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Cited by 26Mangiferin and Mango ExtractsChronic Kidney Disease and DiabetesFerroptosis and cancer prognosis

“Multiomics” Analyses Combined with Systems Pharmacology Reveal the Renoprotection of Mangiferin Monosodium Salt in Rats with Diabetic Nephropathy: Focus on Improvements in Renal Ferroptosis, Renal Inflammation, and Podocyte Insulin Resistance

Zhao, Chuanping, Pu, Zejiang, Gao, Jian, Liu, Chang, Xing, Jianzhong, Lang, Wenbo, Chen, Jinting, Yuan, Chunmao +1 more·2023·Journal of Agricultural and Food Chemistry
DOI 10.1021/acs.jafc.2c05595
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Abstract

We explored the protection of mangiferin monosodium salt (MGM) on kidney injury in rats with streptozotocin (STZ)-induced diabetic nephropathy (DN) by "multiomics" analysis combined with systems pharmacology, with a specific focus on ferroptosis, inflammation, and podocyte insulin resistance (IR) signaling events in kidneys. MGM treatment afforded renoprotective effects on rats with STZ-induced DN by alleviating systemic IR-induced renal inflammation and podocyte IR. These mechanisms were correlated mainly with the MGM treatment-induced inhibition of the mitogen-activated protein kinase/nuclear factor-kappa B axis and activation of the phosphorylated insulin receptor substrate 1(Tyr608)/phosphorylated phosphatidylinositol 3-kinase/phosphorylated protein kinase B axis in the kidneys of DN rats. MGM had an ameliorative function in renal ferroptosis in rats with STZ-induced DN by upregulating mevalonate-mediated antioxidant capacities (glutathione peroxidase 4 and ferroptosis suppressor protein 1/coenzyme Q10 axis) and weakening acyl-CoA synthetase long-chain family member 4-mediated proferroptotic generation of lipid drivers in kidneys. MGM may be a promising alternative strategy for the treatment of DN.

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Crossref · 10.1021/acs.jafc.2c05595

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  • Structural modifications and derivatives such as monosodium MGF enhance efficacy partly via modulation of oxidative stress pathways.

    “Structural modifications and derivatives such as monosodium MGF also enhance efficacy, partly via the modulation of oxidative stress pathways (194).”

    From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [194]

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Authors
Zhao, C., Pu, Z., Gao, J., Liu, C., Xing, J., Lang, W., Chen, J., Yuan, C., & Zhou, C.
Affiliations
  • Hebei University (CN)
  • Department of Monitoring and Analysis, Baoding Environmental Monitoring Center of Hebei Province, 224 Dongfeng Road, Lianchi District, Baoding071000, China
  • Hebei Medical University (CN)
  • State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang550014, China
Corresponding author
Zhou, Chengyan
ORCID
Venue
Journal of Agricultural and Food Chemistry
Publisher
American Chemical Society (ACS)
Published
2022-12-15
Volume
71
Issue
1
Pages
358-381
ISSN
  • 0021-8561 (ISSN-L)
  • 1520-5118
DOI
10.1021/acs.jafc.2c05595
OpenAlex
W4311510828
Cited by
26
References
6
Citations by year
2026: 3 · 2025: 8 · 2024: 9 · 2023: 6
FWCI
5.99
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Agricultural and Food Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Natural Science Foundation of Hebei Province (H2020201291)
  • Guizhou Science and Technology Corporation Platform Talents Fund (QKHRCPT 20195106)
  • State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University (FAMP202006K)
  • Innovation Capacity Improvement Plan of Hebei Province (20567605H)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
Keywords
diabetic nephropathy, renal protection, renal inflammation, IRS-1, mevalonate pathway, GPX4, ferroptosis suppressor protein 1, lipid peroxidation, streptozotocin-induced diabetes, multi-omics, systems pharmacology
MeSH terms
Ferroptosis, Network Pharmacology, Multiomics, Animals, Diabetes Mellitus, Diabetic Nephropathies, Inflammation, Insulin Resistance, Kidney, Streptozocin, Xanthones, Podocytes, Rats

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