The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
Menin: a scaffold protein that controls gene expression and cell signaling
Open accessAbstract
The protein menin is encoded by the MEN1 gene, which is mutated in patients with multiple endocrine neoplasia type 1 (MEN1) syndrome. Although menin acts as a tumor suppressor in endocrine organs, it is required for leukemic transformation in mouse models. Menin possesses these dichotomous functions likely because it can both positively and negatively regulate gene expression as well as interact with a multitude of proteins with diverse functions. Here we review the recent progress in understanding the molecular mechanisms by which menin functions. The crystal structures of menin with different binding partners reveal that menin is a key scaffold protein that functionally crosstalks with various partners to regulate gene transcription and interplay with multiple signaling pathways.
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Cites
Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1
Chandrasekharappa, S. C., Guru, S. C., Manickam, P., Olufemi, S.-E., Collins, F. S., Emmert-Buck, M. R., Debelenko, L. V., Zhuang, Z., Lubensky, I. A., Liotta, L. A., et al. (1997) · Science · doi:10.1126/science.276.5311.404 · Cited by 2,082
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Clinical Practice Guidelines for Multiple Endocrine Neoplasia Type 1 (MEN1)
Thakker, R. V., Newey, P. J., Walls, G. V., Bilezikian, J., Dralle, H., Ebeling, P. R., Melmed, S., Sakurai, A., Tonelli, F., & Brandi, M. L. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1230 · Cited by 1,477
hDOT1L Links Histone Methylation to Leukemogenesis
Okada, Y., Feng, Q., Lin, Y., Jiang, Q., Li, Y., Coffield, V. M., Su, L., Xu, G., & Zhang, Y. (2005) · Cell · doi:10.1016/j.cell.2005.02.020 · Cited by 804
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Menin Associates with a Trithorax Family Histone Methyltransferase Complex and with the Hoxc8 Locus
Hughes, C. M., Rozenblatt-Rosen, O., Milne, T. A., Copeland, T. D., Levine, S. S., Lee, J. C., Hayes, D. N., Shanmugam, K. S., Bhattacharjee, A., Biondi, C. A., et al. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00081-4 · Cited by 645
Menin Interacts with the AP1 Transcription Factor JunD and Represses JunD-Activated Transcription
Agarwal, S. K., Guru, S. C., Heppner, C., Erdos, M. R., Collins, R. M., Park, S. Y., Saggar, S., Chandrasekharappa, S. C., Collins, F. S., Spiegel, A. M., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80967-8 · Cited by 627
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Cited by
Whole-genome landscape of pancreatic neuroendocrine tumours
Initiative, A. P. C. G., Scarpa, A., Chang, D. K., Nones, K., Corbo, V., Patch, A.-M., Bailey, P., Lawlor, R. T., Johns, A. L., Miller, D. K., et al. (2017) · Nature · doi:10.1038/nature21063 · Cited by 999
Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation
Funato, K., Major, T., Lewis, P. W., Allis, C. D., & Tabar, V. (2014) · Science · doi:10.1126/science.1253799 · Cited by 390
Deciphering the multi-scale, quantitative cis-regulatory code
Kim, S., & Wysocka, J. (2023) · Molecular Cell · doi:10.1016/j.molcel.2022.12.032 · Cited by 293
Hemming, M. L., Benson, M. R., Loycano, M. A., Anderson, J. A., Andersen, J. L., Taddei, M. L., Krivtsov, A. V., Aubrey, B. J., Cutler, J. A., Hatton, C., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0646 · Cited by 39
Gonadotropin gene transcription is activated by menin-mediated effects on the chromatin
Wijeweera, A., Haj, M., Feldman, A., Pnueli, L., Luo, Z., & Melamed, P. (2015) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.01.001 · Cited by 17
Metadata
- Authors
- Matkar, S., Thiel, A., & Hua, X.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 38
- Issue
- 8
- Pages
- 394-402
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W1981695027
- Cited by
- 292
- References
- 79
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- green
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