Pyruvate and Metabolic Flexibility: Illuminating a Path Toward Selective Cancer Therapies

Olson, Kristofor A., Schell, John C., Rutter, Jared·2016·Trends in Biochemical Sciences

Cited by (156)

Items 101–156 of 156

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  4. Machine learning based on metabolomics unveils neutrophil extracellular trap-related metabolic signatures in non-small cell lung cancer patients undergoing chemoimmunotherapy
    Li Yu-ning, Jialin Su, Shuhua Tan, Xing‐Long Chen, Tianli Cheng, Zhou Jiang, Yongzhong Luo, Lemeng Zhang · 2024 · World Journal of Clinical Cases
  5. SIX1: A Prognostic Biomarker in Uterine Corpus Endometrial Carcinoma
    Guohua Chen, Quangang Zhao, Xin Yang, Taiyong Wang, Shuhong Yuan, Meng Qi · 2022 · Combinatorial Chemistry & High Throughput Screening
  6. A Pyrazolate Osmium(VI) Nitride Exhibits Anticancer Activity through Modulating Protein Homeostasis in HepG2 Cells
    Chengyang Huang, Wanqiong Huang, Pengchao Ji, Fuling Song, Tao Liu, Meiyang Li, Hongzhi Guo, Yong‐Liang Huang, Cuicui Yu, Chuanxian Wang et al. · 2022 · International Journal of Molecular Sciences
  7. Metabolic Reprogramming and Molecular Rewiring in Cancer: Therapeutic Opportunities
    Anna Meiliana, Nurrani Mustika Dewi, Andi Wijaya · 2021 · The Indonesian Biomedical Journal
  8. p38 MAPK-mediated suppression of Nrf2-MPC2 axis drives metabolic reprogramming which confers imatinib resistance in blast crisis phase of chronic myeloid leukemia
    Manish Bhat, Mythreyi Narasimhan, Ashutosh Shelar, Raghavendra Patwardhan, Santosh Kumar Sandur, Rukmini Govekar · 2025 · Experimental Cell Research
  9. A novel ISM‐SAM strategy, based on gas chromatography/mass spectrometry analysis, to compensate for matrix effects in the determination of pyruvic acid
    Jinhui Zhao, Mingjia Zhang, Jing Guo, Fanyu Meng, Xiaowei Liu, Jiaying Yu, Liyan Liu · 2021 · Rapid Communications in Mass Spectrometry
  10. NDR kinase tricornered genetically interacts with Ccm3 and metabolic enzymes in Drosophila melanogaster tracheal development
    Joshua Hudson, Sayantanee Paul, Alexey N. Veraksa, Amin S. Ghabrial, Kieran F. Harvey, Carole L.C. Poon · 2023 · G3 Genes Genomes Genetics
  11. Metabolomic analysis reveals the biological characteristics of giant congenital melanocytic nevi
    Yajie Chang, Tao Dai, Ge Song, Sanxi Wang, Huile Pei, Guiping Shen, Jianghua Feng · 2024 · Journal of Pharmaceutical and Biomedical Analysis
  12. Characterization of PBMC secretome: Iron-quercetin preconditioning enhances pro-angiogenic and tissue regeneration factors for potential autologous diabetic wound healing applications
    Jiraporn Kantapan, Phattarawadee Innuan, Chonticha Sirikul, Nampeung Anukul, Gwenaël Rolin, Nathupakorn Dechsupa · 2025 · Biochemistry and Biophysics Reports
  13. Histone deacetylases in cancer metabolic reprogramming
    Yu Hyun Jeon, Hyeyeong Seo, Ji Woo Youn, Jung Hoan Yoo, Sang Wu Lee, Soo Yeon Oh, So Hee Kwon · 2026 · Experimental & Molecular Medicine
  14. Mechanisms of chemotherapy resistance in cervical cancer
    Rahaba Makgotso Marima, Benny Mosoane, Nompumelelo Zamokuhle Mtshali, Afra Basera, Mankgopo Kgatle, Godfrey Grech, Zodwa Dlamini · 2024 · Elsevier eBooks
  15. MetDeeCINE: Deciphering Metabolic Regulation through Deep Learning and Multi-Omics
    Takumi Ito, Satoshi Ohno, Yiran Wang, Saori Uematsu, Shinya Kuroda, Hideyuki Shimizu · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  16. Revealing mTOR-Associated lncRNAs as biomarkers and therapeutic targets in lung Adenocarcinoma: Insights from transcriptomic pathways and following a validation with Mendelian randomization
    Jiajian Huang, Xiao Ming Zhu · 2025 · Next research.
  17. The pyruvate dehydrogenase complex in concert with the DNA/RNA-binding protein YBX1 regulates cell senescence and tumorigenesis
    Huan Chen, Jing Shi, Qiuping Wang, Kunming Liang, Shaojun Pei, Yi Zhang, Xiang Shi, Jing Lv, Tian Xia, Di Chen et al. · 2025 · Journal of Biological Chemistry
  18. Metabolic marker profiling of circulating tumour cells in NSCLC patients treated with osimertinib: focus on MCT1 and MCT4
    Karolina Mangani, Evangelia Pantazaka, Evi S. Lianidou, Vassilis Georgoulias, Athanasios Panayotis Kotsakis, Athina N. Markou, Galatea Kallergi · 2026 · Therapeutic Advances in Medical Oncology
  19. Efficient Synthesis of Pyruvic Acid from Biomass based on Gas‐Liquid‐Solid Triphase Bioelectrochemical Cascade Reaction
    Lihui Huang, Siyu Zou, Mengli Zeng, Yaolan Li, Zhiping Liu, Jun Zhang, Xinjian Feng · 2026 · ChemSusChem
  20. Low-dose chronic exposure to hemin and kynurenine enhances metabolic adaptation in a colorectal cancer cell model
    Elien Alderweireldt, Charlotte Grootaert, Stijn Luca, Filip Van Nieuwerburgh, Andreja Rajković, John H. Van Camp, Olivier De Wever · 2026 · Scientific Reports
  21. Proteomic and Metabolomic Profiling Reveal Mitochondrial Transplantation–Mediated Reprogramming in Gastric Cancer Cells
    Ping‐Chen Chen, Chen‐Kai Liu, Ching-Chung Tsai, Erna Sulistyowati, Fu‐An Li, Chung‐Jung Liu, Deng‐Chyang Wu, Shih-Hsuan Chou, Fu-Chen Kuo, Bin Huang · 2026 · The Kaohsiung Journal of Medical Sciences
  22. Western-style diet does not negatively affect the healthy aging benefits of lifelong restrictive feeding
    Aaffien C. Reijne, Alžbeta Talarovičová, Alex Coolen, Jan E. Bruggink, Jolita Čiapaitė, Aycha Bleeker, Albert Kornelis Groen, Dirk‐Jan Reijngoud, Barbara M. Bakker, Gertjan van Dijk · 2022 · Nutrition and Healthy Aging
  23. Intake of palmitic acid and its association with metabolic flexibility in middle-aged individuals: a preliminary study
    Elisabetta Murru, Gianfranca Carta, Claudia Manca, A. Leone, Chiara Murru, Michele Ruggiu, Roberto Solinas, Roberta Montisci, Filippo Tocco, Sebastiano Banni · 2023 · Redox Experimental Medicine
  24. Neonatal necrotizing enterocolitis attenuates adult asthma via eosinophil ferroptosis
    Jiahao Lai, Hao Zhang, Hongfu Li, Fei Li, Dabin Huang, Dan Yang Huang, Xuanna Zhao, Yue Wang, Chi Jiang, Runzhong Huang et al. · 2025 · Cellular Signalling
  25. Potential Mechanism Of Nanoparticles Targeting Cancer Metabolic Pathways: Novel Approaches For Cancer Treatment
    Zia Ud Din, Yasmeen Khan, Amn Zia, Nasira Anbreen, Rifasa Sultan · 2023 · Advances In Clinical And Medical Research
  26. Mitochondria Remodeling in Cancer
    Kenneth J. Dornfeld, Andrew J. Skildum · 2018 · Springer eBooks
  27. Substratbilanzen von Kolonkarzinomen des Menschen während parenteraler Ernährung – Eine Pilotstudie
    Eggert Holm, Barbara Heumann, Dirk Jentschura · 2018 · Aktuelle Ernährungsmedizin
  28. Therapeutic Approaches Targeting Glucose, Glutamine and Lipid Metabolism in Multiple Myeloma
    Berkcan Doğan, Cansu Ozal-Coskun, Reyhan Diz Küçükkaya, Engin Kaptan · 2019 · LLM Dergi
  29. Analysis of Hematopoietic Stem Progenitor Cell Metabolism
    Giorgia Scapin, Marie C. Goulard, Priyanka R. Dharampuriya, Jennifer L. Cillis, Dhvanit I. Shah · 2019 · Journal of Visualized Experiments
  30. A New Pyrazolate Osmium(VI) Nitrido Complex Exhibits Anticancer Activity Through Modulating Protein Homeostasis
    Wen‐Xiu Ni, Chengyang Huang, Wanqiong Huang, Pengchao Ji, Fuling Song, Chuanxian Wang, Tao Liu, Meiyang Li, Hongzhi Guo, Cuicui Yu et al. · 2020 · Research Square
  31. Determinants of the Postprandial Triglyceride Response to a High-fat Meal in Healthy Overweight and Obese Adults.
    Stephanie M. G. Wilson, Adam P. Maes, Carl J. Yeoman, Seth T. Walk, Mary P. Miles · 2021 · Research Square
  32. Magnolol-Functionalized with Naphthalene Sulfonate and Silicone Group as a Novel Receptor For Pyruvate and its Application in Tumor Metabolism Reprogramming
    Tingrui Zhang, Peng Lu, Luo Fan, Dongbin Zheng, Fu Peng, Zhixing Cao, Cheng Yun Peng, Yuyu Fang, Yuzhi Li · 2023 · SSRN Electronic Journal
  33. ZIC1 inhibits the growth of glioblastoma cell U87MG by enhancing CUL5 expression
    Yanna Li, Jiao Li, Weiyi Zhan, Yue Yu, Sihong Xu, Jie Xu, Jia Mei Song, Chen Zhang · 2024 · Research Square
  34. Exploring the Impact of Chrono-Nutrition on Metabolism and Weight Management: A Comprehensive Review
    Mandira Chatterjee, Tanima Paul Das · 2023 · International Journal of Science and Research (IJSR)
  35. Fatty acid-binding proteins and breast cancer
    Asim K. Duttaroy · 2024 · Elsevier eBooks
  36. Tumor metabolism and anti-tumor immunity
    Inna S. Serganova, Roberta Zappasodi · 2024 · Elsevier eBooks
  37. MPC2 Overexpression Drives Mitochondrial Oxidative Phosphorylation and Promotes Progression in Diffuse Large B-Cell Lymphoma
    Haoneng Wu, Qi Zhao, Xiaobo Ma, Ying Zhao, Qing Wang, Jinguang Bai, Songling Huang · 2025 · Biochemical Genetics
  38. FAHD1-mediated pyruvate metabolism in hepatocellular carcinoma: Multi-omics and causal genetic evidence
    Huang Jin, Shijie Liang, Jiamin Sun, Huaping Chen · 2025 · Human Genetics and Genomics Advances
  39. Additional file 1 of Determinants of the postprandial triglyceride response to a high-fat meal in healthy overweight and obese adults
    Wilson, Stephanie M., Adam P. Maes, Carl J. Yeoman, Seth T. Walk, Mary P. Miles · 2021 · Figshare
  40. Additional file 3 of Determinants of the postprandial triglyceride response to a high-fat meal in healthy overweight and obese adults
    Wilson, Stephanie M., Adam P. Maes, Carl J. Yeoman, Seth T. Walk, Mary P. Miles · 2021 · Figshare
  41. Additional file 5 of Determinants of the postprandial triglyceride response to a high-fat meal in healthy overweight and obese adults
    Wilson, Stephanie M., Adam P. Maes, Carl J. Yeoman, Seth T. Walk, Mary P. Miles · 2021 · Figshare
  42. Additional file 4 of Determinants of the postprandial triglyceride response to a high-fat meal in healthy overweight and obese adults
    Wilson, Stephanie M., Adam P. Maes, Carl J. Yeoman, Seth T. Walk, Mary P. Miles · 2021 · Figshare
  43. Additional file 2 of The fitness trade-off between growth and stress resistance determines the phenotypic landscape
    Kim, Dongsan, Chae Young Hwang, Cho, Kwang-Hyun · 2024 · Figshare
  44. Additional file 6 of Determinants of the postprandial triglyceride response to a high-fat meal in healthy overweight and obese adults
    Wilson, Stephanie M., Adam P. Maes, Carl J. Yeoman, Seth T. Walk, Mary P. Miles · 2021 · Figshare
  45. Additional file 3 of The fitness trade-off between growth and stress resistance determines the phenotypic landscape
    Kim, Dongsan, Chae Young Hwang, Cho, Kwang-Hyun · 2024 · Figshare
  46. Additional file 1 of The fitness trade-off between growth and stress resistance determines the phenotypic landscape
    Kim, Dongsan, Chae Young Hwang, Cho, Kwang-Hyun · 2024 · Figshare
  47. Additional file 2 of Determinants of the postprandial triglyceride response to a high-fat meal in healthy overweight and obese adults
    Wilson, Stephanie M., Adam P. Maes, Carl J. Yeoman, Seth T. Walk, Mary P. Miles · 2021 · Figshare
  48. Long-term high throughput agitation culturing with real-time metabolic profiling
    David Lenzen, Sarah Holbrook, Da-Han Kuan, Qinglan Ling, Chen-Han Tsai · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  49. Decoding mitochondrial signaling: neutrophil-tumor cell crosstalk in orchestrating cancer progression
    Qian Shen, Xue Pan, Junchen Li, Yi Li, Jin Lin, Fudong Liu, Xiaochen Jiang, Chunyan Zhang, Bo Pang · 2026 · Journal of Translational Medicine
  50. Role of PKM2 Tetramer in Modulating Endothelial Mitochondrial Dysfunction in a Rat Model of Chronic Thromboembolic Pulmonary Hypertension
    M-X Yang, Z-Z Wu, D-W Wu, M-H Chen, Q-X Wu, N Shao, C-S Deng · 2026 · Physiological Research
  51. Études précliniques des effets d'un mimétique de la superoxyde dismutase, le MnTBAP sur la croissance tumorale et la réponse à la radiothérapie, la modulation de l'interactome des éspèces réactives du stress et l'homéostasie mitochondriale dans un contexte de glioblastome
    Elise Malard · 2023 · theses.fr (ABES)
  52. The pyruvate transporter hermes regulates autophagy and health by modulating ROS production
    Panagiotis D. Velentzas, Fei Chai, Eric H. Baehrecke · 2026 · Cell Reports
  53. Long-term, high-throughput agitated cell culture with real-time metabolic profiling
    David Lenzen, Sarah Holbrook, Yu-Kai Lai, Da-Han Kuan, Qinglan Ling, Chen-Han Tsai · 2026 · Biotechnology and Bioprocess Engineering
  54. Targeting the PD-L1-induced PDK4/GLS metabolic axis overcomes anti-PD-1 resistance in non-small cell lung cancer
    Wenxin Lian, Hui Yang, Yuqi Zhang, Chenchen Liu, Chunyao Fang, Mengyue Xu, Yixing Yang, Yan Wang, Runqiu Jiang, Jing Xu et al. · 2026 · Journal for ImmunoTherapy of Cancer
  55. Association of pyruvate metabolism-related genes with immune infiltration and prognostic value in lung adenocarcinoma
    Fei Wang, Qiong Liang, Xiaotian Liang, Ying Liang, Qi Qin, Chaomian Yang · 2026 · Journal of Pharmacology and Experimental Therapeutics
  56. Monocarboxylate transporters in physiology and cancer: from fundamentals to clinical translation
    Julieta Afonso, Joana Pereira-Vieira, Vera Miranda‐Gonçalves, Sara Granja, Celine Marques Pinheiro, Fátima Baltazar · 2026 · Physiological Reviews