The DOI matches its Crossref record; 104 of the 105 references it cites were found in a registry or an index.
Co-evolution of primordial membranes and membrane proteins
Open accessAbstract
Studies of the past several decades have provided major insights into the structural organization of biological membranes and mechanisms of many membrane molecular machines. However, the origin(s) of the membrane(s) and membrane proteins remains enigmatic. We discuss different concepts of the origin and early evolution of membranes with a focus on the evolution of the (im)permeability to charged molecules such as proteins, nucleic acids and small ions. Reconstruction of the evolution of F-type and A/V-type membrane ATPases (ATP synthases), which are either proton- or sodium-dependent, might help us to understand not only the origin of membrane bioenergetics but also of membranes themselves. We argue that evolution of biological membranes occurred as a process of co-evolution of lipid bilayers, membrane proteins and membrane bioenergetics.
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“Archaea and Bacteria contain primarily A/V-type and F-type subunits, respectively, and eukaryotes harbor complexes of both types”
From ATP synthase evolution on a cross-braced dated tree of life (2023) · cites this paper as [36]
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Metadata
- Authors
- Mulkidjanian, A. Y., Galperin, M. Y., & Koonin, E. V.
- Affiliations
- Osnabrück University (DE)
- National Institutes of Health (US)
- Corresponding author
- Mulkidjanian, Armen Y.
- Koonin, Eugene V.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 34
- Issue
- 4
- Pages
- 206-215
- ISSN
- 0968-0004 (ISSN-L)
- PMC
- PMC2752816
- OpenAlex
- W2153085358
- Cited by
- 169
- References
- 105
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 14 · 2023: 7 · 2022: 9 · 2021: 12 · 2020: 8 · 2019: 9 · 2018: 4 · 2017: 5 · 2016: 9 · 2015: 13 · 2014: 11 · 2013: 14 · 2012: 12
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- U.S. National Library of Medicine (Z01LM000073)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- membrane protein evolution, lipid bilayers, membrane permeability, membrane ATPase, F-type ATP synthase, membrane bioenergetics, coevolution
- MeSH terms
- Adenosine Triphosphatases, Cell Membrane, Biological Evolution, Membrane Proteins, Evolution, Molecular
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