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The ageing epigenome and its rejuvenation

Zhang, Weiqi, Qu, Jing, Liu, Guang-Hui, Belmonte, Juan Carlos Izpisua·2020·Nature Reviews Molecular Cell Biology
DOI 10.1038/s41580-019-0204-5
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Abstract

Ageing is characterized by the functional decline of tissues and organs and the increased risk of ageing-associated disorders. Several 'rejuvenating' interventions have been proposed to delay ageing and the onset of age-associated decline and disease to extend healthspan and lifespan. These interventions include metabolic manipulation, partial reprogramming, heterochronic parabiosis, pharmaceutical administration and senescent cell ablation. As the ageing process is associated with altered epigenetic mechanisms of gene regulation, such as DNA methylation, histone modification and chromatin remodelling, and non-coding RNAs, the manipulation of these mechanisms is central to the effectiveness of age-delaying interventions. This Review discusses the epigenetic changes that occur during ageing and the rapidly increasing knowledge of how these epigenetic mechanisms have an effect on healthspan and lifespan extension, and outlines questions to guide future research on interventions to rejuvenate the epigenome and delay ageing processes.

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  • Loss of epigenetic information has been proposed as a critical cause of aging that precedes many other aspects of age-related deterioration.

    “Among the hallmarks of aging, loss of epigenetic information has been proposed as a critical cause of aging that precedes many other aspects of age-related deterioration 2,[5][6][7][8] .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [8]

  • Epigenetic networks are delicate and their disruption probably initiates other events that cause cells to lose their function over time.

    “suggesting that epigenetic networks are delicate and that their disruption probably initiates other events that cause cells to lose their function over time 8,9 .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [8]

  • Perturbing epigenetic networks leads to extensive changes in gene expression that directly impact proteostasis, nutrient sensing, senescence and several other hallmarks of aging.

    “Perturbing these epigenetic networks leads to extensive changes in gene expression that directly impact proteostasis, nutrient sensing, senescence and several other hallmarks of aging, suggesting that epigenetic networks are delicate and that their disruption probably initiates other events that cause cells to lose their function over time 8,9 .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [8]

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Zhang, W., Qu, J., Liu, G.-H., & Belmonte, J. C. I.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2020-02-04
Volume
21
Issue
3
Pages
137-150
ISSN
  • 1471-0072
  • 1471-0080
DOI
10.1038/s41580-019-0204-5
Cited by
458
References
54
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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