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Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1
Abstract
Multiple endocrine neoplasia–type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized by tumors in parathyroids, enteropancreatic endocrine tissues, and the anterior pituitary. DNA sequencing from a previously identified minimal interval on chromosome 11q13 identified several candidate genes, one of which contained 12 different frameshift, nonsense, missense, and in-frame deletion mutations in 14 probands from 15 families. The MEN1 gene contains 10 exons and encodes a ubiquitously expressed 2.8-kilobase transcript. The predicted 610–amino acid protein product, termed menin, exhibits no apparent similarities to any previously known proteins. The identification of MEN1 will enable improved understanding of the mechanism of endocrine tumorigenesis and should facilitate early diagnosis.
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Cited by
Espina, V., Wulfkuhle, J. D., Calvert, V. S., VanMeter, A., Zhou, W., Coukos, G., Geho, D. H., Petricoin, E. F., & Liotta, L. A. (2006) · Nature Protocols · doi:10.1038/nprot.2006.85 · Cited by 836
Self-citationMenin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes
Yokoyama, A., & Cleary, M. L. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.05.003 · Cited by 555
Epigenetic balance of gene expression by Polycomb and COMPASS families
Piunti, A., & Shilatifard, A. (2016) · Science · doi:10.1126/science.aad9780 · Cited by 524
Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
Grembecka, J., He, S., Shi, A., Purohit, T., Muntean, A. G., Sorenson, R. J., Showalter, H. D., Murai, M. J., Belcher, A. M., Hartley, T., et al. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.773 · Cited by 462
Zollinger-Ellison Syndrome: Clinical Presentation in 261 Patients
Roy, P. K., Venzon, D. J., Shojamanesh, H., Abou-Saif, A., Peghini, P., Doppman, J. L., Gibril, F., & Jensen, R. T. (2000) · Medicine · doi:10.1097/00005792-200011000-00004 · Cited by 351
Metadata
- Authors
- Chandrasekharappa, S. C., Guru, S. C., Manickam, P., Olufemi, S.-E., Collins, F. S., Emmert-Buck, M. R., Debelenko, L. V., Zhuang, Z., Lubensky, I. A., Liotta, L. A., Crabtree, J. S., Wang, Y., Roe, B. A., Weisemann, J., Boguski, M. S., Agarwal, S. K., Kester, M. B., Kim, Y. S., Heppner, C., Dong, Q., Spiegel, A. M., Burns, A. L., & Marx, S. J.
- Venue
- Science
- Published
- 1997-04-18
- Volume
- 276
- Issue
- 5311
- Pages
- 404-407
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2157212789
- Cited by
- 2,082
- References
- 0
- FWCI
- 114.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chandrasekharappa, S. C., Guru, S. C., Manickam, P., Olufemi, S.-E., Collins, F. S., Emmert-Buck, M. R., Debelenko, L. V., Zhuang, Z., Lubensky, I. A., Liotta, L. A., Crabtree, J. S., Wang, Y., Roe, B. A., Weisemann, J., Boguski, M. S., Agarwal, S. K., Kester, M. B., Kim, Y. S., Heppner, C., . . . Marx, S. J. (1997). Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1. Science. https://doi.org/10.1126/science.276.5311.404
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