The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Protein–protein interaction networks: how can a hub protein bind so many different partners?
Open accessAbstract
How can a single hub protein bind so many different partners? Numerous studies have sought differences between hubs and non-hubs to explain what makes a protein a hub and how a shared hub-binding site can be promiscuous, yet at the same time be specific. Here, we suggest that the problem is largely non-existent and resides in the popular representation of protein interaction networks: protein products derived from a single gene, even if different, are clustered in maps into a single node. This leads to the impression that a single protein binds to a very large number of partners. In reality, it does not; rather, protein networks reflect the combination of multiple proteins, each with a distinct conformation.
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“This mechanism appears to be in addition to other mechanisms adopted by hub proteins, such as covalent linkage to protein interaction domains, alternative splicing variants, etc.524”
From Protein Ensembles: How Does Nature Harness Thermodynamic Fluctuations for Life? The Diverse Functional Roles of Conformational Ensembles in the Cell (2016) · cites this paper as [524]
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Self-citationWei, G., Xi, W., Nussinov, R., & Ma, B. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00562 · Cited by 436
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Metadata
- Authors
- Tsai, C.-J., Ma, B., & Nussinov, R.
- Affiliations
- National Cancer Institute (US)
- Tel Aviv University (IL)
- Corresponding author
- Nussinov, Ruth
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 34
- Issue
- 12
- Pages
- 594-600
- ISSN
- 0968-0004 (ISSN-L)
- PMC
- PMC7292551
- OpenAlex
- W1998203484
- Cited by
- 138
- References
- 57
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 8 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 6 · 2014: 14 · 2013: 22 · 2012: 12
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (HHSN261200800001C)
- National Cancer Institute (Z01BC010440, HHSN261200800001E))
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- protein-protein interaction network, hub proteins, binding promiscuity, binding specificity, protein conformation, network representation, protein clustering
- MeSH terms
- Models, Biological, Protein Binding, Proteins
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