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Cited by 309PI3K/AKT/mTOR signaling in cancerProtein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

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PTEN function: the long and the short of it

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Hopkins, Benjamin D., Hodakoski, Cindy, Barrows, Douglas, Mense, Sarah M., Parsons, Ramon E.·2014·Trends in Biochemical Sciences
DOI 10.1016/j.tibs.2014.02.006PMC PMC4043120
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Abstract

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a phosphatase that is frequently altered in cancer. PTEN has phosphatase-dependent and -independent roles, and genetic alterations in PTEN lead to deregulation of protein synthesis, the cell cycle, migration, growth, DNA repair, and survival signaling. PTEN localization, stability, conformation, and phosphatase activity are controlled by an array of protein-protein interactions and post-translational modifications. Thus, PTEN-interacting and -modifying proteins have profound effects on the tumor suppressive functions of PTEN. Moreover, recent studies identified mechanisms by which PTEN can exit cells, via either exosomal export or secretion, and act on neighboring cells. This review focuses on modes of PTEN protein regulation and ways in which perturbations in this regulation may lead to disease.

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Metadata

Authors
Hopkins, B. D., Hodakoski, C., Barrows, D., Mense, S. M., & Parsons, R. E.
Affiliations
Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Parsons, Ramon E.
ORCID
Venue
Trends in Biochemical Sciences
Publisher
Elsevier BV
Published
2014-04
Volume
39
Issue
4
Pages
183-190
ISSN
0968-0004 (ISSN-L)
DOI
10.1016/j.tibs.2014.02.006
PMC
PMC4043120
OpenAlex
W2109559424
Cited by
309
References
125
Citations by year
2026: 13 · 2025: 26 · 2024: 29 · 2023: 21 · 2022: 24 · 2021: 35 · 2020: 36 · 2019: 32 · 2018: 22 · 2017: 22 · 2016: 13 · 2015: 25 · 2014: 11
FWCI
2.23
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Biochemical Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (P01CA097403, R01CA082783, R01CA155117, R01CA184016)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
PTEN, phosphatase and tensin homolog, tumor suppressor, phosphatase activity, protein-protein interaction, post-translational modification, protein stability, cancer, cell cycle regulation, DNA repair, cell migration
MeSH terms
Animals, Cell Cycle, Gene Expression Regulation, Humans, Protein Processing, Post-Translational, Genomic Instability, PTEN Phosphohydrolase

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