The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
Ferritinophagy and ferroptosis in the management of metabolic diseases
Open accessAbstract
Ferroptosis is a form of regulated cell death modality associated with disturbed iron-homeostasis and unrestricted lipid peroxidation. Ample evidence has depicted an essential role for ferroptosis as either the cause or consequence for human diseases, denoting the likely therapeutic promises for targeting ferroptosis in the preservation of human health. Ferritinophagy, a selective form of autophagy, contributes to the initiation of ferroptosis through degradation of ferritin, which triggers labile iron overload (IO), lipid peroxidation, membrane damage, and cell death. In this review, we will delineate the role of ferritinophagy in ferroptosis, and its underlying regulatory mechanisms, to unveil the therapeutic value of ferritinophagy as a target in the combat of ferroptosis to manage metabolic diseases.
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1 retracted
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Self-citationRetractedFerroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
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Autophagy in the Pathogenesis of Disease
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Self-citationACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293
Ferroptosis: molecular mechanisms and health implications
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Self-citationInactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
Kagan, V. E., Mao, G., Qu, F., Angeli, J. P. F., Doll, S., Croix, C. S., Dar, H. H., Liu, B., Tyurin, V. A., Ritov, V. B., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2238 · Cited by 3,029
Autophagy promotes ferroptosis by degradation of ferritin
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Self-citationFerroptosis as a target for protection against cardiomyopathy
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Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
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Cited by
Iron Homeostasis and Ferroptosis in Human Diseases: Mechanisms and Therapeutic Prospects
Ru, Q., Li, Y., Chen, L., Wu, Y., Min, J., & Wang, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01969-z · Cited by 724
The Role of Iron in Cancer Progression
Guo, Q., Li, L., Hou, S., Yuan, Z., Li, C., Zhang, W., Zheng, L., & Li, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.778492 · Cited by 150
Zhao, C., Pu, Z., Gao, J., Liu, C., Xing, J., Lang, W., Chen, J., Yuan, C., & Zhou, C. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c05595 · Cited by 26
PRMT4 interacts with NCOA4 to inhibit ferritinophagy in cisplatin‐induced acute kidney injury
Zhou, L., Deng, Z., Wang, Y., Zhang, H., Yan, S., Kanwar, Y. S., Wang, Y., Dai, Y., & Deng, F. (2024) · The FASEB Journal · doi:10.1096/fj.202302596r · Cited by 16
Metadata
- Authors
- Ajoolabady, A., Aslkhodapasandhokmabad, H., Libby, P., Tuomilehto, J., Lip, G. Y. H., Penninger, J. M., Richardson, D. R., Tang, D., Zhou, H., Wang, S., Klionsky, D. J., Kroemer, G., & Ren, J.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 32
- Issue
- 7
- Pages
- 444-462
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W3162516608
- Cited by
- 334
- References
- 125
- FWCI
- 12.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Ajoolabady, A., Aslkhodapasandhokmabad, H., Libby, P., Tuomilehto, J., Lip, G. Y. H., Penninger, J. M., Richardson, D. R., Tang, D., Zhou, H., Wang, S., Klionsky, D. J., Kroemer, G., & Ren, J. (2021). Ferritinophagy and ferroptosis in the management of metabolic diseases. Trends in Endocrinology & Metabolism. https://doi.org/10.1016/j.tem.2021.04.010
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
