Detection of shortened activated partial thromboplastin times: an evaluation of different commercial reagents

Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis

Koster, T., Vandenbroucke, J. P., Rosendaal, F. R., Briët, E., Rosendaal, F. R., & Blann, A. D. (1995) · The Lancet · doi:10.1016/s0140-6736(95)90166-3 · Cited by 1,131 · see citing works

High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis

Meijers, J. C. M., Tekelenburg, W. L. H., Bouma, B. N., Bertina, R. M., & Rosendaal, F. R. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003093421004 · Cited by 699 · see citing works

Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease

Lane, D. A., & Grant, P. J. (2000) · Blood · doi:10.1182/blood.v95.5.1517.005k48_1517_1532 · Cited by 492 · see citing works

High Plasma Concentration of Factor VIIIc Is a Major Risk Factor for Venous Thromboembolism

Anker, P. I. '., Koopman, M. M. W., Reitsma, P. H., Prins, M. H., van den Ende, A., Buller, H. R., & Kraaijenhagen, R. A. (2000) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613747 · Cited by 490 · see citing works

High levels of factor IX increase the risk of venous thrombosis

Vlieg, A. V. H., van der Linden, I. K., Bertina, R. M., & Rosendaal, F. R. (2000) · Blood · doi:10.1182/blood.v95.12.3678 · Cited by 403 · see citing works

A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism

Tripodi, A., Chantarangkul, V., Martinelli, I., Bucciarelli, P., & Mannucci, P. M. (2004) · Blood · doi:10.1182/blood-2004-03-1042 · Cited by 230 · see citing works

High Prevalence of Elevated Factor VIII Levels in Patients Referred for Thrombophilia Screening: Role of Increased Synthesis and Relationship to the Acute Phase Reaction

O’Donnell, J. S., Tuddenham, E. G. D., Manning, R. A., Kemball‐Cook, G., Johnson, D., & Laffan, M. (1997) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1656061 · Cited by 227 · see citing works

Changes of Plasma Coagulation and Fibrinolysis in Response to Mental Stress

Jern, C., Eriksson, E., Tengborn, L., Risberg, B., Wadenvik, H., & Jern, S. (1989) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646899 · Cited by 206 · see citing works

Effects of short-term glucocorticoids on hemostatic factors in healthy volunteers

Brotman, D. J., Girod, J. P., Posch, A., Jani, J. T., Patel, J. V., Gupta, M. K., Lip, G. Y. H., Reddy, S. S. K., & Kickler, T. S. (2005) · Thrombosis Research · doi:10.1016/j.thromres.2005.06.006 · Cited by 173 · see citing works

Disseminated Intravascular Coagulation: Pathophysiological Mechanisms and Manifestations

Bick, R. L. (1998) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2007-994971 · Cited by 141 · see citing works

Short Activated Partial Thromboplastin Times Are Related to Increased Thrombin Generation and an Increased Risk for Thromboembolism

Korte, W. C., Clarke, S., & Lefkowitz, J. B. (2000) · American Journal of Clinical Pathology · doi:10.1309/g98j-ana9-rmnc-xlyu · Cited by 98 · see citing works

Prediction of recurrent venous thromboembolism by the activated partial thromboplastin time

Hron, G., Eichinger, S., Weltermann, A., Quehenberger, P., Halbmayer, W. M., & Kyrle, P. A. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01868.x · Cited by 77 · see citing works

Alterations of Factor VIII von Willebrand Factor in Clinical Conditions Associated with an Increase in its Plasma Concentration

Lombardi, R. M., Mannucci, P. M., Seghatchian, M. J., Vicente, V., & Coppola, R. (1981) · British Journal of Haematology · doi:10.1111/j.1365-2141.1981.tb07197.x · Cited by 72 · see citing works

Venous Thromboembolism in Acute Stroke

Landi, G. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530270093024 · Cited by 67 · see citing works

Marked elevation of thrombin generation in patients with elevated FVIII:C and venous thromboembolism

O’Donnell, J. S., Mumford, A. D., Manning, R. A., & Laffan, M. (2001) · British Journal of Haematology · doi:10.1046/j.1365-2141.2001.03146.x · Cited by 64 · see citing works

Abnormally short activated partial thromboplastin time values are associated with increased risk of recurrence of venous thromboembolism after oral anticoagulation withdrawal

Legnani, C., Mattarozzi, S., Cini, M., Cosmi, B., Favaretto, E., & Palareti, G. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06130.x · Cited by 59 · see citing works

Abnormally Short Activated Partial Thromboplastin Times Are Related to Elevated Plasma Levels of TAT, F1+2, D-Dimer and FVIII:C

ten Boekel, E., & Bartels, P. (2002) · Pathophysiology of Haemostasis and Thrombosis · doi:10.1159/000065217 · Cited by 51 · see citing works

Partial Thromboplastin Time

Reddy, N. M., Hall, S. W., & MacKintosh, F. R. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.22.2706 · Cited by 46 · see citing works

Subjects with a shortened activated partial thromboplastin time show increased in‐hospital mortality associated with elevated D‐dimer, C‐reactive protein and glucose levels

ten Boekel, E., de Kieviet, W., & Bartels, P. C. M. (2003) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510310002338 · Cited by 12 · see citing works

Thrombin Generation and Factor VIII:C Levels in Patients with Type 1 Diabetes Complicated by Nephropathy

Ibbotson, S. H., Rayner, H. C., Stickland, M. H., Davies, J. A., & Grant, P. J. (1993) · Diabetic Medicine · doi:10.1111/j.1464-5491.1993.tb00075.x · Cited by 7 · see citing works

Activated partial thromboplastin time: results of a case–control study evaluating six commercial reagents in assessing the risk of venous thromboembolism

Tripodi, A., Chantarangkul, V., Asti, D., Martinelli, I., & Mannucci, P. M. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01983.x · Cited by 2 · see citing works

Guidance from the Scientific and Standardization Committee for lupus anticoagulant/antiphospholipid antibodies of the International Society on Thrombosis and Haemostasis

Devreese, K. M. J., de Groot, P. G., de Laat, B., Erkan, D., Favaloro, E. J., Mackie, I., Martinuzzo, M., Ortel, T. L., Pengo, V., Rand, J. H., et al. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15047 · Cited by 439 · see citing works

Statistical Methods Used to Test for Agreement of Medical Instruments Measuring Continuous Variables in Method Comparison Studies: A Systematic Review

Zaki, R. A., Bulgiba, A. M., Ismail, R., & Ismail, N. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037908 · Cited by 303 · see citing works

Lupus anticoagulant detection in anticoagulated patients. Guidance from the Scientific and Standardization Committee for lupus anticoagulant/antiphospholipid antibodies of the International Society on Thrombosis and Haemostasis

Tripodi, A., Cohen, H., & Devreese, K. M. J. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14846 · Cited by 143 · see citing works

Thrombotic antiphospholipid syndrome: A practical guide to diagnosis and management

Sayar, Z., Moll, R., Isenberg, D. A., & Cohen, H. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.10.010 · Cited by 110 · see citing works

Evaluation of the activated partial thromboplastin time assay for clinical monitoring of PEG ylated recombinant factor VIII ( BAY 94‐9027) for haemophilia A

Gu, J., Ramsey, P., Evans, V., Tang, L., Apeler, H., Leong, L., Murphy, J. E., Laux, V., & Myles, T. (2014) · Haemophilia · doi:10.1111/hae.12374 · Cited by 70 · see citing works

Shortened activated partial thromboplastin time: causes and management

Lippi, G., Salvagno, G. L., Ippolito, L., Franchini, M., & Favaloro, E. J. (2010) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0b013e328338dbe8 · Cited by 68 · see citing works

Prothrombin Time and Partial Thromboplastin Time Assay Considerations

Ng, V. L. (2009) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2009.05.002 · Cited by 65 · see citing works

Monitoring of anticoagulation in thrombotic antiphospholipid syndrome

Cohen, H., Efthymiou, M., & Devreese, K. M. J. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15217 · Cited by 56 · see citing works

A laboratory evaluation into the short activated partial thromboplastin time

Mina, A., Favaloro, E. J., Mohammed, S., & Koutts, J. (2010) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0b013e3283365770 · Cited by 54 · see citing works

APTT therapeutic range for monitoring unfractionated heparin therapy. Significant impact of the anti‐Xa reagent used for correlation

Toulon, P. A., Smahi, M., & Pooter, N. D. (2021) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15264 · Cited by 49 · see citing works

Monitoring unfractionated heparin therapy: Lack of standardization of anti‐Xa activity reagents

Smahi, M., Pooter, N. D., Hollestelle, M. J., & Toulon, P. A. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14969 · Cited by 41 · see citing works

Shortened activated partial thromboplastin time, a hemostatic marker for hypercoagulable state during acute coronary event

Abdullah, W. Z., Moufak, S. K., Yusof, Z., Mohamad, M. S., & Musa, K. I. (2010) · Translational research · doi:10.1016/j.trsl.2010.02.001 · Cited by 38 · see citing works

Improving hemocompatibility and accelerating endothelialization of vascular stents by a copper-titanium film

Liu, H., Pan, C., Zhou, S., Li, J., Huang, N., & Dong, L. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.08.028 · Cited by 31 · see citing works

Testing for Lupus Anticoagulants

Moore, G. W. (2022) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0042-1744363 · Cited by 30 · see citing works

Alterations in some blood coagulation parameters in naturally occurring cases of canine babesiosis

Rafaj, R. B., Matijatko, V., Kiš, I., Kučer, N., Živičnjak, T., Lemo, N., Žvorc, Z., Brkljačić, M., & Mrljak, V. (2009) · Acta Veterinaria Hungarica · doi:10.1556/avet.57.2009.2.10 · Cited by 30 · see citing works

Corrosion and ion release behavior of Cu/Ti film prepared via physical vapor deposition in vitro as potential biomaterials for cardiovascular devices

Liu, H., Zhang, D., Shen, F., Zhang, G., & Song, S. (2012) · Applied Surface Science · doi:10.1016/j.apsusc.2012.03.106 · Cited by 23 · see citing works

Relationship between short activated partial thromboplastin times, thrombin generation, procoagulant factors and procoagulant phospholipid activity

Mina, A., Favaloro, E. J., & Koutts, J. (2012) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0b013e32834fa7d6 · Cited by 20 · see citing works

Dynamic APTT parameters: applications in thrombophilia

Sørensen, B., & Ingerslev, J. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04600.x · Cited by 16 · see citing works

Antiphospholipid Syndrome: State of the Art of Clinical Management

Depietri, L., Veropalumbo, M. R., Leone, M. C., & Ghirarduzzi, A. (2023) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-023-07496-3 · Cited by 16 · see citing works

Development of an electrospun biomimetic polyurea scaffold suitable for vascular grafting

Madhavan, K. P. C., Frid, M. G., Hunter, K. S., Shandas, R., Stenmark, K. R., & Park, D. (2017) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33853 · Cited by 14 · see citing works

Investigation on biological properties of tacrolimus-loaded poly(1,3-trimethylene carbonate) in vitro

Hou, R., Wu, L., Wang, J., & Huang, N. (2010) · Applied Surface Science · doi:10.1016/j.apsusc.2010.03.042 · Cited by 14 · see citing works

Survey on antiphospholipid syndrome diagnosis and antithrombotic treatment in patients with ischemic stroke, other brain ischemic injury, or arterial thromboembolism in other sites: communication from ISTH SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies

Cohen, H., Werring, D. J., Chandratheva, A., Mittal, P., Devreese, K. M. J., Isenberg, D. A., Amoura, Z., ANDRADE, D. C. O. D., Baccouche, H., Baldwin, N., et al. (2023) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2023.06.020 · Cited by 11 · see citing works

Hemocompatibility and anti-endothelialization of copper–titanium coating for vena cava filters

Liu, H., Zhang, D., Shen, F., Zhang, G., & Song, S. (2012) · Surface and Coatings Technology · doi:10.1016/j.surfcoat.2012.02.025 · Cited by 10 · see citing works

Anticoagulation Monitoring

Ng, V. (2009) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2009.05.003 · Cited by 9 · see citing works

Vitamin K Deficiency Bleeding in a Standardbred Colt

McGorum, B. C., Henderson, I. S. F., Stirling, D., Wallace, R., Haggart, C. R., & Thomas, A. E. (2009) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2009.0388.x · Cited by 8 · see citing works

Viewpoint: Lupus anticoagulant detection and interpretation in antiphospholipid syndrome

Efthymiou, M., Bertolaccini, M. L., & Cohen, H. (2024) · Rheumatology · doi:10.1093/rheumatology/kead623 · Cited by 5 · see citing works

The clinical significance of a shortened activated partial thromboplastin time in patients with connective tissue disease

Habe, K., Wada, H., Mizutani, K., Matsushima, Y., Kondo, M., & Yamanaka, K. (2021) · Clinical Rheumatology · doi:10.1007/s10067-021-05781-w · Cited by 5 · see citing works

Significantly different coagulation factor activities underlying the variability of ‘normal’ activated partial thromboplastin time

Park, K., Kwon, E.-H., Ma, Y., Park, I.-A., Kim, S.-W., Kim, S., & Kim, H. (2011) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0b013e32834a6136 · Cited by 5 · see citing works

Are shortened aPTT values always to be attributed only to preanalytical problems?

Biljak, V. R., Tomas, M., Lapić, I., & Saračević, A. (2024) · Diagnosis · doi:10.1515/dx-2024-0050 · Cited by 5 · see citing works

Evaluation of Potential Clinical Surrogate Markers of a Trauma Induced Alteration of Clotting Factor Activities

Burggraf, M., Payas, A., Schoeneberg, C., Wegner, A., Kauther, M. D., & Lendemans, S. (2016) · BioMed Research International · doi:10.1155/2016/5614086 · Cited by 4 · see citing works

Comparison of a fluorogenic anti-FXa assay with a central laboratory chromogenic anti-FXa assay for measuring LMWH activity in patient plasmas

Harris, L. F., Castro-López, V., Jenkins, P. V., O’Donnell, J. S., & Killard, A. J. (2011) · Thrombosis Research · doi:10.1016/j.thromres.2011.07.011 · Cited by 4 · see citing works

Covalent Inactivation of Factor VIII Antibodies from Hemophilia A Patients by an Electrophilic FVIII Analog

Planque, S. A., Escobar, M. A., Smith, K. C., Taguchi, H., Nishiyama, Y., Donnachie, E., Pratt, K. P., & Paul, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800589200 · Cited by 3 · see citing works

The Predictive Value of the aCL and Anti-β2GPI at the Time of Acute Deep Vein Thrombosis—A Two-Year Prospective Study

Pirkmajer, K. P., Žigon, P., Boc, A., Podovšovnik, E., Čučnik, S., Mavri, A., Rotar, Ž., & Ambrožič, A. (2021) · Biomedicines · doi:10.3390/biomedicines9080901 · Cited by 3 · see citing works

An inorganic coating and flexible regulating in situ of stent endothelialization by the controllable ion releasing

Liu, H., Pan, C., Liu, Y., & Huang, N. (2018) · Materials Research Bulletin · doi:10.1016/j.materresbull.2018.06.035 · Cited by 2 · see citing works

Peptide analogues of 1811–1818 loop of the A3 subunit of the light chain A3-C1–C2 of FVIII of blood coagulation: biological evaluation

Patsialas, K., Koutsas, C., Makris, P. E., & Liakopoulou-Kyriakides, M. T. (2010) · Amino Acids · doi:10.1007/s00726-009-0464-z · Cited by 2 · see citing works

Novel Clinical and Laboratory Correlations for Antiphospholipid Syndrome

Llorente‐Chávez, A., Canales, S. B., Beverido-Florido, Á. M., & Collazo, A. O. (2025) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2025.07.006 · Cited by 1 · see citing works

Shortened Coagulation Profile in Pregnancy

Dr. Balaji, S., Teja, K. R., Govindaraj, T. B., & Sivani, A. (2022) · Scholars Journal of Applied Medical Sciences · doi:10.36347/sjams.2022.v10i01.018 · Cited by 1 · see citing works

High‐dose glucocorticoid therapy is associated with shortening of activated partial thromboplastin time and prothrombin time

Canovi, S., Pilia, A., Bonelli, E., Bonanno, A., Zaldini, P., & Colla, R. (2021) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.13503

Sensibilidad del TTPa en la detección de una deficiencia de factores de coagulación.

Lombana, M., Ramos, G., Torres, A. M. H., & Sanabria, P. (2012) · Revista Colombiana de Hematología y Oncología · doi:10.51643/22562915.320

Laboratory Monitoring Unfractionated Heparin Treatments: Unanswered Issues

Toulon, P. A. (2026) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.70195

Comparison of four commercially available activated partial thromboplastin time reagents using a semi-automated coagulometer

Shetty, S., Ghosh, K., & Mohanty, D. (2003) · Blood Coagulation & Fibrinolysis · doi:10.1097/00001721-200307000-00011 · Cited by 28 · see citing works

Activated Partial Thromboplastin Time

Italian (C.I.S.M.E.L.) Study Group, CIAVARELLA, N., COCCHERI, S., Mannucci, P. M., Canciani, M. T., Mariani, G., Mori, P. G., Orlando, M., Tentori, L., & Ponari, O. (1981) · Scandinavian Journal of Haematology · doi:10.1111/j.1600-0609.1981.tb01408.x · Cited by 32 · see citing works

Activated partial thromboplastin time. A multicenter evaluation of 11 reagents in the screening of mild haemophilia A.

(1980) · PubMed

Detection of Mild Clotting Factor Deficiencies. Critical Role of the Activated Partial Thromboplastin Time (aPTT) Reagent

Toulon, P. A., Eloit, Y., Smahi, M., Jambou, D., Appert‐Flory, A., & Fischer, F. (2015) · Blood · doi:10.1182/blood.v126.23.3281.3281 · Cited by 6 · see citing works

The APTTCan Monitor for Increased Thrombotic Risk.

Mengshol, S. C., & Lefkowitz, J. B. (2004) · Blood · doi:10.1182/blood.v104.11.3508.3508