Cited by 295Mitochondrial Function and PathologyMetabolism and Genetic DisordersBiochemical Acid Research Studies

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Mitochondrial Complex II: At the Crossroads

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Bezawork-Geleta, Ayenachew, Rohlena, Jakub, Dong, Lanfeng, Pacak, Karel, Neuzil, Jiri·2017·Trends in Biochemical Sciences

DOI 10.1016/j.tibs.2017.01.003PMC PMC7441821

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Abstract

Mitochondrial complex II (CII), also called succinate dehydrogenase (SDH), is a central purveyor of the reprogramming of metabolic and respiratory adaptation in response to various intrinsic and extrinsic stimuli and abnormalities. In this review we discuss recent findings regarding SDH biogenesis, which requires four known assembly factors, and modulation of its enzymatic activity by acetylation, succinylation, phosphorylation, and proteolysis. We further focus on the emerging role of both genetic and epigenetic aberrations leading to SDH dysfunction associated with various clinical manifestations. This review also covers the recent discovery of the role of SDH in inflammation-linked pathologies. Conceivably, SDH is a potential target for several hard-to-treat conditions, including cancer, that remains to be fully exploited.

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Authors: Bezawork-Geleta, A., Rohlena, J., Dong, L., Pacak, K., & Neuzil, J.
Affiliations: Czech Academy of Sciences (CZ)
ORCID: Rohlena, Jakub
Venue: Trends in Biochemical Sciences
Publisher: Elsevier BV
Published: 2017-04
Volume: 42
Issue: 4
Pages: 312-325
ISSN: 0968-0004 (ISSN-L)
DOI: 10.1016/j.tibs.2017.01.003
PMC: PMC7441821
OpenAlex: W2586320694
Cited by: 295
References: 118
Citations by year: 2026: 30 · 2025: 36 · 2024: 35 · 2023: 36 · 2022: 30 · 2021: 45 · 2020: 31 · 2019: 29 · 2018: 17 · 2017: 5
FWCI: 2.10
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Biochemical Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
ASEP (submittedVersion, public-domain)
Griffith Research Online (submittedVersion)
Funders: Australian Research Council (15-02203S)
Czech Science Foundation (16-12719S, 17-20904S)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
Keywords: succinate dehydrogenase, assembly factors, post-translational modification, acetylation, succinylation, phosphorylation, proteolysis, epigenetic aberrations, inflammation, cancer, metabolic reprogramming, respiratory adaptation
MeSH terms: Animals, Humans, Inflammation, Mitochondria, Succinate Dehydrogenase

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Mitochondrial Complex II: At the Crossroads

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