Dissecting ICRAC, a store-operated calcium current

Hogan, Patrick G.; Rao, Anjana

doi:10.1016/j.tibs.2007.03.009

Cited by 117Ion Channels and ReceptorsCalcium signaling and nucleotide metabolismIon channel regulation and function

Dissecting ICRAC, a store-operated calcium current

Hogan, Patrick G., Rao, Anjana·2007·Trends in Biochemical Sciences

DOI 10.1016/j.tibs.2007.03.009

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Abstract

The use of Ca(2+) for intracellular signalling necessitates tight local and global control of cytoplasmic Ca(2+) concentration, and mechanisms for maintaining the net Ca(2+) balance. It has long been recognized that intracellular Ca(2+) stores exert control over Ca(2+) influx at the plasma membrane through a process of store-operated Ca(2+) entry (SOCE). The Ca(2+) current I(CRAC) is the best characterized instance of SOCE, but the elements of the pathway leading to I(CRAC) have eluded biochemical definition for more than a decade. However, the recent identification of key proteins underlying I(CRAC)--STIM1 and Orai1--has led to several insights into this ER-to-plasma membrane signalling system and to the recognition that it is an ancient and conserved mechanism in multicellular organisms.

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The La3+-induced block of Ca2+ currents is a pharmacological hallmark of SOC channels.
“The La 3ϩ -induced block of Ca 2ϩ currents is a pharmacological hallmark of SOC channels (3, 4), further strengthening the functional similarity between CMC and SOC channels in mammalian cells.”
From Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress (2010) · cites this paper as [3]
In eukaryotes, the ER constitutes a finite reservoir of Ca2+ primarily mobilized for signaling that must be replenished to sustain signaling and restore Ca2+ homeostasis.
“It is known that in eukaryotes the ER constitutes a finite reservoir of Ca 2ϩ primarily mobilized for signaling that must be replenished to sustain the duration of signaling and ultimately restore Ca 2ϩ homeostasis in the ER and the cytosol (1-3, 32).”
From Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress (2010) · cites this paper as [3]

Ionic channels of excitable membranes
(1985) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(85)90172-7 · Cited by 7,133 · see citing works
The versatility and universality of calcium signalling
Berridge, M. J., Lipp, P., & Bootman, M. D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036035 · Cited by 5,701 · see citing works
Ionic Channels of Excitable Membranes
Keynes, R. D. (1985) · Trends in Neurosciences · doi:10.1016/0166-2236(85)90088-8 · Cited by 2,600 · see citing works
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate
Streb, H., Irvine, R. F., Berridge, M. J., & Schulz, I. (1983) · Nature · doi:10.1038/306067a0 · Cited by 2,592 · see citing works
A model for receptor-regulated calcium entry
Putney, J. W. (1986) · Cell Calcium · doi:10.1016/0143-4160(86)90026-6 · Cited by 2,575 · see citing works
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
Feske, S., Gwack, Y., Prakriya, M., Srikanth, S., Puppel, S.-H., Tanasă, B., Hogan, P. G., Lewis, R. S., Daly, M. J., & Rao, A. (2006) · Nature · doi:10.1038/nature04702 · Cited by 2,278 · see citing works
Self-citation
STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx
Liou, J., Kim, M. L., Heo, W. D., Jones, J. T., Myers, J. W., Ferrell, J. E., & Meyer, T. (2005) · Current Biology · doi:10.1016/j.cub.2005.05.055 · Cited by 2,126 · see citing works
Store-Operated Calcium Channels
Parekh, A. B., & Putney, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00057.2003 · Cited by 2,089 · see citing works
Calcium oscillations increase the efficiency and specificity of gene expression
Dolmetsch, R. E., Xu, K., & Lewis, R. S. (1998) · Nature · doi:10.1038/31960 · Cited by 1,896 · see citing works
STIM1, an essential and conserved component of store-operated Ca2 + channel function
Roos, J., DiGregorio, P. J., Yeromin, A. V., Ohlsen, K. L., Lioudyno, M., Zhang, S., Safrina, O., Kozak, J. A., Wagner, S. L., Cahalan, M. D., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200502019 · Cited by 1,819 · see citing works
Depletion of intracellular calcium stores activates a calcium current in mast cells
Hoth, M., & Penner, R. (1992) · Nature · doi:10.1038/355353a0 · Cited by 1,743 · see citing works
AN INTRODUCTION TO TRP CHANNELS
Ramsey, I. S., Delling, M., & Clapham, D. E. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040204.100431 · Cited by 1,549 · see citing works
Capacitative calcium entry revisited
Putney, J. W. (1990) · Cell Calcium · doi:10.1016/0143-4160(90)90016-n · Cited by 1,487 · see citing works
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
Zhang, S. L., Yu, Y., Roos, J., Kozak, J. A., Deerinck, T. J., Ellisman, M. H., Stauderman, K. A., & Cahalan, M. D. (2005) · Nature · doi:10.1038/nature04147 · Cited by 1,374 · see citing works
Orai1 is an essential pore subunit of the CRAC channel
Prakriya, M., Feske, S., Gwack, Y., Srikanth, S., Rao, A., & Hogan, P. G. (2006) · Nature · doi:10.1038/nature05122 · Cited by 1,338 · see citing works
Self-citation
CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca 2+ Entry
Vig, M., Peinelt, C., Beck, A., Koomoa, D. L., Rabah, D., Koblan‐Huberson, M., Kraft, S., Turner, H. C., Fleig, A., Penner, R., et al. (2006) · Science · doi:10.1126/science.1127883 · Cited by 1,322 · see citing works
Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences
Rizzuto, R., & Pozzan, T. (2005) · Physiological Reviews · doi:10.1152/physrev.00004.2005 · Cited by 1,201 · see citing works
CORRELATED MORPHOMETRIC AND BIOCHEMICAL STUDIES ON THE LIVER CELL
Weibel, E. R., Stäubli, W., Gnägi, H. R., & Hess, F. A. (1969) · The Journal of Cell Biology · doi:10.1083/jcb.42.1.68 · Cited by 1,142 · see citing works
The TRP Superfamily of Cation Channels
Montell, C. (2005) · Science s STKE · doi:10.1126/stke.2722005re3 · Cited by 993 · see citing works
Genome-wide RNAi screen of Ca 2+ influx identifies genes that regulate Ca 2+ release-activated Ca 2+ channel activity
Zhang, S. L., Yeromin, A. V., Zhang, X. H.-F., Yu, Y., Safrina, O., Penna, A., Roos, J., Stauderman, K. A., & Cahalan, M. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603161103 · Cited by 863 · see citing works
Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression
Li, W., Llopis, J. L., Whitney, M. A., Zlokarnik, G., & Tsien, R. Y. (1998) · Nature · doi:10.1038/31965 · Cited by 845 · see citing works
Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai
Yeromin, A. V., Zhang, S. L., Jiang, W., Yu, Y., Safrina, O., & Cahalan, M. D. (2006) · Nature · doi:10.1038/nature05108 · Cited by 808 · see citing works
Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane
Wu, M. M., Buchanan, J., Luik, R. M., & Lewis, R. S. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200604014 · Cited by 789 · see citing works
Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.
Zweifach, A., & Lewis, R. S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.6295 · Cited by 759 · see citing works
Calcium gradients and buffers in bovine chromaffin cells.
Neher, E., & Augustine, G. J. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019127 · Cited by 753 · see citing works
Calcium release‐activated calcium current in rat mast cells.
Hoth, M., & Penner, R. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019681 · Cited by 726 · see citing works
STIM1 carboxyl-terminus activates native SOC, Icrac and TRPC1 channels
Huang, G. N., Zeng, W., Kim, J. Y., Yuan, J. P., Han, L., Muallem, S., & Worley, P. F. (2006) · Nature Cell Biology · doi:10.1038/ncb1454 · Cited by 641 · see citing works
The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER–plasma membrane junctions
Luik, R. M., Wu, M. M., Buchanan, J., & Lewis, R. S. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200604015 · Cited by 639 · see citing works
Gene regulation mediated by calcium signals in T lymphocytes
Feske, S., Giltnane, J. M., Dolmetsch, R. E., Staudt, L. M., & Rao, A. (2001) · Nature Immunology · doi:10.1038/86318 · Cited by 591 · see citing works
Self-citation
Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
Peinelt, C., Vig, M., Koomoa, D. L., Beck, A., Nadler, M. J. S., Koblan‐Huberson, M., Lis, A., Fleig, A., Penner, R., & Kinet, J. (2006) · Nature Cell Biology · doi:10.1038/ncb1435 · Cited by 581 · see citing works
CRACM1 Multimers Form the Ion-Selective Pore of the CRAC Channel
Vig, M., Beck, A., Billingsley, J. M., Lis, A., Parvez, S., Peinelt, C., Koomoa, D. L., Soboloff, J., Gill, D. L., Fleig, A., et al. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.085 · Cited by 553 · see citing works
Orai1 and STIM Reconstitute Store-operated Calcium Channel Function
Soboloff, J., Spassova, M. A., Tang, X. D., Hewavitharana, T., Xu, W., & Gill, D. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c600126200 · Cited by 550 · see citing works
Large Store-operated Calcium Selective Currents Due to Co-expression of Orai1 or Orai2 with the Intracellular Calcium Sensor, Stim1
Mercer, J. C., DeHaven, W. I., Smyth, J. T., Wedel, B. J., Boyles, R., Bird, G. S. J., & Putney, J. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604589200 · Cited by 546 · see citing works
SARCOPLASMIC RETICULUM AND EXCITATION-CONTRACTION COUPLING IN MAMMALIAN SMOOTH MUSCLES
Devine, C. E., Somlyo, A. V., & Somlyo, A. P. (1972) · The Journal of Cell Biology · doi:10.1083/jcb.52.3.690 · Cited by 529 · see citing works
The endoplasmic reticulum Ca2+ store: a view from the lumen
Meldolesi, J., & Pozzan, T. (1998) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01143-2 · Cited by 528 · see citing works
M olecular D efects in H uman S evere C ombined I mmunodeficiency and A pproaches to I mmune R econstitution
Buckley, R. H. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104614 · Cited by 527 · see citing works
Regulation of calcium influx by second messengers in rat mast cells
Penner, R., Matthews, G., & Neher, E. (1988) · Nature · doi:10.1038/334499a0 · Cited by 494 · see citing works
The organisation and functions of local Ca2+ signals
Bootman, M. D., Lipp, P., & Berridge, M. J. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.12.2213 · Cited by 449 · see citing works
Mitogen-induced oscillations of cytosolic Ca2+ and transmembrane Ca2+ current in human leukemic T cells.
Lewis, R. S., & Cahalan, M. D. (1989) · Cell Regulation · doi:10.1091/mbc.1.1.99 · Cited by 417 · see citing works
Cytokines and immunodeficiency diseases: critical roles of the γc‐dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways
Kovanen, P., & Leonard, W. J. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00203.x · Cited by 409 · see citing works
Repetitive spikes in cytoplasmic calcium evoked by histamine in human endothelial cells
Jacob, R., Merritt, J. E., Hallam, T. J., & RINK, T. J. (1988) · Nature · doi:10.1038/335040a0 · Cited by 408 · see citing works
Stored Ca2+ Depletion-induced Oligomerization of Stromal Interaction Molecule 1 (STIM1) via the EF-SAM Region
Stathopulos, P. B., Li, G.-Y., Plevin, M. J., Ames, J. B., & Ikura, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608247200 · Cited by 404 · see citing works
Biochemical and Functional Characterization of Orai Proteins
Gwack, Y., Srikanth, S., Feske, S., Cruz‐Guilloty, F., Oh‐hora, M., Neems, D. S., Hogan, P. G., & Rao, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609630200 · Cited by 381 · see citing works
Self-citation
Presynaptic calcium and control of vesicle fusion
Schneggenburger, R., & Neher, E. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.05.006 · Cited by 342 · see citing works
Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins
Williams, R. T., Manji, S. S. M., Parker, N. J., HANCOCK, M. S., van Stekelenburg, L., Eid, J.-P., Senior, P. V., Kazenwadel, J., Shandala, T., Saint, R. B., et al. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3570673 · Cited by 325 · see citing works
Flirting in Little Space: The ER/Mitochondria Ca 2+ Liaison
Rizzuto, R., Duchen, M. R., & Pozzan, T. (2004) · Science s STKE · doi:10.1126/stke.2152004re1 · Cited by 319 · see citing works
Coupling of STIM1 to store-operated Ca 2+ entry through its constitutive and inducible movement in the endoplasmic reticulum
Baba, Y., Hayashi, K., Fujii, Y., Mizushima, A., Watarai, H., Wakamori, M., Numaga, T., Mori, Y., Iino, M., Hikida, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608358103 · Cited by 314 · see citing works
STIM1 has a plasma membrane role in the activation of store-operated Ca 2+ channels
Spassova, M. A., Soboloff, J., He, L., Xu, W., Dziadek, M. A., & Gill, D. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510050103 · Cited by 306 · see citing works
Exchange characteristics of the noradrenaline‐sensitive calcium store in vascular smooth muscle cells or rabbit ear artery.
Casteels, R., & Droogmans, G. (1981) · The Journal of Physiology · doi:10.1113/jphysiol.1981.sp013824 · Cited by 290 · see citing works
Separation and Characterization of Currents through Store-operated CRAC Channels and Mg 2+ -inhibited Cation (MIC) Channels
Prakriya, M., & Lewis, R. S. (2002) · The Journal of General Physiology · doi:10.1085/jgp.20028551 · Cited by 270 · see citing works
A novel mechanism for the store-operated calcium influx pathway
Smani, T., Zakharov, S. I., Csutora, P., Leno, E., Trepakova, E. S., & Bolotina, V. M. (2004) · Nature Cell Biology · doi:10.1038/ncb1089 · Cited by 257 · see citing works
The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a primary immunodeficiency.
Partiseti, M., Deist, F. L., Hivroz, C., Fischer, A., Korn, H., & Choquet, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31639-9 · Cited by 255 · see citing works
The calcium channel and the organization of the presynaptic transmitter release face.
Stanley, E. F. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01091-6 · Cited by 255 · see citing works
Fast Exocytosis with Few Ca2+ Channels in Insulin-Secreting Mouse Pancreatic B Cells
Barg, S., Ma, X., Eliasson, L., Galvanovskis, J., Göpel, S. O., Obermüller, S., Platzer, J., Renström, E., Trus, M., Atlas, D., et al. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)75964-4 · Cited by 255 · see citing works
UNLOCKING THE SECRETS OF CELL SIGNALING
Berridge, M. J. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040103.152647 · Cited by 250 · see citing works
STIM2 Is an Inhibitor of STIM1-Mediated Store-Operated Ca2+ Entry
Soboloff, J., Spassova, M. A., Hewavitharana, T., et al. (2006) · Current Biology · doi:10.1016/j.cub.2006.05.051 · Cited by 245 · see citing works
STEREOLOGICAL ANALYSIS OF THE GUINEA PIG PANCREAS
Bolender, R. P. (1974) · The Journal of Cell Biology · doi:10.1083/jcb.61.2.269 · Cited by 241 · see citing works
A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients
Feske, S., Prakriya, M., Rao, A., & Lewis, R. S. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050687 · Cited by 239 · see citing works
Self-citation
Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins
Williams, R. T., Manji, S. S. M., Parker, N. J., et al. (2001) · Biochemical Journal · doi:10.1042/bj3570673 · Cited by 236 · see citing works
Severe combined immunodeficiency. A model disease for molecular immunology and therapy
Fischer, A., Deist, F. L., Hacein‐Bey‐Abina, S., André‐Schmutz, I., Basile, G. D. S., de Villartay, J., & Cavazzana, M. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00223.x · Cited by 233 · see citing works
STIM1: a novel phosphoprotein located at the cell surface
Manji, S. S. M., Parker, N. J., Williams, R. T., van Stekelenburg, L., Pearson, R. B., Dziadek, M. A., & Smith, P. J. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00105-9 · Cited by 232 · see citing works
Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1
Xu, P., Lu, J., Li, Z., Yu, X., Chen, L., & Xu, T. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.134 · Cited by 226 · see citing works
Capacitative Ca2+ Entry Is Closely Linked to the Filling State of Internal Ca2+ Stores: A Study Using Simultaneous Measurements of ICRAC and Intraluminal [Ca2+]
Hofer, A. M., Fasolato, C., & Pozzan, T. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.2.325 · Cited by 214 · see citing works
Muscarinic, alpha‐adrenergic and peptide receptors regulate the same calcium influx sites in the parotid gland.
Putney, J. W. (1977) · The Journal of Physiology · doi:10.1113/jphysiol.1977.sp011851 · Cited by 200 · see citing works
STIM1 regulates Ca2+ entry via arachidonate‐regulated Ca2+‐selective (ARC) channels without store depletion or translocation to the plasma membrane
Mignen, O., Thompson, J. L., & Shuttleworth, T. J. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.122432 · Cited by 192 · see citing works
Identification of stromal cell products that interact with pre-B cells.
Oritani, K., & Kincade, P. W. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.3.771 · Cited by 189 · see citing works
Distinct Properties of CRAC and MIC Channels in RBL Cells
Kozak, J. A., Kerschbaum, H., & Cahalan, M. D. (2002) · The Journal of General Physiology · doi:10.1085/jgp.20028601 · Cited by 181 · see citing works
Dissociation of the store‐operated calcium current ICRAC and the Mg‐nucleotide‐regulated metal ion current MagNuM
Hermosura, M. C., Monteilh‐Zoller, M. K., Scharenberg, A. M., et al. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013361 · Cited by 180 · see citing works
Ca 2+ Entry Through Plasma Membrane IP 3 Receptors
Dellis, O., Dedos, S., Tovey, S. C., Taufiq-Ur-Rahman, Dubel, S. J., & Taylor, C. W. (2006) · Science · doi:10.1126/science.1125203 · Cited by 177 · see citing works
Noradrenaline, vasopressin and angiotensin increase Ca2+ influx by opening a common pool of Ca2+ channels in isolated rat liver cells
Mauger, J., Poggioli, J., Guesdon, F., & Claret, M. (1984) · Biochemical Journal · doi:10.1042/bj2210121 · Cited by 167 · see citing works
Signaling Mechanism for Receptor-activated Canonical Transient Receptor Potential 3 (TRPC3) Channels
Trebak, M., Bird, G. S. J., McKay, R. R., Birnbaumer, L., & Putney, J. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300544200 · Cited by 167 · see citing works
Second messenger‐activated calcium influx in rat peritoneal mast cells.
Matthews, G., Neher, E., & Penner, R. (1989) · The Journal of Physiology · doi:10.1113/jphysiol.1989.sp017830 · Cited by 159 · see citing works
The endoplasmic reticulum: one continuous or several separate Ca2+ stores?
Petersen, O. H., Tepikin, A. V., & Park, M. K. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01787-2 · Cited by 156 · see citing works
Regulation of CRAC Channel Activity by Recruitment of Silent Channels to a High Open-probability Gating Mode
Prakriya, M., & Lewis, R. S. (2006) · The Journal of General Physiology · doi:10.1085/jgp.200609588 · Cited by 147 · see citing works
The Duration of Nuclear Residence of NFAT Determines the Pattern of Cytokine Expression in Human SCID T Cells
Feske, S., Draeger, R., Peter, H., Eichmann, K., & Rao, A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.297 · Cited by 134 · see citing works
Self-citation
Isolation of calcium current and its sensitivity to monovalent cations in dialysed ventricular cells of guinea‐pig.
Matsuda, H., & Noma, A. (1984) · The Journal of Physiology · doi:10.1113/jphysiol.1984.sp015517 · Cited by 130 · see citing works
Calcium fluxes in T lymphocytes.
Donnadieu, E., Bismuth, G., & Trautmann, A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35689-8 · Cited by 129 · see citing works
Ca2+ currents in cerebral artery smooth muscle cells of rat at physiological Ca2+ concentrations.
Rubart, M., Patlak, J. B., & Nelson, M. T. (1996) · The Journal of General Physiology · doi:10.1085/jgp.107.4.459 · Cited by 129 · see citing works
Oscillations of cytosolic calcium in single pancreatic acinar cells stimulated by acetylcholine
Yule, D. I., & Gallacher, D. V. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80951-7 · Cited by 128 · see citing works
Pulsatile Ca2+ extrusion from single pancreatic acinar cells during receptor-activated cytosolic Ca2+ spiking.
Tepikin, A. V., Voronina, S. G., Gallacher, D. V., et al. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49680-4 · Cited by 127 · see citing works
Enhancement of calcium signalling dynamics and stability by delayed modulation of the plasma‐membrane calcium‐ATPase in human T cells
Bautista, D. M., Hoth, M., & Lewis, R. S. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.016154 · Cited by 121 · see citing works
Characteristics of the second inward current in cells isolated from rat ventricular muscle
Mitchell, M. R., Powell, T. L., Terrar, D. A., et al. (1983) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1983.0084 · Cited by 118 · see citing works
Proteins, channels and crowded ions
Eisenberg, B. (2002) · Biophysical Chemistry · doi:10.1016/s0301-4622(02)00302-2 · Cited by 111 · see citing works
Reaction Diffusion Modeling of Calcium Dynamics with Realistic ER Geometry
Means, S., Smith, A. J., Shepherd, J. F., Shadid, J. N., Fowler, J., Wojcikiewicz, R. J. H., Mazel, T., Smith, G. D., & Wilson, B. S. (2006) · Biophysical Journal · doi:10.1529/biophysj.105.075036 · Cited by 108 · see citing works
Role of the store‐operated calcium entry proteins Stim1 and Orai1 in muscarinic cholinergic receptor‐stimulated calcium oscillations in human embryonic kidney cells
Wedel, B. J., Boyles, R., Putney, J. W., et al. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.125641 · Cited by 106 · see citing works
Store depletion triggers the calcium release-activated calcium current ( I CRAC ) in macrovascular endothelial cells: a comparison with Jurkat and embryonic kidney cell lines
Fasolato, C., & Nilius, B. (1998) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050605 · Cited by 102 · see citing works
CIF and other mysteries of the store-operated Ca2+-entry pathway
Bolotina, V. M., & Csutora, P. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.05.009 · Cited by 95 · see citing works
Single L‐type calcium channel conductance with physiological levels of calcium in chick ciliary ganglion neurons.
Church, P. J., & Stanley, E. F. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021665 · Cited by 94 · see citing works
Receptor regulation of calcium release and calcium permeability in parotid gland cells
Putney, J. W., Poggioli, J., & Weiss, S. J. (1981) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1981.0169 · Cited by 90 · see citing works
Mechanisms of valence selectivity in biological ion channels
Corry, B., & Chung, S. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5405-8 · Cited by 89 · see citing works
Calcium binding capacity of the cytosol and endoplasmic reticulum of mouse pancreatic acinar cells
Mogami, H., Gardner, J. M., Gerasimenko, O. V., et al. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0463p.x · Cited by 85 · see citing works
A Store-operated Calcium Channel in Drosophila S2 Cells
Yeromin, A. V., Roos, J., Stauderman, K. A., & Cahalan, M. D. (2004) · The Journal of General Physiology · doi:10.1085/jgp.200308982 · Cited by 80 · see citing works
Permeation and gating properties of the L-type calcium channel in mouse pancreatic beta cells.
Smith, P. A., Aschroft, F. M., & Fewtrell, C. (1993) · The Journal of General Physiology · doi:10.1085/jgp.101.5.767 · Cited by 75 · see citing works
Severe Combined Immunodeficiency
Schwab, M. (2011) · Springer eBooks · doi:10.1007/978-3-642-16483-5_6465 · Cited by 73 · see citing works
Two-Dimensional Determination of the Cellular Ca2+ Binding in Bovine Chromaffin Cells
Naraghi, M., Müller, T. H., & Neher, E. (1998) · Biophysical Journal · doi:10.1016/s0006-3495(98)77606-4 · Cited by 72 · see citing works
Region-specific Activity of the Plasma Membrane Ca2+Pump and Delayed Activation of Ca2+Entry Characterize the Polarized, Agonist-evoked Ca2+Signals in Exocrine Cells
Toescu, E. C., & Petersen, O. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.15.8528 · Cited by 66 · see citing works
Activation Mechanism for CRAC Current and Store-operated Ca2+ Entry
Csutora, P., Zarayskiy, V. V., Peter, K., Monje, F. J., Smani, T., Zakharov, S. I., Litvinov, D. Y., & Bolotina, V. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606504200 · Cited by 61 · see citing works
Immunoglobulin E receptor‐activated calcium conductance in rat mast cells.
Zhang, L., & McCloskey, M. A. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020567 · Cited by 60 · see citing works
Three cation influx currents activated by purinergic receptor stimulation in rat megakaryocytes.
Somasundaram, B., & Mahaut‐Smith, M. P. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020355 · Cited by 60 · see citing works
What is the mechanism of the calcium influx to pancreatic acinar cells evoked by secretagogues?
Petersen, O. H., & Maruyama, Y. (1983) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00584703 · Cited by 54 · see citing works
Activation of human T-lymphocytes
Petrzilka, G. E., & Schroeder, H. E. (1979) · Cell and Tissue Research · doi:10.1007/bf00238051 · Cited by 51 · see citing works
Ion Concentration-Dependence of Rat Cardiac Unitary L-Type Calcium Channel Conductance
Guia, A., Stern, M. D., Lakatta, E. G., et al. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)76242-x · Cited by 49 · see citing works
Function of a STIM1 Homologue in C. elegans: Evidence that Store-operated Ca2+ Entry Is Not Essential for Oscillatory Ca2+ Signaling and ER Ca2+ Homeostasis
Yan, X., Xing, J., Lorin‐Nebel, C., et al. (2006) · The Journal of General Physiology · doi:10.1085/jgp.200609611 · Cited by 49 · see citing works
Identification of Store-independent and Store-operated Ca2+ Conductances in Caenorhabditis elegans Intestinal Epithelial Cells
Estevez, A. Y., Roberts, R. K., & Strange, K. B. (2003) · The Journal of General Physiology · doi:10.1085/jgp.200308804 · Cited by 43 · see citing works
CRAC channel activity in C. elegans is mediated by Orai1 and STIM1 homologues and is essential for ovulation and fertility
Lorin‐Nebel, C., Xing, J., Yan, X., et al. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.124883 · Cited by 41 · see citing works
Store-operated Ca2+ entry: a STIMulating stOrai
Taylor, C. W. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.09.007 · Cited by 37 · see citing works
Calcium feedback mechanisms regulate oscillatory activity of a TRP‐like Ca2+ conductance in C. elegans intestinal cells
Estevez, A. Y., & Strange, K. B. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.091900 · Cited by 26 · see citing works
Receptor-Activated Calcium Entry Channels—Who Does What, and When?
Shuttleworth, T. J. (2004) · Science s STKE · doi:10.1126/stke.2432004pe40 · Cited by 24 · see citing works
An estimate of rapid cytoplasmic calcium buffering in a single smooth muscle cell
Daub, B., & Ganitkevich, V. (2000) · Cell Calcium · doi:10.1054/ceca.1999.0084 · Cited by 22 · see citing works
TRPM channel function in Caenorhabditis elegans
Baylis, H. A., & Goyal, K. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350129 · Cited by 11 · see citing works

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Hong, M.-P., Vu, K., Bautos, J., & Gelli, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.056218 · Cited by 54 · see citing works

Authors: Hogan, P. G., & Rao, A.
Affiliations: Harvard University (US)
Corresponding author: Hogan, Patrick G.
ORCID: Hogan, Patrick G.
Rao, Anjana
Venue: Trends in Biochemical Sciences
Publisher: Elsevier BV
Published: 2007-05
Volume: 32
Issue: 5
Pages: 235-245
ISSN: 0968-0004 (ISSN-L)
DOI: 10.1016/j.tibs.2007.03.009
OpenAlex: W2110248507
Cited by: 117
References: 110
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 9
FWCI: 1.58
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Trends in Biochemical Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (AI 40127, GM 075256)
Topics: Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords: store-operated calcium entry, STIM1, Orai1, intracellular calcium stores, calcium signaling, calcium influx, calcium homeostasis
MeSH terms: Animals, Biological Transport, Calcium, Humans, Models, Biological, Calcium Channels, Calcium Signaling

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Dissecting ICRAC, a store-operated calcium current

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