Pyruvate and metabolic flexibility: illuminating a path toward selective cancer therapies
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Dysregulated metabolism is an emerging hallmark of cancer, and there is abundant interest in developing therapies to selectively target these aberrant metabolic phenotypes. Sitting at the decision-point between mitochondrial carbohydrate oxidation and aerobic glycolysis (i.e., the 'Warburg effect'), the synthesis and consumption of pyruvate is tightly controlled and is often differentially regulated in cancer cells. This review examines recent efforts toward understanding and targeting mitochondrial pyruvate metabolism, and addresses some of the successes, pitfalls, and significant challenges of metabolic therapy to date.
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Lactate produced from glycolysis is excreted from the cell or used in biosynthetic reactions such as aspartate synthesis.
“Lactate, produced from glycolysis, is excreted from the cell or used in biosynthetic reactions such as aspartate synthesis (1).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [1]
Reducing metabolic flexibility in cancer cells may lead to potential treatment options, because metabolic interference can come at a substantial cost to oncogenic potential.
“Indeed, reducing metabolic flexibility in cancer cells may lead to potential treatment options, because metabolic interference can come at a substantial cost to oncogenic potential (1).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [1]
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Biochemistry, Aerobic Glycolysis
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- Authors
- Olson, K. A., Schell, J. C., & Rutter, J.
- Affiliations
- University of Utah (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Rutter, Jared
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 41
- Issue
- 3
- Pages
- 219-230
- ISSN
- 0968-0004 (ISSN-L)
- PMC
- PMC4783264
- OpenAlex
- W2266126951
- Cited by
- 154
- References
- 108
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 17 · 2023: 21 · 2022: 11 · 2021: 22 · 2020: 18 · 2019: 14 · 2018: 7 · 2017: 8 · 2016: 6
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of General Medical Sciences (R01GM094232)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007115)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- pyruvate metabolism, cancer metabolism, metabolic flexibility, aerobic glycolysis, Warburg effect, metabolic therapy
- MeSH terms
- Glycolysis, Humans, Neoplasms, Oxidation-Reduction, Pyruvic Acid
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