Viewpoint: Lupus anticoagulant detection and interpretation in antiphospholipid syndrome

Efthymiou, Maria; Bertolaccini, Maria Laura; Cohen, Hannah

doi:10.1093/rheumatology/kead623

Cited by 5Systemic Lupus Erythematosus ResearchBlood Coagulation and Thrombosis MechanismsVasculitis and related conditions

Viewpoint: Lupus anticoagulant detection and interpretation in antiphospholipid syndrome

Efthymiou, Maria, Bertolaccini, Maria Laura, Cohen, Hannah·2024·Rheumatology

DOI 10.1093/rheumatology/kead623

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Abstract

Lupus anticoagulant (LA) is a well-established risk factor for the clinical manifestations of antiphospholipid syndrome (APS). Accurate LA detection is an essential prerequisite for optimal diagnosis and management of patients with APS or aPL carriers. Variability remains a challenge in LA testing, with reliable detection influenced by multiple factors, including pre-analytical conditions, anticoagulation treatment, choice of tests and procedures performed, as well as interpretation of results, that can lead to false-positives or negatives. A standardised approach to LA testing, following current guidance, based on published data and international consensus, and with attention to detail, is required to underpin accurate detection of LA. Future work should focus on better characterisation of the nature of LA, which may ultimately lead to improved diagnosis and management of patients with APS and aPL carriers. This article reviews current practice and challenges, providing an overview on detection of LA.

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Authors: Efthymiou, M., Bertolaccini, M. L., & Cohen, H.
Affiliations: University College London Hospitals NHS Foundation Trust (GB)
Academic Department of Vascular Surgery, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London , London, UK
Corresponding author: Cohen, Hannah
ORCID: Efthymiou, Maria
Bertolaccini, Maria Laura
Cohen, Hannah
Venue: Rheumatology
Publisher: Oxford University Press (OUP)
Published: 2024-02-01
Volume: 63
Issue: SI
Pages: SI54-SI63
ISSN: 1462-0324 (ISSN-L)
1462-0332
DOI: 10.1093/rheumatology/kead623
OpenAlex: W4391579838
Cited by: 5
References: 112
Citations by year: 2026: 3 · 2024: 2
FWCI: 1.36
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Lara D. Veeken (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: King’s BHF Centre for Award Excellence (RE/18/2/34213)
Topics: Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
Keywords: lupus anticoagulant, antiphospholipid syndrome, pre-analytical variables, anticoagulation, false positives, test interpretation
MeSH terms: Humans, Lupus Coagulation Inhibitor, Antiphospholipid Syndrome

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