The DOI matches its Crossref record; 153 of the 153 references it cites were found in a registry or an index.
Biochemistry of Mitochondrial Coenzyme Q Biosynthesis
Open accessAbstract
Coenzyme Q (CoQ, ubiquinone) is a redox active lipid produced across all domains of life that functions in electron transport and oxidative phosphorylation and whose deficiency causes human diseases. Yet, CoQ biosynthesis has not been fully defined in any organism. Several proteins with unclear molecular functions facilitate CoQ biosynthesis through unknown means, and multiple steps in the pathway are catalyzed by currently unidentified enzymes. Here we highlight recent progress toward filling these knowledge gaps through both traditional biochemistry and cutting-edge “omics” approaches. To help fill the remaining gaps, we present questions framed by the recently discovered CoQ biosynthetic complex and by putative biophysical barriers. Mapping CoQ biosynthesis, metabolism, and transport pathways has great potential to enhance treatment of numerous human diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology
Pagliarini, D. J., Calvo, S. E., Chang, B., Sheth, S. A., Vafai, S. B., Ong, S.-E., Walford, G. A., Sugiana, C., Boneh, A., Chen, W. K., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.016 · Cited by 1,994
Self-citationProteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging
Martell, J. D., Ting, A. Y., Rhee, H., Zou, P., Udeshi, N. D., Mootha, V. K., & Carr, S. A. (2012) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 1,330
Stocker, R., Bowry, V. W., & Frei, B. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.5.1646 · Cited by 793
Mitochondrial disorders as windows into an ancient organelle
Vafai, S. B., & Mootha, V. K. (2012) · Nature · doi:10.1038/nature11707 · Cited by 737
Pyrimidine Nucleotide Biosynthesis in Animals: Genes, Enzymes, and Regulation of UMP Biosynthesis
Jones, M. E. (1980) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.49.070180.001345 · Cited by 721
Mitochondrial protein import: from proteomics to functional mechanisms
Schmidt, O., Pfanner, N., & Meisinger, C. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2959 · Cited by 717
Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.
Frei, B., Kim, M. C., & Ames, B. N. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4879 · Cited by 620
Isolation of a quinone from beef heart mitochondria
Crane, F. L., Hatefi, Y., Lester, R. L., & Widmer, C. (1957) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(57)90457-2 · Cited by 587
A New View into the Regulation of Purine Metabolism: The Purinosome
Pedley, A. M., & Benkovic, S. J. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.09.009 · Cited by 576
PET genes of Saccharomyces cerevisiae
Tzagoloff, A., & Dieckmann, C. L. (1990) · Microbiological Reviews · doi:10.1128/mmbr.54.3.211-225.1990 · Cited by 551
Cited by
Targeting Ferroptosis as a Vulnerability in Cancer
Lei, G., Zhuang, L., & Gan, B. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00459-0 · Cited by 2,252
Mitochondrial regulation of ferroptosis
Gan, B. (2021) · Journal of Cell Biology · doi:10.1083/jcb.202105043 · Cited by 601
Peng, K.-Y., Watt, M. J., Rensen, S., Greve, J. W., Huynh, K., Jayawardana, K. S., Meikle, P. J., & Meex, R. C. R. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m085613 · Cited by 220
Disorders of Human Coenzyme Q10 Metabolism: An Overview
Hargreaves, I., Heaton, R. A., & Mantle, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186695 · Cited by 182
Coenzyme Q10 deficiencies: pathways in yeast and humans
Awad, A. M., Bradley, M. C., Fernández-del-Río, L., Nag, A., Tsui, H. S., & Clarke, C. F. (2018) · Essays in Biochemistry · doi:10.1042/ebc20170106 · Cited by 137
Metadata
- Authors
- Stefely, J. A., & Pagliarini, D. J.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 42
- Issue
- 10
- Pages
- 824-843
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2754373993
- Cited by
- 331
- References
- 153
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Biochemistry of Mitochondrial Coenzyme Q Biosynthesis. https://app.cochat.ai/papers/10.1016/j.tibs.2017.06.008
- The paper
- Stefely, J. A., & Pagliarini, D. J. (2017). Biochemistry of Mitochondrial Coenzyme Q Biosynthesis. Trends in Biochemical Sciences. https://doi.org/10.1016/j.tibs.2017.06.008
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
