., Marshall, S. M., Nahas, M. E., Remuzzi, G., Piras, G., Cosmo, S. D., Viberti, G. C., & (ESPRIT), O. B. O. T. E. S. F. T. P. O. R. D. I. T. 1. D. (2002) · Diabetes · doi:10.2337/diabetes.51.10.3083 · Cited by 313 · see citing works
Kim, M. Y., Lim, J. H., Youn, H. H., Hong, Y. A., Yang, K. S., Park, H., Chung, S., Koh, S. H., Shin, S. J., Choi, B. S., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2747-2 · Cited by 313 · see citing works
Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes
Oh, Y. S., Bae, G. D., Baek, D. J., Park, E., & Jun, H. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00384 · Cited by 307 · see citing works
SGLT2 Protein Expression Is Increased in Human Diabetic Nephropathy
Wang, X. X., Levi, J., Luo, Y., Myakala, K., Herman‐Edelstein, M., Qiu, L., Wang, D., Peng, Y., Grenz, A., Lucia, S. M., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.779520 · Cited by 307 · see citing works
Proctor, G., Jiang, T., Iwahashi, M., Wang, Z., Li, J., & Levi, M. (2006) · Diabetes · doi:10.2337/db05-0603 · Cited by 303 · see citing works
Glatz, J. F. C., & Luiken, J. J. F. P. (2018) · Journal of Lipid Research · doi:10.1194/jlr.r082933 · Cited by 301 · see citing works
Understanding the mechanisms of reversal of type 2 diabetes
Taylor, R., Al-Mrabeh, A., & Sattar, N. (2019) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(19)30076-2 · Cited by 299 · see citing works
Diabetic nephropathy: diagnosis and treatment
Fineberg, D., Jandeleit-Dahm, K. A. M., & Cooper, M. E. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.184 · Cited by 295 · see citing works
Protection of mitochondria prevents high-fat diet–induced glomerulopathy and proximal tubular injury
Szeto, H. H., Liu, S., Soong, Y., Alam, N., Prusky, G. T., & Seshan, S. V. (2016) · Kidney International · doi:10.1016/j.kint.2016.06.013 · Cited by 293 · see citing works
A concise review of non-alcoholic fatty liver disease
Than, N. N., & Newsome, P. N. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.01.001 · Cited by 289 · see citing works
Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes
Hagberg, C. E., Mehlem, A., Falkevall, A., Muhl, L., Fam, B. C., Ortsäter, H., Scotney, P. D., Nyqvist, D., Samén, E., Li, L., et al. (2012) · Nature · doi:10.1038/nature11464 · Cited by 286 · see citing works
CD36 in chronic kidney disease: novel insights and therapeutic opportunities
Yang, X., Okamura, D. M., Lu, X., Chen, Y., Moorhead, J. F., Varghese, Z., & Ruan, X. Z. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.126 · Cited by 264 · see citing works
Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?
Higgins, G. C., & Coughlan, M. T. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12503 · Cited by 251 · see citing works
Disorders of lipid metabolism in nephrotic syndrome: mechanisms and consequences
Vaziri, N. D. (2016) · Kidney International · doi:10.1016/j.kint.2016.02.026 · Cited by 248 · see citing works
Role of sphingolipids in the biogenesis and biological activity of extracellular vesicles
Verderio, C., Gabrielli, M., & Giussani, P. (2018) · Journal of Lipid Research · doi:10.1194/jlr.r083915 · Cited by 237 · see citing works
Wang, C., Pan, Y., Zhang, Q.-Y., Wang, F., & Kong, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038285 · Cited by 233 · see citing works
Charles, M.-A. A., Eschwège, É., Thibult, N., Claude, J., Warnet, J., Rosselin, G., Girard, J. R., & Balkau, B. (1997) · Diabetologia · doi:10.1007/s001250050793 · Cited by 231 · see citing works
Kim, Y., Lim, J. H., Kim, M. Y., Kim, E. N., Yoon, H. E., Shin, S. J., Choi, B. S., Kim, Y.-S., Chang, Y. S., & Park, C. W. (2018) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017060627 · Cited by 229 · see citing works
Lipids, lysosomes, and autophagy
Jaishy, B. P., & Abel, E. D. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r067520 · Cited by 229 · see citing works
Minokoshi, Y., Kahn, C. R., & Kahn, B. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300019200 · Cited by 219 · see citing works
Meex, R. C. R., Blaak, E. E., & van Loon, L. J. C. (2019) · Obesity Reviews · doi:10.1111/obr.12862 · Cited by 218 · see citing works
Decoding Insulin Resistance and Metabolic Syndrome for Promising Therapeutic Intervention
Guo, S. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0584 · Cited by 215 · see citing works
Qin, X., Zhao, Y. S., Gong, J., Huang, W., Su, H., Yuan, F., Fang, K., Wang, D., Li, J., Zou, X., et al. (2019) · Theranostics · doi:10.7150/thno.30640 · Cited by 213 · see citing works
Mitochondrial dysfunction in diabetic kidney disease
Wei, P. Z., & Szeto, C. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.07.005 · Cited by 207 · see citing works
Molecular Mechanism of Cyclodextrin Mediated Cholesterol Extraction
López, C. A., de Vries, A. H., & Marrink, . J. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002020 · Cited by 197 · see citing works
Impact of different ectopic fat depots on cardiovascular and metabolic diseases
Ferrara, D., Montecucco, F., Dallegri, F., & Carbone, F. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28821 · Cited by 195 · cited 2× · see citing works
“These lipid mediators have been associated with the activation of the inflammatory response, ROS production, mitochondrial dysfunction, autophagy deregulation, endoplasmic reticulum stress (ER stress) and apoptosis [69,80,81].”
BackgroundExercise Induced Adipokine Changes and the Metabolic Syndrome
Golbidi, S., & Laher, I. (2014) · Journal of Diabetes Research · doi:10.1155/2014/726861 · Cited by 194 · see citing works
Metabolic profiling reveals new serum biomarkers for differentiating diabetic nephropathy
Hirayama, A., Nakashima, E., Sugimoto, M., Akiyama, S.-I., Sato, W., Maruyama, S., Matsuo, S., Tomita, M., Yuzawa, Y., & Soga, T. (2012) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-6412-x · Cited by 191 · see citing works
Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis
Tanaka, Y., Kume, S., Araki, S., Isshiki, K., Chin‒Kanasaki, M., Sakaguchi, M., Sugimoto, T., Koya, D., Haneda, M., Kashiwagi, A., et al. (2011) · Kidney International · doi:10.1038/ki.2010.530 · Cited by 190 · see citing works
Dyslipidemia in patients with chronic kidney disease
Hager, M., Narla, A. D., & Tannock, L. R. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9402-z · Cited by 188 · see citing works
Impaired β-Oxidation and Altered Complex Lipid Fatty Acid Partitioning with Advancing CKD
Afshinnia, F., Rajendiran, T. M., Soni, T., Byun, J., Wernisch, S., Sas, K. M., Hawkins, J. J., Bellovich, K. A., Gipson, D., Michailidis, G. C., et al. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017030350 · Cited by 187 · see citing works
Lipid droplet proteins and metabolic diseases
Xu, S., Zhang, X., & Liu, P. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.019 · Cited by 185 · see citing works
(2009) · PubMed · Cited by 183 · see citing works
Therapeutic Landscape for NAFLD in 2020
Neuschwander‐Tetri, B. A. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.01.051 · Cited by 183 · see citing works
Falkevall, A., Mehlem, A., Palombo, I., Sahlgren, B. H., Ebarasi, L., He, L., Ytterberg, A. J., Olauson, H., Axelsson, J., Sundelin, B., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.01.004 · Cited by 179 · see citing works
ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes
Ducasa, G. M., Mitrofanova, A. V., Mallela, S. K., Liu, X., Molina, J., Sloan, A. J., Pedigo, C. E., Ge, M., Santos, J. V., Hernandez, Y., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci125316 · Cited by 177 · see citing works
Interactions between kidney disease and diabetes: dangerous liaisons
Pecoits‐Filho, R., Abensur, H., Betônico, C. D. C. R., Machado, A. D., Parente, E. B., Queiroz, M. S., Salles, J. E. N., Titan, S., & Vencio, S. A. C. (2016) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-016-0159-z · Cited by 174 · see citing works
Lipotoxicity in Kidney, Heart, and Skeletal Muscle Dysfunction
Nishi, H., Higashihara, T., & Inagi, R. (2019) · Nutrients · doi:10.3390/nu11071664 · Cited by 174 · see citing works
SGLT2 inhibition and kidney protection
Nespoux, J., & Vallon, V. (2018) · Clinical Science · doi:10.1042/cs20171298 · Cited by 172 · see citing works
Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases
Jang, H., Noh, M. R., Kim, J., & Padanilam, B. J. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00065 · Cited by 170 · see citing works
Tanaka, S., Sugiura, Y., Saito, H., Sugahara, M., Higashijima, Y., Yamaguchi, J., Inagi, R., Suematsu, M., Nangaku, M., & Tanaka, T. (2018) · Kidney International · doi:10.1016/j.kint.2018.04.025 · Cited by 167 · see citing works
APOL1-Associated Nephropathy: A Key Contributor to Racial Disparities in CKD
Freedman, B. I., Limou, S., Ma, L., & Kopp, J. B. (2018) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2018.06.020 · Cited by 163 · see citing works
Fatty Liver and Chronic Kidney Disease: Novel Mechanistic Insights and Therapeutic Opportunities
Musso, G., Cassader, M., Cohney, S. J., Michieli, F. D., Pinach, S., Saba, F., & Gambino, R. (2016) · Diabetes Care · doi:10.2337/dc15-1182 · Cited by 162 · see citing works
Celastrol, an NF-κB Inhibitor, Improves Insulin Resistance and Attenuates Renal Injury in db/db Mice
Kim, J. E., Lee, M., Nam, D. H., Song, H. K., Kang, Y. S., Lee, J. E., Kim, H. W., Joo, J., Hyun, Y. Y., Han, S. Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062068 · Cited by 160 · see citing works
Leehey, D. J., Moinuddin, I., Bast, J. P., Qureshi, S., Jelinek, C. S., Cooper, C., Edwards, L. C., Smith, B. M., & Collins, E. G. (2009) · Cardiovascular Diabetology · doi:10.1186/1475-2840-8-62 · Cited by 156 · see citing works
Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury.
Pedigo, C., Ducasa, G., Leclercq, F., Sloan, A., Mitrofanova, A., Hashmi, T., Molina-David, J., Ge, M., Lassenius, M., Forsblom, C., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85939 · Cited by 156 · see citing works
Han, L., Xia, J., Liang, Q., Wang, Y., Wang, Y., Hu, P., Li, P., & Luo, G. (2011) · Analytica Chimica Acta · doi:10.1016/j.aca.2011.01.034 · Cited by 150 · see citing works
Cyclodextrin Protects Podocytes in Diabetic Kidney Disease
Merscher, S., Guzman, J., Pedigo, C. E., Lehto, M. J., Aguillon, R. A., Mendez, A. J., Lassenius, M. I., Forsblom, C. M., Yoo, T., Villarreal, R., et al. (2013) · Diabetes · doi:10.2337/db13-0399 · Cited by 150 · see citing works
Bussolati, B., Deregibus, M. C., Fonsato, V., Doublier, S., Spatola, T., Procida, S., Carlo, F. D., & Camussi, G. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004080629 · Cited by 149 · see citing works
Oxidant stress in hyperlipidemia-induced renal damage
Scheuer, H., Gwinner, W., Hohbach, J., Gröne, E. F., Brandes, R. P., Malle, E., Olbricht, C. J., Walli, A. K., & Gröne, H. (2000) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2000.278.1.f63 · Cited by 148 · see citing works
ATF6α downregulation of PPARα promotes lipotoxicity-induced tubulointerstitial fibrosis
Jao, T., Nangaku, M., Wu, C.-H., Sugahara, M., Saito, H., Maekawa, H., Ishimoto, Y., Aoe, M., Inoue, T., Tanaka, T., et al. (2019) · Kidney International · doi:10.1016/j.kint.2018.09.023 · Cited by 148 · see citing works
Pena, M. J., Heerspink, H. J. L., Hellemons, M. E., Friedrich, T., Dallmann, G., Lajer, M., Bakker, S. J. L., Gansevoort, R. T., Rossing, P. R., de Zeeuw, D., et al. (2014) · Diabetic Medicine · doi:10.1111/dme.12447 · Cited by 147 · see citing works
Choi, S. R., Lim, J. H., Kim, M. Y., Kim, E. N., Kim, Y., Choi, B. S., Kim, Y.-S., Kim, H. W., Lim, K., Kim, M.-J., et al. (2018) · Metabolism · doi:10.1016/j.metabol.2018.02.004 · Cited by 147 · see citing works
Scheen, A. J. (2019) · Diabetes & Metabolism · doi:10.1016/j.diabet.2019.01.008 · Cited by 146 · see citing works
Systemic and renal lipids in kidney disease development and progression
WAHL, P. W., Ducasa, G. M., & Fornoni, A. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00375.2015 · Cited by 145 · see citing works
Lipotoxicity in the Pancreatic Beta Cell: Not Just Survival and Function, but Proliferation as Well?
Sharma, R. B., & Alonso, L. C. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0492-2 · Cited by 136 · see citing works
Adipocytokines and hepatic fibrosis
Saxena, N. K., & Anania, F. A. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.01.002 · Cited by 136 · see citing works
Tonolo, G., Melis, M. G., Formato, M., Angius, M. F., Carboni, A., Brizzi, P., Ciccarese, M., Cherchi, G. M., & Maioli, M. (2000) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2000.00735.x · Cited by 135 · see citing works
Renal Lipid Metabolism and Lipotoxicity in Diabetes
Thongnak, L., Pongchaidecha, A., & Lungkaphin, A. (2019) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2019.11.004 · Cited by 132 · see citing works
Serum Adiponectin Is Increased in Type 1 Diabetic Patients With Nephropathy
Saraheimo, M., Forsblom, C. M., Fagerudd, J. A., Teppo, A., Pettersson-Fernholm, K., Frystyk, J., Flyvbjerg, A., Groop, P., & on behalf of the FinnDiane Study Group (2005) · Diabetes Care · doi:10.2337/diacare.28.6.1410 · Cited by 131 · see citing works
Mori, J., Patel, V. B., Ramprasath, T., Alrob, O. A., DesAulniers, J., Scholey, J. W., Lopaschuk, G. D., & Oudit, G. Y. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00655.2013 · Cited by 130 · see citing works
Kim, B. H., Lee, E. Y., Choi, R., Nawaboot, J., Lee, E. Y., Lee, E. Y., Kim, H. S., & Chung, C. H. (2016) · Yonsei Medical Journal · doi:10.3349/ymj.2016.57.3.664 · Cited by 130 · see citing works
Immunological evidence for hypochlorite-modified proteins in human kidney.
Malle, E., Woenckhaus, C., Waeg, G., Esterbauer, H., Gröne, E. F., & Gröne, H. (1997) · Europe PMC (PubMed Central) · Cited by 127 · see citing works
Edgerton, D. S., Kraft, G., Smith, M. S., Farmer, B., Williams, P. E., Coate, K. C., Printz, R. L., O’Brien, R. M., & Cherrington, A. D. (2017) · JCI Insight · doi:10.1172/jci.insight.91863 · Cited by 126 · see citing works
Soetikno, V., Sari, F. R., Sukumaran, V., Lakshmanan, A. P., Harima, M., Suzuki, K., Kawachi, H., & Watanabe, K. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.04.013 · Cited by 125 · see citing works
Jiang, T., Liebman, S. E., Lucia, M. S., Li, J., & Levi, M. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00733.x · Cited by 124 · see citing works
Sphingolipid Metabolism: New Insight into Ceramide-Induced Lipotoxicity in Muscle Cells
Bandet, C. L., Tan, S., Bourron, O., Stunff, H. L., & Hajduch, É. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030479 · Cited by 123 · see citing works
Afshinnia, F., Nair, V., Lin, J., Rajendiran, T. M., Soni, T., Byun, J., Sharma, K., Fort, P. E., Gardner, T. W., Looker, H. C., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.130317 · Cited by 122 · see citing works
Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice
Hong, Y. A., Lim, J. H., Kim, M. Y., Kim, T. W., Kim, Y., Yang, K. S., Park, H. S., Choi, S. R., Chung, S., Kim, H. W., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096147 · Cited by 118 · see citing works
Ruan, X. Z., Varghese, Z., Powis, S. H., & Moorhead, J. F. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00025.x · Cited by 115 · see citing works
Van Craenenbroeck, A. H., Van Craenenbroeck, E. M., Van Ackeren, K., Vrints, C. J., Conraads, V. M., Verpooten, G. A., Kouidi, E., & Couttenye, M. M. (2015) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2015.03.015 · Cited by 115 · see citing works
Lipotoxicity in macrophages: evidence from diseases associated with the metabolic syndrome
Prieur, X., Rőszer, T., & Ricote, M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.09.017 · Cited by 115 · see citing works
Nam, D. H., Lee, M. H., Kim, J. E., Song, H. K., Kang, Y. S., Lee, J. E., Kim, H. W., Cha, J. J., Hyun, Y. Y., Kim, S. H., et al. (2012) · Endocrinology · doi:10.1210/en.2011-1423 · Cited by 114 · see citing works
Kang, Y. S., Lee, M., Song, H. K., Ko, G. J., Kwon, O. S., Lim, T. K., Kim, S. H., Han, S. Y., Han, K. H., Lee, J. E., et al. (2010) · Kidney International · doi:10.1038/ki.2010.263 · Cited by 112 · see citing works
Kidney Proximal Tubule Lipoapoptosis Is Regulated by Fatty Acid Transporter-2 (FATP2)
Khan, S., Cabral, P., Schilling, W. P., Schmidt, Z. W., Uddin, A. N., Gingras, A., Madhavan, S. M., Garvin, J. L., & Schelling, J. R. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017030314 · Cited by 111 · see citing works
Wang, C., Li, L., Liu, S., Liao, G., Li, L., Chen, Y., Cheng, J., Lu, Y., & Liu, J. (2018) · PLOS ONE · doi:10.1371/journal.pone.0193473 · Cited by 110 · see citing works
Kim, Y., & Park, C. W. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071782 · Cited by 110 · see citing works
Liu, S., Soong, Y., Seshan, S. V., & Szeto, H. H. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00697.2013 · Cited by 110 · see citing works
Nosadini, R., & Tonolo, G. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.10.002 · Cited by 109 · see citing works
Coughlan, M. T., & Sharma, K. (2016) · Kidney International · doi:10.1016/j.kint.2016.02.043 · Cited by 108 · see citing works
The Coming Age of Flavonoids in the Treatment of Diabetic Complications
Caro-Ordieres, T., Marín‐Royo, G., Opazo-Ríos, L., Jiménez-Castilla, L., Moreno, J. A., Gómez‐Guerrero, C., & Egido, J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020346 · Cited by 107 · see citing works
Self-citationThe Warburg Effect in Diabetic Kidney Disease
Zhang, G., Darshi, M., & Sharma, K. (2018) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2018.01.002 · Cited by 106 · see citing works
Podocytopathy in Diabetes: A Metabolic and Endocrine Disorder
Dı́ez-Sampedro, A., Lenz, O., & Fornoni, A. (2011) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2011.03.035 · Cited by 104 · see citing works
SMPDL3b modulates insulin receptor signaling in diabetic kidney disease
Mitrofanova, A. V., Mallela, S. K., Ducasa, G. M., Yoo, T., Rosenfeld-Gur, E., Zelnik, I. D., Molina, J., Santos, J. V., Ge, M., Sloan, A. J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10584-4 · Cited by 102 · see citing works
Muñoz‐García, B., Moreno, J. A., López‐Franco, Ó., Sanz, A. B., Martı́n-Ventura, J. L., Blanco, J., Jakubowski, A., Burkly, L. C., Ortíz, A., Egido, J., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.194852 · Cited by 101 · see citing works
Self-citationYiu, W. H., Li, R. X., Wong, D. W. L., Wu, H., Chan, K. W., Chan, L. Y. Y., Leung, J. C. K., Lai, K. N., Sacks, S. H., Zhou, W., et al. (2017) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfx336 · Cited by 101 · see citing works
Zha, D., Wu, X., & Gao, P. H. (2017) · Endocrinology · doi:10.1210/en.2016-1765 · Cited by 100 · see citing works
Zhang, C., Shao, M., Yang, H., Chen, L., Yu, L., Cong, W., Tian, H., Zhang, F., Cheng, P., Jin, L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082275 · Cited by 100 · see citing works
Guo, K., Lu, J., Huang, Y., Wu, M., Zhang, L., Yu, H., Zhang, M., Bao, Y., He, C., Chen, H., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125176 · Cited by 98 · see citing works
Targeting Mitochondria and Reactive Oxygen Species-Driven Pathogenesis in Diabetic Nephropathy
Lindblom, R. S. J., Higgins, G. C., Coughlan, M. T., & de Haan, J. B. (2015) · The Review of Diabetic Studies · doi:10.1900/rds.2015.12.134 · Cited by 98 · see citing works
Martínez-García, C., Izquierdo‐Lahuerta, A., Vivas, Y., Velasco, I., Yeo, T.-K., Chen, S., & Medina‐Gómez, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142291 · Cited by 97 · see citing works
Dyslipidemia in diabetic nephropathy
Kawanami, D., Matoba, K., & Utsunomiya, K. (2016) · Renal Replacement Therapy · doi:10.1186/s41100-016-0028-0 · Cited by 95 · see citing works
Jayachandran, M., Wu, Z., Ganesan, K., Khalid, S., Chung, S. M., & Xu, B. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.02.017 · Cited by 94 · see citing works
DeZwaan-McCabe, D., Sheldon, R. D., Gorecki, M. C., Guo, D., Gansemer, E. R., Kaufman, R. J., Rahmouni, K., Gillum, M. P., Taylor, E. B., Teesch, L. M., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.020 · Cited by 93 · see citing works
Farnesoid X Receptor Protects against Kidney Injury in Uninephrectomized Obese Mice
Gai, Z., Gui, T., Hiller, C., & Kullak-Ublick, G. A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.694323 · Cited by 92 · see citing works
Usui, H. K., Shikata, K., Sasaki, M., Okada, S., Matsuda, M., Shikata, Y., Ogawa, D., Kido, Y., Nagase, R., Yozai, K., et al. (2007) · Diabetes · doi:10.2337/db06-0359 · Cited by 91 · see citing works
Tofte, N., Suvitaival, T., Ahonen, L. L., Winther, S. A., Theilade, S., Frimodt‐Møller, M., Ahluwalia, T. S., & Rossing, P. R. (2019) · Scientific Reports · doi:10.1038/s41598-019-52916-w · Cited by 88 · see citing works
Free Fatty Acids and Their Metabolism Affect Function and Survival of Podocytes
Sieber, J., & Jehle, A. W. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00186 · Cited by 88 · see citing works
Combating oxidative stress in diabetic complications with Nrf2 activators: How much is too much?
Tan, S. M., & de Haan, J. B. (2014) · Redox Report · doi:10.1179/1351000214y.0000000087 · Cited by 86 · see citing works
Diabetes reduces the cholesterol exporter ABCA1 in mouse macrophages and kidneys
Tang, C., Kanter, J. E., Bornfeldt, K., LeBoeuf, R. C., & Oram, J. F. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m003525 · Cited by 85 · see citing works
Inflammatory Factors and Exercise in Chronic Kidney Disease
Dungey, M. R., Hull, K. L., Smith, A. C., Burton, J. O., & BISHOP, N. C. (2013) · International Journal of Endocrinology · doi:10.1155/2013/569831 · Cited by 85 · see citing works
Protective effect of thymol on high fat diet induced diabetic nephropathy in C57BL/6J mice
Saravanan, S., & Pari, L. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.11.033 · Cited by 85 · see citing works
Lynch, M. R., Tran, M. T., & Parikh, S. M. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00263.2017 · Cited by 85 · see citing works
Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?
Ashcroft, F. M., Rohm, M., Clark, A., & Brereton, M. F. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.014 · Cited by 84 · see citing works
Smooth muscle cell phenotypic switch
Chaâbane, C., Coen, M., & Bochaton‐Piallat, M. (2014) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000113 · Cited by 82 · see citing works
Foam cell formation containing lipid droplets enriched with free cholesterol by hyperlipidemic serum
Mori, M., Itabe, H., Higashi, Y., Fujimoto, Y., Shiomi, M., Yoshizumi, M., Ouchi, Y., & Takano, T. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31503-0 · Cited by 82 · see citing works
Gastaldelli, A., Repetto, E., Guja, C., Hardy, E., Han, J., Jabbour, S. A., & Ferrannini, E. (2019) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13907 · Cited by 81 · see citing works
Glucose and glycogen in the diabetic kidney: Heroes or villains?
Sullivan, M. A., & Forbes, J. M. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.07.067 · Cited by 81 · see citing works
Katsoulieris, E. N., Mabley, J. G., Samai, M. H., Sharpe, M. A., Green, I. C., & Chatterjee, P. K. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.021 · Cited by 80 · see citing works
Endothelial Fatty Acid Transport: Role of Vascular Endothelial Growth Factor B
Hagberg, C. E., Mehlem, A., Falkevall, A., Muhl, L., & Eriksson, U. (2013) · Physiology · doi:10.1152/physiol.00042.2012 · Cited by 78 · see citing works
Cao, W., Xu, J., Zhou, Z. M., Wang, G. B., Hou, F. F., & Nie, J. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4603 · Cited by 77 · see citing works
Monocytes and macrophages as protagonists in vascular complications of diabetes
Kanter, J. E., Hsu, C.-C., & Bornfeldt, K. E. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00010 · Cited by 76 · see citing works
Subcutaneous Adipocyte Lipolysis Contributes to Circulating Lipid Levels
Rydén, M., & Arner, P. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309759 · Cited by 75 · see citing works
Mishra, R., & Simonson, M. S. (2005) · Cardiovascular Diabetology · doi:10.1186/1475-2840-4-2 · Cited by 73 · see citing works
Ruggiero, C., Elks, C. M., Kruger, C., Cleland, E., Addison, K., Noland, R. C., & Stadler, K. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00484.2013 · Cited by 73 · see citing works
Underlying Mechanisms of Renal Lipotoxicity in Obesity
Escasany, E., Izquierdo‐Lahuerta, A., & Medina‐Gómez, G. (2019) · The Nephron journals/Nephron journals · doi:10.1159/000494694 · Cited by 73 · see citing works
Iwai, T., Kume, S., Chin‒Kanasaki, M., Kuwagata, S., Araki, H., Takeda, N., Sugaya, T., Uzu, T., Maegawa, H., & Araki, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17111868 · Cited by 72 · see citing works
Lipid metabolism and its implications for type 1 diabetes-associated cardiomyopathy
Ritchie, R. H., Zerenturk, E. J., Prakoso, D., & Calkin, A. C. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0249 · Cited by 72 · see citing works
Lipid Droplet Accumulation Is Associated with an Increase in Hyperglycemia-Induced Renal Damage
Kiss, É., Kränzlin, B., Wagenblaβ, K., Bonrouhi, M., Thiery, J., Gröne, E. F., Nordström, V., Teupser, D., Gretz, N., Malle, E., et al. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.11.033 · Cited by 68 · see citing works
Jiang, X., Yu, J., Wang, X., Ge, J., & Li, N. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s195456 · Cited by 68 · see citing works
The Fatty Kidney: Obesity and Renal Disease
Praga, M., & Morales, E. (2016) · The Nephron journals/Nephron journals · doi:10.1159/000447674 · Cited by 67 · see citing works
Koh, E. S., Lim, J. H., Kim, M. Y., Chung, S., Shin, S. J., Choi, B. S., Kim, H. W., Hwang, S. Y., Kim, S. W., Park, C. W., et al. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0563-4 · Cited by 67 · see citing works
Yin, Q., Zhang, R., Li, L., Wang, Y.-T., Liu, J., Zhang, J., Bai, L., Cheng, J., Fu, P., & Liu, F. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.730564 · Cited by 66 · see citing works
Hellmuth, C., Demmelmair, H., Schmitt, I., Peißner, W., Blüher, M., & Koletzko, B. V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074927 · Cited by 66 · see citing works
Pereira, M. J., Skrtic, S., Katsogiannos, P., Abrahamsson, N., Sidibeh, C. O., Dahgam, S., Månsson, M., Risérus, U., Kullberg, J., & Eriksson, J. W. (2016) · Metabolism · doi:10.1016/j.metabol.2016.09.008 · Cited by 65 · see citing works
Zhang, Z., Wu, P., Zhang, J., Wang, S., & Zhang, G. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.01.005 · Cited by 65 · see citing works
Oxidative modification of low-density lipoproteins and the outcome of renal allografts at 11/2 years
Bosmans, J., Holvoet, P., Dauwe, S. E. H., Ysebaert, D., Chapelle, T., Jürgens, A., Kovacic, V., Marck, E. A. V., Broe, M. E. D., & Verpooten, G. A. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00752.x · Cited by 65 · see citing works
Exercise counteracts lipotoxicity by improving lipid turnover and lipid droplet quality
Zacharewicz, E., Hesselink, M. K. C., & Schrauwen, P. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12729 · Cited by 63 · see citing works
Insulin Resistance and NAFLD: A Dangerous Liaison beyond the Genetics
Manco, M. (2017) · Children · doi:10.3390/children4080074 · Cited by 63 · see citing works
Cellular Cholesterol Transport Proteins in Diabetic Nephropathy
Tsun, J. G., Yung, S., Chau, M. K. M., Shiu, S. W. M., Chan, T. M., & Tan, K. C. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105787 · Cited by 62 · see citing works
Hafiane, A., Bielicki, J. K., Johansson, J. O., & Genest, J. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131997 · Cited by 61 · see citing works
Role of PPARγ in renoprotection in Type 2 diabetes: molecular mechanisms and therapeutic potential
Yang, J., Zhang, D., Li, J., Zhang, X., Fan, F., & Guan, Y. (2008) · Clinical Science · doi:10.1042/cs20070462 · Cited by 61 · see citing works
Mehlem, A., Palombo, I., Wang, X., Hagberg, C. E., Eriksson, U., & Falkevall, A. (2016) · Diabetes · doi:10.2337/db15-1231 · Cited by 60 · see citing works
Xiao, L., Zhang, T., Geng, J., Wu, Z., Xu, L., Liu, J., Tian, J., Zhou, Z., Nie, J., & Bai, X. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7634 · Cited by 60 · see citing works
Sastre, C., Rubio‐Navarro, A., Buendía, I., Gómez‐Guerrero, C., Blanco, J., Mas, S., Egido, J., Blanco‐Colio, L. M., Ortíz, A., & Moreno, J. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083713 · Cited by 60 · see citing works
Self-citationNew Era of Lipid-Lowering Drugs
Barter, P. J., & Rye, K. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.012203 · Cited by 59 · see citing works
Susceptibility of Podocytes to Palmitic Acid Is Regulated by Stearoyl-CoA Desaturases 1 and 2
Sieber, J., Weins, A., Kampe, K., Gruber, S., Lindenmeyer, M. T., Cohen, C. D., Orellana, J. M., Mundel, P. H., & Jehle, A. W. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.05.023 · Cited by 59 · see citing works
Macrophage Functions in Atherosclerosis
Zeller, I., & Srivastava, S. (2014) · Circulation Research · doi:10.1161/circresaha.114.305641 · Cited by 56 · see citing works
Abnormal HDL Apolipoprotein A-I and A-II Kinetics in Hemodialysis Patients
Okubo, K., Ikewaki, K., Sakai, S., Tada, N., Kawaguchi, Y., & Mochizuki, S. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000117286.85443.7d · Cited by 56 · see citing works
Taylor, R., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., Sattar, N., Welsh, P., Peters, C., Zhyzhneuskaya, S., et al. (2018) · Diabetologia · doi:10.1007/s00125-017-4503-0 · Cited by 55 · see citing works
Role of oxidized low-density lipoprotein in the atherosclerosis of uremia
Drüeke, T. B., Nguyen‐Khoa, T., Massy, Z. A., Witko‐Sarsat, V., Lacour, B., & Descamps‐Latscha, B. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.59780114.x · Cited by 55 · see citing works
Hosokawa, K., Takata, T., Sugihara, T., Matono, T., Koda, M., Kanda, T., Taniguchi, S., Ida, A., Mae, Y., Yamamoto, M., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010190 · Cited by 54 · see citing works
Kolleritsch, S., Kien, B., Schoiswohl, G., Diwoky, C., Schreiber, R., Heier, C., Maresch, L. K., Schweiger, M., Eichmann, T. O., Stryeck, S., et al. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz119 · Cited by 54 · see citing works
Albumin contributes to kidney disease progression in Alport syndrome
Jarad, G., Knutsen, R. H., Mecham, R. P., & Miner, J. H. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00456.2015 · Cited by 54 · see citing works
Gheith, O. A. A., Sobh, M. A. K., Mohamed, K. E.-S., El-Baz, M. A., El-Husseini, F., Gazarin, S. S., Ahmed, H. A.-E.-H., Rasem, M. W., & Amer, G. M. (2002) · The Nephron journals/Nephron journals · doi:10.1159/000065021 · Cited by 53 · see citing works
Merscher, S., Pedigo, C. E., & Mendez, A. J. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00169 · Cited by 52 · see citing works
SREBP-1 Mediates Angiotensin II-Induced TGF-β1 Upregulation and Glomerular Fibrosis
Wang, T. N., Chen, X., Li, R., Gao, B., Mohammed‐Ali, Z., Lü, C., Yum, V., Dickhout, J. G., & Krepinsky, J. C. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013121332 · Cited by 51 · see citing works
Serum Adiponectin and Renal Dysfunction in Men With Type 2 Diabetes
Lin, J., Hu, F. B., & Curhan, G. C. (2007) · Diabetes Care · doi:10.2337/dc06-1296 · Cited by 51 · see citing works
Flagged first, then by citations
1 of the 257 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The crucial role and mechanism of insulin resistance in metabolic disease
Zhao, X., An, X., Yang, C., Sun, W., Ji, H., & Lian, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1149239 · Cited by 630 · see citing works
Signaling pathways of chronic kidney diseases, implications for therapeutics
Yuan, Q., Tang, B., & Zhang, C. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01036-5 · Cited by 477 · see citing works
Targeting inflammation to treat diabetic kidney disease: the road to 2030
Rayego‐Mateos, S., Rodrigues-Díez, R. R., Fernández‐Fernández, B., Fernández, C. M., Marchant, V. A., Donate‐Correa, J., Navarro‐González, J. F., Ortíz, A., & Ruiz‐Ortega, M. (2022) · Kidney International · doi:10.1016/j.kint.2022.10.030 · Cited by 376 · see citing works
Jiang, W., Xu, C., Du, C., Dong, J., Xu, S., Hu, B.-F., Feng, R., Zang, D., Meng, X., Huang, C., et al. (2021) · Theranostics · doi:10.7150/thno.63735 · Cited by 188 · see citing works
Mitochondrial metabolic reprogramming in diabetic kidney disease
Fan, X., Yang, M., Lang, Y., Lu, S., Kong, Z., Gao, Y., Shen, N., Zhang, D., & Lv, Z. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06833-0 · Cited by 158 · see citing works
Roles and crosstalks of macrophages in diabetic nephropathy
Li, H.-D., You, Y., Shao, B., Wu, W., Wang, Y.-F., Guo, J.-B., Meng, X., & Chen, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1015142 · Cited by 134 · see citing works
Podocyte injury of diabetic nephropathy: Novel mechanism discovery and therapeutic prospects
Li, X., Zhang, Y., Xing, X., Mi, L., Liu, Y., Xu, A., & Zhang, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115670 · Cited by 139 · see citing works
Hou, Y., Tan, E., Shi, H., Ren, X., Wan, X., Wu, W., Chen, Y., Niu, H., Zhu, G., Li, J., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-05078-y · Cited by 127 · see citing works
Han, Y., Xiong, S., Zhao, H., Yang, S., Yang, M., Zhu, X., Jiang, N., Xiong, X., Gao, P., Wei, L., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04326-y · Cited by 120 · see citing works
Dai, Y., Quan, J., Xiong, L., Luo, Y., & Yi, B. (2022) · Renal Failure · doi:10.1080/0886022x.2022.2079522 · Cited by 115 · see citing works
Ferroptosis as a Novel Therapeutic Target for Diabetes and Its Complications
Yang, X., & Yang, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.853822 · Cited by 105 · see citing works
Programmed Cell Death in Diabetic Nephropathy: A Review of Apoptosis, Autophagy, and Necroptosis
Erekat, N. S. (2022) · Medical Science Monitor · doi:10.12659/msm.937766 · Cited by 97 · see citing works
The role of lipotoxicity in kidney disease: From molecular mechanisms to therapeutic prospects
Ren, L., Cui, H., Wang, Y., Ju, F., Cai, Y., Gang, X., & Wang, G. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114465 · Cited by 99 · see citing works
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy
Zhou, Y., Liu, L., Jin, B., Wu, Y., Xu, L., Chang, X., Hu, L., Wang, G., Huang, Y., Song, L., et al. (2023) · Diabetes · doi:10.2337/db22-0680 · Cited by 91 · see citing works
Carpentier, A. C. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00620.2020 · Cited by 89 · see citing works
Lv, L., Zhou, Y., Chen, X., Gong, L., Wu, J., Luo, W., Shen, Y., Han, S., Hu, J., Wang, Y., et al. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s318255 · Cited by 86 · see citing works
Czaja-Stolc, S., Potrykus, M., Stankiewicz, M., Kaska, Ł., & Małgorzewicz, S. (2022) · Nutrients · doi:10.3390/nu14071457 · Cited by 85 · see citing works
Lv, C., Cheng, T., Zhang, B., Sun, K., & Lu, K. (2023) · Renal Failure · doi:10.1080/0886022x.2023.2165103 · Cited by 83 · see citing works
Glucose and glycogen in the diabetic kidney: Heroes or villains?
Sullivan, M. A., & Forbes, J. M. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.07.067 · Cited by 81 · see citing works
Diabetes and its complications: molecular mechanisms, prevention and treatment
Zhao, L., Yuan, J., Yang, Q., Ma, J., Yang, F., Zou, Y., Liu, K., & Liu, F. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02401-w · Cited by 80 · see citing works
Interplay of lipid metabolism and inflammation in podocyte injury
Luo, Z., Chen, Z., Hu, J., & Ding, G. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155718 · Cited by 74 · see citing works
Insulin Resistance, Obesity, and Lipotoxicity
Yazıcı, D., Demir, S. Ç., & Sezer, H. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_14 · Cited by 76 · see citing works
Hu, T., Yue, J., Tang, Q., Cheng, K., Chen, F., Peng, M., Zhou, Q., & Wang, M. (2022) · Food & Function · doi:10.1039/d1fo03958j · Cited by 67 · see citing works
Significance of Metformin Use in Diabetic Kidney Disease
Kawanami, D., Takashi, Y., & Tanabe, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124239 · Cited by 62 · see citing works
Rong, Q., Han, B., Li, Y., Yin, H., Li, J., & Hou, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.729384 · Cited by 59 · see citing works
New Pandemic: Obesity and Associated Nephropathy
Sharma, I., Liao, Y., Zheng, X., & Kanwar, Y. S. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.673556 · Cited by 57 · see citing works
Renoprotective Effects of DPP-4 Inhibitors
Kawanami, D., Takashi, Y., Takahashi, H., Motonaga, R., & Tanabe, M. (2021) · Antioxidants · doi:10.3390/antiox10020246 · Cited by 57 · see citing works
The Updates of Podocyte Lipid Metabolism in Proteinuric Kidney Disease
Sun, Y., Cui, S., Hou, Y., & Yi, F. (2021) · Kidney Diseases · doi:10.1159/000518132 · Cited by 54 · see citing works
Functions of Stress-Induced Lipid Droplets in the Nervous System
Islimye, E., Girard, V., & Gould, A. P. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.863907 · Cited by 55 · see citing works
The mechanisms of glycolipid metabolism disorder on vascular injury in type 2 diabetes
Chen, X., Shi, C., Wang, Y., Yu, H., Zhang, Y., Zhang, J., Li, P., & Gao, J. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.952445 · Cited by 54 · see citing works
Senolytic combination of dasatinib and quercetin attenuates renal damage in diabetic kidney disease
Guo, X., Si, W., Wang, J., Zeng, X., Yu, H., Chen, Y., Zhu, X., & Li, X. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155705 · Cited by 51 · see citing works
Fatty kidney disease: The importance of ectopic fat deposition and the potential value of imaging
Mende, C. W., & EINHORN, D. F. (2021) · Journal of Diabetes · doi:10.1111/1753-0407.13232 · Cited by 49 · see citing works
Liu, H.-J., Miao, H., Yang, J.-Z., Liu, F., Cao, G., & Zhao, Y. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101861 · Cited by 49 · see citing works
Rotten to the Cortex: Ceramide-Mediated Lipotoxicity in Diabetic Kidney Disease
Nicholson, R. J., Pezzolesi, M. G., & Summers, S. A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.622692 · Cited by 49 · see citing works
Du, X., Ma, X., Tan, Y., Shao, F., Li, C., Zhao, Y., Miao, Y., Han, L., Dang, G., Song, Y., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01313-x · Cited by 49 · see citing works
Chen, Y., Liao, L., Wang, B., & Wu, Z. H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1332279 · Cited by 48 · see citing works
Lipotoxic Proximal Tubular Injury: A Primary Event in Diabetic Kidney Disease
Wang, H., Zhang, S., & Guo, J. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.751529 · Cited by 45 · see citing works
Type 2 Diabetes and Alzheimer’s Disease: The Emerging Role of Cellular Lipotoxicity
Marrano, N., Biondi, G., Borrelli, A., Rella, M., Zambetta, T., Gioia, L. D., Caporusso, M., Logroscino, G., Perrini, S., Giorgino, F., et al. (2023) · Biomolecules · doi:10.3390/biom13010183 · Cited by 44 · see citing works
Lin, P., & Duann, P. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.01050 · Cited by 45 · see citing works
Gu, W., Wang, X., Zhao, H., Geng, J., Li, X., Zheng, K., Guan, Y., Hou, X., Wang, C., & Song, G. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174776 · Cited by 44 · see citing works
Advances in energy metabolism in renal fibrosis
Wei, X. S., Hou, Y., Long, M., Jiang, L., & Du, Y. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121033 · Cited by 44 · see citing works
Lu, J., Li, X., Chen, P., Zhang, J.-X., Li, L., Wang, G., Liu, X.-Q., Jiang, C., & Ma, K. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01160-0 · Cited by 42 · see citing works
Wang, Z., Wu, Q., Wang, H., Gao, Y., Nie, K., Tang, Y., Su, H., Hu, M., Gong, J., Fang, K., et al. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154276 · Cited by 42 · see citing works
Mini-Review: GSDME-Mediated Pyroptosis in Diabetic Nephropathy
Li, W., Sun, J., Zhou, X., Lu, Y., Cui, W., & Miao, L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.780790 · Cited by 38 · see citing works
Wang, X., Song, M., Li, X., Su, C., Yang, Y., Wang, K., Liu, C., Zheng, Z., Jia, Y., Ren, S., et al. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00144.2023 · Cited by 38 · see citing works
Molecular mechanism of renal lipid accumulation in diabetic kidney disease
Fang, Z., Liu, R., Xie, J., & He, C. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18364 · Cited by 38 · see citing works
The Potential Roles of Post-Translational Modifications of PPARγ in Treating Diabetes
Ji, X., Zhang, W., Yin, L., Shi, Z., Luan, J., Chen, L., & Liu, L. (2022) · Biomolecules · doi:10.3390/biom12121832 · Cited by 37 · see citing works
Podocyte Death in Diabetic Kidney Disease: Potential Molecular Mechanisms and Therapeutic Targets
Zhong, S., Wang, N., & Zhang, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169035 · Cited by 43 · see citing works
Lipid abnormality in diabetic kidney disease and potential treatment advancements
Tu, Q. M., Jin, H. M., & Yang, X. H. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1503711 · Cited by 37 · see citing works
Çatak, M., Konuk, Ş. G., & Hepşen, S. (2025) · Journal of Diabetes Investigation · doi:10.1111/jdi.70086 · Cited by 37 · see citing works
Takata, T., & Isomoto, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094374 · Cited by 37 · see citing works
Artimovič, P., Špaková, I., Macejková, E., Pribulová, T., Rabajdová, M., Mareková, M., & Závacká, M. (2024) · Genes and Immunity · doi:10.1038/s41435-024-00283-6 · Cited by 36 · see citing works
The dual role of lipids in chronic kidney disease: Pathogenic culprits and therapeutic allies
Giardini, E., Moore, D., Sadlier, D. M., Godson, C., & Brennan, E. P. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.118615 · Cited by 36 · see citing works
Dejenie, T. A., Abebe, E. C., Mengstie, M. A., Seid, M. A., Gebeyehu, N. A., Adella, G. A., Kassie, G. A., Gebrekidan, A. Y., Gesese, M. M., Tegegne, K. D., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1124367 · Cited by 38 · see citing works
Zhao, J., He, K., Du, H., Wei, G., Wen, Y., Wang, J., Zhou, X., & Wang, J. (2022) · PeerJ · doi:10.7717/peerj.13932 · Cited by 34 · see citing works
Chen, Y., Chen, M., Zhu, W., Zhang, Y., Liu, P., & Li, P. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112560 · Cited by 34 · see citing works
Role of sex hormones in diabetic nephropathy
Liu, J., Liu, Z., Sun, W., Luo, L., An, X., Yu, D., & Wang, W. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1135530 · Cited by 34 · see citing works
Yu, Q., Chen, Y., Zhao, Y., Huang, S., Xin, X., Jiang, L., Wang, H., Wu, W., Qu, L., Xiang, C., et al. (2023) · Kidney Diseases · doi:10.1159/000529995 · Cited by 33 · see citing works
Chen, J., Wu, K., Yan, L., Huang, M., Cheng, L., Guan, H., Lin, J., Zhong, M., Wang, X., & Zheng, Z. (2023) · Endocrinology and Metabolism · doi:10.3803/enm.2022.1604 · Cited by 33 · see citing works
Iordan, L., Gaiţă, L., Timar, R. Z., Avram, V. F., Sturza, A., & Timar, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137057 · Cited by 33 · see citing works
Tubular Mas receptor mediates lipid-induced kidney injury
Kong, Y., Zhao, X., Qiu, M., Lin, Y., Feng, P., Li, S., Liang, B., Zhu, Q., Huang, H., Li, C., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-020-03375-z · Cited by 33 · see citing works
Zhu, W., Chen, M., Wang, Y., Chen, Y., Zhang, Y., Wang, Y., Liu, P., & Li, P. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110711 · Cited by 33 · see citing works
The Potential Effects of Dietary Antioxidants in Obesity: A Comprehensive Review of the Literature
Almoraie, N. M., & Shatwan, I. M. (2024) · Healthcare · doi:10.3390/healthcare12040416 · Cited by 32 · see citing works
Chang, J., Yu, Y., Fang, Z., He, H., Wang, D., Teng, J., & Yang, L. (2020) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-020-00618-z · Cited by 32 · see citing works
Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease
Jiang, S., & Su, H. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01323-w · Cited by 33 · see citing works
LncRNA H19: a novel player in the regulation of diabetic kidney disease
Wu, Q., & Huang, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1238981 · Cited by 31 · see citing works
Xie, Y., Yuan, Q., Tang, B., Xie, Y., Cao, Y., Qiu, Y., Zeng, J., Wang, Z., Su, H., & Zhang, C. (2024) · Diabetes · doi:10.2337/db23-0811 · Cited by 31 · see citing works
Macêna, M. D. L., Nunes, L. F. D. S., da Silva, A. F., Pureza, I. R. D. O. M., Praxedes, D. R. S., Santos, J. C. D. F., & Bueno, N. B. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac035 · Cited by 28 · see citing works
Ha, S., Yang, Y., Kim, B. M., Kim, J., Son, M., Kim, D., Yu, H. S., Im, D., Chung, H. Y., & Chung, K. W. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166474 · Cited by 28 · see citing works
Dibenzoylmethane ameliorates lipid-induced inflammation and oxidative injury in diabetic nephropathy
Lee, E. Y., Kwon, M.-H., Kim, H. M., Kim, N., Kim, Y. M., Kim, H. S., Lee, E. Y., & Chung, C. H. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0206 · Cited by 28 · see citing works
Cai, L.-Q., Chen, Y., Xue, H., Yang, Y., Wang, Y., Xu, J., Zhu, C., He, L., & Xiao, Y. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117354 · Cited by 27 · see citing works
Xiao, Y., Deng, J., Li, C., Gong, X., Gui, Z., Huang, J., Zhang, Y., Liu, Y., Ye, X., & Li, X. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153488 · Cited by 27 · see citing works
Moustafa, E. M., Rashed, E. R., Rashed, R. R., & Omar, N. N. (2021) · International Journal of Immunopathology and Pharmacology · doi:10.1177/20587384211016194 · Cited by 27 · see citing works
Escasany, E., Lanzón, B., García-Carrasco, A., Izquierdo‐Lahuerta, A., Torres, L., Corrales, P., Rodríguez‐Rodríguez, A. E., Lima, S. L., Martínez‐Álvarez, C., Rupérez, F. J., et al. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.048249 · Cited by 27 · see citing works
Nagarajan, M., Maadurshni, G. B., & Manivannan, J. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23533 · Cited by 27 · see citing works
Cao, Z., Zhao, H., Fan, J., Shen, Y., Han, L., Jing, G., Zeng, X. L., Jin, X., Zhu, Z., Bian, Q., et al. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01304-5 · Cited by 26 · see citing works
Zhang, J. Y., Liu, C., Peng, Y. H., Fang, Q., Wei, X., Zhang, C., Sun, L., Hu, Z., Hong, J., Gu, W., et al. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02003-5 · Cited by 25 · see citing works
Yang, X., Jiang, D., Wang, Y.-Z., Duan, M.-Y., Huang, Y., Wang, X., Xiang, Z.-M., Sheng, J., & Zhu, Q. (2024) · Renal Failure · doi:10.1080/0886022x.2024.2371988 · Cited by 25 · see citing works
Liu, K., Zhao, X., Qi, X., Hou, D.-L., Li, H.-B., Gu, Y., & Xu, Q. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113388 · Cited by 25 · see citing works
Intermittent Fasting—A Healthy Dietary Pattern for Diabetic Nephropathy
Yang, M., Chen, W., He, L., Liu, D., Zhao, L., & Wang, X. (2022) · Nutrients · doi:10.3390/nu14193995 · Cited by 25 · see citing works
ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders
Cao, X., Song, L., & Yang, J. (2021) · Clinical Science · doi:10.1042/cs20200752 · Cited by 24 · see citing works
Fatty kidney: A possible future for chronic kidney disease research
Kanbay, M., Çöpür, S., Demiray, A., Sag, A. A., Covic, A. C., Ortíz, A., & Tuttle, K. R. (2022) · European Journal of Clinical Investigation · doi:10.1111/eci.13748 · Cited by 24 · see citing works
Zhang, Y., Yao, H., Li, C., Sun, W., Chen, X., Cao, Y. W., Liu, Y., Liu, Y., Chen, J., Qi, J., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6275505 · Cited by 24 · see citing works
The Roles of Fatty Acids and Apolipoproteins in the Kidneys
Pan, X. (2022) · Metabolites · doi:10.3390/metabo12050462 · Cited by 27 · see citing works
Locatelli, M., Macconi, D., Corna, D., Cerullo, D., Rottoli, D., Remuzzi, G., Benigni, A., & Zoja, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158345 · Cited by 26 · see citing works
Opazo-Ríos, L., Matus, Y. S., Rodrigues-Díez, R. R., Carpio, D., Droguett, A., Egido, J., Gómez‐Guerrero, C., & Mezzano, S. A. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001242 · Cited by 24 · see citing works
Self-citationTramontano, D., D'Erasmo, L., Larouche, M., Brisson, D., Lauzière, A., Di Costanzo, A., Bini, S., Minicocci, I., Covino, S., Baratta, F., et al. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119146 · Cited by 23 · see citing works
Fenofibrate Attenuates Renal Tubular Cell Apoptosis by Up-Regulating MCAD in Diabetic Kidney Disease
Tang, C., Deng, X., Qu, J., Miao, Y., Tian, L., Zhang, M., Li, X., Sun, B., & Chen, L. (2023) · Drug Design Development and Therapy · doi:10.2147/dddt.s405266 · Cited by 22 · see citing works
Yu, W., Haoyu, Y., Ling, Z., Xing, H., Pengfei, X., Anzhu, W., Lili, Z., & Linhua, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1549484 · Cited by 22 · see citing works
Tubular Injury in Diabetic Kidney Disease: Early Diagnosis and Intervention Strategies
Lv, Y., Ye, C., Li, Z., Ye, J., Cao, H., Zhang, C., Jiang, H., & Wang, Y. (2025) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.70098 · Cited by 26 · see citing works
Liu, P., Ma, L., Zhao, H., Shen, Z., Zhou, X., Yan, M., Zhao, T., Zhang, H., Qiu, X., & Li, P. (2020) · Journal of Diabetes Research · doi:10.1155/2020/8721536 · Cited by 22 · see citing works
Li, R., Sun, X., Li, P., Li, W., Zhao, L., Zhu, L., & Zhu, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.646113 · Cited by 22 · see citing works
The Astragaloside IV Derivative LS-102 Ameliorates Obesity-Related Nephropathy
Li, Z., Yang, W., Yang, Y., Wu, J., Luo, P., & Liu, Y. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s346546 · Cited by 22 · see citing works
Qi, L., Kang, N., Chen, X., Li, Z., Deng, C., & Chen, S. (2022) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s359811 · Cited by 21 · see citing works
Hong, S., Hong, Y., Lee, M., Keum, B., & Kim, G. (2023) · Nutrients · doi:10.3390/nu15061490 · Cited by 21 · see citing works
Fu, Z., Su, X., Zhou, Q., Feng, H., Ding, R., & Ye, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1192694 · Cited by 21 · see citing works
Exploring the Genetic Conception of Obesity via the Dual Role of FoxO
Behl, T., Kaur, I., Sehgal, A., Singh, S., Zengin, G., Negruţ, N., Nistor-Cseppento, C. D., Pavel, F. M., Aron, R. A. C., & BUNGAU, S. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063179 · Cited by 22 · see citing works
Role of CD36 in Palmitic Acid Lipotoxicity in Neuro-2a Neuroblastoma Cells
Urso, C. J., & Zhou, H. (2021) · Biomolecules · doi:10.3390/biom11111567 · Cited by 21 · see citing works
Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice
Zhang, J., Qiu, L.-J., Liu, Z., Liu, J., Yu, B., Liu, C., Ren, B., Zhang, J., Li, S., Guan, Y., et al. (2024) · Journal of Pineal Research · doi:10.1111/jpi.12964 · Cited by 20 · see citing works
Obesity: The Fat Tissue Disease Version of Cancer
Boubertakh, B., Silvestri, C., & Marzo, V. D. (2022) · Cells · doi:10.3390/cells11121872 · Cited by 20 · see citing works
- Authors
- Opazo-Ríos, L., Mas, S., Marín-Royo, G., Mezzano, S., Gómez-Guerrero, C., Moreno, J. A., & Egido, J.
- Affiliations
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Renal, Vascular and Diabetes Research Laboratory, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), 28040 Madrid, Spain
- Austral University of Chile (CL)
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Corresponding author
- Mas, Sebastián
- Moreno, Juan Antonio
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-04-10
- Volume
- 21
- Issue
- 7
- Pages
- 2632
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7177360
- OpenAlex
- W3015924535
- Cited by
- 363
- References
- 257
- Citations by year
- 2026: 61 · 2025: 68 · 2024: 72 · 2023: 66 · 2022: 61 · 2021: 27 · 2020: 6 · 2019: 1 · 2018: 1
- FWCI
- 6.47
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion)
- Biblos-e Archivo (Universidad Autónoma de Madrid) (submittedVersion, public-domain)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Universidad de Córdoba Insitutional Repository (Universidad de Córdoba) (submittedVersion, cc-by)
- Hispana (submittedVersion)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by)
- Funders
- Instituto de Salud Carlos III (PI17/01495, PI17/00130, SAF2015-63696-R)
- Ministerio de Ciencia e Innovación (DTS17/00203, RTI2018-098788-B-100, DTS19/00093, RYC-2017-22369)
- Fondo Nacional de Desarrollo Científico y Tecnológico (1160465)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- lipotoxicity, diabetic nephropathy, ectopic fat deposition, type 2 diabetes, insulin resistance, hyperinsulinemia, free fatty acids, lipid metabolism, podocyte injury, tubular damage, mesangial cell proliferation, endothelial activation, foam cells, inflammation, oxidative stress, mitochondrial dysfunction, cell death, treatment options
- MeSH terms
- Clinical Decision-Making, Adipose Tissue, Animals, Diabetic Nephropathies, Disease Susceptibility, Fatty Acids, Nonesterified, Glycogen, Humans, Kidney, Mitochondria, Obesity, Prognosis, Signal Transduction, Biomarkers, Disease Management, Dyslipidemias, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review