Cited by 367Bacterial Genetics and BiotechnologyDrug Transport and Resistance MechanismsEscherichia coli research studies

New substrates for TonB-dependent transport: do we only see the ‘tip of the iceberg’?

Schauer, Kristine, Rodionov, Dmitry A., de Reuse, Hilde·2008·Trends in Biochemical Sciences

Abstract

TonB-dependent transport is a mechanism for active uptake across the outer membrane of Gram-negative bacteria. The system promotes transport of rare nutrients and was thought to be restricted to iron complexes and vitamin B12. Recent experimental evidence of TonB-energized transport of nickel and different carbohydrates, in addition to bioinformatic-based predictions, challenges this notion and reveals that the number and variety of TonB-dependent substrates is underestimated. It is becoming clear that the chemical nature of the substrates, the energetic requirements for transport and the subsequent translocation across the cytoplasmic membrane can differ from those of the well-studied systems for iron complexes and vitamin B12. These findings question the understanding of TonB-dependent uptake and provide insights into the adaptation of bacteria to their environments.

Integrity signals

Registry

Crossref · 10.1016/j.tibs.2008.04.012

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69 of 69 references verified0 citation errors · 0 not checkable

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  • OM ferric siderophore receptors are TonB-dependent members of the porin superfamily, called TonB-dependent transporters or ligand-gated porins.

    “OM ferric siderophore receptors are TonB-dependent members of the porin superfamily.Hence, they are called TonB-dependent transporters (14) or ligand-gated porins [LGP (15)], in the latter case because ligand binding activates their TonB-depend ent transport process.”

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Authors
Schauer, K., Rodionov, D. A., & de Reuse, H.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Russian Academy of Sciences (RU)
Venue
Trends in Biochemical Sciences
Publisher
Elsevier BV
Published
2008-07
Volume
33
Issue
7
Pages
330-338
ISSN
0968-0004 (ISSN-L)
OpenAlex
W2130630244
Cited by
360
References
70
Citations by year
2026: 12 · 2025: 20 · 2024: 11 · 2023: 5 · 2022: 25 · 2021: 19 · 2020: 28 · 2019: 20 · 2018: 17 · 2017: 29 · 2016: 28 · 2015: 11 · 2014: 23 · 2013: 30 · 2012: 23
FWCI
1.78
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Biochemical Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutscher Akademischer Austauschdienst
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Keywords
TonB-dependent transport, Gram-negative bacteria, iron complexes, vitamin B12, nickel uptake, carbohydrate transport, substrate specificity, bacterial adaptation
MeSH terms
Bacterial Proteins, Biological Transport, Membrane Proteins, Models, Biological, Phylogeny, Vitamin B 12

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