Cited by 99Tea Polyphenols and EffectsChemotherapy-induced organ toxicity mitigationChronic Kidney Disease and Diabetes

Protective Effects of Epigallocatechin-3-Gallate from Green Tea in Various Kidney Diseases

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Kanlaya, Rattiyaporn, Thongboonkerd, Visith·2019·Advances in Nutrition

Abstract

Kidney diseases are common health problems worldwide. Various etiologies (e.g., diabetes, hypertension, drug-induced nephrotoxicity, infection, cancers) can affect renal function and ultimately lead to development of chronic kidney disease (CKD) and end-stage renal disease (ESRD). The global rise in number of CKD/ESRD patients during recent years has led to tremendous concern to look for effective strategies to prevent or slow progression of CKD and ESRD. Natural compounds derived from herbs or medicinal plants have gained wide attention for scientific scrutiny to achieve such goals. One of such natural compounds that has been extensively investigated is epigallocatechin-3-gallate (EGCG), a major polyphenol found in the tea plant (Camellia sinensis). A growing body of recent evidence has shown that EGCG may be a promising therapeutic or protective agent in various kidney diseases. This article thus highlights recent progress in medical research on beneficial effects of EGCG against a broad spectrum of kidney diseases, including acute kidney injury, cisplatin-induced nephrotoxicity, kidney stone disease, glomerulonephritis, lupus nephritis, renal cell carcinoma, diabetic nephropathy, CKD, and renal fibrosis. The renoprotective mechanisms are also detailed. Finally, future perspectives of medical research on EGCG and its potential use in clinical practice for treatment and prevention of kidney diseases are discussed.

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  • Carotenoids, flavonoids, alkaloids, and other natural products are effective as preventive and therapeutic agents against oxidative mechanisms in kidney diseases.

    “Carotenoids, flavonoids, alkaloids, and other natural products have been shown to be effective as preventive and therapeutic agents against oxidative mechanisms occurring in kidney diseases (Kanlaya and Thongboonkerd 2019).”

    From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Kanlaya and Thongboonkerd 2019

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Authors
Kanlaya, R., & Thongboonkerd, V.
Affiliations
Siriraj Hospital (TH)
Corresponding author
Thongboonkerd, Visith
Venue
Advances in Nutrition
Publisher
Elsevier BV
Published
2019-01
Volume
10
Issue
1
Pages
112-121
ISSN
  • 2156-5376 (ISSN-L)
  • 2161-8313
OpenAlex
W2907766166
Cited by
99
References
120
Citations by year
2026: 12 · 2025: 10 · 2024: 18 · 2023: 22 · 2022: 12 · 2021: 12 · 2020: 8 · 2019: 5
FWCI
4.75
Type
journal article
Language
en
Open access
Locations
  • Advances in Nutrition (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Thailand Research Fund (IRN60W0004, IRG5980006)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Chemotherapy-induced organ toxicity mitigation
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Keywords
epigallocatechin gallate, green tea, Camellia sinensis, polyphenols, kidney disease, chronic kidney disease, end-stage renal disease, acute kidney injury, cisplatin nephrotoxicity, kidney stones, glomerulonephritis, lupus nephritis, renal cell carcinoma, diabetic nephropathy, renal fibrosis, renal protection, natural compounds
MeSH terms
Catechin, Humans, Kidney, Kidney Diseases, Tea, Protective Agents

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