Cited by 178Genomics and Chromatin DynamicsEpigenetics and DNA MethylationSirtuins and Resveratrol in Medicine

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The Metabolic Impact on Histone Acetylation and Transcription in Ageing

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Peleg, Shahaf, Feller, Christian, Ladurner, Andreas G., Imhof, Axel·2016·Trends in Biochemical Sciences

DOI 10.1016/j.tibs.2016.05.008

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Abstract

Loss of cellular homeostasis during aging results in altered tissue functions and leads to a general decline in fitness and, ultimately, death. As animals age, the control of gene expression, which is orchestrated by multiple epigenetic factors, degenerates. In parallel, metabolic activity and mitochondrial protein acetylation levels also change. These two hallmarks of aging are effectively linked through the accumulating evidence that histone acetylation patterns are susceptible to alterations in key metabolites such as acetyl-CoA and NAD(+), allowing chromatin to function as a sensor of cellular metabolism. In this review we discuss experimental data supporting these connections and provide a context for the possible medical and physiological relevance.

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Authors: Peleg, S., Feller, C., Ladurner, A. G., & Imhof, A.
Affiliations: Ludwig-Maximilians-Universität München (DE)
ETH Zurich (CH)
Center for Integrated Protein Science Munich (DE)
Corresponding author: Peleg, Shahaf
Imhof, Axel
ORCID: Peleg, Shahaf
Ladurner, Andreas G.
Imhof, Axel
Venue: Trends in Biochemical Sciences
Publisher: Elsevier BV
Published: 2016-08
Volume: 41
Issue: 8
Pages: 700-711
ISSN: 0968-0004 (ISSN-L)
DOI: 10.1016/j.tibs.2016.05.008
OpenAlex: W2418484636
Cited by: 178
References: 130
Citations by year: 2026: 12 · 2025: 10 · 2024: 13 · 2023: 21 · 2022: 22 · 2021: 23 · 2020: 18 · 2019: 27 · 2018: 11 · 2017: 16 · 2016: 5
FWCI: 1.78
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Trends in Biochemical Sciences (publishedVersion, cc-by)
PubMed (publishedVersion)
Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
ETH Zürich Research Collection
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords: histone acetylation, aging, cellular metabolism, acetyl-CoA, NAD+, mitochondrial protein acetylation, epigenetic regulation, chromatin, gene expression, metabolic homeostasis
MeSH terms: Acetylation, Aging, Animals, Histones, Humans, Transcription, Genetic

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The Metabolic Impact on Histone Acetylation and Transcription in Ageing

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