Cited by 525Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and TherapyNuclear Receptors and Signaling

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Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

Ryan, Brent J., Hoek, Selim, Fon, Edward A., Wade-Martins, Richard·2015·Trends in Biochemical Sciences

DOI 10.1016/j.tibs.2015.02.003

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Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the preferential loss of dopaminergic neurons in the substantia nigra. Mitochondrial dysfunction is increasingly appreciated as a key determinant of dopaminergic neuronal susceptibility in PD and is a feature of both familial and sporadic disease, as well as in toxin-induced Parkinsonism. Recently, the mechanisms by which PD-associated mitochondrial proteins phosphatase and tensin homolog deleted on chromosome 10 (PTEN)-induced putative kinase 1 (PINK1) and parkin function and induce neurodegeneration have been identified. In addition, increasing evidence implicates other PD-associated proteins such as α-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) in mitochondrial dysfunction in genetic cases of PD with the potential for a large functional overlap with sporadic disease. This review highlights how recent advances in understanding familial PD-associated proteins have identified novel mechanisms and therapeutic strategies for addressing mitochondrial dysfunction in PD.

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
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Authors: Ryan, B. J., Hoek, S., Fon, E. A., & Wade-Martins, R.
Affiliations: University of Oxford (GB)
Montreal Neurological Institute and Hospital (CA)
ORCID: Ryan, Brent J.
Fon, Edward A.
Venue: Trends in Biochemical Sciences
Publisher: Elsevier BV
Published: 2015-04
Volume: 40
Issue: 4
Pages: 200-210
ISSN: 0968-0004 (ISSN-L)
DOI: 10.1016/j.tibs.2015.02.003
OpenAlex: W2021439462
Cited by: 524
References: 115
Citations by year: 2026: 25 · 2025: 30 · 2024: 37 · 2023: 28 · 2022: 45 · 2021: 65 · 2020: 56 · 2019: 50 · 2018: 63 · 2017: 53 · 2016: 52 · 2015: 20
FWCI: 8.25
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Biochemical Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: Parkinson's UK (J-0901)
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: Parkinson's disease, mitochondrial dysfunction, mitophagy, PINK1, Parkin, alpha-synuclein, LRRK2, dopaminergic neurons, familial Parkinson's disease, sporadic Parkinson's disease, neurodegeneration, treatment options
MeSH terms: Animals, Humans, Mitochondria, Parkinson Disease, alpha-Synuclein

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Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

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