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Cited by 59Systemic Lupus Erythematosus ResearchBlood Coagulation and Thrombosis MechanismsVasculitis and related conditions

Lupus Anticoagulant Identifies Two Distinct Groups of Patients with Different Antibody Patterns

Pengo, V., Del Ross, T., Ruffatti, A., Bison, E., Cattini, M.G., Pontara, E., Testa, S., Legnani, C. +5 more·2018·Thrombosis Research
DOI 10.1016/j.thromres.2018.11.003
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Abstract

Background Whether antibodies directed to β2-Glycoprotein I (aβ2GPI) are responsible for LA activity is not well defined. However, in the absence of such antibodies the molecule responsible for LA phenomenon is unknown. Objective The aim of this study was the biochemical identification of the target antigen epitope of aPL responsible of LA activity in the absence of aβ2GPI antibodies together with the biological and clinical characteristics of these patients in comparison with classical triple positive patients. Patients/methods A comparison of patients with LA without (LA+/aβ2GPI-) and those with (LA+/aβ2GPI+) associated aβ2GPI antibodies was performed. Size exclusion chromatography and analytical chromatography were used to identify the molecule with LA activity in patients LA+/aβ2GPI-. Results and conclusions Analytical size-exclusion chromatography revealed a peak of 996Kd with LA activity perfectly overlapping that of IgM anti phosphatidylserine/prothrombin (aPS/PT) antibodies. Similarly, all the 25 LA+/aβ2GPI- patients were positive for aPS/PT antibodies. LA+/aβ2GPI- compared to 33 LA+/aβ2GPI+ patients turned out to be significantly older, with a lower rate of previous thromboembolic events and a weaker LA activity. Search for aPS/PT and aβ2GPI antibodies in patients with LA is useful to identify two subgroups of LA at different risk of thromboembolic events.

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Crossref · 10.1016/j.thromres.2018.11.003

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  • aPS/PT can be considered a surrogate of LA as these antibodies generally present in triple-positive patients and are responsible for the majority of LA activity.

    “Test for anti-phosphatydilserine/prothrombin antibodies (aPS/PT), which can be considered a surrogate of LA as these antibodies generally present in triple-positive patients (determining the so-called “tetra-positivity”) and are responsible for the majority of LA activity [88,89].”

    From Lupus Anticoagulant Detection under the Magnifying Glass (2023) · cites this paper as [88]

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Authors
Pengo, V., Del Ross, T., Ruffatti, A., Bison, E., Cattini, M. G., Pontara, E., Testa, S., Legnani, C., Pozzi, N., Peterle, D., Acquasaliente, L., De Filippis, V., & Denas, G.
Affiliations
  • University of Padua (IT)
  • Istituti Ospitalieri di Cremona (IT)
  • University of Bologna (IT)
  • Saint Louis University (US)
Corresponding author
Pengo, V.
ORCID
Venue
Thrombosis Research
Publisher
Elsevier BV
Published
2018-12
Volume
172
Pages
172-178
ISSN
0049-3848 (ISSN-L)
DOI
10.1016/j.thromres.2018.11.003
OpenAlex
W2899593773
Cited by
59
References
5
Citations by year
2026: 5 · 2025: 1 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 20 · 2019: 4
FWCI
6.83
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Thrombosis Research (publishedVersion)
  • PubMed (publishedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
Keywords
lupus anticoagulant, beta2-glycoprotein I, anti-phosphatidylserine/prothrombin antibodies, antiphosphatidylserine antibodies, anti-prothrombin antibodies, thromboembolic risk, size exclusion chromatography, autoantibody patterns
MeSH terms
Adult, Aged, Aged, 80 and over, Antibodies, Child, Female, Humans, Immunoglobulin M, Male, Middle Aged, Phosphatidylserines, Prothrombin, Thromboembolism, Lupus Coagulation Inhibitor, beta 2-Glycoprotein I

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